PT3774823T - Polimorfo de neridronato de sódio e processo para a sua preparação - Google Patents

Polimorfo de neridronato de sódio e processo para a sua preparação

Info

Publication number
PT3774823T
PT3774823T PT197219900T PT19721990T PT3774823T PT 3774823 T PT3774823 T PT 3774823T PT 197219900 T PT197219900 T PT 197219900T PT 19721990 T PT19721990 T PT 19721990T PT 3774823 T PT3774823 T PT 3774823T
Authority
PT
Portugal
Prior art keywords
polymorph
preparation process
sodium neridronate
neridronate
sodium
Prior art date
Application number
PT197219900T
Other languages
English (en)
Original Assignee
Abiogen Pharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa
Publication of PT3774823T publication Critical patent/PT3774823T/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PT197219900T 2018-04-10 2019-04-10 Polimorfo de neridronato de sódio e processo para a sua preparação PT3774823T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18166508.4A EP3553067A1 (en) 2018-04-10 2018-04-10 Polymorph of sodium neridronate and preparation process thereof

Publications (1)

Publication Number Publication Date
PT3774823T true PT3774823T (pt) 2022-02-28

Family

ID=62495533

Family Applications (1)

Application Number Title Priority Date Filing Date
PT197219900T PT3774823T (pt) 2018-04-10 2019-04-10 Polimorfo de neridronato de sódio e processo para a sua preparação

Country Status (18)

Country Link
US (1) US10815257B2 (pt)
EP (2) EP3553067A1 (pt)
JP (1) JP7042359B2 (pt)
CN (1) CN112204043B (pt)
AU (1) AU2019250339B2 (pt)
CA (2) CA3096316C (pt)
CY (1) CY1125059T1 (pt)
DK (1) DK3774823T3 (pt)
ES (1) ES2908072T3 (pt)
HR (1) HRP20220248T1 (pt)
HU (1) HUE058239T2 (pt)
LT (1) LT3774823T (pt)
MX (1) MX385449B (pt)
PL (1) PL3774823T3 (pt)
PT (1) PT3774823T (pt)
SI (1) SI3774823T1 (pt)
SM (1) SMT202200166T1 (pt)
WO (1) WO2019197437A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900008391A1 (it) 2019-06-07 2020-12-07 Abiogen Pharma Spa Procedimento di preparazione del polimorfo f di sodio neridronato

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3032871A1 (de) * 1980-09-01 1982-04-15 Vysoká škola chemicko-technologická Praha, Praha 6-amino-1-hydroxyhexyliden-diphosphonsaeure, ihre salze und ein verfahren zur herstellung derselben
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1246992B (it) 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
KR100681282B1 (ko) * 2002-05-17 2007-02-12 테바 파마슈티컬 인더스트리즈 리미티드 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법
WO2008004000A1 (en) 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
CN101125863B (zh) * 2007-08-31 2011-07-27 浙江新东港药业股份有限公司 一种阿仑膦酸新的制备方法
WO2010035664A1 (ja) * 2008-09-24 2010-04-01 田辺三菱製薬株式会社 ビスホスホン酸誘導体の製法
CN104072538A (zh) * 2014-07-10 2014-10-01 陕西汉江药业集团股份有限公司 一种双膦酸盐类药物的合成方法

Also Published As

Publication number Publication date
EP3774823B1 (en) 2021-12-08
WO2019197437A1 (en) 2019-10-17
CA3096316C (en) 2022-02-22
CA3126088A1 (en) 2019-10-17
JP7042359B2 (ja) 2022-03-25
LT3774823T (lt) 2022-03-10
US20190308999A1 (en) 2019-10-10
CA3096316A1 (en) 2019-10-17
US10815257B2 (en) 2020-10-27
CN112204043B (zh) 2023-11-17
EP3553067A1 (en) 2019-10-16
SMT202200166T1 (it) 2022-05-12
ES2908072T3 (es) 2022-04-27
AU2019250339B2 (en) 2021-07-15
JP2021512939A (ja) 2021-05-20
MX385449B (es) 2025-03-18
SI3774823T1 (sl) 2022-04-29
EP3774823A1 (en) 2021-02-17
PL3774823T3 (pl) 2022-05-02
HUE058239T2 (hu) 2022-07-28
CA3126088C (en) 2023-09-12
DK3774823T3 (da) 2022-02-14
MX2020010744A (es) 2021-08-19
HRP20220248T1 (hr) 2022-04-29
CY1125059T1 (el) 2024-02-16
CN112204043A (zh) 2021-01-08
AU2019250339A1 (en) 2020-11-26

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