PT3810582T - Uma abordagem de ativação de c-h organo-pseudocatalítica em um só recipiente para a preparação de vortioxetina e intermediário de vortioxetina - Google Patents
Uma abordagem de ativação de c-h organo-pseudocatalítica em um só recipiente para a preparação de vortioxetina e intermediário de vortioxetinaInfo
- Publication number
- PT3810582T PT3810582T PT197342504T PT19734250T PT3810582T PT 3810582 T PT3810582 T PT 3810582T PT 197342504 T PT197342504 T PT 197342504T PT 19734250 T PT19734250 T PT 19734250T PT 3810582 T PT3810582 T PT 3810582T
- Authority
- PT
- Portugal
- Prior art keywords
- vortioxetine
- pseudocatalytic
- organo
- pot
- preparation
- Prior art date
Links
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 title 2
- 229960002263 vortioxetine Drugs 0.000 title 2
- 238000010499 C–H functionalization reaction Methods 0.000 title 1
- 238000005580 one pot reaction Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
- C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
- C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2018025164 | 2018-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3810582T true PT3810582T (pt) | 2024-04-09 |
Family
ID=67107369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT197342504T PT3810582T (pt) | 2018-06-20 | 2019-06-19 | Uma abordagem de ativação de c-h organo-pseudocatalítica em um só recipiente para a preparação de vortioxetina e intermediário de vortioxetina |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11198671B2 (pt) |
| EP (1) | EP3810582B1 (pt) |
| JP (1) | JP7389761B2 (pt) |
| CN (1) | CN112424177B (pt) |
| ES (1) | ES2976985T3 (pt) |
| PL (1) | PL3810582T3 (pt) |
| PT (1) | PT3810582T (pt) |
| SI (1) | SI3810582T1 (pt) |
| WO (1) | WO2019242889A1 (pt) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| RS58683B1 (sr) | 2012-01-03 | 2019-06-28 | H Lundbeck As | Postupak za proizvodnju 1-[2-(2,4-dimetil-fenilsulfanil)-fenil]-piperazina |
| WO2014161976A1 (en) | 2013-04-04 | 2014-10-09 | Lek Pharmaceuticals D.D. | New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine |
| JP2014234376A (ja) | 2013-06-04 | 2014-12-15 | 国立大学法人 名古屋工業大学 | トリフルオロメタンスルホニル基を含む超原子価ヨウ素イリドを用いるトリフルオロメチルチオ化法 |
| EP2930171A1 (en) * | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN103922978A (zh) | 2014-05-07 | 2014-07-16 | 江南大学 | 一种简单、绿色制备新型材料芳香族硫醚的方法 |
| CN104230852B (zh) | 2014-08-29 | 2017-03-29 | 桑迪亚医药技术（上海）有限责任公司 | 沃替西汀的合成方法 |
| EP3023417B1 (en) | 2014-11-21 | 2017-06-28 | Dipharma Francis S.r.l. | Process for the preparation of an antidepressant and the intermediates thereof |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| AU2016224930A1 (en) * | 2015-02-25 | 2017-09-07 | Lupin Limited | Process for the preparation of Vortioxetine |
| CN104829557B (zh) | 2015-04-23 | 2017-06-27 | 山东百诺医药股份有限公司 | 一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用 |
| IN2015CH06843A (pt) * | 2015-12-23 | 2017-06-30 | ||
| IN201641001393A (pt) * | 2016-01-14 | 2017-07-21 | ||
| WO2017215636A1 (zh) | 2016-06-16 | 2017-12-21 | 广东东阳光药业有限公司 | 二芳基硫醚哌嗪类化合物及其制备方法和用途 |
| WO2018154451A1 (en) * | 2017-02-23 | 2018-08-30 | Unichem Laboratories Ltd | An improved process for preparation and purification of vortioxetine hydrobromide |
-
2019
- 2019-06-19 PT PT197342504T patent/PT3810582T/pt unknown
- 2019-06-19 CN CN201980041114.1A patent/CN112424177B/zh active Active
- 2019-06-19 SI SI201930732T patent/SI3810582T1/sl unknown
- 2019-06-19 PL PL19734250.4T patent/PL3810582T3/pl unknown
- 2019-06-19 WO PCT/EP2019/025189 patent/WO2019242889A1/en not_active Ceased
- 2019-06-19 EP EP19734250.4A patent/EP3810582B1/en active Active
- 2019-06-19 JP JP2020571494A patent/JP7389761B2/ja active Active
- 2019-06-19 US US17/251,808 patent/US11198671B2/en active Active
- 2019-06-19 ES ES19734250T patent/ES2976985T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20210163407A1 (en) | 2021-06-03 |
| PL3810582T3 (pl) | 2024-05-13 |
| SI3810582T1 (sl) | 2024-05-31 |
| EP3810582B1 (en) | 2024-01-03 |
| CN112424177B (zh) | 2024-05-03 |
| US11198671B2 (en) | 2021-12-14 |
| ES2976985T3 (es) | 2024-08-14 |
| CN112424177A (zh) | 2021-02-26 |
| EP3810582A1 (en) | 2021-04-28 |
| WO2019242889A1 (en) | 2019-12-26 |
| JP7389761B2 (ja) | 2023-11-30 |
| JP2021527705A (ja) | 2021-10-14 |
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