PT3883647T - Macrólidos com 13 membros substituídos com c10-alquileno e suas utilizações - Google Patents

Macrólidos com 13 membros substituídos com c10-alquileno e suas utilizações

Info

Publication number
PT3883647T
PT3883647T PT198213514T PT19821351T PT3883647T PT 3883647 T PT3883647 T PT 3883647T PT 198213514 T PT198213514 T PT 198213514T PT 19821351 T PT19821351 T PT 19821351T PT 3883647 T PT3883647 T PT 3883647T
Authority
PT
Portugal
Prior art keywords
alkylene
membered macrolides
macrolides
membered
Prior art date
Application number
PT198213514T
Other languages
English (en)
Original Assignee
Harvard College
Zikani Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=68916562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3883647(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College, Zikani Therapeutics Inc filed Critical Harvard College
Publication of PT3883647T publication Critical patent/PT3883647T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT198213514T 2018-11-19 2019-11-18 Macrólidos com 13 membros substituídos com c10-alquileno e suas utilizações PT3883647T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862769383P 2018-11-19 2018-11-19

Publications (1)

Publication Number Publication Date
PT3883647T true PT3883647T (pt) 2026-02-26

Family

ID=68916562

Family Applications (1)

Application Number Title Priority Date Filing Date
PT198213514T PT3883647T (pt) 2018-11-19 2019-11-18 Macrólidos com 13 membros substituídos com c10-alquileno e suas utilizações

Country Status (18)

Country Link
US (1) US12552825B2 (pt)
EP (1) EP3883647B1 (pt)
JP (2) JP7551610B2 (pt)
KR (1) KR102929869B1 (pt)
CN (1) CN113573779A (pt)
AU (1) AU2019385333B2 (pt)
BR (1) BR112021009624A2 (pt)
CA (1) CA3120148A1 (pt)
DK (1) DK3883647T3 (pt)
ES (1) ES3063764T3 (pt)
FI (1) FI3883647T3 (pt)
IL (1) IL283194B2 (pt)
LT (1) LT3883647T (pt)
MX (1) MX2021005423A (pt)
PT (1) PT3883647T (pt)
SG (1) SG11202105227QA (pt)
SM (1) SMT202600094T1 (pt)
WO (1) WO2020106627A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202313065A (zh) * 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2023250513A1 (en) * 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
JP2025530776A (ja) 2022-09-01 2025-09-17 ジカニ セラピューティクス， インコーポレイテッド １３員環マクロライドを使用した家族性大腸腺腫症の処置

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides
UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків
NZ526120A (en) * 1999-11-09 2005-02-25 Pfizer Prod Inc 13-membered azalides and their use as antibiotic agents
CA2407448A1 (en) * 2000-04-27 2001-11-01 Pfizer Products Inc. The use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals
JP4311203B2 (ja) 2001-08-08 2009-08-12 大正製薬株式会社 １１ａ−アザライド化合物及びその製造方法
HRP20030381B1 (en) * 2003-05-14 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A
WO2004108744A2 (en) * 2003-05-19 2004-12-16 Prasad K Deshpande Azalides and azaketolides having antimicrobial activity
WO2005042554A1 (en) * 2003-10-30 2005-05-12 Rib-X Pharmaceuticals, Inc. Bifunctional macrolide heterocyclic compounds and methods of making and using the same
WO2007012464A1 (en) * 2005-07-26 2007-02-01 Merckle Gmbh Macrolide conjugates of pyrrolizine and indolizine compounds as inhibitors of 5-lipooxygenase and cyclooxygenase
JP5015016B2 (ja) * 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
WO2012001089A1 (en) * 2010-07-01 2012-01-05 Novartis Ag Antibiotic compositions
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
US9982005B2 (en) 2013-04-04 2018-05-29 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
CA2978670A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Synthesis of desosamines
US20180273573A1 (en) * 2015-10-01 2018-09-27 Memorial Sloan-Kettering Cancer Center Inhibitors of menaquinone biosynthesis
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof

Also Published As

Publication number Publication date
EP3883647A1 (en) 2021-09-29
ES3063764T3 (en) 2026-04-20
IL283194B1 (en) 2024-11-01
AU2019385333A1 (en) 2021-07-01
CN113573779A (zh) 2021-10-29
MX2021005423A (es) 2021-09-08
SMT202600094T1 (it) 2026-03-09
US12552825B2 (en) 2026-02-17
IL283194A (en) 2021-06-30
JP2022507776A (ja) 2022-01-18
JP7551610B2 (ja) 2024-09-17
BR112021009624A2 (pt) 2021-08-10
US20230093692A1 (en) 2023-03-23
CA3120148A1 (en) 2020-05-28
KR102929869B1 (ko) 2026-02-23
AU2019385333B2 (en) 2025-04-17
KR20210133950A (ko) 2021-11-08
FI3883647T3 (fi) 2026-03-25
EP3883647B1 (en) 2026-02-11
IL283194B2 (en) 2025-03-01
DK3883647T3 (da) 2026-03-23
JP2025000636A (ja) 2025-01-07
SG11202105227QA (en) 2021-06-29
LT3883647T (lt) 2026-03-25
WO2020106627A1 (en) 2020-05-28

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