PT4178548T - Composições farmacêuticas compreendendo (s)-4-(4-(4-((((2-(2,6 dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrilo e métodos de utilização das mesmas - Google Patents

Composições farmacêuticas compreendendo (s)-4-(4-(4-((((2-(2,6 dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrilo e métodos de utilização das mesmas

Info

Publication number
PT4178548T
PT4178548T PT217551191T PT21755119T PT4178548T PT 4178548 T PT4178548 T PT 4178548T PT 217551191 T PT217551191 T PT 217551191T PT 21755119 T PT21755119 T PT 21755119T PT 4178548 T PT4178548 T PT 4178548T
Authority
PT
Portugal
Prior art keywords
dioxopiperidin
oxoisoindolin
fluorobenzonitrile
piperazin
oxy
Prior art date
Application number
PT217551191T
Other languages
English (en)
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of PT4178548T publication Critical patent/PT4178548T/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PT217551191T 2020-07-07 2021-07-06 Composições farmacêuticas compreendendo (s)-4-(4-(4-((((2-(2,6 dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrilo e métodos de utilização das mesmas PT4178548T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063048998P 2020-07-07 2020-07-07

Publications (1)

Publication Number Publication Date
PT4178548T true PT4178548T (pt) 2024-10-22

Family

ID=77338767

Family Applications (1)

Application Number Title Priority Date Filing Date
PT217551191T PT4178548T (pt) 2020-07-07 2021-07-06 Composições farmacêuticas compreendendo (s)-4-(4-(4-((((2-(2,6 dioxopiperidin-3-il)-1-oxoisoindolin-4-il)oxi)metil)benzil)piperazin-1-il)-3-fluorobenzonitrilo e métodos de utilização das mesmas

Country Status (22)

Country Link
US (2) US12472176B2 (pt)
EP (2) EP4178548B1 (pt)
JP (1) JP2023533314A (pt)
KR (1) KR20230035598A (pt)
CN (1) CN115867261B (pt)
AU (1) AU2021305052A1 (pt)
BR (1) BR112023000248A2 (pt)
CA (1) CA3184460A1 (pt)
DK (1) DK4178548T3 (pt)
ES (1) ES2988714T3 (pt)
FI (1) FI4178548T3 (pt)
HR (1) HRP20241162T1 (pt)
HU (1) HUE068476T2 (pt)
IL (1) IL299657A (pt)
LT (1) LT4178548T (pt)
MX (1) MX2023000292A (pt)
PL (1) PL4178548T3 (pt)
PT (1) PT4178548T (pt)
RS (1) RS66027B1 (pt)
SI (1) SI4178548T1 (pt)
SM (1) SMT202400374T1 (pt)
WO (1) WO2022010854A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230042057A (ko) * 2020-07-20 2023-03-27 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 황-함유 이소인돌린 유도체, 및 이의 제조 방법 및 이의 의학적 용도

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US5855887A (en) 1995-07-25 1999-01-05 The Regents Of The University Of California Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
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WO2004056875A1 (en) 2002-12-23 2004-07-08 Wyeth Antibodies against pd-1 and uses therefor
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
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Also Published As

Publication number Publication date
FI4178548T3 (fi) 2024-08-14
RS66027B1 (sr) 2024-11-29
SI4178548T1 (sl) 2024-10-30
EP4178548A1 (en) 2023-05-17
PL4178548T3 (pl) 2024-11-12
ES2988714T3 (es) 2024-11-21
US12472176B2 (en) 2025-11-18
BR112023000248A2 (pt) 2023-01-31
KR20230035598A (ko) 2023-03-14
EP4438043B1 (en) 2026-02-25
IL299657A (en) 2023-03-01
CN115867261B (zh) 2025-05-23
HUE068476T2 (hu) 2024-12-28
US20260034122A1 (en) 2026-02-05
US20230270742A1 (en) 2023-08-31
HRP20241162T1 (hr) 2024-11-22
DK4178548T3 (da) 2024-08-19
AU2021305052A1 (en) 2023-02-09
EP4438043C0 (en) 2026-02-25
CA3184460A1 (en) 2022-01-13
EP4178548B1 (en) 2024-07-24
JP2023533314A (ja) 2023-08-02
EP4438043A2 (en) 2024-10-02
LT4178548T (lt) 2024-09-25
SMT202400374T1 (it) 2024-11-15
CN115867261A (zh) 2023-03-28
EP4438043A3 (en) 2024-11-27
MX2023000292A (es) 2023-02-09
WO2022010854A1 (en) 2022-01-13

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