PT657431E - Esteres de 4-fenil-3-substituida-1,4-di-hidropiridina com actividade cerebral - Google Patents
Esteres de 4-fenil-3-substituida-1,4-di-hidropiridina com actividade cerebralInfo
- Publication number
- PT657431E PT657431E PT94118672T PT94118672T PT657431E PT 657431 E PT657431 E PT 657431E PT 94118672 T PT94118672 T PT 94118672T PT 94118672 T PT94118672 T PT 94118672T PT 657431 E PT657431 E PT 657431E
- Authority
- PT
- Portugal
- Prior art keywords
- esters
- phenyl
- substituted
- hydridine
- dihydro
- Prior art date
Links
- 230000002490 cerebral effect Effects 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- -1 4-Phenyl 3-substituted 1,4-dihydropyridine esters Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 150000003935 benzaldehydes Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4342196A DE4342196A1 (de) | 1993-12-10 | 1993-12-10 | Neue 4-Phenyl-substituierte 1,4-Dihydropyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT657431E true PT657431E (pt) | 2003-07-31 |
Family
ID=6504701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94118672T PT657431E (pt) | 1993-12-10 | 1994-11-28 | Esteres de 4-fenil-3-substituida-1,4-di-hidropiridina com actividade cerebral |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5731333A (pt) |
| EP (1) | EP0657431B1 (pt) |
| JP (1) | JPH07196613A (pt) |
| AT (1) | ATE232849T1 (pt) |
| CA (1) | CA2137519A1 (pt) |
| DE (2) | DE4342196A1 (pt) |
| DK (1) | DK0657431T3 (pt) |
| ES (1) | ES2191671T3 (pt) |
| PT (1) | PT657431E (pt) |
| SI (1) | SI0657431T1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7238197B2 (en) * | 2000-05-30 | 2007-07-03 | Devax, Inc. | Endoprosthesis deployment system for treating vascular bifurcations |
| WO2000024716A1 (en) * | 1998-10-23 | 2000-05-04 | Ajinomoto Co., Inc. | Dihydropyridine derivatives and drug compositions containing the same |
| MX2011012015A (es) * | 2009-05-15 | 2012-04-30 | Univ Kentucky Res Found | Tratamiento de deterioro cognitivo leve y enfermedad de alzheimer. |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1963188A1 (de) * | 1969-12-17 | 1971-06-24 | Bayer Ag | Neue Cyanphenyl-1,4-dihydropyridinderivate |
| US3932646A (en) * | 1971-04-10 | 1976-01-13 | Farbenfabriken Bayer Ag | Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate |
| DE2218644C3 (de) * | 1972-04-18 | 1982-08-19 | Bayer Ag, 5090 Leverkusen | Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2815578C2 (de) * | 1978-04-11 | 1986-01-16 | Bayer Ag, 5090 Leverkusen | Neue pharmazeutische Verwendung von Nimodipin |
| SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2935451A1 (de) * | 1979-09-01 | 1981-03-19 | Bayer Ag, 5090 Leverkusen | Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel |
| DE3208628A1 (de) * | 1982-03-10 | 1983-09-22 | Bayer Ag, 5090 Leverkusen | Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3209274A1 (de) * | 1982-03-13 | 1983-09-15 | Bayer Ag, 5090 Leverkusen | Pyridincarbonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3239273A1 (de) * | 1982-10-23 | 1984-04-26 | Bayer Ag, 5090 Leverkusen | Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| US5137889A (en) * | 1983-12-02 | 1992-08-11 | Otsuka Pharmaceutical Co., Ltd. | Dihydropyridine derivatives and process for preparing the same |
| EP0394243A1 (de) * | 1987-05-22 | 1990-10-31 | Byk Gulden Lomberg Chemische Fabrik GmbH | Verfahren zur herstellung von carbonsäuren |
| DE3718398A1 (de) * | 1987-06-02 | 1988-12-22 | Troponwerke Gmbh & Co Kg | Neue kombinationspraeparate mit antidepressiver wirkung |
| US5114946A (en) * | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| DE3806277A1 (de) * | 1988-02-27 | 1989-09-07 | Troponwerke Gmbh & Co Kg | Verwendung von 1,4-dihydropyridin-derivaten |
| DE4011695A1 (de) * | 1990-04-11 | 1991-10-17 | Bayer Ag | Verwendung von n-alkylierten 1,4-dihydropyridindicarbonsaeureestern als arzneimittel, neue verbindungen und verfahren zu ihrer herstellung |
| DE4125271A1 (de) * | 1991-07-31 | 1993-02-11 | Bayer Ag | Neue n-alkylierte 1,4-dihydropyridindicarbonsaeureester |
| WO1993006082A1 (en) * | 1991-09-13 | 1993-04-01 | Merck & Co., Inc. | Process for the preparation of 4-substituted-1,4-dihydropyridines |
| DK0595164T3 (da) * | 1992-10-30 | 1997-05-26 | Bayer Ag | 4-Heterocyclophenyl-substituerede dihydropyridiner |
-
1993
- 1993-12-10 DE DE4342196A patent/DE4342196A1/de not_active Withdrawn
-
1994
- 1994-11-28 DE DE59410244T patent/DE59410244D1/de not_active Expired - Fee Related
- 1994-11-28 AT AT94118672T patent/ATE232849T1/de not_active IP Right Cessation
- 1994-11-28 EP EP94118672A patent/EP0657431B1/de not_active Expired - Lifetime
- 1994-11-28 DK DK94118672T patent/DK0657431T3/da active
- 1994-11-28 SI SI9430435T patent/SI0657431T1/xx unknown
- 1994-11-28 ES ES94118672T patent/ES2191671T3/es not_active Expired - Lifetime
- 1994-11-28 PT PT94118672T patent/PT657431E/pt unknown
- 1994-12-02 US US08/348,696 patent/US5731333A/en not_active Expired - Fee Related
- 1994-12-07 CA CA002137519A patent/CA2137519A1/en not_active Abandoned
- 1994-12-07 JP JP6330293A patent/JPH07196613A/ja active Pending
-
1997
- 1997-12-10 US US08/988,114 patent/US6066655A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0657431B1 (de) | 2003-02-19 |
| DE4342196A1 (de) | 1995-06-14 |
| ES2191671T3 (es) | 2003-09-16 |
| ATE232849T1 (de) | 2003-03-15 |
| EP0657431A1 (de) | 1995-06-14 |
| JPH07196613A (ja) | 1995-08-01 |
| CA2137519A1 (en) | 1995-06-11 |
| SI0657431T1 (en) | 2003-04-30 |
| DK0657431T3 (da) | 2003-06-10 |
| US6066655A (en) | 2000-05-23 |
| US5731333A (en) | 1998-03-24 |
| DE59410244D1 (de) | 2003-03-27 |
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