PT67654B - Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex - Google Patents

Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Info

Publication number: PT67654B
Authority: PT; Portugal
Prior art keywords: aryl; preparation; direct coupling; magnesium halide; propionic acids
Prior art date: 1977-02-16

Application number

PT67654A

Other languages

English (en)

Portuguese (pt)

Other versions

PT67654A (en

Original Assignee

Syntex Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-16

Filing date

1978-02-14

Publication date

1979-07-19

1977-12-19 Priority claimed from US05/863,290 external-priority patent/US4144397A/en

1978-02-14 Application filed by Syntex Corp filed Critical Syntex Corp

1978-03-01 Publication of PT67654A publication Critical patent/PT67654A/pt

1979-07-19 Publication of PT67654B publication Critical patent/PT67654B/pt

Links

-1 magnesium halide Chemical class 0.000 title abstract 2
230000008878 coupling Effects 0.000 title 1
238000010168 coupling process Methods 0.000 title 1
238000005859 coupling reaction Methods 0.000 title 1
229910052749 magnesium Inorganic materials 0.000 title 1
239000011777 magnesium Substances 0.000 title 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
239000000010 aprotic solvent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/14—Monocyclic dicarboxylic acids
- C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
- C07C63/24—1,3 - Benzenedicarboxylic acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT67654A 1977-02-16 1978-02-14 Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex PT67654B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76907077A	1977-02-16	1977-02-16
US05/863,290 US4144397A (en)	1977-02-16	1977-12-19	Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Publications (2)

Publication Number	Publication Date
PT67654A PT67654A (en)	1978-03-01
PT67654B true PT67654B (en)	1979-07-19

Family

ID=27118118

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT67654A PT67654B (en)	1977-02-16	1978-02-14	Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex

Country Status (18)

Country	Link
CH (3)	CH640499A5 (da)
DD (3)	DD137099A5 (da)
DK (1)	DK156898C (da)
ES (1)	ES467037A1 (da)
FI (1)	FI64571C (da)
HK (2)	HK25383A (da)
HU (2)	HU183210B (da)
IE (1)	IE46614B1 (da)
IL (1)	IL54019A (da)
IT (1)	IT1107880B (da)
MY (2)	MY8400039A (da)
NO (1)	NO145435C (da)
NZ (1)	NZ186472A (da)
PL (1)	PL108144B1 (da)
PT (1)	PT67654B (da)
SE (3)	SE430155B (da)
SU (2)	SU1003749A3 (da)
YU (3)	YU41427B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8915531D0 (en) *	1989-07-06	1989-08-23	Ass Octel	Alkaline earth,transition and lanthanide metal inorganic salt complexes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1459084A (en) *	1973-05-24	1976-12-22	Boots Co Ltd	Preparation of arylalkanoic acid

1978
- 1978-02-09 HU HU802271A patent/HU183210B/hu unknown
- 1978-02-09 HU HU78SI1618A patent/HU179309B/hu unknown
- 1978-02-09 FI FI780417A patent/FI64571C/fi not_active IP Right Cessation
- 1978-02-10 IL IL54019A patent/IL54019A/xx unknown
- 1978-02-10 IT IT67279/78A patent/IT1107880B/it active
- 1978-02-13 DK DK064578A patent/DK156898C/da not_active IP Right Cessation
- 1978-02-13 SE SE7801648A patent/SE430155B/sv not_active IP Right Cessation
- 1978-02-13 YU YU329/78A patent/YU41427B/xx unknown
- 1978-02-14 IE IE320/78A patent/IE46614B1/en not_active IP Right Cessation
- 1978-02-14 NZ NZ186472A patent/NZ186472A/xx unknown
- 1978-02-14 PT PT67654A patent/PT67654B/pt unknown
- 1978-02-15 NO NO780524A patent/NO145435C/no unknown
- 1978-02-15 DD DD78203717A patent/DD137099A5/xx not_active IP Right Cessation
- 1978-02-15 CH CH167578A patent/CH640499A5/de not_active IP Right Cessation
- 1978-02-15 SU SU782580499A patent/SU1003749A3/ru active
- 1978-02-15 DD DD78214578A patent/DD148212A5/de not_active IP Right Cessation
- 1978-02-15 DD DD78214577A patent/DD145107A5/de not_active IP Right Cessation
- 1978-02-16 PL PL1978204667A patent/PL108144B1/pl unknown
- 1978-02-16 ES ES467037A patent/ES467037A1/es not_active Expired
- 1978-10-11 SU SU782672198A patent/SU963462A3/ru active
1982
- 1982-03-09 SE SE8201458A patent/SE453093B/sv not_active IP Right Cessation
- 1982-03-09 SE SE8201459A patent/SE453094B/sv not_active IP Right Cessation
- 1982-09-07 CH CH531782A patent/CH640498A5/de not_active IP Right Cessation
- 1982-09-07 CH CH531882A patent/CH640500A5/de not_active IP Right Cessation
1983
- 1983-03-10 YU YU587/83A patent/YU43302B/xx unknown
- 1983-03-10 YU YU588/83A patent/YU42843B/xx unknown
- 1983-08-04 HK HK253/83A patent/HK25383A/xx not_active IP Right Cessation
- 1983-08-04 HK HK254/83A patent/HK25483A/xx not_active IP Right Cessation
1984
- 1984-12-30 MY MY39/84A patent/MY8400039A/xx unknown
- 1984-12-30 MY MY40/84A patent/MY8400040A/xx unknown

Also Published As

Publication number	Publication date
DK156898B (da)	1989-10-16
IL54019A (en)	1981-06-29
HU183210B (en)	1984-04-28
DD137099A5 (de)	1979-08-15
CH640499A5 (en)	1984-01-13
SE8201459L (sv)	1982-03-09
CH640498A5 (en)	1984-01-13
YU32978A (en)	1983-06-30
IT1107880B (it)	1985-12-02
YU43302B (en)	1989-06-30
DK156898C (da)	1990-03-12
SE8201458L (sv)	1982-03-09
NO145435B (no)	1981-12-14
IE46614B1 (en)	1983-08-10
DD148212A5 (de)	1981-05-13
FI780417A7 (fi)	1978-08-17
IT7867279A0 (it)	1978-02-10
YU58883A (en)	1983-12-31
PT67654A (en)	1978-03-01
PL108144B1 (pl)	1980-03-31
NO780524L (no)	1978-08-17
MY8400039A (en)	1984-12-31
FI64571B (fi)	1983-08-31
DK64578A (da)	1978-08-17
HK25483A (en)	1983-08-12
IE780320L (en)	1978-08-16
NO145435C (no)	1982-03-24
SE453094B (sv)	1988-01-11
YU58783A (en)	1983-12-31
NZ186472A (en)	1979-08-31
FI64571C (fi)	1983-12-12
MY8400040A (en)	1984-12-31
CH640500A5 (en)	1984-01-13
YU41427B (en)	1987-06-30
ES467037A1 (es)	1978-11-01
SE430155B (sv)	1983-10-24
HK25383A (en)	1983-08-12
YU42843B (en)	1988-12-31
DD145107A5 (de)	1980-11-19
SU1003749A3 (ru)	1983-03-07
SE453093B (sv)	1988-01-11
SU963462A3 (ru)	1982-09-30
HU179309B (en)	1982-09-28
PL204667A1 (pl)	1978-12-04
IL54019A0 (en)	1978-04-30
SE7801648L (sv)	1978-08-17

Publication	Publication Date	Title
FR2381736A1 (fr)	1978-09-22	Complexe mixte d'halogenure de magnesium de certains acides 2-aryl-propioniques et procede pour leur preparation
PT67654A (en)	1978-03-01	Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex
ES423233A1 (es)	1976-07-01	Procedimiento para la preparacion de nuevas 2-fenilamino- imidazolinas-(2) sustituidas.
GB1479156A (en)	1977-07-06	11,12-secoprostaglandins
ES445263A1 (es)	1977-06-01	Un procedimiento para preparar un nuevo derivado de dimer- captoetileter.
JPS5665838A (en)	1981-06-03	Preparation of beta-alkoxymethoxymethyl halide
JPS5265237A (en)	1977-05-30	Preparation of hydroquinone derivatives
JPS55139332A (en)	1980-10-31	Phenol ether compound
JPS5265236A (en)	1977-05-30	Preparation of hydroquinone derivatives
JPS55153777A (en)	1980-11-29	Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester
JPS55118425A (en)	1980-09-11	Preparation of alkenyl halide
ES472098A1 (es)	1979-03-16	Procedimiento para la preparacion de un complejo de haloge- nuro de magnesio mixto de acido alfa-bromo propionico.
JPS5473772A (en)	1979-06-13	Isoxazoline-3-one derivative
JPS56166172A (en)	1981-12-21	Preparation of alkylindoles
ZA78922B (en)	1979-09-26	Preparation of 2-aryl-propionic acids by direct coupling utilizing a mixed magnesium halide complex
JPS57209240A (en)	1982-12-22	Preparation of magnesium enolate of isophorone
JPS5634647A (en)	1981-04-06	Preparation of phenoxyalkene derivative
KR830000668A (ko)	1983-04-18	직접 커플링 방식에 의한 2-아릴-프로피온산 중간물질의 제조방법
ES472097A1 (es)	1979-04-01	Procedimiento para la obtencion de un complejo de halogenurode magnesio mixto del acido 2-aril propionico.
JPS5444636A (en)	1979-04-09	Production of tetrabromobisphenol-s
JPS549250A (en)	1979-01-24	Synthesis of n-mono-substituted aminobenzophenone derivatives
JPS56113795A (en)	1981-09-07	2'-deoxy-3',5'-di-o-acetyl-5-fluorouridine derivative, its preparation and antitumor agent containing the same
JPS5622743A (en)	1981-03-03	Preparation of 2-hydroxy-4-alkoxybenzophenones
ES478504A1 (es)	1979-05-16	Un procedimiento para la preparacion de trans-2,8-dibencil- ciclooctanona.
JPS559059A (en)	1980-01-22	Preparation of dicyclohexyl neophyltin halide