PT70486A - Process for preparing 1,2,4,5-tetra-alkyl-4-arylpiperidines - Google Patents

Process for preparing 1,2,4,5-tetra-alkyl-4-arylpiperidines

Info

Publication number: PT70486A
Authority: PT; Portugal
Prior art keywords: arylpiperidines; tetra; alkyl; preparing
Prior art date: 1978-11-29

Application number

PT70486A

Other languages

English (en)

Inventor

Dennis Michael Zimmerman

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-29

Filing date

1979-11-22

Publication date

1979-12-01

1979-11-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1979-12-01 Publication of PT70486A publication Critical patent/PT70486A/pt

Links

238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)

PT70486A 1978-11-29 1979-11-22 Process for preparing 1,2,4,5-tetra-alkyl-4-arylpiperidines PT70486A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/965,137 US4284635A (en)	1978-11-29	1978-11-29	Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines

Publications (1)

Publication Number	Publication Date
PT70486A true PT70486A (en)	1979-12-01

Family

ID=25509504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT70486A PT70486A (en)	1978-11-29	1979-11-22	Process for preparing 1,2,4,5-tetra-alkyl-4-arylpiperidines

Country Status (26)

Country	Link
US (1)	US4284635A (pt)
EP (1)	EP0013078A3 (pt)
JP (1)	JPS5573657A (pt)
KR (1)	KR830001214A (pt)
AR (1)	AR224138A1 (pt)
AT (1)	ATA750879A (pt)
AU (1)	AU529136B2 (pt)
BE (1)	BE880220A (pt)
CA (1)	CA1121357A (pt)
DD (1)	DD147537A5 (pt)
DK (1)	DK504979A (pt)
EG (1)	EG14137A (pt)
ES (2)	ES8101551A1 (pt)
FI (1)	FI793663A7 (pt)
FR (2)	FR2442836A1 (pt)
GB (1)	GB2038812B (pt)
GR (1)	GR72292B (pt)
HU (1)	HU178532B (pt)
IL (1)	IL58793A0 (pt)
IT (1)	IT1126406B (pt)
LU (1)	LU81923A1 (pt)
PH (1)	PH15420A (pt)
PL (1)	PL123672B1 (pt)
PT (1)	PT70486A (pt)
SU (1)	SU967275A3 (pt)
ZA (1)	ZA796336B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5212183A (en) *	1981-11-14	1993-05-18	Basf Aktiengesellschaft	4-(p-tert.-butylphenyl)-3-methylpiperidines substituted at the nitrogen, their quaternary salts and their use as fungicides
US4485109A (en) *	1982-05-07	1984-11-27	E. I. Du Pont De Nemours And Company	4-Aryl-4-piperidinecarbinols
US4581456A (en) *	1983-09-21	1986-04-08	Eli Lilly And Company	Processes for preparing picenadol precursors and novel intermediates thereof
ZW10287A1 (en) *	1986-07-15	1988-01-13	Hoffmann La Roche	Tetrahydronaphthaline and indane derivatives
EP0299549A3 (en) *	1987-07-09	1989-02-08	Duphar International Research B.V	Tertiary 2,5-dialkyl-3-phenyl-piperidine derivatives having opiate-antagonistic activity
CA1337418C (en) *	1988-03-28	1995-10-24	Engelbert Ciganek	4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5136040A (en) *	1991-02-26	1992-08-04	Eli Lilly And Company	Preparation of substituted tetrahydropyridines
US5270328A (en) *	1991-03-29	1993-12-14	Eli Lilly And Company	Peripherally selective piperidine opioid antagonists
US5250542A (en) *	1991-03-29	1993-10-05	Eli Lilly And Company	Peripherally selective piperidine carboxylate opioid antagonists
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
GB9912413D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
GB9912415D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
GB9912416D0 (en) *	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
GB9912417D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
GB9912410D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy
GB9912411D0 (en)	1999-05-28	1999-07-28	Pfizer Ltd	Compounds useful in therapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2892842A (en) *		1959-06-30		Their preparation
US2956058A (en) *	1957-08-19	1960-10-11	Lilly Co Eli	Novel substituted piperidines and pyrrolidines
US3043845A (en) *	1958-12-29	1962-07-10	Abbott Lab	Phenylmethylpiperidine derivatives
US3080372A (en) *	1960-03-25	1963-03-05	Res Lab Dr C Janssen	1-aroylalkyl-4-arylpiperidine derivatives
NL123743C (pt) *	1963-09-18
US3574219A (en) *	1967-09-27	1971-04-06	Tanabe Seiyaku Co	1-(beta-hydroxyphenethyl)-2,3-dimethyl-3-(3-hydroxyphenyl)-piperidine
US3936468A (en) *	1969-10-27	1976-02-03	Sumitomo Chemical Company, Ltd.	Phenylbutanol derivatives
GB1403942A (en) *	1973-04-05	1975-08-28	Ciba Geigy Ag	Piperidine derivatives
AR206937A1 (es) *	1974-09-06	1976-08-31	Lilly Co Eli	Procedimiento para preparar compuestos de 1-sustituido-4-alquil-4-fenil-piperidina
US4115400A (en) *	1976-05-27	1978-09-19	Eli Lilly And Company	1-Azoniabicyclo[3.1.0]hexanes
ZA777356B (en) *	1976-12-17	1979-01-31	Rohm & Haas	Arthropod repellents

1978
- 1978-11-29 US US05/965,137 patent/US4284635A/en not_active Expired - Lifetime
1979
- 1979-11-22 CA CA000340379A patent/CA1121357A/en not_active Expired
- 1979-11-22 EP EP79302674A patent/EP0013078A3/en not_active Ceased
- 1979-11-22 AU AU53100/79A patent/AU529136B2/en not_active Expired - Fee Related
- 1979-11-22 PT PT70486A patent/PT70486A/pt unknown
- 1979-11-22 ZA ZA00796336A patent/ZA796336B/xx unknown
- 1979-11-22 GB GB7940422A patent/GB2038812B/en not_active Expired
- 1979-11-22 FI FI793663A patent/FI793663A7/fi not_active Application Discontinuation
- 1979-11-23 PH PH23322A patent/PH15420A/en unknown
- 1979-11-23 IL IL58793A patent/IL58793A0/xx unknown
- 1979-11-23 BE BE1/9621A patent/BE880220A/fr unknown
- 1979-11-23 FR FR7928977A patent/FR2442836A1/fr active Granted
- 1979-11-26 PL PL1979219885A patent/PL123672B1/pl unknown
- 1979-11-26 LU LU81923A patent/LU81923A1/fr unknown
- 1979-11-26 JP JP15349279A patent/JPS5573657A/ja active Pending
- 1979-11-27 GR GR60608A patent/GR72292B/el unknown
- 1979-11-27 HU HU79EI892A patent/HU178532B/hu unknown
- 1979-11-27 IT IT27614/79A patent/IT1126406B/it active
- 1979-11-27 AT AT0750879A patent/ATA750879A/de not_active Application Discontinuation
- 1979-11-27 AR AR279039A patent/AR224138A1/es active
- 1979-11-27 EG EG708/79A patent/EG14137A/xx active
- 1979-11-28 ES ES486425A patent/ES8101551A1/es not_active Expired
- 1979-11-28 KR KR1019790004179A patent/KR830001214A/ko active Pending
- 1979-11-28 SU SU792847573A patent/SU967275A3/ru active
- 1979-11-28 DK DK504979A patent/DK504979A/da unknown
- 1979-11-29 DD DD79217246A patent/DD147537A5/de unknown
1980
- 1980-05-13 FR FR8010755A patent/FR2453154A1/fr active Granted
- 1980-07-31 ES ES493915A patent/ES8200664A1/es not_active Expired

Also Published As

Publication number	Publication date
LU81923A1 (fr)	1980-04-22
EP0013078A2 (en)	1980-07-09
PH15420A (en)	1983-01-07
EG14137A (en)	1983-09-30
ES486425A0 (es)	1980-12-16
AU5310079A (en)	1980-05-29
AU529136B2 (en)	1983-05-26
FR2442836A1 (fr)	1980-06-27
BE880220A (fr)	1980-05-23
ES493915A0 (es)	1981-11-16
KR830001214A (ko)	1983-04-29
FR2453154B1 (pt)	1983-05-27
AR224138A1 (es)	1981-10-30
ES8101551A1 (es)	1980-12-16
CA1121357A (en)	1982-04-06
GR72292B (pt)	1983-10-17
DD147537A5 (de)	1981-04-08
ATA750879A (de)	1983-03-15
PL123672B1 (en)	1982-11-30
ES8200664A1 (es)	1981-11-16
FR2453154A1 (fr)	1980-10-31
IT1126406B (it)	1986-05-21
JPS5573657A (en)	1980-06-03
DK504979A (da)	1980-05-30
PL219885A1 (pt)	1980-12-01
ZA796336B (en)	1981-06-24
GB2038812B (en)	1983-01-06
EP0013078A3 (en)	1980-10-01
US4284635A (en)	1981-08-18
FR2442836B1 (pt)	1983-07-29
IL58793A0 (en)	1980-02-29
FI793663A7 (fi)	1980-05-30
GB2038812A (en)	1980-07-30
IT7927614A0 (it)	1979-11-27
SU967275A3 (ru)	1982-10-15
HU178532B (en)	1982-05-28

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