PT730608E - Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes - Google Patents

Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes

Info

Publication number: PT730608E
Authority: PT; Portugal
Prior art keywords: complement; compositions; producing; methods; proeins
Prior art date: 1993-05-17

Application number

PT94917961T

Other languages

English (en)

Inventor

Charles W Rittershaus

Carol A Toth

Original Assignee

Avant Immunotherapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-17

Filing date

1994-05-12

Publication date

2002-09-30

1994-05-12 Application filed by Avant Immunotherapeutics Inc filed Critical Avant Immunotherapeutics Inc

2002-09-30 Publication of PT730608E publication Critical patent/PT730608E/pt

Links

239000000203 mixture Substances 0.000 title abstract 7
230000000295 complement effect Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
-1 CARBON HYDRATES Chemical class 0.000 title 1
229910052799 carbon Inorganic materials 0.000 title 1
206010061218 Inflammation Diseases 0.000 abstract 2
230000024203 complement activation Effects 0.000 abstract 2
230000004054 inflammatory process Effects 0.000 abstract 2
102000000989 Complement System Proteins Human genes 0.000 abstract 1
108010069112 Complement System Proteins Proteins 0.000 abstract 1
102000003800 Selectins Human genes 0.000 abstract 1
108090000184 Selectins Proteins 0.000 abstract 1
NIGUVXFURDGQKZ-KRAHZTDDSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-KRAHZTDDSA-N 0.000 abstract 1
SFZBBUSDVJSDGR-XWFYHZIMSA-N beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-beta-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O[C@H]2[C@H]([C@@H](CO)O[C@@H](O)[C@@H]2O)O)[C@@H]1NC(C)=O SFZBBUSDVJSDGR-XWFYHZIMSA-N 0.000 abstract 1
125000000837 carbohydrate group Chemical group 0.000 abstract 1
102000006834 complement receptors Human genes 0.000 abstract 1
108010047295 complement receptors Proteins 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000005732 intercellular adhesion Effects 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Cell Biology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Carbon And Carbon Compounds (AREA)

PT94917961T 1993-05-17 1994-05-12 Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes PT730608E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6198293A	1993-05-17	1993-05-17

Publications (1)

Publication Number	Publication Date
PT730608E true PT730608E (pt)	2002-09-30

Family

ID=22039478

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT94917961T PT730608E (pt)	1993-05-17	1994-05-12	Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes

Country Status (11)

Country	Link
US (1)	US6193979B1 (pt)
EP (1)	EP0730608B1 (pt)
JP (1)	JP3662021B2 (pt)
AT (1)	ATE215094T1 (pt)
CA (1)	CA2162600C (pt)
DE (1)	DE69430253T2 (pt)
DK (1)	DK0730608T3 (pt)
ES (1)	ES2174876T3 (pt)
PT (1)	PT730608E (pt)
SG (1)	SG52383A1 (pt)
WO (1)	WO1994026786A1 (pt)

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EP1685145A2 (en) *	2003-11-19	2006-08-02	GlycoMimetics, Inc.	Glycomimetic antagonists for both e- and p-selectins
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WO2006127906A1 (en) *	2005-05-25	2006-11-30	Glycomimetics, Inc.	Heterobifunctional compounds for selectin inhibition
CA2654440C (en) *	2005-06-06	2013-09-03	Girish J. Kotwal	Methods for treatment or prophylaxis of atherosclerosis and reperfusion injury
US20070004625A1 (en) *	2005-06-30	2007-01-04	Li Liang-Man	Use of complement inhibitory proteins to treat spinal cord injury
EP1738763A1 (en)	2005-06-30	2007-01-03	AVANT Immunotherapeutics, Inc.	Use of complement inhibitory proteins to treat spinal cord injury
JP5175190B2 (ja) *	2005-08-09	2013-04-03	グリコミメティクス，インコーポレイテッド	シュードモナス由来のｐａ−ｉｌレクチン、ｐａ−ｉｉｌレクチンまたは両方のレクチンのグリコミメティック阻害剤
US7728117B2 (en)	2005-09-02	2010-06-01	Glycomimetics, Inc.	Heterobifunctional pan-selectin inhibitors
US20090176717A1 (en) *	2006-06-01	2009-07-09	Glycomimetics, Inc.	Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2074132B1 (en)	2006-10-12	2013-05-15	GlycoMimetics, Inc.	Glycomimetic replacements for hexoses and n-acetyl hexosamines
US8664176B2 (en) *	2006-10-20	2014-03-04	Celldex Therapeutics, Inc.	Treatment for age-related macular degeneration and other diseases of the eye
EP2457573A1 (en) *	2007-02-09	2012-05-30	GlycoMimetics, Inc.	Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines
US8039442B2 (en) *	2007-07-18	2011-10-18	Glycomimetics, Inc.	Compounds and methods for treatment of sickle cell disease or complications associated therewith
WO2009126556A1 (en) *	2008-04-08	2009-10-15	Glycomimetics, Inc.	Pan-selectin inhibitor with enhanced pharmacokinetic activity
CA2727788A1 (en) *	2008-06-13	2009-12-17	Glycomimetics, Inc.	Treatment of cancers of the blood using selected glycomimetic compounds
US8410066B2 (en)	2009-05-01	2013-04-02	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US8921328B2 (en)	2010-09-14	2014-12-30	Glycomimetics, Inc.	E-selectin antagonists
CN103237557A (zh) *	2010-09-15	2013-08-07	赛尔戴克斯治疗公司	用可溶性I型补体受体(sCR1)治疗慢性肾病
EP2632476B1 (en)	2010-10-27	2017-06-14	Celldex Therapeutics, Inc.	Method of improving transplant function using soluble complement receptor type i (scr1)
SI2794626T1 (en)	2011-12-22	2018-02-28	Glycomimetics, Inc.	E-SELECTINE ANTAGONIST COMPOUNDS
LT2928476T (lt)	2012-12-07	2018-05-25	Glycomimetics, Inc.	Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
WO2015103438A2 (en)	2014-01-02	2015-07-09	Genelux Corporation	Oncolytic virus adjunct therapy with agents that increase virus infectivity
HUE045542T2 (hu)	2014-12-03	2019-12-30	Glycomimetics Inc	E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai
WO2017127422A1 (en)	2016-01-22	2017-07-27	Glycomimetics, Inc.	Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en)	2016-03-02	2017-09-08	Glycomimetics, Inc.	Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en)	2016-08-08	2022-03-09	GlycoMimetics, Inc.	Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
CA3037850A1 (en)	2016-10-07	2018-04-12	Glycomimetics, Inc.	Highly potent multimeric e-selectin antagonists
CA3054605A1 (en)	2017-03-15	2018-09-20	Glycomimetics, Inc.	Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en)	2017-11-30	2020-10-07	GlycoMimetics, Inc.	Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en)	2017-12-29	2020-11-04	GlycoMimetics, Inc.	Heterobifunctional inhibitors of e-selectin and galectin-3
US11707474B2 (en)	2018-03-05	2023-07-25	Glycomimetics, Inc.	Methods for treating acute myeloid leukemia and related conditions
AU2019268410B2 (en)	2018-05-16	2025-01-02	Csl Limited	Soluble complement receptor type 1 variants and uses thereof
US11845771B2 (en)	2018-12-27	2023-12-19	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectin and galectin-3
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1994
- 1994-05-12 SG SG1996003777A patent/SG52383A1/en unknown
- 1994-05-12 ES ES94917961T patent/ES2174876T3/es not_active Expired - Lifetime
- 1994-05-12 DK DK94917961T patent/DK0730608T3/da active
- 1994-05-12 DE DE69430253T patent/DE69430253T2/de not_active Expired - Fee Related
- 1994-05-12 WO PCT/US1994/005285 patent/WO1994026786A1/en not_active Ceased
- 1994-05-12 PT PT94917961T patent/PT730608E/pt unknown
- 1994-05-12 EP EP94917961A patent/EP0730608B1/en not_active Expired - Lifetime
- 1994-05-12 JP JP52569594A patent/JP3662021B2/ja not_active Expired - Fee Related
- 1994-05-12 AT AT94917961T patent/ATE215094T1/de not_active IP Right Cessation
- 1994-05-12 CA CA002162600A patent/CA2162600C/en not_active Expired - Fee Related
1995
- 1995-05-25 US US08/450,274 patent/US6193979B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6947594A (en)	1994-12-12
CA2162600A1 (en)	1994-11-24
AU678486B2 (en)	1997-05-29
ATE215094T1 (de)	2002-04-15
JPH08510257A (ja)	1996-10-29
JP3662021B2 (ja)	2005-06-22
US6193979B1 (en)	2001-02-27
WO1994026786A1 (en)	1994-11-24
DE69430253T2 (de)	2002-11-14
DK0730608T3 (da)	2002-07-22
EP0730608A4 (en)	1998-12-02
ES2174876T3 (es)	2002-11-16
CA2162600C (en)	2000-07-11
EP0730608B1 (en)	2002-03-27
DE69430253D1 (de)	2002-05-02
SG52383A1 (en)	1998-09-28
EP0730608A1 (en)	1996-09-11

Publication	Publication Date	Title
SG52383A1 (en)	1998-09-28	Compositions comprising complement related proteins and carbohydrates and methods for producing and using said compositions
RU95108231A (ru)	1997-03-20	Glp-1-молекулярный комплекс, фармацевтическая композиция и способ получения комплекса
AR040603A1 (es)	2005-04-13	El uso de un anticuerpo anti-tnfalfa neutralizador de alta afinidad en la fabricacion de un medicamento y conjunto de elementos
ES2102196T3 (es)	1997-07-16	Periferializacion de celulas pluripotenciales hematopoyeticas.
GR3007096T3 (pt)	1993-07-30
MX9702932A (es)	1998-04-30	L-ribofuranosilnucleosidos.
BR9812469A (pt)	2002-02-05	Composições farmacêuticas contendo proteina de plasma
YU34196A (sh)	1999-03-04	Peptidi i jedinjenja koja se vezuju za receptor
DE3587434D1 (de)	1993-08-12	Antivirale pharmazeutische zusammensetzungen und ihrer verwendung.
UA39158C2 (uk)	2001-06-15	Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
ATE473759T1 (de)	2010-07-15	Bifunktionelle moleküle sowie darauf basierende therapien.
CA2015060A1 (en)	1990-11-05	Novel antibody delivery system for biological response modifiers
AU3572797A (en)	1998-01-07	Screening compounds for the ability to alter the production of amyloid-beta peptide (x-$m(g)41)
PL323046A1 (en)	1998-03-02	Procedures related to arterio-vascular and vascular transplants: method and compositions
DK0839026T3 (da)	2002-01-21	Micellære polyether-blokcopolymerkompositioner til målretning af biologiske midler
EP0902789A4 (pt)	1999-04-14
SE8605295D0 (sv)	1986-12-10	Monoclonal antibodies cross-reactive and crossprotective against p. aeruginosa serotypes
UA26403A (uk)	1999-08-30	Похідhі n-заміщеhого 4-феhіл-4-піперидиhкарбоксаміду та їх фармацевтичhо прийhятhі солі, що проявляють аhестезувальhу та аhальгезувальhу дію, спосіб їх одержаhhя та фармацевтичhа композиція
SE8700467D0 (sv)	1987-02-06	Cross-protective human monoclonal antibody compositions
ATE527358T1 (de)	2011-10-15	Ribosomen inaktivierendes protein vom typ-1
BG102250A (en)	1999-02-26	The use of marigold-extracted glycosides for the treatment of psoriasis
ATE376824T1 (de)	2007-11-15	Verwendung von hyaluronan zur herstellung eines medikaments zur erhöhung der wirksamkeit von zytotoxischen arzneimitteln
WO1999016791A3 (en)	1999-05-20	Compounds and methods for regulating cell adhesion
DK1107795T3 (da)	2003-03-24	Thiomolybdat associeret med mindst ét carbohydrat og dets anvendelse til forebyggelse eller behandling af sygdomme kendetegnet ved aberrerende vascularisation, såsom cancer, maculadegeneration af våd type, rheumatoid arthritis
MX9101958A (es)	1992-07-08	Inhibidores de acat de urea de aminosulfonilo