ATE473759T1 - Bifunktionelle moleküle sowie darauf basierende therapien. - Google Patents

Bifunktionelle moleküle sowie darauf basierende therapien.

Info

Publication number
ATE473759T1
ATE473759T1 AT99924431T AT99924431T ATE473759T1 AT E473759 T1 ATE473759 T1 AT E473759T1 AT 99924431 T AT99924431 T AT 99924431T AT 99924431 T AT99924431 T AT 99924431T AT E473759 T1 ATE473759 T1 AT E473759T1
Authority
AT
Austria
Prior art keywords
therapies
bifunctional
bifunctional molecule
bifunctional molecules
host
Prior art date
Application number
AT99924431T
Other languages
English (en)
Inventor
Roger Briesewitz
Gerald Crabtree
Thomas Wandless
Gregory Ray
Kurt Vogel
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE473759T1 publication Critical patent/ATE473759T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug one of the codrug's components being an antibiotic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)
AT99924431T 1998-05-22 1999-05-21 Bifunktionelle moleküle sowie darauf basierende therapien. ATE473759T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8645198P 1998-05-22 1998-05-22
PCT/US1999/011296 WO1999061055A1 (en) 1998-05-22 1999-05-21 Bifunctional molecules and therapies based thereon

Publications (1)

Publication Number Publication Date
ATE473759T1 true ATE473759T1 (de) 2010-07-15

Family

ID=22198654

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99924431T ATE473759T1 (de) 1998-05-22 1999-05-21 Bifunktionelle moleküle sowie darauf basierende therapien.

Country Status (8)

Country Link
US (3) US6372712B1 (de)
EP (1) EP1079859B1 (de)
AT (1) ATE473759T1 (de)
AU (1) AU4093799A (de)
CA (1) CA2330611A1 (de)
DE (1) DE69942578D1 (de)
ES (1) ES2347027T3 (de)
WO (1) WO1999061055A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE473759T1 (de) * 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
US7425541B2 (en) * 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
WO2001021661A1 (en) * 1999-09-20 2001-03-29 Novo Nordisk A/S BIVALENT INHIBITOR OF FVIIa/TF/FXa COMPLEX
AU1776501A (en) * 1999-11-19 2001-05-30 Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
EP1229924A4 (de) * 1999-11-19 2004-12-15 Univ Leland Stanford Junior Gezielte bifunctionelle moleküle und darauf gegründete therapien
US6887842B1 (en) * 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
US7220552B1 (en) 1999-11-19 2007-05-22 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and their use in the disruption of protein-protein interactions
JP4931313B2 (ja) * 2000-01-11 2012-05-16 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド ポリファーマコフォア剤
US6511962B1 (en) * 2000-07-17 2003-01-28 Micrologix Biotech Inc. Derivatives of laspartomycin and preparation and use thereof
US20030077826A1 (en) * 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
AU2002322720B2 (en) * 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004037848A2 (en) * 2002-05-17 2004-05-06 Slanetz Alfred E Process for determining target function and identifying drug leads
CA2491661A1 (en) * 2002-07-12 2004-01-22 Biomarin Pharmaceutical Inc. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates
MXPA05000615A (es) * 2002-07-16 2005-11-17 Medexis S A Conjugados esteroideos, preparacion de los mismos y usos de los mismos.
GR1004274B (el) * 2002-07-16 2003-06-23 Medexis ���� Συμπλοκα στεροειδων ορμονων με πρωτεινες: νεες ουσιες για την ειδικη ανιχνευση και καταστροφη καρκινικων κυτταρων προερχομενων απο στερεους ογκους και αιματολογικες κακοηθειες
JP5576007B2 (ja) * 2003-01-27 2014-08-20 エンドサイト・インコーポレイテッド ビタミン受容体結合性薬剤送達結合体
US7485706B2 (en) * 2003-07-30 2009-02-03 The Board Of Trustees Of The Leland Stanford Junior University Neurodegenerative protein aggregation inhibition methods and compounds
GB0320459D0 (en) * 2003-09-01 2003-10-01 Selective Antibodies Ltd Assay methods and materials
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
US20050148534A1 (en) * 2003-09-22 2005-07-07 Castellino Angelo J. Small molecule compositions and methods for increasing drug efficiency using compositions thereof
CA2448995A1 (en) * 2003-11-12 2005-05-12 James Keenan Device and method for attracting diseased cells and foreign substances
US7541330B2 (en) * 2004-06-15 2009-06-02 Kosan Biosciences Incorporated Conjugates with reduced adverse systemic effects
JP5149620B2 (ja) 2004-07-23 2013-02-20 エンドサイト，インコーポレイテッド ２価リンカーおよびその結合体
WO2007027963A2 (en) * 2005-08-30 2007-03-08 The Board Of Trustees Of The Leland Stanford Junior University Methods of screening bifunctional molecules for modulated pharmacokinetic properties
WO2007053792A2 (en) * 2005-11-05 2007-05-10 Amplyx Pharmaceuticals, Inc. Improving the pharmacokinetics of protease inhibitors and other drugs
US7943775B2 (en) * 2006-06-21 2011-05-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Small molecules for imaging protein-protein interactions
US20080306098A1 (en) * 2006-11-06 2008-12-11 Mutz Mitchell W Pharmacokinetics of protease inhibitors and other drugs
NZ580132A (en) 2007-03-14 2012-11-30 Endocyte Inc Binding ligand linked drug delivery conjugates of tubulysins to vitamins
US20090054334A1 (en) * 2007-05-23 2009-02-26 Mutz Mitchell W Combinatorial improvement of bifunctional drug properties
US20090053245A1 (en) * 2007-05-29 2009-02-26 Mutz Mitchell W Pharmacokinetics and Efficacy of Anti-Angiogenic Drugs and Drugs Treating Diseases of the Blood
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
CN104383553A (zh) 2007-06-25 2015-03-04 恩多塞特公司 含有亲水性间隔区接头的共轭物
WO2009055042A1 (en) * 2007-10-24 2009-04-30 Amplyx Pharmaceuticals, Inc. Enhancing the efficacy of anti-infective therapeutics
WO2009055562A1 (en) 2007-10-25 2009-04-30 Endocyte, Inc. Tubulysins and processes for preparing
WO2012047762A2 (en) * 2010-10-08 2012-04-12 Amplyx Pharmaceuticals, Inc. Antifungal agents
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
WO2012174489A2 (en) * 2011-06-15 2012-12-20 The Ohio State University Small molecule composite surfaces as inhibitors of protein-protein interactions
SI2794626T1 (en) 2011-12-22 2018-02-28 Glycomimetics, Inc. E-SELECTINE ANTAGONIST COMPOUNDS
US10080805B2 (en) 2012-02-24 2018-09-25 Purdue Research Foundation Cholecystokinin B receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
US20140079636A1 (en) 2012-04-16 2014-03-20 Dinesh U. Chimmanamada Targeted therapeutics
US20150119435A1 (en) * 2012-05-11 2015-04-30 Yale University Compounds useful for promoting protein degradation and methods using same
KR20220051197A (ko) 2012-05-17 2022-04-26 익스텐드 바이오사이언시즈, 인크. 개선된 약물 전달용 캐리어
JP2015536323A (ja) 2012-10-16 2015-12-21 エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． 非天然アミノ酸を含む薬物送達結合体および使用方法
LT2928476T (lt) 2012-12-07 2018-05-25 Glycomimetics, Inc. Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
EP3035938B1 (de) 2013-09-10 2020-08-19 Madrigal Pharmaceuticals, Inc. Zielgerichtete therapeutika
WO2015066053A2 (en) * 2013-10-28 2015-05-07 Synta Pharmaceuticals Corp. Targeted therapeutics
WO2015116774A1 (en) 2014-01-29 2015-08-06 Synta Pharmaceuticals Corp. Targeted therapeutics
CN106456795A (zh) 2014-03-03 2017-02-22 辛塔医药品有限公司 靶向治疗学
EP3131586A4 (de) 2014-03-18 2017-10-25 Madrigal Pharmaceuticals, Inc. Zielgerichtete therapeutika
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
US10736932B2 (en) 2014-05-20 2020-08-11 Ohio State Innovation Foundation Small molecule Ras inhibitors
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
HUE045542T2 (hu) 2014-12-03 2019-12-30 Glycomimetics Inc E-szelektinek és CXCR4 kemokin receptorok heterobifunkcionális inhibitorai
TW201629069A (zh) * 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
EP4289950A3 (de) 2015-01-09 2024-01-24 Revolution Medicines, Inc. Makrozyklische verbindungen mit beteiligung an einer kooperativen bindung und medizinische verwendungen davon
EP3355930A4 (de) * 2015-10-01 2019-03-06 Warp Drive Bio, Inc. Verfahren und reagenzien zur analyse von protein-protein-schnittstellen
WO2017147240A1 (en) 2016-02-23 2017-08-31 Tarveda Therapeutics, Inc. Hsp90 targeted conjugates and particles and formulations thereof
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3443001B1 (de) 2016-04-11 2025-04-30 Obsidian Therapeutics, Inc. Regulierte bioschaltkreissysteme
KR102359972B1 (ko) 2016-04-12 2022-02-10 징코 바이오웍스, 인크. 화합물의 제조를 위한 조성물 및 방법
EP3497131B1 (de) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Kombination von t-zell-checkpoint-inhibitoren mit e-selectin- oder cxcr4-inhibitoren oder mit heterobifunktionellen e-selectin- wie auch cxcr4-inhibitoren
CA3037850A1 (en) 2016-10-07 2018-04-12 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
WO2018081592A2 (en) 2016-10-28 2018-05-03 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CA3054605A1 (en) 2017-03-15 2018-09-20 Glycomimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
JP2020524156A (ja) 2017-06-20 2020-08-13 マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 標的治療薬を含む併用療法
JP2020524154A (ja) 2017-06-20 2020-08-13 マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 標的治療薬
EP3717013A1 (de) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Verfahren zur mobilisierung von knochenmarkinfiltrierenden lymphozyten und deren verwendung
EP3732186A1 (de) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunktionale inhibitoren von e-selektin und galectin-3
US11707474B2 (en) 2018-03-05 2023-07-25 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
US12594275B2 (en) 2019-02-07 2026-04-07 The Regents Of The University Of California Immunophilin binding agents and uses thereof
CN114867735A (zh) 2019-11-04 2022-08-05 锐新医药公司 Ras抑制剂
PE20221277A1 (es) 2019-11-04 2022-09-05 Revolution Medicines Inc Inhibidores de ras
CN114786777A (zh) 2019-11-04 2022-07-22 锐新医药公司 Ras抑制剂
AU2021345111B2 (en) 2020-09-15 2025-11-27 Revolution Medicines, Inc. Indole derivatives as Ras inhibitors in the treatment of cancer
WO2022099058A1 (en) * 2020-11-09 2022-05-12 The General Hospital Corporation Methods of determining surface glycan density
CR20230558A (es) 2021-05-05 2024-01-24 Revolution Medicines Inc Inhibidores de ras para el tratamiento del cáncer
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
EP4593867A2 (de) 2022-09-30 2025-08-06 Extend Biosciences, Inc. Langwirkendes parathormon
US12558428B2 (en) 2024-03-08 2026-02-24 Halda Therapeutics Opco, Inc. Heterobifunctional compounds and their use in treating disease

Family Cites Families (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US45570A (en) * 1864-12-27 abbeceombie
US3852468A (en) 1967-02-27 1974-12-03 Ici Ltd Alkanolamine derivatives as {62 -adrenergic blocking agents
US3832470A (en) 1968-01-29 1974-08-27 H Russek Treatment of angina pectoris with a long-acting vasodilating agent and a beta adrenergic receptor blocking agent
BE757385A (fr) 1969-10-13 1971-04-13 American Cyanamid Co Derives de chloropregnane acetonides utilisables comme substances contraceptives
US3670079A (en) 1970-10-06 1972-06-13 Merck & Co Inc Anabolic agents
US3982010A (en) 1971-10-27 1976-09-21 Syntex (U.S.A.) Inc. Thiazole cardiovascular agents
US4001421A (en) 1971-10-27 1977-01-04 Syntex (U.S.A.) Inc. Thiazole cardiovascular agents
US4180583A (en) 1972-01-28 1979-12-25 Richardson-Merrell Inc. Olefinic 4-substituted piperidino derivatives as therapeutics
US3965257A (en) 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US4011321A (en) 1973-12-19 1977-03-08 Smith Kline & French Laboratories Limited Pharmaceutical compositions and methods of inhibiting β-adrenergic receptors
US3931197A (en) 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3940407A (en) 1974-09-16 1976-02-24 Syntex (U.S.A.) Inc. β-Adrenergic blocking agents in the 1,2,3-thiadiazole series
US4000282A (en) 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
SE422580B (sv) 1975-08-07 1982-03-15 Hoffmann La Roche Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
US4049805A (en) 1975-09-30 1977-09-20 Akzona Incorporated Steroidal erythropoietic agents and therapeutic compositions and methods
US4004005A (en) 1975-09-30 1977-01-18 Akzona Incorporated Steroidal erythropoietic agents and therapeutic compositions and methods
FR2330383A1 (fr) 1975-11-06 1977-06-03 Synthelabo Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment
US4082843A (en) 1975-11-26 1978-04-04 Smith Kline & French Laboratories Limited 3-(3-(3-Substituted amino-2-hydroxypropoxy)phenyl)-6-hydrazino pyridazines and their use as vasodilators and β-adrenergic blocking agents
US4092419A (en) 1976-06-15 1978-05-30 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
DE2644833A1 (de) 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung
US4314943A (en) 1977-07-13 1982-02-09 Mead Johnson & Company Heterocyclic substituted aryloxy 3-indolyl-tertiary butylaminopropanols
US4247710A (en) 1978-02-08 1981-01-27 Hoffmann-La Roche Inc. Intermediate in the production of adrenergic blocking agents
US4329289A (en) 1978-02-08 1982-05-11 Hoffmann-La Roche Inc. Adrenergic blocking agents
US4281189A (en) 1979-09-06 1981-07-28 Hoffmann-La Roche Inc. Sulfonamide intermediates for adrenergic blocking agents
US4285873A (en) 1979-09-06 1981-08-25 Hoffmann-La Roche Inc. Adrenergic blocking agents
US4278608A (en) 1979-09-06 1981-07-14 Hoffmann-La Roche Inc. Adrenergic blocking agents
US4304721A (en) 1979-09-06 1981-12-08 Hoffmann-La Roche Inc. Adrenergic blocking agents
DE2943776A1 (de) 1979-10-26 1981-05-14 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
MC1357A1 (fr) 1979-12-07 1981-08-10 Hoffmann La Roche Derives de 2,3-indoledione
IE810250L (en) 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4710495A (en) 1980-07-10 1987-12-01 Otsuka Pharmaceutical Co., Ltd. Soft steroids having anti-inflammatory activity
US4996335A (en) 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
US4393210A (en) 1980-08-28 1983-07-12 Seiyaku Co., Ltd. 1(2H)-Isoquinolone compounds and acid addition salts thereof
US4568679A (en) 1980-12-23 1986-02-04 Merck & Co., Inc. Aralkylaminoethanol heterocyclic compounds
ZA8231B (en) 1981-01-09 1982-11-24 Roussel Uclaf New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained
EP0081006B1 (de) 1981-12-08 1985-09-25 Smithkline Beckman Corporation Pharmazeutische Zusammensetzungen mit Gehalt an 7,8-Dihydroxy-1-(hydroxy-phenyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-Derivaten und an einem beta-adrenergischen Blocker
US4588530A (en) 1982-07-30 1986-05-13 Florida Agricultural And Mechanical University Anti-inflammatory prednisolone steroids
ES524796A0 (es) 1982-08-20 1984-05-01 Nativelle Sa Ets Procedimiento de preparacion de nuevos derivos de amino-14 esteroides
US4495102A (en) 1982-09-03 1985-01-22 G. D. Searle & Co. Aminoalkyl steroids
FR2533928A1 (fr) 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives dichlores de la serie du 16a-methyl pregnane, leur procede de preparation et leur application comme medicaments
JPS59139400A (ja) 1983-01-31 1984-08-10 Shionogi & Co Ltd 抗アルドステロン活性ステロイド誘導体
US4552871A (en) 1983-04-13 1985-11-12 Ciba Geigy Corporation Steroids of the 20-spiroxane series, processes for the manufacture thereof, pharmaceutical preparations containing such compounds and the use of the latter
EP0123734A1 (de) 1983-04-29 1984-11-07 Gist-Brocades N.V. 17-(Isocyano-sulfonylmethylen)-Steroide, 17-(Formamido-sulfonylmethylen)-Steroide und ihre Herstellung
FR2547587B1 (fr) 1983-06-14 1985-10-25 Roussel Uclaf Steroides radioactifs, leur procede de preparation, leur application a la mise en evidence des recepteurs de glucocorticoides et au dosage du nombre de sites de fixation
US4512986A (en) 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
US4541956A (en) 1983-07-28 1985-09-17 Unique Technologies, Inc. Tin steroids and their use as antineoplastic agents
US4634693A (en) 1983-07-28 1987-01-06 Cardarelli Nathan F Tin steroids and their uses
US5656621A (en) 1983-08-02 1997-08-12 Research Corporation Tech., Inc. Steroids useful as anti-cancer and anti-obesity agents
CA1252778A (en) 1983-08-25 1989-04-18 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Steroids
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
US4560557A (en) 1983-11-10 1985-12-24 University Patents, Inc. Silicon and sulfur steroids as irreversible inhibitors of hormone biosynthesis
US5202347A (en) 1984-03-14 1993-04-13 Bodor Nicholas S Soft β-adrenergic blocking agents
US5135926A (en) 1984-03-14 1992-08-04 Bodor Nicholas S Soft β-adrenergic blocking agents
US5334601A (en) 1984-03-14 1994-08-02 Bodor Nicholas S Soft β-adrenergic blocking agents
US4829086A (en) 1984-03-14 1989-05-09 Bodor Nicholas S Soft β-adrenergic blocking agents
US4701450A (en) 1984-03-21 1987-10-20 Akzo N.V. Steroids for use as immunomodulators
US4579867A (en) 1984-04-09 1986-04-01 American Hospital Supply Corporation Stable pharmaceutical compositions of short-acting β-adrenergic receptor blocking agents
US4670551A (en) 1984-06-21 1987-06-02 Ciba-Geigy Corporation Epoxy steroids
FR2569408B1 (fr) 1984-08-24 1986-10-03 Roussel Uclaf Nouveaux steroides substitues en position 10 par un radical comportant une double ou triple liaison, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant
US4567000A (en) 1984-08-31 1986-01-28 The Upjohn Company 11-Difluoromethylene steroids
US4711856A (en) 1984-09-19 1987-12-08 Mayo Medical Resources Nuclear binding assay for steroid receptor functionality in cancerous cells
FR2571727B1 (fr) 1984-10-16 1987-06-12 Roussel Uclaf Nouveaux produits steroides comportant, en position 23, un radical dihydro oxazolyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20 cetopregnanes et intermediaires de cette application
EP0188010A1 (de) 1985-01-14 1986-07-23 Gist-Brocades N.V. Verfahren zur Herstellung von Steroiden, insbesondere von Zwischenprodukten in der Herstellung von Proligestonen und verwandte Verbindungen und erhaltene Zwischenprodukte
FR2576025B1 (fr) 1985-01-14 1987-01-23 Roussel Uclaf Nouveaux steroides substitues en position 10, leur procede et les intermediaires de preparation, leur application comme medicaments, les compositions pharmaceutiques les contenant
US4782058A (en) 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
JP2617706B2 (ja) 1985-05-01 1997-06-04 富士薬品工業 株式会社 ３α，５−シクロ−２２，２３−ジヒドロキシ−５α−ステロイド化合物
US4861765A (en) 1985-06-26 1989-08-29 Jouveinal 21-alkyl-, cycloalkyl- or aryl-substituted thio steroids and pharmaceutical compositions containing them
US4923892A (en) 1985-08-17 1990-05-08 Burroughs Wellcome Co. Tricyclic aromatic compounds
US5382661A (en) 1985-09-12 1995-01-17 The Upjohn Company Pyrazinylpiperazinyl steroids
US5373095A (en) 1985-10-18 1994-12-13 The Upjohn Company Steroid compounds
US4975537A (en) 1985-10-23 1990-12-04 The Upjohn Company Δ9(11) -angiostatic steroids
GB8600489D0 (en) 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside steroids
GB8600490D0 (en) 1986-01-09 1986-02-12 Erba Farmitalia Aminoglycoside norcholanic acid lactams
FR2596395B1 (fr) 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US4861763A (en) 1986-09-17 1989-08-29 Research Triangle Institute 17 α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and their progestational use
US4774236A (en) 1986-09-17 1988-09-27 Research Triangle Institute 17α-(substituted-methyl)-17β-hydroxy/esterified hydroxy steroids and pharmaceutical compositions containing them
IL84135A (en) 1986-10-10 1992-08-18 Roussel Uclaf 9-alpha-hydroxy steroids,process for their preparation,process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing said steroids
FR2607816B1 (fr) 1986-12-05 1989-03-31 Roussel Uclaf Nouveaux produits steroides comportant, en position 23, un radical sulfinyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20-cetopregnanes et des intermediaires de cette preparation
US5702688A (en) 1986-12-23 1997-12-30 Tristrata Technology, Inc. Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use
US5272140A (en) 1987-01-23 1993-12-21 Akzo N.V. 11-aryl steroid derivatives
US4888336A (en) 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5034548A (en) 1987-01-30 1991-07-23 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
US5041432A (en) 1987-01-30 1991-08-20 E. I. Du Pont De Nemours And Company Steroid derivatives useful as hypocholesterolemics
US5017618A (en) 1987-03-16 1991-05-21 University Of Florida Labile derivatives of ketone analogs of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers
US4910226A (en) 1987-04-29 1990-03-20 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
US5041433A (en) 1987-04-29 1991-08-20 Smithkline Beecham Corporation 11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase
FR2620707B1 (fr) 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2621316B1 (fr) 1987-10-02 1991-06-21 Nativelle Sa Ets Nouveaux esters d'acide androstane 17-carboxylique, procede pour leur preparation, et medicament les contenant
US4927807A (en) 1987-10-06 1990-05-22 Abbott Laboratories Glaucoma treatment
US5346887A (en) 1987-10-06 1994-09-13 Abbott Laboratories Glaucoma treatment
US4874855A (en) 1987-11-04 1989-10-17 Dainippon Ink And Chemicals, Inc. Steroid compounds and process of preparing the same
US4910192A (en) 1987-12-04 1990-03-20 Sri International Topically active steroidal anti-inflammatory agents
EP0322081B1 (de) 1987-12-23 1992-12-16 Roussel-Uclaf Mikrobiologische Herstellung von 9-Alpha-hydroxy-17-keto-steroiden
US4835157A (en) 1988-03-15 1989-05-30 Ortho Pharmaceutical Corporation Thieno- and furopyrimidine-2,4-dione piperidine derivatives as serotonin antagonists and alpha adrenergic blocking agents
AU618350B2 (en) 1988-04-08 1991-12-19 Aventis Pharma S.A. 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
US4868167A (en) 1988-05-20 1989-09-19 University Of Pittsburgh Novel peptidyl amino steroids
US4954446A (en) 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors
US5096892A (en) 1988-05-27 1992-03-17 The Children's Medical Center Corporation Arylsulfatase inhibition and potentiation of angiostatic steroids and heparin
DE3854089T2 (de) 1988-07-05 1995-11-02 Kuraray Co Steroid-verbindungen.
DE3832303A1 (de) 1988-09-20 1990-04-12 Schering Ag 11ss-phenyl-14ssh-steroide
US4882322A (en) 1988-10-27 1989-11-21 Merrell Dow Pharmaceuticals Inc. 3β,17β-hydroxy-substituted steroids and related steroidal compounds
US5371078A (en) 1988-10-31 1994-12-06 Alcon Laboratories, Inc. Angiostatic steroids and methods and compositions for controlling ocular hypertension
US4882319A (en) 1988-12-23 1989-11-21 Smithkline Beckman Corporation Phosphonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
US4937237A (en) 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
US4946834A (en) 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5026882A (en) 1988-12-23 1991-06-25 Smithkline Beecham Corporation Phosphinic acid substituted steroids as inhibitors of steroid 5α-reductase
US4970205A (en) 1988-12-23 1990-11-13 Smithkline Beecham Corporation Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-α-reductase
HU203562B (en) 1989-03-09 1991-08-28 Richter Gedeon Vegyeszet Process for producing new steroide diols and pharmaceutical compositions containing them
HU203769B (en) 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
FR2644789B1 (fr) 1989-03-22 1995-02-03 Roussel Uclaf Nouveaux steroides 19-nor, 3-ceto comportant une chaine en 17 aminosubstituee, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
DE3917274A1 (de) 1989-05-24 1990-11-29 Schering Ag 9(alpha)-hydroxy-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US5116867A (en) 1989-06-30 1992-05-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services D-propranolol as a selective adenosine antagonist
SE509359C2 (sv) 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US5032586A (en) 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5215972A (en) 1989-11-22 1993-06-01 Hoffmann-La Roche Inc. Steroids
US5491136A (en) 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5099037A (en) 1989-12-20 1992-03-24 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors
FR2656310B1 (fr) 1989-12-22 1992-05-07 Roussel Uclaf Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2656309B1 (fr) 1989-12-22 1992-05-07 Roussel Uclaf Nouveaux produits sterouides comportant en position 10, un radical ethyle substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
GB9003939D0 (en) 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
FR2658516B1 (fr) 1990-02-22 1992-06-12 Roussel Uclaf Nouveaux produits sterouides comportant un radical spiro en position 17, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5219879A (en) 1990-03-05 1993-06-15 Du Pont Merck Pharmaceutical Company Heterocyclic steroid compounds
US5116829A (en) 1990-04-23 1992-05-26 Kao Corporation Steroid compounds
JP3294844B2 (ja) 1990-04-30 2002-06-24 ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム ステロイド５α―リダクターゼ
US5209926A (en) 1990-06-12 1993-05-11 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5252319A (en) 1990-06-12 1993-10-12 Insite Vision Incorporated Aminosteroids for ophthalmic use
US5256408A (en) 1990-06-12 1993-10-26 Insite Vision Incorporated Aminosteroids for ophthalmic use
DE4021433A1 (de) 1990-07-04 1992-01-09 Schering Ag Antiandrogene mit steroid(3,2-c)pyrazol-struktur
US5091528A (en) 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5612034A (en) 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
US5843440A (en) 1990-10-03 1998-12-01 Redcell Canada, Inc. Cellular and serum protein anchors for modulating pharmacokinetics
DE4038128A1 (de) 1990-11-27 1992-06-04 Schering Ag 8-en-19, 11(beta)-ueberbrueckte steroide, deren herstellung und diese enthaltende pharmazeutische praeparate
US5126488A (en) 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors
US5166201A (en) 1990-11-30 1992-11-24 Merrell Dow Pharmaceuticals Inc. 2β,19-ethylene bridged steroids as aromatase inhibitors
US5883087A (en) 1991-01-07 1999-03-16 Pherin Corporation Androstane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5888995A (en) 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
IT1250410B (it) 1991-02-14 1995-04-07 Simes Composti steroidei attivi sul sistema cardiovascolare
US5658957A (en) 1991-03-01 1997-08-19 Warner Lambert Company Immunostimulating wound healing compositions and method for preparing and using same
US5614561A (en) 1991-03-01 1997-03-25 Warner-Lambert Company Antihistamine-wound healing compositions and methods for preparing and using same
US5863938A (en) 1991-03-01 1999-01-26 Warner Lambert Company Antibacterial-wound healing compositions and methods for preparing and using same
US5648380A (en) 1991-03-01 1997-07-15 Warner-Lambert Company Anti-inflammatory wound healing compositions and methods for preparing and using same
US5663208A (en) 1991-03-01 1997-09-02 Warner-Lambert Company Antifungal wound healing compositions and methods for preparing and using same
US5674912A (en) 1991-03-01 1997-10-07 Warner-Lambert Company Sunscreen-wound healing compositions and methods for preparing and using same
US5646190A (en) 1991-03-01 1997-07-08 Warner-Lambert Company Acne treating-wound healing compositions and methods for preparing and using same
US5602183A (en) 1991-03-01 1997-02-11 Warner-Lambert Company Dermatological wound healing compositions and methods for preparing and using same
US5652274A (en) 1991-03-01 1997-07-29 Martin; Alain Therapeutic-wound healing compositions and methods for preparing and using same
US5641814A (en) 1991-03-01 1997-06-24 Warner-Lambert Company Antikeratolytic-wound healing compositions and methods for preparing and using same
US5874479A (en) 1991-03-01 1999-02-23 Warner-Lambert Company Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same
US5633285A (en) 1991-03-01 1997-05-27 Warner-Lambert Company Cytoprotective wound healing compositions and methods for preparing and using same
US5856364A (en) 1991-03-01 1999-01-05 Warner Lambert Company Therapeutic antiviral-wound healing compositions and methods for preparing and using same
IT1259419B (it) 1991-05-24 1996-03-18 Erba Carlo Spa Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
GB9118478D0 (en) 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9118465D0 (en) 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5338837A (en) 1991-12-13 1994-08-16 The Trustees Of Princeton University Glycosylated steroid derivatives for transport across biological membranes and process for making same
DE69231281T2 (de) 1991-12-17 2001-03-01 Biovail Technologies Ltd.(N.D.Ges.D.Staates Delaware), Chantilly Zusammensetzung und verfahren zur ulcusprävention und -behandlung
ZA929315B (en) 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
US5206415A (en) 1991-12-20 1993-04-27 Washington University Tricyclic steroid analogs
JP2746041B2 (ja) 1992-02-14 1998-04-28 三菱化学株式会社 新規なステロイド誘導体
FR2688004A1 (fr) 1992-02-27 1993-09-03 Roussel Uclaf Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments.
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
WO1993017715A1 (en) 1992-03-05 1993-09-16 Board Of Regents, The University Of Texas System Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
EP0725074A3 (de) 1992-04-20 1996-11-20 Sankyo Co Verbindungen zur Verwendung also Zwischenprodukte zur Herstellung von Androst-3,5-dien-3-carboxy-Derivaten
US5698720A (en) 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
GB9210880D0 (en) 1992-05-21 1992-07-08 Smithkline Beecham Corp Compounds
FR2691968B1 (fr) 1992-06-04 1994-07-29 Roussel Uclaf Nouveau procede de preparation d'un derive sterouide 11-ceto.
HU212308B (en) 1992-06-09 1996-05-28 Richter Gedeon Vegyeszet Process for producing novel pregnane steroids and pharmaceutical compositions containing the same
JP2578399B2 (ja) 1992-06-26 1997-02-05 ファイザー インク． ステロイド−β−Ｏ−セロビオシドヘプタアルカノエートの製造方法
CA2100514C (en) 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
US5382657A (en) 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
US5561124A (en) 1992-11-18 1996-10-01 Webb; Robert L. 17-α-acyl steroids which inhibit 5-α-reductase
US5506221A (en) 1992-12-24 1996-04-09 University Of British Columbia Contignasterol, and related 3-alpha hydroxy-6-alpha hydroxy-7-beta hydroxy-15-keto-14-beta steroids useful as anti-inflammatory and anti-thrombosis agents
FR2700339B1 (fr) 1993-01-14 1995-03-03 Roussel Uclaf Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires.
SG47557A1 (en) 1993-01-29 1998-04-17 American Cyanamid Co Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents
US5710144A (en) 1993-02-08 1998-01-20 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
US5869337A (en) 1993-02-12 1999-02-09 President And Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
US5834266A (en) 1993-02-12 1998-11-10 President & Fellows Of Harvard College Regulated apoptosis
US5830462A (en) 1993-02-12 1998-11-03 President & Fellows Of Harvard College Regulated transcription of targeted genes and other biological events
EP1978095A1 (de) 1993-02-12 2008-10-08 The Board Of Trustees Of The Leland Stanford Junior University Regulierte Transkription gezielter Gene und anderer biologischer Ereignisse
DE69412596T2 (de) 1993-03-10 1999-03-04 Magainin Pharmaceuticals Inc., Plymouth Meeting, Pa. Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
FR2706454B1 (fr) 1993-06-17 1995-09-15 Roussel Uclaf Nouveaux 19-Nor stéroïdes, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les contenant.
JPH09503645A (ja) 1993-07-16 1997-04-15 ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニアー・ユニバーシティ 制御されたアポトーシス
EP0712311B1 (de) 1993-08-04 1998-10-07 Akzo Nobel N.V. Antiglucocorticoidsteroide zur behandlung von angststörungen
WO1995005389A1 (en) 1993-08-18 1995-02-23 The Board Of Trustees Of The Leland Stanford Junior University Sequence-specific glycoconjugate transcriptional antagonists
US5580892A (en) 1993-10-22 1996-12-03 Allergan Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
ATE177751T1 (de) 1993-10-27 1999-04-15 Merrell Pharma Inc Delta 16 ungesättigtes c17 heterocyclische steroide zur verwendung als steroid c17-20 lyase inhibitoren
ATE173271T1 (de) 1993-12-15 1998-11-15 Taisho Pharmaceutical Co Ltd Sterin epoxid verbindungen zur krebsbehandlung
US5462950A (en) 1993-12-21 1995-10-31 Eli Lilly And Company Methods of treating menstrual symptoms and compositions therefore
CA2136803A1 (en) 1993-12-22 1995-06-23 Kazumi Ogata Steroid derivatives
US5646136A (en) 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
DK0758340T3 (da) 1994-05-02 1999-08-30 Merrell Pharma Inc Fremgangsmåde til fremstilling af 4-amino-delta 4-3-ketosteroider via 4-nitro-delta 4-3-ketosteroider
FR2721927B1 (fr) 1994-07-01 1996-08-09 Roussel Uclaf Nouveau procede de preparation de derives steroides 20-oxo 17 alpha, 21-dihydroxyles et nouveaux intermediaires
US5563131A (en) 1994-08-04 1996-10-08 Pherin Corporation Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5792757A (en) 1994-08-04 1998-08-11 Pherin Pharmaceuticals 19-nor-pregnane steroids as neurochemical initiators of change in human hypothalamic function
EP0776335A4 (de) 1994-08-18 1999-09-15 Ariad Gene Therapeutics Inc Regulierbare elimination der genexpression, genproduktfunktion und gentechnologisch hergestellte wirtszellen
JPH11511643A (ja) 1994-10-25 1999-10-12 ザ・ボード・オブ・トラスティーズ・オブ・ザ・リランド・スタンフォード・ジュニア・ユニバーシティ 遺伝子工学処理された細胞の条件的形質転換
IL115659A (en) 1994-10-27 2000-06-01 Akzo Nobel Nv Steroids with a 17-spiromethylene lactone or lactol group process for their preparation and pharmaceutical compositions containing them
DE69534551T2 (de) 1994-11-01 2006-06-22 Ariad Gene Therapeutics, Inc., Cambridge Neue Methode zum Auffinden und Bewerten biologisch aktiver Moleküle
US5661141A (en) 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
IT1282286B1 (it) 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
US5763361A (en) 1995-10-23 1998-06-09 Merck & Co., Inc. 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors
US5707984A (en) 1995-12-08 1998-01-13 G. D. Searle & Co. Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs
US5792758A (en) 1995-12-08 1998-08-11 G. D. Searle & Co. Steroid nitrite ester derivatives useful as anti-inflammatory drugs
DE19547648A1 (de) 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
JP2000504316A (ja) 1996-01-12 2000-04-11 コンジュケム インコーポレイテッド 診断造影用の細胞蛋白質及び血清蛋白質アンカー
US6277583B1 (en) 1996-02-07 2001-08-21 Conjuchem, Inc. Affinity labeling libraries and applications thereof
US5837698A (en) 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
FR2749012B1 (fr) 1996-05-22 1998-08-07 Hoechst Marion Roussel Inc Nouveaux steroides 1 ou 6-hydroxyles, leur procede de preparation, leur application a titre de medicament et les compositions pharmaceutiques les renfermant
US5840733A (en) 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
AU4351897A (en) 1996-09-16 1998-04-02 Conjuchem, Inc. Affinity labeling libraries with tagged leaving groups
US5763432A (en) 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
US5855907A (en) 1997-03-24 1999-01-05 Peyman; Gholam A. Method of treatment of migraine
KR20010006280A (ko) 1997-04-11 2001-01-26 어드밴스드 메디슨 인코포레이티드 다수개의 활성 잔기를 제공하는 분자
WO1998047916A1 (en) 1997-04-18 1998-10-29 President And Fellows Of Harvard College Bifunctional polypeptides for cell-specific viral targeting
US5866558A (en) 1997-05-08 1999-02-02 Regents Of The University Of Minnesota 6-alkynyl steroids
WO1998051702A1 (en) 1997-05-14 1998-11-19 Sloan-Kettering Institute For Cancer Research Methods and compositions for destruction of selected proteins
US5880115A (en) 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
ATE473759T1 (de) * 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
AU4543899A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
AU769235B2 (en) 1999-04-09 2004-01-22 Sloan-Kettering Institute For Cancer Research Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases
US6887842B1 (en) * 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug

Also Published As

Publication number Publication date
EP1079859A4 (de) 2004-12-08
WO1999061055A1 (en) 1999-12-02
EP1079859B1 (de) 2010-07-14
US20050209146A1 (en) 2005-09-22
DE69942578D1 (de) 2010-08-26
CA2330611A1 (en) 1999-12-02
US6921531B2 (en) 2005-07-26
ES2347027T3 (es) 2010-10-22
EP1079859A1 (de) 2001-03-07
US7390784B2 (en) 2008-06-24
AU4093799A (en) 1999-12-13
US6372712B1 (en) 2002-04-16
US20020147133A1 (en) 2002-10-10

Similar Documents

Publication Publication Date Title
DE69942578D1 (de) Bifunktionelle moleküle sowie darauf basierende therapien.
CA2413190A1 (en) Methods for treating rheumatic diseases using a soluble ctla4 molecule
WO2002083171A3 (en) Cancer treatment by using fap-alpha specific antibodies
DK1242115T3 (da) Kemisk programmerbar immunitet
PT730608E (pt) Composicoes compreendendo hidratos de carbono e proeinas relacionadas pelo complemento e metodos para produzir e utilizar as referidas composicoes
ES2181006T3 (es) Uso de amidas de acidos de piridil alcanos, piridil alquenos y/o piridil alquinos en el tratamiento de tumores o en inmunosupresion.
OA07388A (fr) Nouveaux conjugués associant, par liaison convalente, une enzyme et un anticorps et associations médicamenteuses utilisant lesdits conjugués.
ATE386808T1 (de) Arzneimittelzubereitungen für die behandlung von alpha-galactosidase a-mangel
RU95108231A (ru) Glp-1-молекулярный комплекс, фармацевтическая композиция и способ получения комплекса
FI956019A0 (fi) Eristettyjä peptidejä, jotka muodostavat komplekseja MHC-molekyyli HLA-C-klooni-10:n kanssa, ja niiden käyttö
DE69128543D1 (de) Monoklonale antikörper der maus
ATE369878T1 (de) Träger-pharmaka-konjugate
TR199901949T2 (xx) Lemfositik t�m�rler i�in �areler.
DE60329839D1 (de) Behandlung und verhütung von gewebeschäden, die mit erhöhter produktion von c-reactivem protein verbunden sind
ATE304709T1 (de) Substanzen mit verzweigten linkermolekülen
ATE296312T1 (de) Metalkomplexbildner
ATE222124T1 (de) Chemische mittel
ATE183192T1 (de) Neue colon-oder ilean-spezifische steroid derivate
TR199900770T2 (xx) Nazal poliplerin tedavisinde bir H+, K+-ATPase'�n kullan�lmas�.
DE69422712D1 (de) Tris-platin-komplexe
AU2002360350A1 (en) Peptides that home to tumor lymphatic vasculature and methods of using same
DE50212918D1 (de) Polypeptid, dessen konjugat doxorubicin enthält, uetzung
WO2001008708A3 (en) Enhanced delivery via serpin enzyme complex receptor ligands
EP1414299A4 (de) Im wesentlichen homogenes, biologisch beeinflussendes material mit einem vorbestimmten verhältnis von biologisch beeinflussender komponente zu zell-targeting-komponente, verfahren zur herstellung eines solchen materials und anwendungsverfahren dafür
NO954442L (no) Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties