PT731835E - Oligonucleotidos anti-sentido possuindo actividade inibidora de tumorigenicidade - Google Patents

Oligonucleotidos anti-sentido possuindo actividade inibidora de tumorigenicidade

Info

Publication number
PT731835E
PT731835E PT95904165T PT95904165T PT731835E PT 731835 E PT731835 E PT 731835E PT 95904165 T PT95904165 T PT 95904165T PT 95904165 T PT95904165 T PT 95904165T PT 731835 E PT731835 E PT 731835E
Authority
PT
Portugal
Prior art keywords
tumorigenicity
oligonucleotidos
sense
activity inhibitor
possessing activity
Prior art date
Application number
PT95904165T
Other languages
English (en)
Inventor
Eric Von Hofe
Moshe Szyf
Original Assignee
Univ Mcgill
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mcgill, Hybridon Inc filed Critical Univ Mcgill
Publication of PT731835E publication Critical patent/PT731835E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
PT95904165T 1993-12-01 1994-11-30 Oligonucleotidos anti-sentido possuindo actividade inibidora de tumorigenicidade PT731835E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/161,673 US5578716A (en) 1993-12-01 1993-12-01 DNA methyltransferase antisense oligonucleotides

Publications (1)

Publication Number Publication Date
PT731835E true PT731835E (pt) 2002-11-29

Family

ID=22582230

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95904165T PT731835E (pt) 1993-12-01 1994-11-30 Oligonucleotidos anti-sentido possuindo actividade inibidora de tumorigenicidade

Country Status (10)

Country Link
US (3) US5578716A (pt)
EP (1) EP0731835B1 (pt)
JP (1) JPH09511125A (pt)
AT (1) ATE221914T1 (pt)
CA (1) CA2177732C (pt)
DE (1) DE69431164T2 (pt)
DK (1) DK0731835T3 (pt)
ES (1) ES2180622T3 (pt)
PT (1) PT731835E (pt)
WO (1) WO1995015378A1 (pt)

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AU663702B2 (en) * 1991-03-06 1995-10-19 Board Of Regents, The University Of Texas System Methods and compositions for the selective inhibition of gene expression

Also Published As

Publication number Publication date
US5919772A (en) 1999-07-06
DE69431164T2 (de) 2003-05-08
CA2177732A1 (en) 1995-06-08
US5578716A (en) 1996-11-26
ES2180622T3 (es) 2003-02-16
EP0731835B1 (en) 2002-08-07
AU700264B2 (en) 1998-12-24
WO1995015378A1 (en) 1995-06-08
ATE221914T1 (de) 2002-08-15
DE69431164D1 (de) 2002-09-12
DK0731835T3 (da) 2002-10-28
JPH09511125A (ja) 1997-11-11
EP0731835A1 (en) 1996-09-18
US6054439A (en) 2000-04-25
CA2177732C (en) 2004-04-27
AU1296195A (en) 1995-06-19

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