PT737207E - Inibidores de plasmina humana derivados de dominios kunitz - Google Patents
Inibidores de plasmina humana derivados de dominios kunitzInfo
- Publication number
- PT737207E PT737207E PT95908460T PT95908460T PT737207E PT 737207 E PT737207 E PT 737207E PT 95908460 T PT95908460 T PT 95908460T PT 95908460 T PT95908460 T PT 95908460T PT 737207 E PT737207 E PT 737207E
- Authority
- PT
- Portugal
- Prior art keywords
- kunitz domains
- human plasma
- inhibitors derived
- plasma inhibitors
- nucleic acids
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229940012957 plasmin Drugs 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/515—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics
- C04B35/58—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides
- C04B35/584—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride
- C04B35/593—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering
- C04B35/5935—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on non-oxide ceramics based on borides, nitrides, i.e. nitrides, oxynitrides, carbonitrides or oxycarbonitrides or silicides based on silicon nitride obtained by pressure sintering obtained by gas pressure sintering
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Ceramic Engineering (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Manufacturing & Machinery (AREA)
- Gastroenterology & Hepatology (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Amplifiers (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17965894A | 1994-01-11 | 1994-01-11 | |
| US20826594A | 1994-03-10 | 1994-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT737207E true PT737207E (pt) | 2005-02-28 |
Family
ID=26875521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95908460T PT737207E (pt) | 1994-01-11 | 1995-01-11 | Inibidores de plasmina humana derivados de dominios kunitz |
| PT04022346T PT1489097E (pt) | 1994-01-11 | 1995-01-11 | Inibidores de plasmina humana derivados de domínios kunitz e ácidos nucleicos codificando os mesmos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT04022346T PT1489097E (pt) | 1994-01-11 | 1995-01-11 | Inibidores de plasmina humana derivados de domínios kunitz e ácidos nucleicos codificando os mesmos |
Country Status (10)
| Country | Link |
|---|---|
| US (11) | US6010880A (pt) |
| EP (2) | EP0737207B1 (pt) |
| JP (5) | JP4137997B2 (pt) |
| AT (2) | ATE529444T1 (pt) |
| CA (1) | CA2180954C (pt) |
| DE (1) | DE69533544T2 (pt) |
| DK (2) | DK0737207T3 (pt) |
| ES (2) | ES2375561T3 (pt) |
| PT (2) | PT737207E (pt) |
| WO (1) | WO1995018830A2 (pt) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US5663143A (en) * | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| ATE529444T1 (de) * | 1994-01-11 | 2011-11-15 | Dyax Corp | Inhibitoren des humanplasmins, die sich von den kunitz domänen ableiten |
| US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
| WO1996040224A1 (en) * | 1995-06-07 | 1996-12-19 | Chiron Corporation | Regulation of cytokine synthesis and release |
| US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| WO1997033996A2 (en) | 1996-03-11 | 1997-09-18 | Bayer Corporation | Human bikunin |
| EP2336313A1 (en) | 1997-01-08 | 2011-06-22 | Life Technologies Corporation | Methods for production of proteins |
| US20060025329A1 (en) * | 1997-02-06 | 2006-02-02 | Todd Hembrough | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
| US5981471A (en) | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| US6946439B2 (en) | 1997-02-06 | 2005-09-20 | Entre Med, Inc. | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
| US20020076728A1 (en) * | 1997-03-21 | 2002-06-20 | Maclennan John Moore | Engineering affinity ligands for macromolecules |
| US6087473A (en) * | 1999-05-26 | 2000-07-11 | Zymogenetics, Inc. | Kunitz domain polypeptide and materials and methods for making it |
| CA2342072C (en) * | 1998-09-03 | 2005-01-11 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
| US6380354B1 (en) | 1998-09-03 | 2002-04-30 | Zymogenetics, Inc. | Kunitz domain polypeptide zkun6 |
| US5994310A (en) * | 1998-09-03 | 1999-11-30 | Bayer Corporation | Peptide ligands for affinity purification of human Factor VIII |
| US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
| US20030032146A1 (en) * | 2001-07-10 | 2003-02-13 | Dwulet Francis Edward | Enzyme/tag binding and detection system |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| CA2475382A1 (en) * | 2002-02-07 | 2003-08-14 | Delta Biotechnology Limited | Albumin-fused anti-angiogenesis peptides |
| US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| DK2311432T3 (en) | 2002-06-07 | 2015-02-02 | Dyax Corp | Modified Kunitz domain polypeptides and their use in reducing ischemia or the onset of a systemic inflammatory response associated with a surgical procedure |
| TR201900937T4 (tr) | 2002-08-28 | 2019-02-21 | Dyax Corp | Organların ve dokuların muhafaza edilmesine yönelik yöntem. |
| JP2007524348A (ja) * | 2003-01-07 | 2007-08-30 | ダイアックス、コープ | クニッツドメインライブラリー |
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| AU2004268145B2 (en) * | 2003-08-29 | 2010-09-16 | Takeda Pharmaceutical Company Limited | Poly-PEGylated protease inhibitors |
| US7740973B2 (en) * | 2004-08-05 | 2010-06-22 | General Motors Corporation | Modular electrochemical power system |
| US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| CA2587775A1 (en) * | 2004-11-22 | 2006-06-01 | Dyax Corp. | Plasmin-inhibitory therapies |
| US8841259B2 (en) * | 2005-02-24 | 2014-09-23 | Joslin Diabetes Center | Compositions and methods for treating vascular permeability |
| GB0521404D0 (en) * | 2005-10-20 | 2005-11-30 | Ares Trading Sa | Kunitz domain containing protein |
| US20080090760A2 (en) * | 2005-12-09 | 2008-04-17 | Todd Hembrough | Compositions and Methods for Inhibiting Cellular Proliferation |
| US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| DK1976985T3 (da) * | 2005-12-29 | 2013-10-21 | Univ California | Fremgangsmåder og præparater relateret til mutant Kunitz-domæne I af TFPI-2 |
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| AU2013202021B2 (en) * | 2005-12-29 | 2016-03-10 | The Regents Of The University Of California | Methods and compositions related to mutant Kunitz domain of TFPI-2 |
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| EP1994153A2 (en) * | 2006-03-08 | 2008-11-26 | Bayer HealthCare AG | Chimeric kunitz domains and their use |
| EP2001500A4 (en) * | 2006-03-10 | 2010-07-28 | Dyax Corp | FORMULATIONS FOR ECALLANTIDE |
| ES2601554T3 (es) * | 2006-03-16 | 2017-02-15 | Dyax Corp. | Péptidos inhibidores de calicreína plasmática para uso en el tratamiento de trastornos oftálmicos |
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-
1995
- 1995-01-11 AT AT04022346T patent/ATE529444T1/de active
- 1995-01-11 DE DE69533544T patent/DE69533544T2/de not_active Expired - Lifetime
- 1995-01-11 EP EP95908460A patent/EP0737207B1/en not_active Expired - Lifetime
- 1995-01-11 JP JP51866795A patent/JP4137997B2/ja not_active Expired - Fee Related
- 1995-01-11 AT AT95908460T patent/ATE277081T1/de active
- 1995-01-11 PT PT95908460T patent/PT737207E/pt unknown
- 1995-01-11 DK DK95908460T patent/DK0737207T3/da active
- 1995-01-11 EP EP04022346A patent/EP1489097B1/en not_active Expired - Lifetime
- 1995-01-11 ES ES04022346T patent/ES2375561T3/es not_active Expired - Lifetime
- 1995-01-11 US US08/676,124 patent/US6010880A/en not_active Expired - Lifetime
- 1995-01-11 CA CA002180954A patent/CA2180954C/en not_active Expired - Fee Related
- 1995-01-11 ES ES95908460T patent/ES2229236T3/es not_active Expired - Lifetime
- 1995-01-11 PT PT04022346T patent/PT1489097E/pt unknown
- 1995-01-11 WO PCT/US1995/000298 patent/WO1995018830A2/en not_active Ceased
- 1995-01-11 DK DK04022346.3T patent/DK1489097T3/da active
-
1999
- 1999-01-29 US US09/240,136 patent/US6103499A/en not_active Expired - Lifetime
- 1999-10-08 US US09/414,878 patent/US6071723A/en not_active Expired - Lifetime
-
2000
- 2000-08-15 US US09/638,770 patent/US6423498B1/en not_active Expired - Fee Related
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2002
- 2002-06-11 US US10/167,351 patent/US6953674B2/en not_active Expired - Fee Related
-
2005
- 2005-03-18 US US11/083,742 patent/US8431359B2/en not_active Expired - Fee Related
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2007
- 2007-10-24 JP JP2007276165A patent/JP2008113657A/ja active Pending
- 2007-10-30 US US11/928,448 patent/US7919462B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/928,351 patent/US20090036365A1/en not_active Abandoned
- 2007-10-30 US US11/928,497 patent/US20080182283A1/en not_active Abandoned
- 2007-10-31 US US11/932,411 patent/US20090023651A1/en not_active Abandoned
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2008
- 2008-11-19 JP JP2008295610A patent/JP2009183281A/ja active Pending
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2011
- 2011-02-25 US US13/034,967 patent/US20110152193A1/en not_active Abandoned
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2012
- 2012-02-29 JP JP2012044051A patent/JP2012111779A/ja active Pending
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2013
- 2013-06-19 JP JP2013128491A patent/JP2013249302A/ja active Pending
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