PT742720E - Co-administracao de polipeptideos mutantes de interleuquina-3 com csf's para producao de celulas hematopoieticas multi-linhagem - Google Patents

Co-administracao de polipeptideos mutantes de interleuquina-3 com csf's para producao de celulas hematopoieticas multi-linhagem

Info

Publication number
PT742720E
PT742720E PT95911589T PT95911589T PT742720E PT 742720 E PT742720 E PT 742720E PT 95911589 T PT95911589 T PT 95911589T PT 95911589 T PT95911589 T PT 95911589T PT 742720 E PT742720 E PT 742720E
Authority
PT
Portugal
Prior art keywords
csf
interleukin
linhage
polyepeptide
mutants
Prior art date
Application number
PT95911589T
Other languages
English (en)
Inventor
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumnan Paik
John Warren Thomas
Christopher S Bauer
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT742720E publication Critical patent/PT742720E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PT95911589T 1994-02-04 1995-02-02 Co-administracao de polipeptideos mutantes de interleuquina-3 com csf's para producao de celulas hematopoieticas multi-linhagem PT742720E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/193,373 US6153183A (en) 1992-11-24 1994-02-04 Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production

Publications (1)

Publication Number Publication Date
PT742720E true PT742720E (pt) 2003-09-30

Family

ID=22713377

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95911589T PT742720E (pt) 1994-02-04 1995-02-02 Co-administracao de polipeptideos mutantes de interleuquina-3 com csf's para producao de celulas hematopoieticas multi-linhagem

Country Status (10)

Country Link
US (4) US6153183A (pt)
EP (1) EP0742720B1 (pt)
AT (1) ATE239496T1 (pt)
AU (1) AU1909995A (pt)
CA (1) CA2182474A1 (pt)
DE (1) DE69530676T2 (pt)
DK (1) DK0742720T3 (pt)
ES (1) ES2199242T3 (pt)
PT (1) PT742720E (pt)
WO (1) WO1995020977A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
AU2866599A (en) * 1998-02-17 1999-08-30 Hyseq, Inc. A novel interleukin-3 and uses thereof
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
EP1425304B9 (en) * 2001-07-11 2010-09-08 Maxygen, Inc. G-csf conjugates
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
KR20080027291A (ko) 2005-06-01 2008-03-26 맥시겐 홀딩스 엘티디 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법
US8226162B2 (en) * 2009-09-11 2012-07-24 Campbell Corey A Child safety seat

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
UA39161C2 (uk) 1984-07-06 2001-06-15 Новартіс Аг Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
GR871029B (en) 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
EP0790307A1 (en) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molecular cloning and expression of human IL-3
AU1496688A (en) * 1987-01-20 1988-08-10 Immunex Corporation Human interleukin-3 proteins
EP0345249A1 (de) * 1987-02-12 1989-12-13 Peter Herbrig Badeplattform für boote
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
AU5355790A (en) * 1989-04-19 1990-11-16 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
EP0810285A3 (en) * 1989-08-14 1998-07-08 Gist-Brocades B.V. Mutants of human Interleukin-3
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
WO1992006116A1 (en) 1990-09-28 1992-04-16 Ortho Pharmaceutical Corporation Hybrid growth factors
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
EP0609280B1 (en) * 1991-10-07 1999-04-21 Medvet Science Pty. Ltd. Human il-3 variants
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
EP1361273A3 (en) * 1992-11-24 2004-02-11 G.D. Searle & Co. Interleukin-3 (IL-3) multiple mutation polypeptides
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
US6379662B1 (en) 2002-04-30
ATE239496T1 (de) 2003-05-15
EP0742720A1 (en) 1996-11-20
DE69530676D1 (de) 2003-06-12
DK0742720T3 (da) 2003-08-25
EP0742720B1 (en) 2003-05-07
US6153183A (en) 2000-11-28
CA2182474A1 (en) 1995-08-10
US6060047A (en) 2000-05-09
US6093395A (en) 2000-07-25
ES2199242T3 (es) 2004-02-16
DE69530676T2 (de) 2004-03-18
WO1995020977A1 (en) 1995-08-10
AU1909995A (en) 1995-08-21

Similar Documents

Publication Publication Date Title
PT741576E (pt) Co-administracao de mutantes de interleucina-3 com factores estimuladores de colonias
EP1482044A3 (en) Multivariant IL-3 hematopoiesis fusion protein
EP1323737A3 (en) Il-3 variant hematopoiesis fusion protein
AU8149491A (en) New forms of colony stimulating factor-1
AU7087891A (en) Modified hil-6
AU6003990A (en) Human gp130 protein
RU2008146718A (ru) Способы лечения неврологических состояний с применением гематопоэтических факторов роста
CA2193993A1 (en) New hil-4 mutant proteins used as antagonists or partial agonists of human interleukin 4
ES8704976A1 (es) Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre.
AU631312B2 (en) Muteins of the granulocyte colony stimulating factor (g-csf)
EP0218531A3 (en) Immunogenic peptides of human interleukin-1 and the corresponding anti-peptide antibodies
AU637139B2 (en) Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use
PT742720E (pt) Co-administracao de polipeptideos mutantes de interleuquina-3 com csf's para producao de celulas hematopoieticas multi-linhagem
IT8421436A1 (it) Un plasmide ricombinante, un microorganismo trasformante, un segmento di polideossiribonucleotide, un procedimento per produrre una proteina biologicamente attiva e la proteina così prodotta
EP0835661A3 (en) Human interferon-Beta2A for use as a medicament
MX9702341A (es) Citoquina designada lerk-6.
ATE145939T1 (de) Mitogen für die glatte muskulatur und dessen kodierende dns
WO2000027881A3 (de) Menschliche interleukin -10 mutantenproteine
AU2103800A (en) Recombinant growth factor with the biological activity of a g-csf (granulocyte colony stimulating factor)