PT788480E - Cristalizacao de levobupivacaina e seus analogos - Google Patents

Cristalizacao de levobupivacaina e seus analogos

Info

Publication number: PT788480E
Authority: PT; Portugal
Prior art keywords: pct; levobupivacaine; analogs; crystallization; sec
Prior art date: 1994-10-25

Application number

PT95934738T

Other languages

English (en)

Inventor

Marianne Langston

Benjamin Mark Skead

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-25

Filing date

1995-10-23

Publication date

2003-12-31

1994-10-25 Priority claimed from GB9421476A external-priority patent/GB9421476D0/en

1995-03-10 Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en

1995-10-23 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2003-12-31 Publication of PT788480E publication Critical patent/PT788480E/pt

Links

238000002425 crystallisation Methods 0.000 title 1
230000008025 crystallization Effects 0.000 title 1
LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title 1
229960004288 levobupivacaine Drugs 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Investigating Or Analysing Biological Materials (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Epoxy Compounds (AREA)

PT95934738T 1994-10-25 1995-10-23 Cristalizacao de levobupivacaina e seus analogos PT788480E (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9421476A GB9421476D0 (en)	1994-10-25	1994-10-25	Process and salt
GBGB9504926.8A GB9504926D0 (en)	1995-03-10	1995-03-10	Crystallisation

Publications (1)

Publication Number	Publication Date
PT788480E true PT788480E (pt)	2003-12-31

Family

ID=26305863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95934738T PT788480E (pt)	1994-10-25	1995-10-23	Cristalizacao de levobupivacaina e seus analogos

Country Status (16)

Country	Link
US (1)	US5994548A (pt)
EP (1)	EP0788480B1 (pt)
JP (1)	JP3911545B2 (pt)
AT (1)	ATE245629T1 (pt)
AU (1)	AU698637B2 (pt)
CA (1)	CA2200355C (pt)
DE (1)	DE69531356T2 (pt)
DK (1)	DK0788480T3 (pt)
ES (1)	ES2202375T3 (pt)
FI (1)	FI117438B (pt)
HU (1)	HU227420B1 (pt)
MX (1)	MX9703024A (pt)
NO (1)	NO309266B1 (pt)
PL (1)	PL183210B1 (pt)
PT (1)	PT788480E (pt)
WO (1)	WO1996012699A1 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0002246A (pt) *	2000-04-06	2003-04-15	Cristalia Prod Quimicos Farm	Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) *	2001-10-10	2021-05-25	Cristalia Produtos Quim Farmaceuticos Ltda	n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en)	2002-06-25	2004-01-01	Guohua Chen	Short duration depot formulations
EP2218448B1 (en)	2002-12-13	2015-09-23	Durect Corporation	Oral drug delivery system comprising high viscosity liquid carrier materials
US7094812B2 (en) *	2003-04-24	2006-08-22	Xerox Corporations	Colorant compositions
US6790267B1 (en) *	2003-04-24	2004-09-14	Xerox Corporation	Colorant compositions
DK2767292T3 (en)	2004-09-17	2016-12-19	Durect Corp	RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
US20070027105A1 (en)	2005-07-26	2007-02-01	Alza Corporation	Peroxide removal from drug delivery vehicle
WO2007123405A1 (en) *	2006-04-25	2007-11-01	Dishman Pharmaceuticals And Chemicals Ltd.	Ropivacaine hydrochloride anhydrate and the preparation thereof
AU2007325918B2 (en)	2006-11-03	2013-10-17	Durect Corporation	Transdermal delivery systems comprising bupivacaine
EP2067471B1 (en)	2007-12-06	2018-02-14	Durect Corporation	Oral pharmaceutical dosage forms
ES2383714T3 (es) *	2008-01-15	2012-06-25	Pharmathen S.A.	Proceso para preparar un compuesto (S)-1-alquil-2',6'-pipecoloxilidídico
US20100260844A1 (en)	2008-11-03	2010-10-14	Scicinski Jan J	Oral pharmaceutical dosage forms
CN103073484B (zh) *	2013-01-28	2014-10-22	山东诚创医药技术开发有限公司	一种甲哌卡因及其光学对映体的制备方法
CA2905131A1 (en)	2013-03-15	2014-09-18	Durect Corporation	Compositions with a rheological modifier to reduce dissolution variability
CN109475505A (zh)	2016-07-06	2019-03-15	度瑞公司	具有药物组成物、屏障层及药物层的口服剂型
CA3048485C (en) *	2016-12-26	2022-07-19	Cellix Bio Private Limited	Compositions and methods for the treatment of chronic pain
WO2021146215A1 (en)	2020-01-13	2021-07-22	Durect Corporation	Sustained release drug delivery systems with reduced impurities and related methods
CA3203561A1 (en)	2021-01-12	2022-07-21	Adrian Neil Verity	Sustained release drug delivery systems and related methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE341404B (pt) *	1967-05-18	1971-12-27	Sterling Drug Inc
US4695576A (en) *	1984-07-09	1987-09-22	Astra Lake Medel Aktiebolag	L-N-n-propylpipecolic acid-2,6-xylidide

1995
- 1995-10-23 WO PCT/GB1995/002513 patent/WO1996012699A1/en not_active Ceased
- 1995-10-23 DE DE69531356T patent/DE69531356T2/de not_active Expired - Lifetime
- 1995-10-23 PL PL95319829A patent/PL183210B1/pl unknown
- 1995-10-23 AU AU37048/95A patent/AU698637B2/en not_active Expired
- 1995-10-23 PT PT95934738T patent/PT788480E/pt unknown
- 1995-10-23 CA CA002200355A patent/CA2200355C/en not_active Expired - Lifetime
- 1995-10-23 AT AT95934738T patent/ATE245629T1/de active
- 1995-10-23 EP EP95934738A patent/EP0788480B1/en not_active Expired - Lifetime
- 1995-10-23 JP JP51373896A patent/JP3911545B2/ja not_active Expired - Lifetime
- 1995-10-23 US US08/849,418 patent/US5994548A/en not_active Expired - Lifetime
- 1995-10-23 MX MX9703024A patent/MX9703024A/es unknown
- 1995-10-23 HU HU9702372A patent/HU227420B1/hu unknown
- 1995-10-23 DK DK95934738T patent/DK0788480T3/da active
- 1995-10-23 ES ES95934738T patent/ES2202375T3/es not_active Expired - Lifetime
1997
- 1997-04-22 FI FI971711A patent/FI117438B/fi not_active IP Right Cessation
- 1997-04-24 NO NO971903A patent/NO309266B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU3704895A (en)	1996-05-15
JP3911545B2 (ja)	2007-05-09
HUT77631A (hu)	1998-06-29
PL319829A1 (en)	1997-09-01
JPH10507464A (ja)	1998-07-21
DK0788480T3 (da)	2003-09-29
FI117438B (fi)	2006-10-13
MX9703024A (es)	1997-10-31
HU227420B1 (en)	2011-05-30
WO1996012699A1 (en)	1996-05-02
FI971711A0 (fi)	1997-04-22
CA2200355A1 (en)	1996-05-02
FI971711L (fi)	1997-04-22
AU698637B2 (en)	1998-11-05
EP0788480A1 (en)	1997-08-13
PL183210B1 (pl)	2002-06-28
DE69531356T2 (de)	2004-05-27
US5994548A (en)	1999-11-30
NO971903D0 (no)	1997-04-24
EP0788480B1 (en)	2003-07-23
DE69531356D1 (de)	2003-08-28
NO309266B1 (no)	2001-01-08
NO971903L (no)	1997-04-24
ES2202375T3 (es)	2004-04-01
ATE245629T1 (de)	2003-08-15
CA2200355C (en)	2007-03-06

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