DK0788480T3 - Krystallisering af levobupivacain og analoger deraf - Google Patents

Krystallisering af levobupivacain og analoger deraf

Info

Publication number: DK0788480T3
Authority: DK; Denmark
Prior art keywords: pct; levobupivacaine; analogues; crystallization; sec
Prior art date: 1994-10-25

Application number

DK95934738T

Other languages

English (en)

Inventor

Marianne Langston

Benjamin Mark Skead

Original Assignee

Darwin Discovery Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-25

Filing date

1995-10-23

Publication date

2003-09-29

1994-10-25 Priority claimed from GB9421476A external-priority patent/GB9421476D0/en

1995-03-10 Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en

1995-10-23 Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd

2003-09-29 Application granted granted Critical

2003-09-29 Publication of DK0788480T3 publication Critical patent/DK0788480T3/da

Links

238000002425 crystallisation Methods 0.000 title 1
230000008025 crystallization Effects 0.000 title 1
LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 title 1
229960004288 levobupivacaine Drugs 0.000 title 1
239000003795 chemical substances by application Substances 0.000 abstract 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
235000002906 tartaric acid Nutrition 0.000 abstract 1
239000011975 tartaric acid Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Saccharide Compounds (AREA)
Epoxy Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

DK95934738T 1994-10-25 1995-10-23 Krystallisering af levobupivacain og analoger deraf DK0788480T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9421476A GB9421476D0 (en)	1994-10-25	1994-10-25	Process and salt
GBGB9504926.8A GB9504926D0 (en)	1995-03-10	1995-03-10	Crystallisation
PCT/GB1995/002513 WO1996012699A1 (en)	1994-10-25	1995-10-23	Crystallisation of levobupivacaine and analogues thereof

Publications (1)

Publication Number	Publication Date
DK0788480T3 true DK0788480T3 (da)	2003-09-29

Family

ID=26305863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95934738T DK0788480T3 (da)	1994-10-25	1995-10-23	Krystallisering af levobupivacain og analoger deraf

Country Status (16)

Country	Link
US (1)	US5994548A (da)
EP (1)	EP0788480B1 (da)
JP (1)	JP3911545B2 (da)
AT (1)	ATE245629T1 (da)
AU (1)	AU698637B2 (da)
CA (1)	CA2200355C (da)
DE (1)	DE69531356T2 (da)
DK (1)	DK0788480T3 (da)
ES (1)	ES2202375T3 (da)
FI (1)	FI117438B (da)
HU (1)	HU227420B1 (da)
MX (1)	MX9703024A (da)
NO (1)	NO309266B1 (da)
PL (1)	PL183210B1 (da)
PT (1)	PT788480E (da)
WO (1)	WO1996012699A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0002246A (pt) *	2000-04-06	2003-04-15	Cristalia Prod Quimicos Farm	Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) *	2001-10-10	2021-05-25	Cristalia Produtos Quim Farmaceuticos Ltda	n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en)	2002-06-25	2004-01-01	Guohua Chen	Short duration depot formulations
ATE482695T1 (de) *	2002-12-13	2010-10-15	Durect Corp	Orale darreichungsform mit flüssigen hochviskosen trägersystemen
US7094812B2 (en) *	2003-04-24	2006-08-22	Xerox Corporations	Colorant compositions
US6790267B1 (en) *	2003-04-24	2004-09-14	Xerox Corporation	Colorant compositions
BRPI0515372B8 (pt)	2004-09-17	2021-05-25	Durect Corp	composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico
US20070027105A1 (en)	2005-07-26	2007-02-01	Alza Corporation	Peroxide removal from drug delivery vehicle
JP2009535327A (ja) *	2006-04-25	2009-10-01	ディシュマン・ファーマシューティカルズ・アンド・ケミカルズ・リミテッド	ロピバカイン塩酸塩無水物およびその調製
PL2117521T3 (pl)	2006-11-03	2012-11-30	Durect Corp	Transdermalne systemy dostarczania zawierające bupiwakainę
WO2009075782A1 (en)	2007-12-06	2009-06-18	Durect Corporation	Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
ATE555093T1 (de) *	2008-01-15	2012-05-15	Pharmathen Sa	Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung
US20100260844A1 (en)	2008-11-03	2010-10-14	Scicinski Jan J	Oral pharmaceutical dosage forms
CN103073484B (zh) *	2013-01-28	2014-10-22	山东诚创医药技术开发有限公司	一种甲哌卡因及其光学对映体的制备方法
CA2905131A1 (en)	2013-03-15	2014-09-18	Durect Corporation	Compositions with a rheological modifier to reduce dissolution variability
US12274794B2 (en)	2016-07-06	2025-04-15	Orient Pharma Co., Ltd.	Oral dosage form with drug composition, barrier layer and drug layer
CN110325179A (zh) *	2016-12-26	2019-10-11	塞尔利克斯生物私人有限公司	用于治疗慢性疼痛的组合物和方法
CA3167217A1 (en)	2020-01-13	2021-07-22	Durect Corporation	Sustained release drug delivery systems with reduced impurities and related methods
CN116940358A (zh)	2021-01-12	2023-10-24	度勒科特公司	持续释放药物递送系统和有关的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE341404B (da) *	1967-05-18	1971-12-27	Sterling Drug Inc
US4695576A (en) *	1984-07-09	1987-09-22	Astra Lake Medel Aktiebolag	L-N-n-propylpipecolic acid-2,6-xylidide

1995
- 1995-10-23 CA CA002200355A patent/CA2200355C/en not_active Expired - Lifetime
- 1995-10-23 ES ES95934738T patent/ES2202375T3/es not_active Expired - Lifetime
- 1995-10-23 WO PCT/GB1995/002513 patent/WO1996012699A1/en not_active Ceased
- 1995-10-23 AU AU37048/95A patent/AU698637B2/en not_active Expired
- 1995-10-23 US US08/849,418 patent/US5994548A/en not_active Expired - Lifetime
- 1995-10-23 HU HU9702372A patent/HU227420B1/hu unknown
- 1995-10-23 PT PT95934738T patent/PT788480E/pt unknown
- 1995-10-23 EP EP95934738A patent/EP0788480B1/en not_active Expired - Lifetime
- 1995-10-23 DK DK95934738T patent/DK0788480T3/da active
- 1995-10-23 PL PL95319829A patent/PL183210B1/pl unknown
- 1995-10-23 DE DE69531356T patent/DE69531356T2/de not_active Expired - Lifetime
- 1995-10-23 AT AT95934738T patent/ATE245629T1/de active
- 1995-10-23 MX MX9703024A patent/MX9703024A/es unknown
- 1995-10-23 JP JP51373896A patent/JP3911545B2/ja not_active Expired - Lifetime
1997
- 1997-04-22 FI FI971711A patent/FI117438B/fi not_active IP Right Cessation
- 1997-04-24 NO NO971903A patent/NO309266B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU3704895A (en)	1996-05-15
FI117438B (fi)	2006-10-13
JPH10507464A (ja)	1998-07-21
ATE245629T1 (de)	2003-08-15
CA2200355C (en)	2007-03-06
PT788480E (pt)	2003-12-31
EP0788480A1 (en)	1997-08-13
FI971711A0 (fi)	1997-04-22
EP0788480B1 (en)	2003-07-23
NO971903D0 (no)	1997-04-24
DE69531356D1 (de)	2003-08-28
MX9703024A (es)	1997-10-31
WO1996012699A1 (en)	1996-05-02
FI971711L (fi)	1997-04-22
ES2202375T3 (es)	2004-04-01
JP3911545B2 (ja)	2007-05-09
CA2200355A1 (en)	1996-05-02
DE69531356T2 (de)	2004-05-27
PL183210B1 (pl)	2002-06-28
NO971903L (no)	1997-04-24
HUT77631A (hu)	1998-06-29
AU698637B2 (en)	1998-11-05
PL319829A1 (en)	1997-09-01
NO309266B1 (no)	2001-01-08
HU227420B1 (en)	2011-05-30
US5994548A (en)	1999-11-30

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