PT792643E - Derivados de benzimidazol sua preparacao e uso terapeutico - Google Patents

Derivados de benzimidazol sua preparacao e uso terapeutico

Info

Publication number: PT792643E
Authority: PT; Portugal
Prior art keywords: preparation; therapeutic use; benzimidazole derivatives; ischemia; mammal
Prior art date: 1996-02-29

Application number

PT97301172T

Other languages

English (en)

Inventor

Thomas A Beyer

Delvin R Knight Jr

Banavara L Mylari

Peter J Oates

Wayne R Tracey

Eric A Pettipher

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-29

Filing date

1997-02-21

Publication date

2002-08-30

1997-02-21 Application filed by Pfizer filed Critical Pfizer

2002-08-30 Publication of PT792643E publication Critical patent/PT792643E/pt

Links

229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
229940118148 Aldose reductase inhibitor Drugs 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 abstract 1
210000005003 heart tissue Anatomy 0.000 abstract 1
208000028867 ischemia Diseases 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000000451 tissue damage Effects 0.000 abstract 1
231100000827 tissue damage Toxicity 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01021—Aldehyde reductase (1.1.1.21), i.e. aldose-reductase

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Heart & Thoracic Surgery (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Plant Substances (AREA)

PT97301172T 1996-02-29 1997-02-21 Derivados de benzimidazol sua preparacao e uso terapeutico PT792643E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US1270796P	1996-02-29	1996-02-29

Publications (1)

Publication Number	Publication Date
PT792643E true PT792643E (pt)	2002-08-30

Family

ID=21756300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97301172T PT792643E (pt)	1996-02-29	1997-02-21	Derivados de benzimidazol sua preparacao e uso terapeutico

Country Status (14)

Country	Link
US (1)	US6127367A (pt)
EP (1)	EP0792643B1 (pt)
JP (1)	JPH09316003A (pt)
KR (1)	KR970061252A (pt)
CN (1)	CN1081460C (pt)
AT (1)	ATE216239T1 (pt)
AU (1)	AU724327B2 (pt)
CA (1)	CA2198564C (pt)
DE (1)	DE69711972T2 (pt)
DK (1)	DK0792643T3 (pt)
ES (1)	ES2172748T3 (pt)
IL (1)	IL120264A0 (pt)
PT (1)	PT792643E (pt)
ZA (1)	ZA971717B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0982306A3 (en) *	1998-08-21	2000-07-05	Pfizer Products Inc.	Polymorph of zopolrestat monohydrate
US7151102B2 (en)	2000-10-30	2006-12-19	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
WO2002098421A1 (en) *	2001-06-05	2002-12-12	University Of Maryland, Baltimore	Novel treatment for neurological and psychiatric disorders
DE60335359D1 (de)	2002-04-30	2011-01-27	Kudos Pharm Ltd	Phthalazinonderivate
US7449464B2 (en)	2003-03-12	2008-11-11	Kudos Pharmaceuticals Limited	Phthalazinone derivatives
GB0305681D0 (en)	2003-03-12	2003-04-16	Kudos Pharm Ltd	Phthalazinone derivatives
GB0419072D0 (en)	2004-08-26	2004-09-29	Kudos Pharm Ltd	Phthalazinone derivatives
US20110092566A1 (en) *	2004-11-19	2011-04-21	Srivastava Satish K	Treatment of cancer with aldose reductase inhibitors
GB0521373D0 (en)	2005-10-20	2005-11-30	Kudos Pharm Ltd	Pthalazinone derivatives
DK1961420T3 (da) *	2005-12-16	2012-08-27	Sanwa Kagaku Kenkyusho Co	Middel til forebyggelse og behandling af akut nyresvigt
KR20080108465A (ko) *	2006-02-20	2008-12-15	가부시키가이샤산와카가쿠켄큐쇼	뇌졸중에 있어서의 뇌허혈 또는 뇌허혈 재관류 장해의 예방또는 치료제
UY30639A1 (es)	2006-10-17	2008-05-31	Kudos Pharm Ltd	Derivados sustituidos de 2h-ftalazin-1-ona, sus formas cristalinas, proceso de preparacion y aplicaciones
ES2409930T3 (es) *	2007-01-31	2013-06-28	Sanwa Kagaku Kenkyusho Co., Ltd	Agente protector del nervio de la retina o del nervio óptico
US8273746B2 (en) *	2007-03-23	2012-09-25	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibitors
MX2010002749A (es)	2007-09-14	2010-06-25	Astrazeneca Ab	Derivados de ftalazinona.
CA2702429A1 (en)	2007-10-17	2009-04-23	Kudos Pharmaceuticals Limited	Crystalline form l 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one
US20110236394A1 (en) *	2007-11-15	2011-09-29	Universite Laval	Methods for the regulation of the prostaglandin f synthase (pgfs) activity of akr1b1 and uses thereof
AR070221A1 (es)	2008-01-23	2010-03-25	Astrazeneca Ab	Derivados de ftalazinona inhibidores de polimerasas, composiciones farmaceuticas que los contienen y usos de los mismos para prevenir y/o tratar tumores cancerigenos,lesiones isquemicas y otras enfermedades asociadas.
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition
ES2598178T5 (es)	2008-10-07	2023-12-26	Kudos Pharm Ltd	Formulación farmacéutica 514
CA2822672C (en)	2010-12-23	2018-06-05	The Board Of Regents Of The University Of Texas System	Methods for treating copd
EP3529410B1 (en)	2016-10-19	2022-04-20	Spectrum Brands, Inc.	Portable steam generator base for iron
WO2022197487A1 (en)	2021-03-18	2022-09-22	Banavara MYLARI	Combination of aldose reductase inhibitors and probenecid for the treatment of diabetic complications
KR102888312B1 (ko) *	2022-09-07	2025-11-20	애니머스큐어 주식회사	알도오즈 환원효소 억제제를 포함하는 근원 세포 증식 및 분화 촉진용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4492706A (en) *	1983-08-01	1985-01-08	American Home Products Corporation	Method of lowering lipid levels
US4939140A (en) *	1985-11-07	1990-07-03	Pfizer Inc.	Heterocyclic oxophthalazinyl acetic acids
EP0310931A3 (en) *	1987-10-08	1990-10-03	Ethyl Corporation	Poultry feed
FR2665440B1 (fr) *	1990-07-31	1994-02-04	Lipha	Nouveaux cycloalkylsulfonamides substitues, procedes de preparation et medicaments les contenant.
US5064830A (en) *	1990-08-02	1991-11-12	Pfizer Inc.	Lowering of blood uric acid levels
JP3049284B2 (ja) *	1990-11-07	2000-06-05	株式会社三和化学研究所	ヒダントイン誘導体並びにそれを有効成分とする糖尿病合併症及び循環器系疾患の予防及び治療剤
US5391551A (en) *	1993-05-10	1995-02-21	Pfizer Inc.	Method of lowering blood lipid levels
US5834466A (en) *	1994-12-22	1998-11-10	The Regents Of The University Of California	Method for protecting of heart by limiting metabolic and ionic abnormalities developed during ischemia, following ischemia or resulting from ischemia
CA2208485A1 (en) *	1994-12-22	1996-06-27	Ravichandran Ramasamy	Method for protecting the heart from ischemia
CZ293016B6 (cs) *	1995-06-01	2004-01-14	Sankyo Company Limited	Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem

1997
- 1997-02-20 IL IL12026497A patent/IL120264A0/xx not_active IP Right Cessation
- 1997-02-20 US US08/803,301 patent/US6127367A/en not_active Expired - Fee Related
- 1997-02-21 DK DK97301172T patent/DK0792643T3/da active
- 1997-02-21 PT PT97301172T patent/PT792643E/pt unknown
- 1997-02-21 DE DE69711972T patent/DE69711972T2/de not_active Expired - Fee Related
- 1997-02-21 ES ES97301172T patent/ES2172748T3/es not_active Expired - Lifetime
- 1997-02-21 EP EP97301172A patent/EP0792643B1/en not_active Expired - Lifetime
- 1997-02-21 AT AT97301172T patent/ATE216239T1/de not_active IP Right Cessation
- 1997-02-24 JP JP9039071A patent/JPH09316003A/ja active Pending
- 1997-02-26 CA CA002198564A patent/CA2198564C/en not_active Expired - Fee Related
- 1997-02-27 CN CN97102574A patent/CN1081460C/zh not_active Expired - Fee Related
- 1997-02-27 ZA ZA971717A patent/ZA971717B/xx unknown
- 1997-02-28 KR KR1019970006780A patent/KR970061252A/ko not_active Ceased
- 1997-02-28 AU AU15010/97A patent/AU724327B2/en not_active Ceased

Also Published As

Publication number	Publication date
ATE216239T1 (de)	2002-05-15
US6127367A (en)	2000-10-03
AU724327B2 (en)	2000-09-14
KR970061252A (ko)	1997-09-12
DK0792643T3 (da)	2002-07-22
MX9701533A (es)	1998-06-30
DE69711972T2 (de)	2002-08-29
CA2198564A1 (en)	1997-08-29
CN1168794A (zh)	1997-12-31
EP0792643B1 (en)	2002-04-17
ES2172748T3 (es)	2002-10-01
CN1081460C (zh)	2002-03-27
EP0792643A1 (en)	1997-09-03
JPH09316003A (ja)	1997-12-09
IL120264A0 (en)	1997-06-10
ZA971717B (en)	1998-08-27
AU1501097A (en)	1997-09-04
CA2198564C (en)	2000-06-27
DE69711972D1 (de)	2002-05-23

Publication	Publication Date	Title
PT792643E (pt)	2002-08-30	Derivados de benzimidazol sua preparacao e uso terapeutico
EE04190B1 (et)	2003-12-15	Asendatud bensopüraani derivaatide kasutamine põletiku raviks
TR28762A (tr)	1997-02-20	Fungisidal optik bakimdan aktif 2-imidazolin-5-one ve 2-imidazolin-5-tion türevleri.
LU92024I2 (fr)	2012-08-20	Pasireotide et ses dérivés pharmaceutiquement acceptables (SIGNIFOR)
BR9711627A (pt)	1999-08-24	Derivados de cido propiÄnico e seu uso
FI952033A7 (fi)	1995-11-04	Farmakologisesti aktiiviset pyrrolopyrimidiinijohdannaiset
BR9808181B1 (pt)	2009-01-13	uso de um conservante de madeira e bandagem para a pàs-proteÇço de madeira.
AU3965900A (en)	2000-11-10	Cyclo-alkyl substituted benzimidazoles and their use as parp inhibitors
BR9707812A (pt)	1999-07-27	Composto composto farmacêutica e uso do composto
BR9707808A (pt)	1999-07-27	Composto composição farmacêutica e uso do composto
DE69528843D1 (de)	2002-12-19	Pharmakologisch aktive 2-mercaptobenzimidazolderivate
NO20005271D0 (no)	2000-10-19	Optisk aktive tetrahydrobenzindol-derivater
DE69710333D1 (de)	2002-03-21	Cyclopentan(en)säure-2-alkenyl-derivate als therapeutika in der behandlung der okulären hypertonie
IT1311753B1 (it)	2002-03-19	Amplificatore a fibra ottica e dispositivo di amplificazione otticaper trasmissione ottica bidirezionale utilizzante l'amplificatore a
ITMI920785A1 (it)	1993-10-01	Microsfere biodegradabili ad uso farmaceutico e cosmetico
AU3347493A (en)	1993-08-03	Pharmaceutically active substituted benzimidazole derivatives
NO20026243D0 (no)	2002-12-27	7-hydroksyepiandrosteron med neurobeskyttende aktivitet
FI970165L (fi)	1997-03-14	(S)-atenosyyli-L-metioniinin (SAMe) ja sen fysiologisesti hyväksyttävien suolojen käyttö tilapäisen fokaalisen iskemian aiheuttamien reperfuusiovammojen hoitamiseksi
ATE228372T1 (de)	2002-12-15	Hcg und derivate als matrixmetalloprotease- inhibitoren
DK0791355T3 (da)	2002-06-17	Fremgangsmåde til reduktion af vævsbeskadigelse forbundet med iskæmi
IT8848208A0 (it)	1988-07-19	Uso terapeutico del derivato estere isopropilico del monosialogangliosi de in patologie ad interessamento nervoso con componente infiammatoria
IT1291513B1 (it)	1999-01-11	Procedimento e dispositivo per la produzione di una piattina ottica
KR980004704U (ko)	1998-03-30	모니터의 스위블 장치
FR2795143B1 (fr)	2002-05-10	Verin pneumatique telescopique
TR199500881A1 (tr)	1997-02-21	S-triazinilaminostilben türevleri ve bunlarin optik beyazlatma maddeleri olarak kullanilmalari.