PT80940B - Processo para a preparacao de derivados tetraciclicos da espiro-hidantoina uteis inibidores da reductase da aldose - Google Patents

Processo para a preparacao de derivados tetraciclicos da espiro-hidantoina uteis inibidores da reductase da aldose

Info

Publication number: PT80940B
Authority: PT; Portugal
Prior art keywords: conh; chem; disclosed; aldose reductase; derivatives
Prior art date: 1984-08-14

Application number

PT80940A

Other languages

English (en)

Other versions

PT80940A (en

Inventor

Rodney Caughren Schnur

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-14

Filing date

1985-08-12

Publication date

1987-12-30

1985-08-12 Application filed by Pfizer filed Critical Pfizer

1985-09-01 Publication of PT80940A publication Critical patent/PT80940A/pt

1987-12-30 Publication of PT80940B publication Critical patent/PT80940B/pt

Links

239000003288 aldose reductase inhibitor Substances 0.000 title 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
208000002249 Diabetes Complications Diseases 0.000 abstract 2
206010012655 Diabetic complications Diseases 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Chemical group 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
-1 hydroxy, methyl Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
QAHZIGHCEBUNGT-QMGFNSACSA-N (5r,6s,7s,8r,9r)-6,7,8-trihydroxy-9-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)C[C@]11C(=O)NC(=O)N1 QAHZIGHCEBUNGT-QMGFNSACSA-N 0.000 abstract 1
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Oil, Petroleum & Natural Gas (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT80940A 1984-08-14 1985-08-12 Processo para a preparacao de derivados tetraciclicos da espiro-hidantoina uteis inibidores da reductase da aldose PT80940B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1984/001290 WO1986001107A1 (en)	1984-08-14	1984-08-14	Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making

Publications (2)

Publication Number	Publication Date
PT80940A PT80940A (en)	1985-09-01
PT80940B true PT80940B (pt)	1987-12-30

Family

ID=22182231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT80940A PT80940B (pt)	1984-08-14	1985-08-12	Processo para a preparacao de derivados tetraciclicos da espiro-hidantoina uteis inibidores da reductase da aldose

Country Status (24)

Country	Link
US (1)	US4656169A (pt)
EP (1)	EP0173497B1 (pt)
JP (1)	JPS6147486A (pt)
KR (1)	KR870000624B1 (pt)
AT (1)	ATE46162T1 (pt)
AU (1)	AU553699B2 (pt)
CA (1)	CA1255304A (pt)
DD (1)	DD236529A5 (pt)
DE (1)	DE3572818D1 (pt)
DK (1)	DK366685A (pt)
ES (2)	ES8704495A1 (pt)
FI (1)	FI82695C (pt)
GR (1)	GR851968B (pt)
IE (1)	IE58123B1 (pt)
IL (1)	IL76076A0 (pt)
IN (2)	IN166581B (pt)
NO (1)	NO164101C (pt)
NZ (1)	NZ213085A (pt)
PH (1)	PH22910A (pt)
PL (2)	PL145221B1 (pt)
PT (1)	PT80940B (pt)
WO (1)	WO1986001107A1 (pt)
YU (1)	YU44894B (pt)
ZA (1)	ZA856102B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202339A (en) *	1987-08-28	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
FI902028A7 (fi) *	1988-08-24	1990-04-23	Mochida Pharm Co Ltd	Hydantoiinijohdannaisia
TW202450B (pt) *	1991-06-26	1993-03-21	Dainippon Pharmaceutical Co

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4193996A (en) *	1979-04-04	1980-03-18	Pfizer Inc.	Spiro-quinolone hydantoins
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives

1984
- 1984-08-14 WO PCT/US1984/001290 patent/WO1986001107A1/en not_active Ceased
- 1984-08-14 US US06/854,588 patent/US4656169A/en not_active Expired - Fee Related
1985
- 1985-07-15 IN IN552/DEL/85A patent/IN166581B/en unknown
- 1985-08-08 AT AT85305636T patent/ATE46162T1/de not_active IP Right Cessation
- 1985-08-08 EP EP85305636A patent/EP0173497B1/en not_active Expired
- 1985-08-08 DE DE8585305636T patent/DE3572818D1/de not_active Expired
- 1985-08-12 ES ES546093A patent/ES8704495A1/es not_active Expired
- 1985-08-12 IL IL76076A patent/IL76076A0/xx not_active IP Right Cessation
- 1985-08-12 DD DD85279599A patent/DD236529A5/de not_active IP Right Cessation
- 1985-08-12 JP JP60177463A patent/JPS6147486A/ja active Granted
- 1985-08-12 PT PT80940A patent/PT80940B/pt not_active IP Right Cessation
- 1985-08-12 CA CA000488544A patent/CA1255304A/en not_active Expired
- 1985-08-12 GR GR851968A patent/GR851968B/el unknown
- 1985-08-13 AU AU46126/85A patent/AU553699B2/en not_active Ceased
- 1985-08-13 DK DK366685A patent/DK366685A/da not_active Application Discontinuation
- 1985-08-13 IE IE199185A patent/IE58123B1/en not_active IP Right Cessation
- 1985-08-13 KR KR1019850005822A patent/KR870000624B1/ko not_active Expired
- 1985-08-13 PL PL1985254960A patent/PL145221B1/pl unknown
- 1985-08-13 YU YU1290/85A patent/YU44894B/xx unknown
- 1985-08-13 ZA ZA856102A patent/ZA856102B/xx unknown
- 1985-08-13 PL PL1985261413A patent/PL147875B1/pl unknown
- 1985-08-13 NZ NZ213085A patent/NZ213085A/en unknown
- 1985-08-14 PH PH32632A patent/PH22910A/en unknown
1986
- 1986-02-13 ES ES551963A patent/ES8801831A1/es not_active Expired
- 1986-04-11 NO NO86861425A patent/NO164101C/no unknown
- 1986-04-11 FI FI861544A patent/FI82695C/fi not_active IP Right Cessation
1987
- 1987-06-17 IN IN522/DEL/87A patent/IN166590B/en unknown

Also Published As

Publication number	Publication date
ES8704495A1 (es)	1987-04-01
YU129085A (en)	1988-04-30
PL254960A1 (en)	1987-01-12
FI861544A0 (fi)	1986-04-11
ES8801831A1 (es)	1988-02-16
YU44894B (en)	1991-04-30
DK366685A (da)	1986-02-15
ES551963A0 (es)	1988-02-16
ZA856102B (en)	1987-03-25
PL261413A1 (en)	1988-01-21
GR851968B (pt)	1985-12-13
AU4612685A (en)	1986-02-20
DE3572818D1 (en)	1989-10-12
EP0173497B1 (en)	1989-09-06
IN166581B (pt)	1990-06-09
ES546093A0 (es)	1987-04-01
NO861425L (no)	1986-04-11
JPH0339512B2 (pt)	1991-06-14
ATE46162T1 (de)	1989-09-15
EP0173497A1 (en)	1986-03-05
PL145221B1 (en)	1988-08-31
KR870000624B1 (ko)	1987-03-26
DK366685D0 (da)	1985-08-13
IE58123B1 (en)	1993-07-14
FI82695B (fi)	1990-12-31
PT80940A (en)	1985-09-01
US4656169A (en)	1987-04-07
FI861544A7 (fi)	1986-04-11
KR860001811A (ko)	1986-03-22
IE851991L (en)	1986-02-14
WO1986001107A1 (en)	1986-02-27
NZ213085A (en)	1988-03-30
AU553699B2 (en)	1986-07-24
IL76076A0 (en)	1985-12-31
JPS6147486A (ja)	1986-03-07
PH22910A (en)	1989-01-24
NO164101B (no)	1990-05-21
NO164101C (no)	1990-08-29
CA1255304A (en)	1989-06-06
DD236529A5 (de)	1986-06-11
IN166590B (pt)	1990-06-09
PL147875B1 (en)	1989-08-31
FI82695C (fi)	1991-04-10

Legal Events

Date

Code

Title

Description

1996-04-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19951231

Publication	Publication Date	Title
DK561485A (da)	1986-06-06	Vitamin d3 derivater substitueret ved 2-stillingen
ATE259826T1 (de)	2004-03-15	Glycinamidederivate mit funktionalisierter alkyl- und alkenylseitenkette als inhibitoren der farnesyltransferase
CA2321639A1 (en)	1999-09-23	Bicyclo[2.2.1]heptanes and related compounds
ATE117979T1 (de)	1995-02-15	Isoprenoide phospholipase a2 inhibitoren und sie enthaltende zusammensetzungen.
PT90623A (pt)	1989-11-30	Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease
TR199802193T2 (xx)	1999-02-22	Halo-S�bstit�e Edilmi� Protein Kinaz C �nhibit�rleri.
DE3572818D1 (en)	1989-10-12	Tetracyclic spiro-hydantoin aldose reductase inhibitors
JPS5681578A (en)	1981-07-03	Novel thioalkyl amide derivative
DK89182A (da)	1982-09-03	Fremgangsmaade til fremstilling af n-naphthoylglycinderivater
ATE110375T1 (de)	1994-09-15	1-phenylalkyl-3-phenylharnstoff-derivate.
MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
PT99360A (pt)	1992-09-30	Processo para a preparacao de carbamatos de oxi-sulfonilo e de composicoes farmaceuticas que os contem
AU5914094A (en)	1994-10-06	Process for the preparation of aminotriazine derivatives
ATE127449T1 (de)	1995-09-15	Anilinderivate und verfahren zu ihrer herstellung.
ES2044883T3 (es)	1994-01-16	Procedimiento para preparar quinoxalinas sustituidas.
HUT37598A (en)	1986-01-23	Process for production of derivatives of 1,4-dihydripirizin
ES8500227A1 (es)	1984-10-01	Procedimiento para la preparacion de alquileteres de acido 1-alquil- o 1,4-dialquil-1h--pirrol-2-acetico.