NO861425L - Fremgangsmaate for fremstilling av tetracykliske spiro-hydantoin-derivater som er aldose reduktase-inhibitorer. - Google Patents

Fremgangsmaate for fremstilling av tetracykliske spiro-hydantoin-derivater som er aldose reduktase-inhibitorer.

Info

Publication number: NO861425L
Authority: NO; Norway
Prior art keywords: conh; chem; disclosed; aldose reductase; derivatives
Prior art date: 1984-08-14

Application number

NO861425A

Other languages

English (en)

Other versions

NO164101B (no

NO164101C (no

Inventor

Rodney C Schnur

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-14

Filing date

1986-04-11

Publication date

1986-04-11

1986-04-11 Application filed by Pfizer filed Critical Pfizer

1986-04-11 Publication of NO861425L publication Critical patent/NO861425L/no

1990-05-21 Publication of NO164101B publication Critical patent/NO164101B/no

1990-08-29 Publication of NO164101C publication Critical patent/NO164101C/no

Links

QAHZIGHCEBUNGT-QMGFNSACSA-N (5r,6s,7s,8r,9r)-6,7,8-trihydroxy-9-(hydroxymethyl)-1,3-diazaspiro[4.5]decane-2,4-dione Chemical class O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)C[C@]11C(=O)NC(=O)N1 QAHZIGHCEBUNGT-QMGFNSACSA-N 0.000 title abstract 2
239000003288 aldose reductase inhibitor Substances 0.000 title 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title 1
208000002249 Diabetes Complications Diseases 0.000 abstract 2
206010012655 Diabetic complications Diseases 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Chemical group 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
-1 hydroxy, methyl Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 abstract 1
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Oil, Petroleum & Natural Gas (AREA)
Ophthalmology & Optometry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO86861425A 1984-08-14 1986-04-11 Analogifremgangsmaate for fremstilling av terapeutisk aktive tetracykliske spiro-hydantoin-derivater. NO164101C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1984/001290 WO1986001107A1 (en)	1984-08-14	1984-08-14	Tetracyclic spiro-hydantoin aldose reductase inhibitors, compositions and methods of making

Publications (3)

Publication Number	Publication Date
NO861425L true NO861425L (no)	1986-04-11
NO164101B NO164101B (no)	1990-05-21
NO164101C NO164101C (no)	1990-08-29

Family

ID=22182231

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO86861425A NO164101C (no)	1984-08-14	1986-04-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetracykliske spiro-hydantoin-derivater.

Country Status (24)

Country	Link
US (1)	US4656169A (no)
EP (1)	EP0173497B1 (no)
JP (1)	JPS6147486A (no)
KR (1)	KR870000624B1 (no)
AT (1)	ATE46162T1 (no)
AU (1)	AU553699B2 (no)
CA (1)	CA1255304A (no)
DD (1)	DD236529A5 (no)
DE (1)	DE3572818D1 (no)
DK (1)	DK366685A (no)
ES (2)	ES8704495A1 (no)
FI (1)	FI82695C (no)
GR (1)	GR851968B (no)
IE (1)	IE58123B1 (no)
IL (1)	IL76076A0 (no)
IN (2)	IN166581B (no)
NO (1)	NO164101C (no)
NZ (1)	NZ213085A (no)
PH (1)	PH22910A (no)
PL (2)	PL145221B1 (no)
PT (1)	PT80940B (no)
WO (1)	WO1986001107A1 (no)
YU (1)	YU44894B (no)
ZA (1)	ZA856102B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5202339A (en) *	1987-08-28	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
FI902028A7 (fi) *	1988-08-24	1990-04-23	Mochida Pharm Co Ltd	Hydantoiinijohdannaisia
TW202450B (no) *	1991-06-26	1993-03-21	Dainippon Pharmaceutical Co

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4193996A (en) *	1979-04-04	1980-03-18	Pfizer Inc.	Spiro-quinolone hydantoins
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives

1984
- 1984-08-14 WO PCT/US1984/001290 patent/WO1986001107A1/en not_active Ceased
- 1984-08-14 US US06/854,588 patent/US4656169A/en not_active Expired - Fee Related
1985
- 1985-07-15 IN IN552/DEL/85A patent/IN166581B/en unknown
- 1985-08-08 AT AT85305636T patent/ATE46162T1/de not_active IP Right Cessation
- 1985-08-08 EP EP85305636A patent/EP0173497B1/en not_active Expired
- 1985-08-08 DE DE8585305636T patent/DE3572818D1/de not_active Expired
- 1985-08-12 ES ES546093A patent/ES8704495A1/es not_active Expired
- 1985-08-12 IL IL76076A patent/IL76076A0/xx not_active IP Right Cessation
- 1985-08-12 DD DD85279599A patent/DD236529A5/de not_active IP Right Cessation
- 1985-08-12 JP JP60177463A patent/JPS6147486A/ja active Granted
- 1985-08-12 PT PT80940A patent/PT80940B/pt not_active IP Right Cessation
- 1985-08-12 CA CA000488544A patent/CA1255304A/en not_active Expired
- 1985-08-12 GR GR851968A patent/GR851968B/el unknown
- 1985-08-13 AU AU46126/85A patent/AU553699B2/en not_active Ceased
- 1985-08-13 DK DK366685A patent/DK366685A/da not_active Application Discontinuation
- 1985-08-13 IE IE199185A patent/IE58123B1/en not_active IP Right Cessation
- 1985-08-13 KR KR1019850005822A patent/KR870000624B1/ko not_active Expired
- 1985-08-13 PL PL1985254960A patent/PL145221B1/pl unknown
- 1985-08-13 YU YU1290/85A patent/YU44894B/xx unknown
- 1985-08-13 ZA ZA856102A patent/ZA856102B/xx unknown
- 1985-08-13 PL PL1985261413A patent/PL147875B1/pl unknown
- 1985-08-13 NZ NZ213085A patent/NZ213085A/en unknown
- 1985-08-14 PH PH32632A patent/PH22910A/en unknown
1986
- 1986-02-13 ES ES551963A patent/ES8801831A1/es not_active Expired
- 1986-04-11 NO NO86861425A patent/NO164101C/no unknown
- 1986-04-11 FI FI861544A patent/FI82695C/fi not_active IP Right Cessation
1987
- 1987-06-17 IN IN522/DEL/87A patent/IN166590B/en unknown

Also Published As

Publication number	Publication date
ES8704495A1 (es)	1987-04-01
YU129085A (en)	1988-04-30
PL254960A1 (en)	1987-01-12
FI861544A0 (fi)	1986-04-11
ES8801831A1 (es)	1988-02-16
YU44894B (en)	1991-04-30
DK366685A (da)	1986-02-15
ES551963A0 (es)	1988-02-16
ZA856102B (en)	1987-03-25
PL261413A1 (en)	1988-01-21
GR851968B (no)	1985-12-13
AU4612685A (en)	1986-02-20
DE3572818D1 (en)	1989-10-12
EP0173497B1 (en)	1989-09-06
IN166581B (no)	1990-06-09
ES546093A0 (es)	1987-04-01
JPH0339512B2 (no)	1991-06-14
ATE46162T1 (de)	1989-09-15
EP0173497A1 (en)	1986-03-05
PL145221B1 (en)	1988-08-31
KR870000624B1 (ko)	1987-03-26
DK366685D0 (da)	1985-08-13
IE58123B1 (en)	1993-07-14
FI82695B (fi)	1990-12-31
PT80940A (en)	1985-09-01
US4656169A (en)	1987-04-07
FI861544A7 (fi)	1986-04-11
KR860001811A (ko)	1986-03-22
IE851991L (en)	1986-02-14
WO1986001107A1 (en)	1986-02-27
NZ213085A (en)	1988-03-30
AU553699B2 (en)	1986-07-24
IL76076A0 (en)	1985-12-31
JPS6147486A (ja)	1986-03-07
PT80940B (pt)	1987-12-30
PH22910A (en)	1989-01-24
NO164101B (no)	1990-05-21
NO164101C (no)	1990-08-29
CA1255304A (en)	1989-06-06
DD236529A5 (de)	1986-06-11
IN166590B (no)	1990-06-09
PL147875B1 (en)	1989-08-31
FI82695C (fi)	1991-04-10

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CA2321639A1 (en)	1999-09-23	Bicyclo[2.2.1]heptanes and related compounds
DK561485A (da)	1986-06-06	Vitamin d3 derivater substitueret ved 2-stillingen
ATE117979T1 (de)	1995-02-15	Isoprenoide phospholipase a2 inhibitoren und sie enthaltende zusammensetzungen.
TR199802193T2 (xx)	1999-02-22	Halo-S�bstit�e Edilmi� Protein Kinaz C �nhibit�rleri.
HU913062D0 (en)	1992-01-28	Method for producing benzol, pyridyl and pyridine derivatives and pharmaceutical preparatives containing such compounds
DE3572818D1 (en)	1989-10-12	Tetracyclic spiro-hydantoin aldose reductase inhibitors
DE69530510D1 (de)	2003-05-28	Chinazolinon enthaltende arzneimittel und verfahren zu deren verwendung
DK89182A (da)	1982-09-03	Fremgangsmaade til fremstilling af n-naphthoylglycinderivater
JPS5681578A (en)	1981-07-03	Novel thioalkyl amide derivative
ATE203012T1 (de)	2001-07-15	4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen
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MY131544A (en)	2007-08-30	Fluorinated 4-aminoandrostadienone derivatives and process for their preparation
ATE110375T1 (de)	1994-09-15	1-phenylalkyl-3-phenylharnstoff-derivate.
DE69529807D1 (de)	2003-04-10	Neue Parabansäure-Derivate als Aldose-Reduktase Inhibitoren
AU540454B2 (en)	1984-11-15	Method for treating inflammation
ES2044883T3 (es)	1994-01-16	Procedimiento para preparar quinoxalinas sustituidas.
ES8407475A1 (es)	1984-10-01	"un procedimiento para la preparacion de derivados de hidroxiimino y alcoxiimino de 1,4-dihidropiridina"
SE8205767L (sv)	1983-04-23	Vissa mono-substituerade 4-fenyl-4-oxo-2-butensyraderivat till anvendning som lekemedel samt kompositioner innehallande dem
JPS5692279A (en)	1981-07-25	Thiazolidine derivative