PT80954B - Processo de preparacao de novos derivados de triptamina e sua aplicacao - Google Patents

Processo de preparacao de novos derivados de triptamina e sua aplicacao

Info

Publication number: PT80954B
Authority: PT; Portugal
Prior art keywords: lower alkyl; phenyl; triptamine; derivatives; new
Prior art date: 1984-08-17

Application number

PT80954A

Other languages

English (en)

Other versions

PT80954A (de

Inventor

Thomas Glaser

Jorg Traber

Siegfrield Raddatz

Allen George

Original Assignee

Troponwerke Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-17

Filing date

1985-08-14

Publication date

1987-12-30

1985-08-14 Application filed by Troponwerke Gmbh & Co Kg filed Critical Troponwerke Gmbh & Co Kg

1985-09-01 Publication of PT80954A publication Critical patent/PT80954A/pt

1987-12-30 Publication of PT80954B publication Critical patent/PT80954B/pt

Links

238000002360 preparation method Methods 0.000 title 1
APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical class C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
-1 cyano, carbamoyl Chemical group 0.000 abstract 1
239000000539 dimer Substances 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT80954A 1984-08-17 1985-08-14 Processo de preparacao de novos derivados de triptamina e sua aplicacao PT80954B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843430284 DE3430284A1 (de)	1984-08-17	1984-08-17	Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number	Publication Date
PT80954A PT80954A (de)	1985-09-01
PT80954B true PT80954B (pt)	1987-12-30

Family

ID=6243280

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT80954A PT80954B (pt)	1984-08-17	1985-08-14	Processo de preparacao de novos derivados de triptamina e sua aplicacao

Country Status (19)

Country	Link
US (1)	US4870085A (pt)
EP (1)	EP0171728B1 (pt)
JP (1)	JPS6169774A (pt)
KR (1)	KR910006637B1 (pt)
CN (1)	CN85101761A (pt)
AT (1)	ATE41930T1 (pt)
AU (1)	AU580321B2 (pt)
DE (2)	DE3430284A1 (pt)
DK (1)	DK374085A (pt)
ES (1)	ES8801824A1 (pt)
FI (1)	FI853134A7 (pt)
GR (1)	GR851986B (pt)
HU (1)	HU195208B (pt)
IL (1)	IL76088A (pt)
NO (1)	NO165343C (pt)
NZ (1)	NZ213104A (pt)
PH (1)	PH21048A (pt)
PT (1)	PT80954B (pt)
ZA (1)	ZA856227B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0242973B1 (en) *	1986-03-17	1991-07-17	Glaxo Group Limited	Indole derivatives, method for their preparation and pharmaceutical compositions containing them
US4808581A (en) *	1986-03-17	1989-02-28	Glaxo Group Limited	Imidazolyl- indolylpropanones as 5-HT3 receptor antagonists
GB8810748D0 (en) *	1988-05-06	1988-06-08	Beecham Wuelfing Gmbh & Co Kg	Novel treatment
US5162375A (en) *	1988-05-06	1992-11-10	Beecham Group P.L.C.	Treatment of neuronal degeneration with 5HT1A agonists
GB8819024D0 (en) *	1988-08-10	1988-09-14	Glaxo Group Ltd	Chemical compounds
CZ288351B6 (en) *	1990-06-07	2001-05-16	Astrazeneca Ab	Nitrogenous heterocyclic compound, process of its preparation and use as well as a medicament containing thereof
US5317103A (en) *	1991-01-15	1994-05-31	Merck Sharp & Dohme Limited	Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists
CZ283018B6 (cs) *	1991-02-01	1997-12-17	Merck Sharp And Dohme Limited	Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
IL106445A (en) *	1992-07-30	1998-01-04	Merck Sharp & Dohme	History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
DK139593D0 (da) *	1993-12-16	1993-12-16	Lundbeck & Co As H	Compounds
EP0804434A1 (en) *	1994-08-02	1997-11-05	MERCK SHARP & DOHME LTD.	Azetidine, pyrrolidine and piperidine derivatives
FR2733984B1 (fr) *	1995-05-10	1997-07-04	Rhone Poulenc Rorer Sa	Derives de tryptamine, leur preparation et les medicaments les contenant
US5856510A (en) *	1996-12-16	1999-01-05	Allelix Biopharmaceuticals Inc.	5-alkenyl and 5-alkynyl indole compounds
US5998462A (en) *	1996-12-16	1999-12-07	Allelix Biopharmaceuticals Inc.	5-alkyl indole compounds
US6100291A (en) *	1998-03-16	2000-08-08	Allelix Biopharmaceuticals Inc.	Pyrrolidine-indole compounds having 5-HT6 affinity
US6133287A (en) *	1998-03-24	2000-10-17	Allelix Biopharmaceuticals Inc.	Piperidine-indole compounds having 5-HT6 affinity
CA2356638A1 (en) *	1998-12-23	2000-07-06	Nps Allelix Corp.	Indole and indolizidine derivatives for the treatment of migraine
TWI310035B (en)	2000-04-28	2009-05-21	Acadia Pharm Inc	Muscarinic agonists
BRPI0517438A (pt) *	2004-10-25	2008-10-07	Lilly Co Eli	composto, método para tratar a condição associada com atividade de receptor muscarìnico m4, uso do composto, e, composição farmacêutica
CN103183629A (zh) *	2013-03-15	2013-07-03	张家港威胜生物医药有限公司	一种重要医药化工中间体5-溴吲哚高效合成工艺
CN104292145A (zh) *	2014-10-12	2015-01-21	湖南华腾制药有限公司	一种6-溴吲哚衍生物的制备方法
KR102990903B1 (ko)	2024-01-24	2026-07-14	우석대학교 산학협력단	신규한 세로토닌 유도체, 이의 제조방법 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3183235A (en) *	1961-06-27	1965-05-11	Sterling Drug Inc	1-[3-, 2-, and 1-indolyl-lower-alkanoyl] piperidines
US3821387A (en) *	1965-10-23	1974-06-28	Robins Co Inc A H	The treatment of parkinsonism with 3-(omega-substituted alkyl)-indoles
US3907812A (en) *	1969-07-16	1975-09-23	Sumitomo Chemical Co	Butyrophenone derivatives
US3732248A (en) *	1969-12-15	1973-05-08	Pfizer	3-substituted-1-phenyl indolinones
BE795457A (fr) *	1972-02-16	1973-08-16	Clin Midy	Amines indoliques, leur preparation et leur application en therapeutiques
FR2506310A1 (fr) *	1981-05-22	1982-11-26	Pharmindustrie	((alkyl- et alcenyl-3 piperidyl-4)-2 ethyl)-3 indoles et leur utilisation comme medicaments
FR2506309A1 (fr) *	1981-05-22	1982-11-26	Pharmindustrie	((tetra- et hexahydro pyridyl-4)-2 ethyl)-3 indoles et leur utilisation comme medicaments

1984
- 1984-08-17 DE DE19843430284 patent/DE3430284A1/de not_active Withdrawn
1985
- 1985-04-01 CN CN198585101761A patent/CN85101761A/zh active Pending
- 1985-07-31 NO NO853036A patent/NO165343C/no unknown
- 1985-08-05 DE DE8585109808T patent/DE3569242D1/de not_active Expired
- 1985-08-05 EP EP85109808A patent/EP0171728B1/de not_active Expired
- 1985-08-05 AT AT85109808T patent/ATE41930T1/de not_active IP Right Cessation
- 1985-08-09 AU AU45971/85A patent/AU580321B2/en not_active Ceased
- 1985-08-12 ES ES546091A patent/ES8801824A1/es not_active Expired
- 1985-08-14 IL IL76088A patent/IL76088A/xx unknown
- 1985-08-14 GR GR851986A patent/GR851986B/el unknown
- 1985-08-14 NZ NZ213104A patent/NZ213104A/xx unknown
- 1985-08-14 PT PT80954A patent/PT80954B/pt not_active IP Right Cessation
- 1985-08-15 FI FI853134A patent/FI853134A7/fi not_active Application Discontinuation
- 1985-08-16 HU HU853174A patent/HU195208B/hu not_active IP Right Cessation
- 1985-08-16 DK DK374085A patent/DK374085A/da not_active Application Discontinuation
- 1985-08-16 KR KR1019850005903A patent/KR910006637B1/ko not_active Expired
- 1985-08-16 PH PH32653A patent/PH21048A/en unknown
- 1985-08-16 JP JP60179515A patent/JPS6169774A/ja active Pending
- 1985-08-16 ZA ZA856227A patent/ZA856227B/xx unknown
1988
- 1988-03-30 US US07/175,066 patent/US4870085A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US4870085A (en)	1989-09-26
PT80954A (de)	1985-09-01
HU195208B (en)	1988-04-28
AU4597185A (en)	1986-02-20
DK374085A (da)	1986-02-18
ATE41930T1 (de)	1989-04-15
IL76088A0 (en)	1985-12-31
FI853134L (fi)	1986-02-18
KR870002124A (ko)	1987-03-30
KR910006637B1 (ko)	1991-08-29
FI853134A7 (fi)	1986-02-18
NZ213104A (en)	1988-07-28
EP0171728B1 (de)	1989-04-05
NO165343C (no)	1991-01-30
JPS6169774A (ja)	1986-04-10
ES8801824A1 (es)	1988-02-16
DE3569242D1 (en)	1989-05-11
EP0171728A1 (de)	1986-02-19
AU580321B2 (en)	1989-01-12
PH21048A (en)	1987-07-03
ZA856227B (en)	1986-04-30
NO853036L (no)	1986-02-18
FI853134A0 (fi)	1985-08-15
NO165343B (no)	1990-10-22
HUT39443A (en)	1986-09-29
ES546091A0 (es)	1988-02-16
CN85101761A (zh)	1987-02-04
DE3430284A1 (de)	1986-02-27
DK374085D0 (da)	1985-08-16
GR851986B (pt)	1985-12-10
IL76088A (en)	1990-03-19

Legal Events

Date

Code

Title

Description

1992-09-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19911229

Publication	Publication Date	Title
AU580321B2 (en)	1989-01-12	New tryptamine derivatives, a process for their preparation, and their use
SE8004002L (sv)	1981-11-30	Terapeutiskt anvendbara tetralinderivat
FI853622L (fi)	1986-03-23	Diarylacetylener, deras framstaellning och anvaendning.
FI853624L (fi)	1986-03-23	1-substituerade tetralinderivat, deras framstaellning och anvaendning.
EP0224163A3 (en)	1989-03-15	Propyl amines, process for their preparation and their use as fungicides
ES552348A0 (es)	1987-10-16	Procedimiento de preparar agentes anticonvulsivos derivados de aminoacidos
DK415789A (da)	1990-02-27	Tetracykliske antidepressive midler
ES515872A0 (es)	1983-06-01	"procedimiento para la preparacion de nuevos derivados de acidos 4-fenoxialcarboxilicos sustituidos con radicales haterociclicos".
GR79170B (pt)	1984-10-02
DK0734384T3 (da)	2001-01-02	3-substituerede 1-arylindolforbindelser
FI841992A0 (fi)	1984-05-17	Substituerade isokinolinderivat.
GR82272B (pt)	1984-12-13
BR8805537A (pt)	1989-07-04	Composicoes herbicidas ou reguladoras do crescimento de plantas,processo para obtencao de compostos,utilizacao de tais compostos,processo para combate de crescimento indesejado de plantas ou para regulagem de crescimento de plantas,e processo para obtencao de isocianatos de n-sultamsulfonila intermediarios para os ditos compostos
AU545800B2 (en)	1985-08-01	New compounds
MA20461A1 (fr)	1985-12-31	Procede de preparation de nouveaux derives de l'isoxazoloquinoleine
DE3362036D1 (en)	1986-03-13	Ketene-o,o-acetates and process for their preparation
BG50501A3 (bg)	1992-08-14	Метод за получаване на 1,5-бензтиазепинови производни