PT83328A - Processo para a preparacao de inibidores de colagenase a base de acido hidroxamico - Google Patents

Processo para a preparacao de inibidores de colagenase a base de acido hidroxamico

Info

Publication number
PT83328A
PT83328A PT83328A PT8332886A PT83328A PT 83328 A PT83328 A PT 83328A PT 83328 A PT83328 A PT 83328A PT 8332886 A PT8332886 A PT 8332886A PT 83328 A PT83328 A PT 83328A
Authority
PT
Portugal
Prior art keywords
preparation
hydroxamic acid
inhibitors based
collagenase inhibitors
collagenase
Prior art date
Application number
PT83328A
Other languages
English (en)
Other versions
PT83328B (pt
Inventor
Jonathan Philip Dickens
David Keith Donald
Geoffrey Kneen
William Roger Mckay
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/774,491 external-priority patent/US4599361A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT83328A publication Critical patent/PT83328A/pt
Publication of PT83328B publication Critical patent/PT83328B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT83328A 1985-09-10 1986-09-08 Processo para a preparacao de inibidores de colagenase a base de acido hidroxamico PT83328B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/774,491 US4599361A (en) 1985-09-10 1985-09-10 Hydroxamic acid based collagenase inhibitors
US06/880,130 US4743587A (en) 1985-09-10 1986-07-07 Hydroxamic acid based collagenase inhibitors

Publications (2)

Publication Number Publication Date
PT83328A true PT83328A (pt) 1986-10-01
PT83328B PT83328B (pt) 1988-07-29

Family

ID=27118893

Family Applications (1)

Application Number Title Priority Date Filing Date
PT83328A PT83328B (pt) 1985-09-10 1986-09-08 Processo para a preparacao de inibidores de colagenase a base de acido hidroxamico

Country Status (14)

Country Link
US (1) US4743587A (pt)
EP (1) EP0214639B1 (pt)
JP (1) JPH0764800B2 (pt)
CA (1) CA1329397C (pt)
DE (1) DE3671891D1 (pt)
DK (1) DK169029B1 (pt)
FI (1) FI84472C (pt)
GR (1) GR862286B (pt)
IE (1) IE58770B1 (pt)
IL (1) IL79971A (pt)
NO (1) NO164092C (pt)
NZ (1) NZ217491A (pt)
PH (1) PH24182A (pt)
PT (1) PT83328B (pt)

Families Citing this family (64)

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US5166212A (en) * 1985-12-06 1992-11-24 Ciba-Geigy Corporation Certain n-substituted butyramide derivatives
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
US4939299A (en) * 1986-12-04 1990-07-03 Monsanto Company Succinyl dihydroxamic acids
FR2609289B1 (fr) * 1987-01-06 1991-03-29 Bellon Labor Sa Roger Nouveaux composes a activite d'inhibiteurs de collagenase, procede pour les preparer et compositions pharmaceutiques contenant ces composes
US5686422A (en) * 1987-03-17 1997-11-11 Research Corporation Technologies, Inc. Synthetic inhibitors of mammalian collagenase
JP2573006B2 (ja) * 1987-12-17 1997-01-16 富士薬品工業株式会社 新規なヒドロキサム酸誘導体
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8827305D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds
GB8919251D0 (en) * 1989-08-24 1989-10-04 British Bio Technology Compounds
EP0512071B1 (en) * 1990-01-25 1996-10-30 Children's Hospital Method and compositions for inhibiting angiogenesis
US5892112A (en) * 1990-11-21 1999-04-06 Glycomed Incorporated Process for preparing synthetic matrix metalloprotease inhibitors
US5114953A (en) * 1990-11-21 1992-05-19 University Of Florida Treatment for tissue ulceration
US5268384A (en) * 1990-11-21 1993-12-07 Galardy Richard E Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
US5239078A (en) * 1990-11-21 1993-08-24 Glycomed Incorporated Matrix metalloprotease inhibitors
WO1992009565A1 (en) * 1990-12-03 1992-06-11 Celltech Limited Peptidyl derivatives
US5889058A (en) * 1990-12-03 1999-03-30 Celltech Limited Peptidyl derivatives
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
GB9102635D0 (en) * 1991-02-07 1991-03-27 British Bio Technology Compounds
WO1992022523A2 (en) * 1991-06-14 1992-12-23 Research Corporation Technologies, Inc. Peptide derivatives of collagenase inhibitor
US5530161A (en) * 1991-07-08 1996-06-25 British Bio-Technology Limited Hydroxamic acid based collagenase inhibitors
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
GB9211707D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
GB9211706D0 (en) * 1992-06-03 1992-07-15 Celltech Ltd Peptidyl derivatives
US5318964A (en) * 1992-06-11 1994-06-07 Hoffmann-La Roche Inc. Hydroxamic derivatives and pharmaceutical compositions
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
GB9220845D0 (en) * 1992-10-03 1992-11-18 British Bio Technology Vasoactive peptide inhibition
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
US5403824A (en) * 1993-03-19 1995-04-04 The Procter & Gamble Company Methods for the treatment of osteoporosis
WO1995004715A1 (en) * 1993-08-09 1995-02-16 Kanebo, Ltd. Acylphenylglycine derivative and preventive and remedy for diseases caused by increased collagenase activity containing said compound as active ingredient
GB9501737D0 (en) * 1994-04-25 1995-03-22 Hoffmann La Roche Hydroxamic acid derivatives
EP0763012B1 (en) * 1994-05-28 1999-06-09 British Biotech Pharmaceuticals Limited Succinyl hydroxamic acid, n-formyl-n-hydroxy amino carboxylic acid and succinic acid amide derivatives as metalloprotease inhibitors
GB9411088D0 (en) * 1994-06-03 1994-07-27 Hoffmann La Roche Hydroxylamine derivatives
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) * 1995-03-21 1997-09-30 The Procter & Gamble Company Lactam-containing hydroxamic acids
GB9601041D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Novel compounds
BR9712019A (pt) * 1996-09-10 1999-08-24 British Biotech Pharm Derivados de cidos hirox-mico citoest ticos
EP0911319A1 (en) * 1997-09-01 1999-04-28 Roche Diagnostics GmbH Malonic acid based matrix metalloproteinase inhibitors
GB9804504D0 (en) * 1998-03-03 1998-04-29 Leo Pharm Prod Ltd Matrix metalloproteinase inhibitors
RU2187499C2 (ru) * 1998-03-12 2002-08-20 Бритиш Биотех Фармасьютикалс Лимитед Цитостатические агенты
US6329418B1 (en) 1998-04-14 2001-12-11 The Procter & Gamble Company Substituted pyrrolidine hydroxamate metalloprotease inhibitors
US6696456B1 (en) 1999-10-14 2004-02-24 The Procter & Gamble Company Beta disubstituted metalloprotease inhibitors
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
PL357275A1 (en) * 2000-03-21 2004-07-26 The Procter & Gamble Company Carbocyclic side chain containing metalloprotease inhibitors
IL151250A0 (en) * 2000-03-21 2003-04-10 Procter & Gamble Difluorobutyric acid metalloprotease inhibitors
EP1265864A1 (en) * 2000-03-21 2002-12-18 The Procter & Gamble Company Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
AU2001239549A1 (en) * 2000-03-24 2001-10-03 Akzo Nobel N.V. Keratinocyte growth inhibitors and hydroxamic acid derivatives
ES2433440T3 (es) 2003-04-04 2013-12-11 Yeda Research And Development Co. Ltd. Anticuerpos contra MMP2 o MMP9 y composiciones farmacéuticas que contienen los mismos útiles para inhibir la actividad de dichas metaloproteínas
US20060112494A1 (en) * 2004-12-01 2006-06-01 David Oppong Method of protecting an animal skin product from metalloproteinase activity
GB0722484D0 (en) * 2007-11-15 2007-12-27 Ucl Business Plc Solid compositions
GB0818907D0 (en) * 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
CN103896796B (zh) 2009-05-28 2016-04-27 诺华股份有限公司 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物
EP2435402B1 (en) 2009-05-28 2016-04-13 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
US8697078B2 (en) 2010-01-27 2014-04-15 Yeda Research And Development Co. Ltd. Antibodies that inhibit metalloproteins
ES2688457T3 (es) 2010-10-28 2018-11-02 Yeda Research And Development Co. Ltd. Métodos de generación de anticuerpos contra metaloenzimas
CU24330B1 (es) 2013-02-14 2018-03-13 Novartis Ag Derivados del ácido 4-((1,1) bifenil-4-il)-3-(3-fosfonopropanamido) butanoico, activos como inhibidores de nep (endopeptidasa neutral)
US9102635B2 (en) 2013-02-14 2015-08-11 Novartis Ag Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy
IL264768A (en) 2019-02-10 2020-08-31 Sagi Irit Anti-matrix metalloproteinase 7 (mmp-7) inhibitory antibody and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH438351A (de) * 1959-09-25 1967-06-30 Ciba Geigy Verfahren zur Herstellung neuer Wuchsstoffe
US3471476A (en) * 1964-05-18 1969-10-07 Tino Gaeumann Trihydroxamic acids
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4028401A (en) * 1976-07-01 1977-06-07 Morton-Norwich Products, Inc. (Substituted)ureidoacetohydroxamic acids
NZ201010A (en) * 1981-06-19 1986-02-21 Ciba Geigy Ag The treatment of inflammation diseases using desferrioxamine
FR2518088B1 (fr) * 1981-12-16 1987-11-27 Roques Bernard Nouveaux derives d'aminoacides, et leur application therapeutique
US4419365A (en) * 1981-12-21 1983-12-06 Ciba-Geigy Corporation Method of treating Alzheimer's disease

Also Published As

Publication number Publication date
AU6240886A (en) 1987-03-12
IE58770B1 (en) 1993-11-03
EP0214639B1 (en) 1990-06-13
IL79971A (en) 1990-11-05
DK427686A (da) 1987-03-11
DK169029B1 (da) 1994-08-01
PH24182A (en) 1990-03-22
NO863581L (no) 1987-03-11
FI863607A0 (fi) 1986-09-08
JPH0764800B2 (ja) 1995-07-12
EP0214639A3 (en) 1988-02-17
IL79971A0 (en) 1986-12-31
NZ217491A (en) 1989-10-27
AU588362B2 (en) 1989-09-14
FI863607A7 (fi) 1987-03-11
DK427686D0 (da) 1986-09-08
DE3671891D1 (de) 1990-07-19
FI84472C (fi) 1991-12-10
NO164092B (no) 1990-05-21
JPS62103052A (ja) 1987-05-13
NO164092C (no) 1990-08-29
CA1329397C (en) 1994-05-10
FI84472B (fi) 1991-08-30
IE862404L (en) 1987-03-10
GR862286B (en) 1987-01-12
US4743587A (en) 1988-05-10
NO863581D0 (no) 1986-09-08
EP0214639A2 (en) 1987-03-18
PT83328B (pt) 1988-07-29

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