PT845988E - Novas isoquinolinas fundidas como ligandos do receptor da dopamina - Google Patents

Novas isoquinolinas fundidas como ligandos do receptor da dopamina

Info

Publication number
PT845988E
PT845988E PT96928941T PT96928941T PT845988E PT 845988 E PT845988 E PT 845988E PT 96928941 T PT96928941 T PT 96928941T PT 96928941 T PT96928941 T PT 96928941T PT 845988 E PT845988 E PT 845988E
Authority
PT
Portugal
Prior art keywords
receptor ligands
diphamine
new
compounds
dopamine
Prior art date
Application number
PT96928941T
Other languages
English (en)
Inventor
David E Nichols
Richard Mailman
Debasis Ghosh
Original Assignee
Univ North Carolina
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Purdue Research Foundation filed Critical Univ North Carolina
Publication of PT845988E publication Critical patent/PT845988E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
PT96928941T 1995-08-18 1996-08-16 Novas isoquinolinas fundidas como ligandos do receptor da dopamina PT845988E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US251995P 1995-08-18 1995-08-18

Publications (1)

Publication Number Publication Date
PT845988E true PT845988E (pt) 2002-05-31

Family

ID=21701148

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96928941T PT845988E (pt) 1995-08-18 1996-08-16 Novas isoquinolinas fundidas como ligandos do receptor da dopamina

Country Status (18)

Country Link
US (2) US5959110A (pt)
EP (1) EP0845988B1 (pt)
JP (1) JP2000505046A (pt)
CN (1) CN1199338A (pt)
AT (1) ATE209915T1 (pt)
AU (1) AU700688B2 (pt)
BR (1) BR9610323A (pt)
CA (1) CA2227585A1 (pt)
DE (1) DE69617700T2 (pt)
DK (1) DK0845988T3 (pt)
ES (1) ES2169257T3 (pt)
IL (1) IL122974A (pt)
MX (1) MX9801179A (pt)
NO (1) NO308658B1 (pt)
NZ (1) NZ316312A (pt)
PT (1) PT845988E (pt)
RU (1) RU2177001C2 (pt)
WO (1) WO1997006799A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU700688B2 (en) * 1995-08-18 1999-01-14 Purdue Research Foundation Novel fused isoquinolines as dopamine receptor ligands
KR20030027020A (ko) * 2000-08-11 2003-04-03 펄듀 리서치 파운데이션 디나프솔린의 제조 공정
MXPA03006265A (es) * 2001-01-16 2004-06-25 Purdue Research Foundation Metodo de tratamiento de disfuncion relacionada con dopamina mediante administracion de un agonista de receptor de dopamina d1 completo, sin generacion de tolerancia.
DE60220800D1 (de) * 2001-08-10 2007-08-02 Purdue Research Foundation Chirales dinapsolin
AU2003217430B2 (en) * 2002-02-15 2008-10-23 Darpharma, Inc. Mono-ester and asymmetrically substituted Di-ester pro-drugs of the dopamine D1 receptor agonists
JP2004190007A (ja) * 2002-11-27 2004-07-08 Konica Minolta Holdings Inc 色素およびインクジェット記録液
WO2005029077A1 (en) * 2003-09-24 2005-03-31 Biacore Ab Method and system for molecular interaction analysis
WO2007098462A2 (en) * 2006-02-21 2007-08-30 Purdue Research Foundation Trans-fused chromenoisoquinolines, synthesis and methods for use
RS53866B1 (sr) * 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
US9359303B2 (en) 2009-04-21 2016-06-07 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
CN110068645B (zh) * 2019-04-03 2021-09-03 上海药明奥测医疗科技有限公司 液质联用检测尿液中环磷酸腺苷的方法
CA3148598A1 (en) 2019-07-30 2021-02-04 Mayo Foundation For Medical Education And Research Compounds and methods for treating fibrotic pathologies
WO2022164996A1 (en) * 2021-01-29 2022-08-04 Mayo Foundation For Medical Education And Research Methods of treating ocular fibrotic pathologies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346090A (en) * 1977-07-21 1982-08-24 Ayerst, Mckenna & Harrison Ltd. 13-Chloro-benzocycloheptapyridoisoquinolines and use as neuroleptics
HU180234B (en) * 1979-01-22 1983-02-28 Lilly Co Eli Process for producing oktahydro-pyrasolo-aracket-3,4-g-bracket closed-quinolines
DE3624607A1 (de) * 1986-07-21 1988-01-28 Boehringer Ingelheim Kg Neue tetrahydrobenzothiazolo-chinoline ihre herstellung und verwendung
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5047536A (en) * 1989-03-17 1991-09-10 Purdue Research Foundation Hexahydrobenzo(A)phenanthridine compounds
IE912999A1 (en) * 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
CA2054569A1 (en) * 1990-11-07 1992-05-08 Masanobu Suzuki Process for preparing benzo¬c|phenanthridinium derivatives, and novel compounds prepared by said process
AU4391493A (en) * 1992-05-26 1993-12-30 Purdue Research Foundation Substituted-hexahydrobenzo(A)phenanthridines
AU700688B2 (en) * 1995-08-18 1999-01-14 Purdue Research Foundation Novel fused isoquinolines as dopamine receptor ligands

Also Published As

Publication number Publication date
AU700688B2 (en) 1999-01-14
AU6851396A (en) 1997-03-12
RU2177001C2 (ru) 2001-12-20
IL122974A (en) 2000-11-21
NZ316312A (en) 1999-06-29
ES2169257T3 (es) 2002-07-01
EP0845988A4 (en) 1998-11-11
EP0845988B1 (en) 2001-12-05
DE69617700T2 (de) 2002-07-18
DE69617700D1 (de) 2002-01-17
NO980688D0 (no) 1998-02-18
CN1199338A (zh) 1998-11-18
US5959110A (en) 1999-09-28
MX9801179A (es) 1998-04-30
DK0845988T3 (da) 2002-04-02
WO1997006799A1 (en) 1997-02-27
BR9610323A (pt) 1999-12-21
EP0845988A1 (en) 1998-06-10
US6194423B1 (en) 2001-02-27
ATE209915T1 (de) 2001-12-15
IL122974A0 (en) 1998-08-16
JP2000505046A (ja) 2000-04-25
NO308658B1 (no) 2000-10-09
CA2227585A1 (en) 1997-02-27
NO980688L (no) 1998-02-18

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