ATE209915T1 - Neue kondensierten isochinoline als dopamin- rezeptor-liganden - Google Patents

Neue kondensierten isochinoline als dopamin- rezeptor-liganden

Info

Publication number
ATE209915T1
ATE209915T1 AT96928941T AT96928941T ATE209915T1 AT E209915 T1 ATE209915 T1 AT E209915T1 AT 96928941 T AT96928941 T AT 96928941T AT 96928941 T AT96928941 T AT 96928941T AT E209915 T1 ATE209915 T1 AT E209915T1
Authority
AT
Austria
Prior art keywords
receptor ligands
isochinolines
dopamine receptor
new condensed
compounds
Prior art date
Application number
AT96928941T
Other languages
English (en)
Inventor
David E Nichols
Richard Mailman
Original Assignee
Purdue Research Foundation
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Univ North Carolina filed Critical Purdue Research Foundation
Application granted granted Critical
Publication of ATE209915T1 publication Critical patent/ATE209915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT96928941T 1995-08-18 1996-08-16 Neue kondensierten isochinoline als dopamin- rezeptor-liganden ATE209915T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US251995P 1995-08-18 1995-08-18
PCT/US1996/013416 WO1997006799A1 (en) 1995-08-18 1996-08-16 Novel fused isoquinolines as dopamine receptor ligands

Publications (1)

Publication Number Publication Date
ATE209915T1 true ATE209915T1 (de) 2001-12-15

Family

ID=21701148

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928941T ATE209915T1 (de) 1995-08-18 1996-08-16 Neue kondensierten isochinoline als dopamin- rezeptor-liganden

Country Status (18)

Country Link
US (2) US5959110A (de)
EP (1) EP0845988B1 (de)
JP (1) JP2000505046A (de)
CN (1) CN1199338A (de)
AT (1) ATE209915T1 (de)
AU (1) AU700688B2 (de)
BR (1) BR9610323A (de)
CA (1) CA2227585A1 (de)
DE (1) DE69617700T2 (de)
DK (1) DK0845988T3 (de)
ES (1) ES2169257T3 (de)
IL (1) IL122974A (de)
MX (1) MX9801179A (de)
NO (1) NO308658B1 (de)
NZ (1) NZ316312A (de)
PT (1) PT845988E (de)
RU (1) RU2177001C2 (de)
WO (1) WO1997006799A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE209915T1 (de) * 1995-08-18 2001-12-15 Purdue Research Foundation Neue kondensierten isochinoline als dopamin- rezeptor-liganden
EP1320367A4 (de) * 2000-08-11 2007-01-17 Purdue Research Foundation Verfahren zur herstellung von dinapsolin
US6916823B2 (en) * 2001-01-16 2005-07-12 Purdue Research Foundation Method of treatment of dopamine-related dysfunction
US7091212B2 (en) 2001-08-10 2006-08-15 Purdue Research Foundation Chiral dinapsoline
JP2005526728A (ja) * 2002-02-15 2005-09-08 ダーファーマ，インコーポレイテッド ドーパミンｄ１受容体アゴニストのモノエステルプロドラッグおよび非対称置換ジエステルプロドラッグ
JP2004190007A (ja) * 2002-11-27 2004-07-08 Konica Minolta Holdings Inc 色素およびインクジェット記録液
JP2007506967A (ja) * 2003-09-24 2007-03-22 ビアコーレ・アー・ベー 分子相互作用分析の方法及びシステム
WO2007098462A2 (en) * 2006-02-21 2007-08-30 Purdue Research Foundation Trans-fused chromenoisoquinolines, synthesis and methods for use
AP2975A (en) * 2008-07-16 2014-09-30 Richter Gedeon Nyrt Pharmaceutical formulations containing dopamine receptor ligands
US9359303B2 (en) 2009-04-21 2016-06-07 Purdue Research Foundation Octahydrobenzoisoquinoline modulators of dopamine receptors and uses therefor
CN110068645B (zh) * 2019-04-03 2021-09-03 上海药明奥测医疗科技有限公司 液质联用检测尿液中环磷酸腺苷的方法
KR20220041847A (ko) 2019-07-30 2022-04-01 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 섬유성 병리를 치료하기 위한 화합물 및 방법
US20240043396A1 (en) * 2021-01-29 2024-02-08 Mayo Foundation For Medical Education And Research Methods of treating ocular fibrotic pathologies

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4346090A (en) * 1977-07-21 1982-08-24 Ayerst, Mckenna & Harrison Ltd. 13-Chloro-benzocycloheptapyridoisoquinolines and use as neuroleptics
HU180234B (en) * 1979-01-22 1983-02-28 Lilly Co Eli Process for producing oktahydro-pyrasolo-aracket-3,4-g-bracket closed-quinolines
DE3624607A1 (de) * 1986-07-21 1988-01-28 Boehringer Ingelheim Kg Neue tetrahydrobenzothiazolo-chinoline ihre herstellung und verwendung
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5047536A (en) * 1989-03-17 1991-09-10 Purdue Research Foundation Hexahydrobenzo(A)phenanthridine compounds
IE912999A1 (en) * 1990-09-07 1992-03-11 Abbott Lab Phenanthridine compounds
CA2054569A1 (en) * 1990-11-07 1992-05-08 Masanobu Suzuki Process for preparing benzo¬c|phenanthridinium derivatives, and novel compounds prepared by said process
DE69334206D1 (de) * 1992-05-26 2008-04-03 Purdue Research Foundation Substituierte hexahydrobenzo(a) phenanthridine
ATE209915T1 (de) * 1995-08-18 2001-12-15 Purdue Research Foundation Neue kondensierten isochinoline als dopamin- rezeptor-liganden

Also Published As

Publication number Publication date
DK0845988T3 (da) 2002-04-02
EP0845988A4 (de) 1998-11-11
AU6851396A (en) 1997-03-12
IL122974A0 (en) 1998-08-16
MX9801179A (es) 1998-04-30
IL122974A (en) 2000-11-21
NO980688D0 (no) 1998-02-18
PT845988E (pt) 2002-05-31
US6194423B1 (en) 2001-02-27
BR9610323A (pt) 1999-12-21
DE69617700D1 (de) 2002-01-17
CA2227585A1 (en) 1997-02-27
EP0845988B1 (de) 2001-12-05
NO308658B1 (no) 2000-10-09
US5959110A (en) 1999-09-28
JP2000505046A (ja) 2000-04-25
AU700688B2 (en) 1999-01-14
NO980688L (no) 1998-02-18
RU2177001C2 (ru) 2001-12-20
ES2169257T3 (es) 2002-07-01
CN1199338A (zh) 1998-11-18
WO1997006799A1 (en) 1997-02-27
NZ316312A (en) 1999-06-29
EP0845988A1 (de) 1998-06-10
DE69617700T2 (de) 2002-07-18

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee