PT85444B - Processo para a preparacao de di- e tri-peptidos inibidores da renina e de medicamentos que os contem - Google Patents

Processo para a preparacao de di- e tri-peptidos inibidores da renina e de medicamentos que os contem Download PDF

Info

Publication number: PT85444B
Authority: PT; Portugal
Prior art keywords: alkyl; formula; group; compound; aryl
Prior art date: 1986-07-30

Application number

PT85444A

Other languages

English (en)

Portuguese (pt)

Other versions

PT85444A (de

Inventor

Heinz-Werner Kleemann

Adalbert Wagner

Dieter Ruppert

Bernward Scholkens

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-30

Filing date

1987-07-29

Publication date

1990-06-29

1987-07-29 Application filed by Hoechst Ag filed Critical Hoechst Ag

1987-08-01 Publication of PT85444A publication Critical patent/PT85444A/de

1990-06-29 Publication of PT85444B publication Critical patent/PT85444B/pt

Links

238000000034 method Methods 0.000 title claims description 28
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238000002360 preparation method Methods 0.000 title claims description 14
239000003814 drug Substances 0.000 title description 3
239000003112 inhibitor Substances 0.000 title description 2
-1 alkoxy- (c ^ -C ') Chemical group 0.000 claims description 73
150000001875 compounds Chemical class 0.000 claims description 63
239000001257 hydrogen Substances 0.000 claims description 25
229910052739 hydrogen Inorganic materials 0.000 claims description 25
150000003839 salts Chemical class 0.000 claims description 21
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 7
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

PT85444A 1986-07-30 1987-07-29 Processo para a preparacao de di- e tri-peptidos inibidores da renina e de medicamentos que os contem PT85444B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3625687		1986-07-30
DE19863627877 DE3627877A1 (de)	1986-07-30	1986-08-16	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (2)

Publication Number	Publication Date
PT85444A PT85444A (de)	1987-08-01
PT85444B true PT85444B (pt)	1990-06-29

Family

ID=25846039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT85444A PT85444B (pt)	1986-07-30	1987-07-29	Processo para a preparacao de di- e tri-peptidos inibidores da renina e de medicamentos que os contem

Country Status (14)

Country	Link
US (1)	US4855286A (de)
EP (1)	EP0255082B1 (de)
KR (1)	KR880001696A (de)
AU (1)	AU607429B2 (de)
CA (1)	CA1307622C (de)
DE (2)	DE3627877A1 (de)
DK (1)	DK396187A (de)
FI (1)	FI89498C (de)
HU (1)	HU200474B (de)
IL (1)	IL83357A (de)
NO (1)	NO176104C (de)
NZ (1)	NZ221222A (de)
PH (1)	PH27463A (de)
PT (1)	PT85444B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU204285B (en) *	1986-10-31	1991-12-30	Pfizer	Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
IL87614A0 (en) *	1987-09-16	1989-01-31	Abbott Lab	Peptidylheterocycles
DE3732971A1 (de) *	1987-09-30	1989-04-20	Hoechst Ag	Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3839126A1 (de) *	1988-11-19	1990-05-23	Hoechst Ag	Renin-hemmende harnstoffderivate von dipeptiden, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3839559A1 (de) *	1988-11-24	1990-05-31	Hoechst Ag	Renin-hemmende aminodiol-derivate
DE3841520A1 (de) *	1988-12-09	1990-06-13	Hoechst Ag	Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3841732A1 (de) *	1988-12-10	1990-06-13	Hoechst Ag	Dipeptid-derivate mit enzym-inhibitorischer wirkung
DE3913290A1 (de) *	1989-04-22	1990-10-25	Hoechst Ag	Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
DE3913272A1 (de) *	1989-04-22	1990-10-25	Hoechst Ag	Dipeptid-derivate mit enzym-inhibitorischer wirkung
US5126326A (en) *	1989-06-06	1992-06-30	Bio-Mega, Inc.	Enzyme inhibiting peptide derivatives
US5212157A (en) *	1989-06-06	1993-05-18	Bio-Mega, Inc.	Enzyme inhibitors
ATE135368T1 (de) *	1989-09-12	1996-03-15	Hoechst Ag	Aminosäurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0569487A1 (de) *	1991-01-31	1993-11-18	Abbott Laboratories	Endothelin konvertierende enzyminhibitoren
US5258362A (en) *	1991-06-11	1993-11-02	Abbott Laboratories	Renin inhibiting compounds
US5340828A (en) *	1991-09-30	1994-08-23	Merck & Co., Inc.	Inhibitors of farnesyl protein transferase
US5559256A (en) *	1992-07-20	1996-09-24	E. R. Squibb & Sons, Inc.	Aminediol protease inhibitors
US5491166A (en) *	1992-12-22	1996-02-13	Eli Lilly And Company	Inhibitors of HIV protease useful for the treatment of AIDS
US7045519B2 (en) *	1998-06-19	2006-05-16	Chiron Corporation	Inhibitors of glycogen synthase kinase 3
DE69919707T2 (de)	1998-06-19	2005-09-01	Chiron Corp., Emeryville	Glycogen synthase kinase 3 inhibitoren

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US4479941A (en) *	1981-12-10	1984-10-30	Merck & Co., Inc.	Renin inhibitory peptides having PHE13 delection
US4668770A (en) *	1982-12-27	1987-05-26	Merck & Co., Inc.	Renin inhibitory tripeptides
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
US4485099A (en) *	1983-06-15	1984-11-27	Merck & Co., Inc.	Renin inhibitors containing a C-terminal amide cycle
US4477440A (en) *	1983-09-14	1984-10-16	Merck & Co., Inc.	Renin inhibitors containing an n-terminal disulfide cycle
US4477441A (en) *	1983-09-14	1984-10-16	Merck & Co., Inc.	Renin inhibitors containing a C-terminal disulfide cycle
JPS60163899A (ja) *	1984-02-03	1985-08-26	Sankyo Co Ltd	レニン阻害ペプチド類
US4665052A (en) *	1984-03-27	1987-05-12	Merck & Co., Inc.	Renin inhibitors containing homophe8 and a C-terminal amide cycle
US4668663A (en) *	1984-03-27	1987-05-26	Merck & Co., Inc.	Renin inhibitors containing homophe8
US4661473A (en) *	1984-03-27	1987-04-28	Merck & Co., Inc.	Renin inhibitors containing peptide isosteres
US4636491A (en) *	1984-03-27	1987-01-13	Merck & Co., Inc.	Renin inhibitory peptides having improved solubility
US4663310A (en) *	1984-04-04	1987-05-05	Merck & Co., Inc.	Renin inhibitors containing 2-substituted statine
EP0163237A3 (de) *	1984-05-29	1988-04-27	Merck & Co. Inc.	Di- und tripeptidale Renin-Hemmungsstoffe
US4652551A (en) *	1984-06-22	1987-03-24	Abbott Laboratories	Renin inhibiting compounds
DK356085A (da) *	1984-08-06	1986-02-07	Upjohn Co	Reninhaemmende peptid eller et farmaceutisk acceptabelt syreadditionssalt deraf
US4616088A (en) *	1984-10-29	1986-10-07	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitor
US4727060A (en) *	1984-11-13	1988-02-23	Ciba-Geigy Corporation	Novel 5-amino-4-hydroxyvaleryl derivatives
US4609641A (en) *	1984-12-03	1986-09-02	Merck & Co., Inc.	Renin-inhibitory peptide analogs
US4629724A (en) *	1984-12-03	1986-12-16	E. R. Squibb & Sons, Inc.	Amino acid ester and amide renin inhibitors
US4665193A (en) *	1984-12-14	1987-05-12	E. R. Squibb & Sons, Inc.	Amino acid ester renin inhibitors
DK34086A (da) *	1985-01-23	1986-07-24	Abbott Lab	Peptidylaminodioler
US4657931A (en) *	1985-05-15	1987-04-14	G. D. Searle & Co.	N-(acyldipeptidyl)-aminoglycols
US4705846A (en) *	1986-03-27	1987-11-10	The Upjohn Company	Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert
US4743584A (en) *	1986-10-07	1988-05-10	Merck & Co., Inc.	C-terminal amide cyclic renin inhibitors containing peptide isosteres

1986
- 1986-08-16 DE DE19863627877 patent/DE3627877A1/de not_active Withdrawn
1987
- 1987-07-27 DE DE87110847T patent/DE3788313D1/de not_active Expired - Fee Related
- 1987-07-27 EP EP87110847A patent/EP0255082B1/de not_active Expired - Lifetime
- 1987-07-28 FI FI873295A patent/FI89498C/fi not_active IP Right Cessation
- 1987-07-28 PH PH35594A patent/PH27463A/en unknown
- 1987-07-28 NZ NZ221222A patent/NZ221222A/xx unknown
- 1987-07-28 US US07/078,843 patent/US4855286A/en not_active Expired - Fee Related
- 1987-07-28 IL IL83357A patent/IL83357A/xx unknown
- 1987-07-29 HU HU873504A patent/HU200474B/hu not_active IP Right Cessation
- 1987-07-29 NO NO873183A patent/NO176104C/no unknown
- 1987-07-29 PT PT85444A patent/PT85444B/pt not_active IP Right Cessation
- 1987-07-29 CA CA000543282A patent/CA1307622C/en not_active Expired - Fee Related
- 1987-07-29 DK DK396187A patent/DK396187A/da unknown
- 1987-07-29 AU AU76241/87A patent/AU607429B2/en not_active Ceased
- 1987-07-30 KR KR1019870008328A patent/KR880001696A/ko not_active Ceased

Also Published As

Publication number	Publication date
NO873183D0 (no)	1987-07-29
HUT44580A (en)	1988-03-28
KR880001696A (ko)	1988-04-26
NO176104B (no)	1994-10-24
DK396187A (da)	1988-01-31
EP0255082B1 (de)	1993-12-01
PT85444A (de)	1987-08-01
FI89498C (fi)	1993-10-11
DK396187D0 (da)	1987-07-29
PH27463A (en)	1993-07-09
CA1307622C (en)	1992-09-15
DE3627877A1 (de)	1988-02-04
EP0255082A3 (en)	1990-04-04
FI873295A0 (fi)	1987-07-28
IL83357A (en)	1993-05-13
EP0255082A2 (de)	1988-02-03
AU607429B2 (en)	1991-03-07
NZ221222A (en)	1989-12-21
IL83357A0 (en)	1987-12-31
AU7624187A (en)	1988-02-04
NO873183L (no)	1988-02-01
FI873295A7 (fi)	1988-01-31
US4855286A (en)	1989-08-08
HU200474B (en)	1990-06-28
FI89498B (fi)	1993-06-30
NO176104C (no)	1995-02-01
DE3788313D1 (de)	1994-01-13

Legal Events

Date

Code

Title

Description

1994-11-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940630

Publication	Publication Date	Title
AU608379B2 (en)	1991-03-28	Renin inhibitors
US5700827A (en)	1997-12-23	Amino acid derivatives, processes for the manufacture thereof and pharmaceutical compositions (II) containing these compounds
US5597804A (en)	1997-01-28	N-sulfonylarginine keto-amide compounds
JPH10503176A (ja)	1998-03-24	酵素インヒビターとしての３−アミノ−２−オキソ−１−ピペリジン酢酸誘導体
US4855286A (en)	1989-08-08	Renin-inhibiting di- and tripeptides, a process for their preparation, agents containing them, and their use
PT92442A (pt)	1990-06-29	Processo para a preparacao de derivados de acido-beta-amini-boronico e de composicoes farmaceuticas que os contem
AU622015B2 (en)	1992-03-26	Dipeptide derivatives having enzyme-inhibitory action
EP0373549B1 (de)	1993-09-01	Enzym-hemmende Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und ihre Verwendung
EP0187037A2 (de)	1986-07-09	Piperidinderivate, deren Herstellung und Benützung
US5204357A (en)	1993-04-20	Renin-inhibiting amino acid derivatives
AU624579B2 (en)	1992-06-18	Renin-inhibiting dipeptides, a process for the preparation thereof, agents containing them, and their use
JPS62265263A (ja)	1987-11-18	置換４−アミノ−３−ヒドロキシ酪酸誘導体およびその製造方法
JPS62258349A (ja)	1987-11-10	置換された４−アミノ−３−ヒドロキシ酪酸誘導体およびそれらの製造法
AU616071B2 (en)	1991-10-17	Renin-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof
DE19653036A1 (de)	1998-06-25	Cyclopeptidderivate
AU622014B2 (en)	1992-03-26	Renin-inhibiting dipeptides, a process for their preparation, agents containing them and their use
JPS6348252A (ja)	1988-02-29	レニンを阻害するジ−およびトリペプチドおよびそれらの製法
WO1992010510A1 (de)	1992-06-25	Dithiolano- und dithianoglycinhaltige renininhibitorische peptide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DD295377A5 (de)	1991-10-31	Aminosaeurederivate mit reninhemmenden eigenschaften, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung