PT86561A - Neue tricyclische benzimidazole verfahren zu ihrer herstellung und verwendung als arzneimittel - Google Patents

Neue tricyclische benzimidazole verfahren zu ihrer herstellung und verwendung als arzneimittel

Info

Publication number: PT86561A
Authority: PT; Portugal
Prior art keywords: groups; group; heteroatoms; hydroxyl; alkyl
Prior art date: 1987-01-17

Application number

PT86561A

Other languages

English (en)

Portuguese (pt)

Other versions

PT86561B (pt

Inventor

Alfred Mertens

Wolfgang Von Der Saal

Erwin Boehm

Klaus Strein

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-17

Filing date

1988-01-15

Publication date

1988-02-01

1988-01-15 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1988-02-01 Publication of PT86561A publication Critical patent/PT86561A/de

1991-12-31 Publication of PT86561B publication Critical patent/PT86561B/pt

Links

HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000005842 heteroatom Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 nitro, amino Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 abstract 1
125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
210000003743 erythrocyte Anatomy 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Amplifiers (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT86561A 1987-01-17 1988-01-15 Processo para a preparacao de novos benzimidazois triciclicos e de composicoes farmaceuticas que os contem PT86561B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873701277 DE3701277A1 (de)	1987-01-17	1987-01-17	Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
PT86561A true PT86561A (de)	1988-02-01
PT86561B PT86561B (pt)	1991-12-31

Family

ID=6319010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT86561A PT86561B (pt)	1987-01-17	1988-01-15	Processo para a preparacao de novos benzimidazois triciclicos e de composicoes farmaceuticas que os contem

Country Status (14)

Country	Link
US (2)	US4954498A (de)
EP (1)	EP0275888B1 (de)
JP (1)	JPS63192773A (de)
KR (1)	KR880009019A (de)
AT (1)	ATE103915T1 (de)
DD (1)	DD272649A5 (de)
DE (2)	DE3701277A1 (de)
DK (1)	DK14688A (de)
FI (1)	FI880182A7 (de)
HU (1)	HU205354B (de)
IL (1)	IL85069A0 (de)
MX (1)	MX10126A (de)
PT (1)	PT86561B (de)
ZA (1)	ZA88263B (de)

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DE4027592A1 (de) *	1990-08-31	1992-03-05	Beiersdorf Ag	Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
JPH07509215A (ja) *	1990-11-14	1995-10-12	カイロン　コーポレイション	ジヒドロ葉酸還元酵素の特異的阻害およびそのための化合物
CA2148082A1 (en) *	1993-09-03	1995-03-09	Daisuke Machii	Imidazoquinazoline derivatives
US5476851A (en) *	1994-09-08	1995-12-19	Rhone-Poulenc Rorer Pharmaceuticals, Inc.	Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase
US6329375B1 (en)	1997-08-05	2001-12-11	Sugen, Inc.	Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
US5932580A (en) *	1997-12-01	1999-08-03	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	PDGF receptor kinase inhibitory compounds their preparation and compositions
US6114532A (en) *	1998-02-03	2000-09-05	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
JP2002502844A (ja) *	1998-02-03	2002-01-29	ベーリンガーインゲルハイムファルマコマンディトゲゼルシャフト	５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
US6087368A (en) *	1998-06-08	2000-07-11	Bristol-Myers Squibb Company	Quinazolinone inhibitors of cGMP phosphodiesterase
AU4719799A (en) *	1998-06-30	2000-01-17	Du Pont Pharmaceuticals Company	Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
US6358954B1 (en) *	1999-11-09	2002-03-19	Yissum Research Development Company Of The Hebrew University Of Jerusalem	PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
US6423844B1 (en)	2001-06-06	2002-07-23	The United States Of America As Represented By The Secretary Of The Navy	Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
ES2316777T3 (es) *	2002-02-15	2009-04-16	Glaxo Group Limited	Moduladores de receptores vainilloides.
US7470712B2 (en) *	2004-01-21	2008-12-30	Bristol-Myers Squibb Company	Amino-benzazoles as P2Y1 receptor inhibitors
US7285569B2 (en)	2004-09-24	2007-10-23	Hoff Hoffmann-La Roche Inc.	Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) *	2004-12-17	2006-06-29	Guy Georges	Tricyclic heterocycles
US7462639B2 (en) *	2005-04-14	2008-12-09	Hoffmann-La Roche Inc.	Aminopyrazole derivatives
JP2008533181A (ja) *	2005-04-14	2008-08-21	エフ．ホフマン−ラロシュアーゲー	三環式アゾール誘導体、それらの製造及び医薬品としての使用
US20090143375A1 (en) *	2005-12-15	2009-06-04	F. Hoffmann-La Roche Ag	Tricyclic Lactam Derivatives, Their Manufacture and Use as Pharmaceutical Agents
MX2008011860A (es) *	2006-03-23	2008-09-30	Hoffmann La Roche	Derivados de indazol substituidos, su manufactura y uso como agentes farmaceuticos.
US20140309257A1 (en) *	2011-11-11	2014-10-16	The Regents Of The University Of Colorado, A Body Corporate	Topoisomerase inhibitors and methods of making and use as therapeutic agents
EP3363800A1 (de) *	2013-10-03	2018-08-22	Kura Oncology, Inc.	Heterocyclische inhibitoren von erk und verfahren zur verwendung
CN111278816B (zh) *	2017-09-04	2024-03-15	C4医药公司	二氢喹啉酮
CN112638881B (zh)	2018-07-31	2025-01-07	普林斯顿大学托管委员会	用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物
CA3168533A1 (en) *	2020-01-24	2021-07-29	The Trustees Of Princeton University	Heterocyclic compounds and uses thereof
KR102925139B1 (ko)	2021-04-22	2026-02-10	카요테라 인코포레이티드	헤테로시클릭 화합물 및 이의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN148930B (de) *	1977-09-19	1981-07-25	Hoffmann La Roche
US4352931A (en) *	1980-05-22	1982-10-05	Siegfried Aktiengesellschaft	Lin-benzoaminopurinols
CH644116A5 (de) *	1980-08-21	1984-07-13	Hoffmann La Roche	Imidazolderivate.
DE3410168A1 (de) *	1984-03-20	1985-09-26	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3445669A1 (de) *	1984-12-14	1986-06-19	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) *	1985-01-18	1986-07-24	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3524067A1 (de) *	1985-07-05	1987-01-08	Boehringer Mannheim Gmbh	Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

1987
- 1987-01-17 DE DE19873701277 patent/DE3701277A1/de not_active Withdrawn
1988
- 1988-01-11 IL IL85069A patent/IL85069A0/xx unknown
- 1988-01-11 DE DE88100223T patent/DE3888854D1/de not_active Expired - Fee Related
- 1988-01-11 EP EP88100223A patent/EP0275888B1/de not_active Expired - Lifetime
- 1988-01-11 AT AT88100223T patent/ATE103915T1/de not_active IP Right Cessation
- 1988-01-13 DK DK014688A patent/DK14688A/da not_active Application Discontinuation
- 1988-01-15 ZA ZA880263A patent/ZA88263B/xx unknown
- 1988-01-15 HU HU88161A patent/HU205354B/hu unknown
- 1988-01-15 US US07/144,514 patent/US4954498A/en not_active Expired - Fee Related
- 1988-01-15 FI FI880182A patent/FI880182A7/fi not_active Application Discontinuation
- 1988-01-15 PT PT86561A patent/PT86561B/pt not_active IP Right Cessation
- 1988-01-15 DD DD88312252A patent/DD272649A5/de unknown
- 1988-01-15 MX MX1012688A patent/MX10126A/es unknown
- 1988-01-16 KR KR1019880000316A patent/KR880009019A/ko not_active Withdrawn
- 1988-01-18 JP JP63007108A patent/JPS63192773A/ja active Pending
1990
- 1990-06-25 US US07/543,350 patent/US5116843A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI880182A0 (fi)	1988-01-15
HU205354B (en)	1992-04-28
EP0275888A2 (de)	1988-07-27
KR880009019A (ko)	1988-09-13
EP0275888A3 (en)	1989-09-27
DD272649A5 (de)	1989-10-18
US4954498A (en)	1990-09-04
DK14688A (da)	1988-07-18
ATE103915T1 (de)	1994-04-15
DE3701277A1 (de)	1988-07-28
DE3888854D1 (de)	1994-05-11
US5116843A (en)	1992-05-26
AU605822B2 (en)	1991-01-24
HUT46915A (en)	1988-12-28
FI880182A7 (fi)	1988-07-18
MX10126A (es)	1993-11-01
EP0275888B1 (de)	1994-04-06
PT86561B (pt)	1991-12-31
IL85069A0 (en)	1988-06-30
AU1031688A (en)	1988-07-21
DK14688D0 (da)	1988-01-13
ZA88263B (en)	1988-06-29
JPS63192773A (ja)	1988-08-10

Legal Events

Date

Code

Title

Description

1994-05-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19931231

Publication	Publication Date	Title
PT86561A (de)	1988-02-01	Neue tricyclische benzimidazole verfahren zu ihrer herstellung und verwendung als arzneimittel
KR880005093A (ko)	1988-06-28	5-알킬벤즈이미다졸, 그의 제조방법 및 이들을 함유하는 약제학적 조성물
MX9206939A (es)	1993-06-01	Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
DE3676313D1 (de)	1991-02-07	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte.
FI820199L (fi)	1982-08-28	Imidazodiazepiner
ATE106400T1 (de)	1994-06-15	Substituierte 3h-indole, verfahren zu ihrer herstellung sowie arzneimittel.
ES2052768T3 (es)	1994-07-16	Derivados de imidazol ii.
NO158459C (no)	1988-09-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutanderivater.
ATE13885T1 (de)	1985-07-15	Phenylpiperazinderivate von hetarylphenolen und hetarylanilinen, ihre herstellung und diese enthaltende therapeutische mittel.
ATE48276T1 (de)	1989-12-15	1,6-naphthyridin-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel.
ATE139441T1 (de)	1996-07-15	Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
DE58902884D1 (de)	1993-01-14	Thienyloxy-alkylamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DK13280A (da)	1980-07-14	Fremgangsmaade til fremstilling af hexahydro-1,4-oxazepiner
DE58904677D1 (de)	1993-07-22	Heterocyclisch substituierte 5,7-dihydro-pyrrolo(3,2-f)benzoxazol-6-one, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel.
DK141187D0 (da)	1987-03-19	1-(3-(2-dialkylaminoethoxy)-2-thienyl)-3-phenyl-1-propanoner og syreadditionssalte deraf, fremgangsmaade af saadanne forbindelser samt farmaceutiske praeparater indeholdende disse
PT71965B (en)	1982-03-31	Process for preparing aminoalkyl benzofuran derivatives
ATE62675T1 (de)	1991-05-15	2-selenomethyl-1,4-dihydropyridine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.