DK14688D0 - Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler - Google Patents

Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler

Info

Publication number: DK14688D0
Authority: DK; Denmark
Prior art keywords: groups; group; heteroatoms; hydroxyl; alkyl
Prior art date: 1987-01-17

Application number

DK014688A

Other languages

English (en)

Other versions

DK14688A (da

Inventor

Alfred Mertens

Wolfgang Von Der Saal

Erwin Boehm

Klaus Strein

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-17

Filing date

1988-01-13

Publication date

1988-01-13

1988-01-13 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1988-01-13 Publication of DK14688D0 publication Critical patent/DK14688D0/da

1988-07-18 Publication of DK14688A publication Critical patent/DK14688A/da

Links

150000001556 benzimidazoles Chemical class 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000005842 heteroatom Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
-1 nitro, amino Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 1
125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 abstract 1
125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000004103 aminoalkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
239000000470 constituent Substances 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
210000003743 erythrocyte Anatomy 0.000 abstract 1
125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Amplifiers (AREA)
Diaphragms For Electromechanical Transducers (AREA)

DK014688A 1987-01-17 1988-01-13 Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler DK14688A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873701277 DE3701277A1 (de)	1987-01-17	1987-01-17	Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel

Publications (2)

Publication Number	Publication Date
DK14688D0 true DK14688D0 (da)	1988-01-13
DK14688A DK14688A (da)	1988-07-18

Family

ID=6319010

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK014688A DK14688A (da)	1987-01-17	1988-01-13	Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler

Country Status (14)

Country	Link
US (2)	US4954498A (da)
EP (1)	EP0275888B1 (da)
JP (1)	JPS63192773A (da)
KR (1)	KR880009019A (da)
AT (1)	ATE103915T1 (da)
DD (1)	DD272649A5 (da)
DE (2)	DE3701277A1 (da)
DK (1)	DK14688A (da)
FI (1)	FI880182A7 (da)
HU (1)	HU205354B (da)
IL (1)	IL85069A0 (da)
MX (1)	MX10126A (da)
PT (1)	PT86561B (da)
ZA (1)	ZA88263B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4027592A1 (de) *	1990-08-31	1992-03-05	Beiersdorf Ag	Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
IE913974A1 (en) *	1990-11-14	1992-05-20	Protos Corp	Specific inhibition of dihydrofolate reductase and compounds¹therefor
WO1995006648A1 (fr) *	1993-09-03	1995-03-09	Kyowa Hakko Kogyo Co., Ltd.	Derive d'imidazoquinazoline
US5476851A (en) *	1994-09-08	1995-12-19	Rhone-Poulenc Rorer Pharmaceuticals, Inc.	Pyrazolo[3,4-g]quinoxaline compounds which inhibit PDGF receptor protein tyrosine kinase
WO1999007701A1 (en) *	1997-08-05	1999-02-18	Sugen, Inc.	Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
US5932580A (en) *	1997-12-01	1999-08-03	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	PDGF receptor kinase inhibitory compounds their preparation and compositions
US6114532A (en) *	1998-02-03	2000-09-05	Boehringer Ingelheim Pharma Kg	Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals
JP2002502844A (ja) *	1998-02-03	2002-01-29	ベーリンガーインゲルハイムファルマコマンディトゲゼルシャフト	５員複素環縮合ベンゾ誘導体、その調製及び医薬品としてのそれらの使用
US6087368A (en) *	1998-06-08	2000-07-11	Bristol-Myers Squibb Company	Quinazolinone inhibitors of cGMP phosphodiesterase
AU4719799A (en) *	1998-06-30	2000-01-17	Du Pont Pharmaceuticals Company	Substituted quinolin-2(1h)-ones useful as hiv reverse transcriptase inhibitors
US6358954B1 (en) *	1999-11-09	2002-03-19	Yissum Research Development Company Of The Hebrew University Of Jerusalem	PDGF receptor kinase inhibitory compounds, their preparation, purification and pharmaceutical compositions including same
US6423844B1 (en)	2001-06-06	2002-07-23	The United States Of America As Represented By The Secretary Of The Navy	Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
AR038420A1 (es) *	2002-02-15	2005-01-12	Glaxo Group Ltd	Compuesto de amida, procedimiento para la preparacion del mismo, su uso para la fabricacion de un medicamento y composicion farmaceutica que lo comprende
US7470712B2 (en) *	2004-01-21	2008-12-30	Bristol-Myers Squibb Company	Amino-benzazoles as P2Y1 receptor inhibitors
US7285569B2 (en)	2004-09-24	2007-10-23	Hoff Hoffmann-La Roche Inc.	Tricycles, their manufacture and use as pharmaceutical agents
US20060142247A1 (en) *	2004-12-17	2006-06-29	Guy Georges	Tricyclic heterocycles
KR20070113286A (ko) *	2005-04-14	2007-11-28	에프. 호프만-라 로슈 아게	아미노피라졸 유도체, 이의 제조 및 약학 제제로서의 용도
US20060235013A1 (en) *	2005-04-14	2006-10-19	Guy Georges	Tricyclic azole derivatives
KR20080063833A (ko) *	2005-12-15	2008-07-07	에프. 호프만-라 로슈 아게	트리시클릭 락탐 유도체, 이의 제조 및 약학적 제제로서의용도
US20090291968A1 (en) *	2006-03-23	2009-11-26	Guy Georges	Substituted indazole derivatives, their manufacture and use as pharmaceutical agents
US20140309257A1 (en) *	2011-11-11	2014-10-16	The Regents Of The University Of Colorado, A Body Corporate	Topoisomerase inhibitors and methods of making and use as therapeutic agents
SMT201800205T1 (it)	2013-10-03	2018-05-02	Kura Oncology Inc	Inibitori di erk e metodi d'uso
EP3679028A1 (en)	2017-09-04	2020-07-15	C4 Therapeutics, Inc.	Dihydroquinolinones
CN112638881B (zh) *	2018-07-31	2025-01-07	普林斯顿大学托管委员会	用于治疗转移性和化疗耐受性癌症的四氢喹啉衍生物
IL294705A (en) *	2020-01-24	2022-09-01	Univ Princeton	Heterocyclic compounds and their uses
WO2022226383A1 (en)	2021-04-22	2022-10-27	Kayothera Inc.	Heterocyclic compounds and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN148930B (da) *	1977-09-19	1981-07-25	Hoffmann La Roche
US4352931A (en) *	1980-05-22	1982-10-05	Siegfried Aktiengesellschaft	Lin-benzoaminopurinols
CH644116A5 (de) *	1980-08-21	1984-07-13	Hoffmann La Roche	Imidazolderivate.
DE3410168A1 (de) *	1984-03-20	1985-09-26	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue isochinolin-dione, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3445669A1 (de) *	1984-12-14	1986-06-19	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3501497A1 (de) *	1985-01-18	1986-07-24	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3524067A1 (de) *	1985-07-05	1987-01-08	Boehringer Mannheim Gmbh	Neue benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

1987
- 1987-01-17 DE DE19873701277 patent/DE3701277A1/de not_active Withdrawn
1988
- 1988-01-11 IL IL85069A patent/IL85069A0/xx unknown
- 1988-01-11 EP EP88100223A patent/EP0275888B1/de not_active Expired - Lifetime
- 1988-01-11 AT AT88100223T patent/ATE103915T1/de not_active IP Right Cessation
- 1988-01-11 DE DE88100223T patent/DE3888854D1/de not_active Expired - Fee Related
- 1988-01-13 DK DK014688A patent/DK14688A/da not_active Application Discontinuation
- 1988-01-15 HU HU88161A patent/HU205354B/hu unknown
- 1988-01-15 PT PT86561A patent/PT86561B/pt not_active IP Right Cessation
- 1988-01-15 DD DD88312252A patent/DD272649A5/de unknown
- 1988-01-15 ZA ZA880263A patent/ZA88263B/xx unknown
- 1988-01-15 US US07/144,514 patent/US4954498A/en not_active Expired - Fee Related
- 1988-01-15 FI FI880182A patent/FI880182A7/fi not_active Application Discontinuation
- 1988-01-15 MX MX1012688A patent/MX10126A/es unknown
- 1988-01-16 KR KR1019880000316A patent/KR880009019A/ko not_active Withdrawn
- 1988-01-18 JP JP63007108A patent/JPS63192773A/ja active Pending
1990
- 1990-06-25 US US07/543,350 patent/US5116843A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE3888854D1 (de)	1994-05-11
AU1031688A (en)	1988-07-21
FI880182A0 (fi)	1988-01-15
IL85069A0 (en)	1988-06-30
ZA88263B (en)	1988-06-29
PT86561B (pt)	1991-12-31
MX10126A (es)	1993-11-01
DD272649A5 (de)	1989-10-18
US5116843A (en)	1992-05-26
FI880182A7 (fi)	1988-07-18
DK14688A (da)	1988-07-18
PT86561A (de)	1988-02-01
JPS63192773A (ja)	1988-08-10
EP0275888A2 (de)	1988-07-27
DE3701277A1 (de)	1988-07-28
HU205354B (en)	1992-04-28
EP0275888A3 (en)	1989-09-27
US4954498A (en)	1990-09-04
KR880009019A (ko)	1988-09-13
ATE103915T1 (de)	1994-04-15
EP0275888B1 (de)	1994-04-06
HUT46915A (en)	1988-12-28
AU605822B2 (en)	1991-01-24

Legal Events

Date	Code	Title	Description
1993-06-14	AHS	Application shelved for other reasons than non-payment

Publication	Publication Date	Title
DK14688A (da)	1988-07-18	Hidtil ukendte tricykliske benzimidazoler, fremgangsmaade til fremstilling deraf samt anvendelse i laegemidler
KR880005093A (ko)	1988-06-28	5-알킬벤즈이미다졸, 그의 제조방법 및 이들을 함유하는 약제학적 조성물
MX9206939A (es)	1993-06-01	Derivados de piperazina, procedimiento para su preparacion y composicion farmaceutica que los comprende
DK444581A (da)	1982-04-09	Beta-lactam-forbindelser og farmaceutisk taalelige salte deraf fremgangsmaade til deres fremstilling og deres anvendelse
AU1415583A (en)	1983-11-17	Dihydropyridine derivatives
FI81579B (fi)	1990-07-31	Foerfarande foer framstaellning av farmakologiskt aktiva 6,7-dihydro-3h,5h-pyrrolo/2,3-f/bensimidazol-6-oner.
ATE105557T1 (de)	1994-05-15	N-hetaryl-imidazolderivate.
BG90783A (bg)	1993-12-24	Метод за получаване на амиди и гуанидини с хипогликемично действие
NO814299L (no)	1982-06-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive trisubstituerte pyrimido(5,4-d)pyrimidiner
ATE106400T1 (de)	1994-06-15	Substituierte 3h-indole, verfahren zu ihrer herstellung sowie arzneimittel.
NO158459C (no)	1988-09-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenyl-cyklobutanderivater.
DK384485D0 (da)	1985-08-23	1,6-naphthyridinderivater med kardilaterende virkning
DK397687A (da)	1988-02-01	Substituerede pyrido oe2,3-baaoe1,4aabenzodiazepin-6-oner samt laegemidler med indhold af saadanne forbindelser
DK13280A (da)	1980-07-14	Fremgangsmaade til fremstilling af hexahydro-1,4-oxazepiner
DK139889A (da)	1989-09-25	Heterocyklisk substituerede 5,7-dihydro-pyrrolooe3,2-faabenzoxazol-6-oner, fremgangsmaade til deres fremstilling samt laegemidler indeholdende disse
NO173010C (no)	1993-10-13	Analogifremgangsmaate for fremstilling av terapeutisk aktivt sulfonanilid
ES2063157T3 (es)	1995-01-01	Nuevos derivados del indol, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK164318C (da)	1992-11-02	1-oe3-(2-dialkylaminoethoxy)-2-thienylaa-3-phenyl-1-propanonforbindelser eller syreadditionssalte deraf, fremgangsmaade til fremstilling af saadanne forbindelser samt farmaceutiske praeparater indeholdende disse
ATE11413T1 (de)	1985-02-15	Aminoalkylbenzofuran-derivate, ihre herstellung und sie enthaltende zusammensetzungen.
IT1205114B (it)	1989-03-15	2-selenometil-1,4-diidropiridine,procedimento per la loro preparazione e composizioni farmaceutiche che le contengono
NO166586C (no)	1991-08-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalka-(b)-pyrazolo(3,4-d)-pyrridin-3-on-derivater.