PT86657A - 1-(4-hydroxy-3,5-di-tert.butyl-benzoyl)-homopiperazin verschiedene von dessen derivaten verfahren zur herstellung dieser verbindungen die sie enthaltende arzneimittel und ihre verwendung - Google Patents

1-(4-hydroxy-3,5-di-tert.butyl-benzoyl)-homopiperazin verschiedene von dessen derivaten verfahren zur herstellung dieser verbindungen die sie enthaltende arzneimittel und ihre verwendung

Info

Publication number: PT86657A
Authority: PT; Portugal
Prior art keywords: tert; hydroxy; homopiperazin; benzoyl; butyl
Prior art date: 1987-01-30

Application number

PT86657A

Other languages

English (en)

Other versions

PT86657B (pt

Inventor

Erhard Wolf

Erhard Rossmanith

Robert R Bartlett

Rudolf Schleyerbach

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-01-30

Filing date

1988-01-28

Publication date

1988-02-01

1988-01-28 Application filed by Hoechst Ag filed Critical Hoechst Ag

1988-02-01 Publication of PT86657A publication Critical patent/PT86657A/pt

1992-02-28 Publication of PT86657B publication Critical patent/PT86657B/pt

Links

229940079593 drug Drugs 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
230000002757 inflammatory effect Effects 0.000 abstract 2
LYRRSBJFMOFHBF-UHFFFAOYSA-N 1,4-diazepan-1-yl-(3,5-ditert-butyl-4-hydroxyphenyl)methanone Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(C(=O)N2CCNCCC2)=C1 LYRRSBJFMOFHBF-UHFFFAOYSA-N 0.000 abstract 1
FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 abstract 1
208000025747 Rheumatic disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
230000000552 rheumatic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fats And Perfumes (AREA)
Lubricants (AREA)
Polyesters Or Polycarbonates (AREA)

PT86657A 1987-01-30 1988-01-28 Processo para a preparacao de 1-(4-hidroxi-3,5-di-tert.-butil-benzoil)-homopiperazina, dos seus derivados e de composicoes farmaceuticas que os contenham PT86657B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873702755 DE3702755A1 (de)	1987-01-30	1987-01-30	3,5-di-tert.-butyl-4-hydroxybenzoesaeureamid, verschiedene von dessen derivaten, verfahren zur herstellung dieser verbindungen, die sie enthaltenden arzneimittel und ihre verwendung

Publications (2)

Publication Number	Publication Date
PT86657A true PT86657A (pt)	1988-02-01
PT86657B PT86657B (pt)	1992-02-28

Family

ID=6319853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT86657A PT86657B (pt)	1987-01-30	1988-01-28	Processo para a preparacao de 1-(4-hidroxi-3,5-di-tert.-butil-benzoil)-homopiperazina, dos seus derivados e de composicoes farmaceuticas que os contenham

Country Status (20)

Country	Link
US (1)	US4829061A (pt)
EP (1)	EP0276803B1 (pt)
JP (1)	JPS63192758A (pt)
KR (1)	KR880008997A (pt)
AT (1)	ATE68488T1 (pt)
AU (1)	AU600793B2 (pt)
CA (1)	CA1300619C (pt)
DE (2)	DE3702755A1 (pt)
DK (1)	DK47888A (pt)
ES (1)	ES2041705T3 (pt)
FI (1)	FI85469C (pt)
GR (1)	GR3003523T3 (pt)
HU (1)	HU200334B (pt)
IE (1)	IE880249L (pt)
IL (1)	IL85228A (pt)
NO (1)	NO170332C (pt)
NZ (1)	NZ223336A (pt)
PH (1)	PH24649A (pt)
PT (1)	PT86657B (pt)
ZA (1)	ZA88642B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE951044C (de) *	1954-08-24	1956-10-18	Heinrich Gueltig	Verfahren zum UEberziehen zugeschnittener Flaschenkorken mit einem mindestens vorwiegend Paraffin enthaltenden UEberzug
DE3834532A1 (de) *	1988-10-11	1990-04-12	Behringwerke Ag	Verwendung von homopiperazinen zur herstellung eines arzneimittels fuer das vorbeugen gegen und die behandlung von organabstossungsreaktionen
US5281623A (en) *	1990-08-27	1994-01-25	Eli Lilly And Company	Method for treating inflammation
ZA916555B (en) *	1990-08-27	1993-04-28	Lilly Co Eli	Method of treating inflammatory bowel disease
US5280046A (en) *	1991-02-22	1994-01-18	The University Of Colorado Foundation, Inc.	Method of treating type I diabetes
AU666318B2 (en) *	1991-06-28	1996-02-08	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
US5939412A (en) *	1992-06-26	1999-08-17	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
NZ314922A (en) *	1992-12-21	1998-11-25	Smithkline Beecham Corp	Benzodiazepinones; nitrogen containing heterocyclic intermediates and pharmaceutical compositions
US6403578B1 (en)	1993-12-21	2002-06-11	Smithkline Beecham Corporation	Bicyclic fibrinogen antagonists
MA23420A1 (fr) *	1994-01-07	1995-10-01	Smithkline Beecham Corp	Antagonistes bicycliques de fibrinogene.
US6458784B1 (en)	1994-06-29	2002-10-01	Smithkline Beecham Corporation	Vitronectin receptor antagonists
US5977101A (en) *	1995-06-29	1999-11-02	Smithkline Beecham Corporation	Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
DE19737334A1 (de) *	1997-08-27	1999-03-04	Solvay Pharm Gmbh	7-Phenyl-1,4-diazepan-Derivate, sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19747644C2 (de) *	1997-10-29	2001-02-22	Inst Polymerforschung Dresden	Sterisch gehinderte Phenole und Verfahren zu ihrer Herstellung
WO2002080928A1 (en) *	2001-04-03	2002-10-17	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2006115509A2 (en)	2004-06-24	2006-11-02	Novartis Vaccines And Diagnostics Inc.	Small molecule immunopotentiators and assays for their detection
US10449198B2 (en)	2016-07-01	2019-10-22	The University Of Liverpool	Method for treating pain
BR112020008371A2 (pt)	2017-10-27	2020-11-03	Esteve Pharmaceuticals, S.A.	novos derivados de alcoxiamino para tratamento de dor e condições relacionadas à dor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4066614A (en) *	1974-12-30	1978-01-03	American Cyanamid Company	Heterocyclicamides of hindered 3,5-dialkyl-4-hydroxybenzoic acids and use as light stabilizers in polyolefins
US4404302A (en) *	1982-05-27	1983-09-13	Ferro Corporation	Acylated hindered hexahydropyrimidines and their use as light stabilizing agents
CA1277663C (en) *	1985-02-04	1990-12-11	Richard A. Mueller	Heterocyclic amides

1987
- 1987-01-30 DE DE19873702755 patent/DE3702755A1/de not_active Withdrawn
1988
- 1988-01-26 ES ES198888101054T patent/ES2041705T3/es not_active Expired - Lifetime
- 1988-01-26 DE DE8888101054T patent/DE3865443D1/de not_active Expired - Fee Related
- 1988-01-26 AT AT88101054T patent/ATE68488T1/de not_active IP Right Cessation
- 1988-01-26 EP EP88101054A patent/EP0276803B1/de not_active Expired - Lifetime
- 1988-01-28 FI FI880387A patent/FI85469C/fi not_active IP Right Cessation
- 1988-01-28 HU HU88390A patent/HU200334B/hu not_active IP Right Cessation
- 1988-01-28 IL IL85228A patent/IL85228A/xx not_active IP Right Cessation
- 1988-01-28 NZ NZ223336A patent/NZ223336A/xx unknown
- 1988-01-28 PT PT86657A patent/PT86657B/pt active IP Right Grant
- 1988-01-28 US US07/149,602 patent/US4829061A/en not_active Expired - Fee Related
- 1988-01-29 AU AU10999/88A patent/AU600793B2/en not_active Ceased
- 1988-01-29 JP JP63017514A patent/JPS63192758A/ja active Pending
- 1988-01-29 CA CA000557741A patent/CA1300619C/en not_active Expired - Fee Related
- 1988-01-29 PH PH36433A patent/PH24649A/en unknown
- 1988-01-29 NO NO880407A patent/NO170332C/no unknown
- 1988-01-29 KR KR1019880000766A patent/KR880008997A/ko not_active Ceased
- 1988-01-29 DK DK047888A patent/DK47888A/da not_active Application Discontinuation
- 1988-01-29 ZA ZA88642A patent/ZA88642B/xx unknown
- 1988-01-29 IE IE880249A patent/IE880249L/xx unknown
1992
- 1992-01-08 GR GR910401655T patent/GR3003523T3/el unknown

Also Published As

Publication number	Publication date
EP0276803A1 (de)	1988-08-03
DE3865443D1 (de)	1991-11-21
AU600793B2 (en)	1990-08-23
FI880387A0 (fi)	1988-01-28
AU1099988A (en)	1988-08-04
DE3702755A1 (de)	1988-08-11
HUT46683A (en)	1988-11-28
NO880407D0 (no)	1988-01-29
NZ223336A (en)	1989-09-27
HU200334B (en)	1990-05-28
US4829061A (en)	1989-05-09
IL85228A0 (en)	1988-07-31
ATE68488T1 (de)	1991-11-15
CA1300619C (en)	1992-05-12
GR3003523T3 (pt)	1993-03-16
NO170332B (no)	1992-06-29
IL85228A (en)	1993-08-18
ZA88642B (en)	1988-09-28
NO880407L (no)	1988-08-01
JPS63192758A (ja)	1988-08-10
NO170332C (no)	1992-10-07
PH24649A (en)	1990-09-07
DK47888D0 (da)	1988-01-29
KR880008997A (ko)	1988-09-13
FI85469C (fi)	1992-04-27
FI880387L (fi)	1988-07-31
ES2041705T3 (es)	1993-12-01
PT86657B (pt)	1992-02-28
IE880249L (en)	1988-07-30
EP0276803B1 (de)	1991-10-16
FI85469B (fi)	1992-01-15
DK47888A (da)	1988-07-31

Similar Documents

Publication	Publication Date	Title
PT86657A (pt)	1988-02-01	1-(4-hydroxy-3,5-di-tert.butyl-benzoyl)-homopiperazin verschiedene von dessen derivaten verfahren zur herstellung dieser verbindungen die sie enthaltende arzneimittel und ihre verwendung
DE68923819D1 (de)	1995-09-21	Verwendung von gamma-Hydroxy-Buttersäuresalzen zur Herstellung von pharmazeutischen Zusammensetzungen zur Verwendung bei der Behandlung von Alkoholismus und die hergestellten Zusammensetzungen.
NO304793B1 (no)	1999-02-15	nor-gallesyrederivater, og anvendelse av dem for fremstilling av legemiddel
DE69131627D1 (de)	1999-10-21	Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung
ATE73657T1 (de)	1992-04-15	Verwendung von gamma-linolensaeure und verwandten verbindungen zur herstellung eubnes arzneimittels zur behandlung von endometriose.
DE68914858D1 (de)	1994-06-01	Verfahren zur Herstellung von Formaldehyd und dessen Derivaten.
ATE20238T1 (de)	1986-06-15	Verfahren zur herstellung von ganglioside derivaten und ihre verwendung in pharmaceutischen zusammensetzungen.
RU95111308A (ru)	1996-12-27	Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
FI891210A0 (fi)	1989-03-14	Tiosulfinsyraderivat, deras anvaendning vid inflammationssjukdomar samt laekemedel innehaollande dessa aemnen.
IL87561A (en)	1993-02-21	4-aminoethyl-2,3-dihydro- 2-benzimidazol and thione derivatives and pharmaceutical compositions containing the same
ATE112276T1 (de)	1994-10-15	Aryl-chinolyl-substituierte 1,4-dihydropyridin- dicarbonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
ATE234613T1 (de)	2003-04-15	Verwendung von comt inhibitoren zur herstellung eines arzneimittels zur vorbeugung von diabetischen vaskulären funktionsstörungen
EP0370499A3 (de)	1991-06-05	Verwendung von Benzomorphanen zur Zytoprotektion
ATE87002T1 (de)	1993-04-15	Substituierte 3-phenyl-7h-thiazolo(3,2 -b> (1,2,4>triazin-7-one, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung, sowie einige bei der herstellung der genannten verbindungen gebildete zwischenprodukte.
DE3870912D1 (de)	1992-06-17	4,4'-(perfluorisopropyliden)dicyclohexanol, dessen abkoemmling und verfahren zur herstellung davon.
DE59207086D1 (de)	1996-10-17	Die Verwendung von 1-(5-Oxohexyl)-3-methyl-7-n-propyl-xanthin in der Gefässchirurgie
DE69302279D1 (de)	1996-05-23	3-und 5-substituierte 1,2,3,4,-oxatriazol-5-imin derivate, verfahren zu deren herstellung, diese enthaltende arzneimittel und verwendung dieser verbindungen zur herstellung von arzneimitteln
DE58906571D1 (de)	1994-02-10	2-Aminocarbonsäuren und deren Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel.
HU9202229D0 (en)	1992-10-28	Method for manufacturing new pharmaceutical preparatives containing 2-oxo-benzimidaazoline-1-carboxylic acid derivatives
DE3888697D1 (de)	1994-04-28	2,3-thiomorpholinedion-2-oxim-derivate, arzneimittelzusammensetzungen und verfahren zur herstellung.
DE3862404D1 (de)	1991-05-23	Benzylaminoaryl-dihydropyridinelactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
ATE103279T1 (de)	1994-04-15	2,3-thiomorpholinedion-2-oxim-derivate, arzneimittelzusammensetzungen und verfahren zur herstellung.
ATA16784A (de)	1990-02-15	Verwendung von 3-substituierten tetrahydropyrrolo(1,2-a)pyrimidin-derivaten sowie von deren saeureadditions- und quaternaeren salzen zur herstellung von pharmazeutischen praeparaten
DE19775036I2 (de)	2009-11-05	Arzneimittel zur Behandlung von Augenentzündung.
ATA452779A (de)	1980-06-15	Verfahren zur herstellung von neuen 4,5,6,7- tetrahydro-2h-benzo(c)pyrrolderivaten und ihren pharmazeutisch annehmbaren saeureadditionssalzen

Legal Events

Date	Code	Title	Description
1992-02-28	FG3A	Patent granted, date of granting	Effective date: 19910808