PT88230A - Processo para o isolamento de proteinas basicas a partir de proteinas que as contem - Google Patents

Processo para o isolamento de proteinas basicas a partir de proteinas que as contem

Info

Publication number
PT88230A
PT88230A PT88230A PT8823088A PT88230A PT 88230 A PT88230 A PT 88230A PT 88230 A PT88230 A PT 88230A PT 8823088 A PT8823088 A PT 8823088A PT 88230 A PT88230 A PT 88230A
Authority
PT
Portugal
Prior art keywords
proteins
isolation
basic
basic proteins
clevage
Prior art date
Application number
PT88230A
Other languages
English (en)
Other versions
PT88230B (pt
Inventor
Michael Dorschug
Rainer Obermeier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PT88230A publication Critical patent/PT88230A/pt
Publication of PT88230B publication Critical patent/PT88230B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT88230A 1987-08-11 1988-08-10 Processo para o isolamento de proteinas basicas a partir de proteinas que as contem PT88230B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873726655 DE3726655A1 (de) 1987-08-11 1987-08-11 Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten

Publications (2)

Publication Number Publication Date
PT88230A true PT88230A (pt) 1989-06-30
PT88230B PT88230B (pt) 1995-03-01

Family

ID=6333496

Family Applications (1)

Application Number Title Priority Date Filing Date
PT88230A PT88230B (pt) 1987-08-11 1988-08-10 Processo para o isolamento de proteinas basicas a partir de proteinas que as contem

Country Status (19)

Country Link
US (1) US5101013A (pt)
EP (1) EP0305760B1 (pt)
JP (1) JP2587867B2 (pt)
KR (1) KR0129539B1 (pt)
AT (1) ATE96447T1 (pt)
AU (1) AU609170B2 (pt)
CA (1) CA1340237C (pt)
DE (2) DE3726655A1 (pt)
DK (1) DK173502B1 (pt)
ES (1) ES2047007T3 (pt)
FI (1) FI91875C (pt)
HU (1) HU198218B (pt)
IE (1) IE61557B1 (pt)
IL (1) IL87385A (pt)
NO (1) NO175004C (pt)
NZ (1) NZ225746A (pt)
PH (1) PH26874A (pt)
PT (1) PT88230B (pt)
ZA (1) ZA885871B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0600372T3 (da) * 1992-12-02 1997-08-11 Hoechst Ag Fremgangsmåde til fremstilling af proinsulin med korrekt forbundne cystinbroer.
DK0821006T3 (da) 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
DE19652713C2 (de) * 1996-12-18 2001-11-22 Aventis Pharma Gmbh Verfahren zur Reinigung von Insulin und Insulinderivaten durch Chromatographie an stark saurem Kationenaustauscher
KR100341297B1 (ko) * 1997-03-29 2002-11-16 주식회사종근당 재조합활성형프로인슐린의분리.정제방법
DE19726167B4 (de) 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
WO2000055203A1 (en) * 1999-03-15 2000-09-21 Novo Nordisk A/S Ion exchange chromatographic separation of glp-1 and related peptides
US6444788B1 (en) * 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) * 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
DE10235168A1 (de) * 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
SE0300791D0 (sv) * 2003-03-20 2003-03-20 Amersham Biosciences Ab Use of ph-responsive polymers
EP1664108B1 (en) * 2003-08-21 2009-10-14 Novo Nordisk A/S Separation of polypeptides comprising a racemized amino acid
JP4984161B2 (ja) * 2005-08-04 2012-07-25 東洋製罐株式会社 プラスチックボトル殺菌方法
CN102256618A (zh) 2008-10-17 2011-11-23 赛诺菲-安万特德国有限公司 胰岛素和glp-1激动剂的组合
PL2451437T3 (pl) 2009-07-06 2017-05-31 Sanofi-Aventis Deutschland Gmbh Wodne preparaty insuliny zawierające metioninę
FR2947818B1 (fr) * 2009-07-09 2011-07-29 Inst Superieur Des Sciences Agronomiques Agroalimentaires Horticoles Et Du Paysage Agro Campus Ouest Utilisation d'un coproduit issu d'un procede d'extraction du lysozyme a partir de blanc d'oeuf, pour l'obtention d'au moins une proteine basique de blanc d'oeuf
NZ599847A (en) 2009-11-13 2013-09-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
WO2012028172A1 (en) 2010-08-30 2012-03-08 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es) 2011-08-29 2014-04-09 Sanofi Aventis Deutschland Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
EP2748181B1 (en) * 2011-09-30 2016-03-30 GE Healthcare BioProcess R&D AB Method for purification of cleaved pro-insulin
EP2931301B2 (en) 2012-12-17 2021-09-15 Merck Sharp & Dohme Corp. Process for purifying insulin and analogues thereof
EP3116531B1 (en) 2014-03-14 2021-10-20 Merck Sharp & Dohme Corp. Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
PE20171622A1 (es) 2014-12-12 2017-11-02 Sanofi Aventis Deutschland Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
JPWO2018147393A1 (ja) * 2017-02-10 2019-11-21 三菱ケミカル株式会社 ヒトインスリン精製用分離剤及びヒトインスリンの精製方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2629568C3 (de) * 1976-07-01 1981-09-10 Hoechst Ag, 6000 Frankfurt Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten
NL7713966A (nl) * 1976-12-27 1978-06-29 Univ Minnesota Werkwijze voor het behandelen van insuline.
DK311477A (da) * 1977-07-08 1979-01-09 Leo Lab Fremgangsmaade ved fremstilling af rent insulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
DE3486491T2 (de) * 1983-04-25 2003-01-16 Chiron Corp., Emeryville Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren
DE3440988A1 (de) * 1984-11-09 1986-07-10 Hoechst Ag, 6230 Frankfurt Verfahren zur spaltung von peptiden und proteinen an der methionyl-bindung
DE3511269A1 (de) * 1985-04-12 1986-10-09 Veb Berlin-Chemie, Ddr 1199 Berlin Verfahren zur reinigung von insulin
JPS6379591A (ja) * 1986-09-22 1988-04-09 Mitsui Toatsu Chem Inc ｔＰＡの精製方法
AU607988B2 (en) * 1987-04-21 1991-03-21 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
DE68919647T2 (de) * 1988-10-26 1995-05-11 American Cyanamid Co Verfahren zur Verringerung des Aggregatinhaltes in Wachstumshormonen gleichenden Stoffen.

Also Published As

Publication number Publication date
IL87385A (en) 1993-08-18
EP0305760A2 (de) 1989-03-08
IE882441L (en) 1989-02-11
FI91875C (fi) 1994-08-25
FI883708A0 (fi) 1988-08-09
DE3885214D1 (de) 1993-12-02
ZA885871B (en) 1989-04-26
EP0305760B1 (de) 1993-10-27
AU609170B2 (en) 1991-04-26
NO175004B (no) 1994-05-09
JP2587867B2 (ja) 1997-03-05
NO175004C (no) 1994-08-17
DE3726655A1 (de) 1989-02-23
DK173502B1 (da) 2001-01-08
AU2059188A (en) 1989-02-16
KR0129539B1 (ko) 1998-04-04
FI883708L (fi) 1989-02-12
NO883554L (no) 1989-02-13
ES2047007T3 (es) 1994-02-16
CA1340237C (en) 1998-12-15
IE61557B1 (en) 1994-11-16
HU198218B (en) 1989-08-28
KR890003799A (ko) 1989-04-18
ATE96447T1 (de) 1993-11-15
NZ225746A (en) 1990-11-27
EP0305760A3 (en) 1990-06-06
PH26874A (en) 1992-11-16
JPS6486896A (en) 1989-03-31
PT88230B (pt) 1995-03-01
DK447688A (da) 1989-02-12
IL87385A0 (en) 1989-01-31
HUT47958A (en) 1989-04-28
NO883554D0 (no) 1988-08-10
FI91875B (fi) 1994-05-13
US5101013A (en) 1992-03-31
DK447688D0 (da) 1988-08-10

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FG3A Patent granted, date of granting

Effective date: 19940809

PC3A Transfer or assignment

Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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Effective date: 20090809