ATE71375T1 - Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen. - Google Patents

Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.

Info

Publication number: ATE71375T1
Authority: AT; Austria
Prior art keywords: compounds; dihydrochinoline; oxo; fluoro; derivatives
Prior art date: 1986-10-20

Application number

AT87309267T

Other languages

English (en)

Inventor

John Michael Domagala

Thomas Frederick Mich

Joseph Peter Sanchez

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-20

Filing date

1987-10-20

Publication date

1992-01-15

1987-10-20 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1992-01-15 Application granted granted Critical

1992-01-15 Publication of ATE71375T1 publication Critical patent/ATE71375T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
239000000825 pharmaceutical preparation Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
CSAYVSRENVQAPV-UHFFFAOYSA-N N1=CC=CC2=CC=CC=C21.C1=CC=C2ONC(C(=O)O)=CC2=C1 Chemical class N1=CC=CC2=CC=CC=C21.C1=CC=C2ONC(C(=O)O)=CC2=C1 CSAYVSRENVQAPV-UHFFFAOYSA-N 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT87309267T 1986-10-20 1987-10-20 Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen. ATE71375T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/920,536 US4822801A (en)	1984-07-20	1986-10-20	4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
EP87309267A EP0265230B1 (de)	1986-10-20	1987-10-20	Substituierte 6-Fluor-4-oxo-1,4-dihydrochinolin-3-Carbonsäuren; deren Derivate; diese Verbindung enthaltende pharmazeutische Zubereitungen und Verfahren zur Herstellung dieser Verbindungen

Publications (1)

Publication Number	Publication Date
ATE71375T1 true ATE71375T1 (de)	1992-01-15

Family

ID=25443916

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT87309267T ATE71375T1 (de)	1986-10-20	1987-10-20	Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeure ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.

Country Status (17)

Country	Link
US (1)	US4822801A (de)
EP (1)	EP0265230B1 (de)
JP (2)	JP2750117B2 (de)
KR (1)	KR880005137A (de)
AT (1)	ATE71375T1 (de)
AU (1)	AU643489B2 (de)
CA (1)	CA1336089C (de)
DE (1)	DE3775882D1 (de)
DK (1)	DK543787A (de)
ES (1)	ES2040261T3 (de)
FI (1)	FI874570A7 (de)
GR (1)	GR3003548T3 (de)
IE (1)	IE64492B1 (de)
NO (1)	NO874350L (de)
PH (3)	PH24199A (de)
PT (1)	PT85943B (de)
ZA (1)	ZA877887B (de)

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DE19652239A1 (de) *	1996-12-16	1998-06-18	Bayer Ag	Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen
US6387928B1 (en)	1997-09-15	2002-05-14	The Procter & Gamble Co.	Antimicrobial quinolones, their compositions and uses
ES2321042T3 (es) *	1997-09-15	2009-06-01	THE PROCTER & GAMBLE COMPANY	Quinolonas antimicrobianas, composiciones y usos de las mismas.
US7098219B2 (en)	2000-08-01	2006-08-29	Wockhart Limited	Inhibitors of cellular efflux pumps of microbes
US6964966B2 (en)	2001-04-25	2005-11-15	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) *	2001-04-25	2005-04-12	Wockhardt Limited	Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
JP4468701B2 (ja) *	2002-03-18	2010-05-26	杏林製薬株式会社	耐性菌に有効な１０−（３−シクロプロピルアミノメチル−１−ピロリジニル）ピリドベンズオキサジンカルボン酸誘導体
US6664267B1 (en)	2002-05-28	2003-12-16	Wockhardt Limited	Crystalline fluoroquinolone arginine salt form
WO2005023805A1 (en) *	2003-09-04	2005-03-17	Wockhardt Limited	Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
SG144936A1 (en)	2003-09-10	2008-08-28	Kyorin Seiyaku Kk	7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
WO2005111030A1 (en) *	2004-05-12	2005-11-24	Warner-Lambert Company Llc	Quinolone antibacterial agents
US20090156577A1 (en) *	2004-09-09	2009-06-18	Benjamin Davis	7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
US7563805B2 (en)	2005-05-19	2009-07-21	Daiichi Pharmaceutical Co., Ltd.	Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2007106537A2 (en)	2006-03-13	2007-09-20	Activx Biosciences, Inc.	Aminoquinolones as gsk-3 inhibitors
PL2001862T3 (pl) *	2006-03-28	2011-09-30	Warner Chilcott Co Llc	Jabłczany oraz odmiany polimorficzne kwasu (3S,5S)-7-[3-amino-5-metylo-piperydynylo]-1-cyklopropylo-1,4-dihydro-8-metoksy-4-okso-3-chinolinokarboksylowego
WO2007110835A2 (en) *	2006-03-28	2007-10-04	The Procter & Gamble Company	A coupling process for preparing quinolone intermediates
EP1999106B1 (de) *	2006-03-28	2012-06-27	TaiGen Biotechnology Co., Ltd.	Hybridreduktionsverfahren zur herstellung von chinolon-zwischenverbindungen
CA2688008A1 (en) *	2007-05-24	2008-11-27	Kyorin Pharmaceutical Co., Ltd.	Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
US7902227B2 (en) *	2007-07-27	2011-03-08	Janssen Pharmaceutica Nv.	C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
CN101855228B (zh)	2007-09-11	2012-10-24	杏林制药株式会社	作为gsk-3抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮
US8476261B2 (en)	2007-09-12	2013-07-02	Kyorin Pharmaceutical Co., Ltd.	Spirocyclic aminoquinolones as GSK-3 inhibitors
WO2009064836A2 (en) *	2007-11-15	2009-05-22	University Of Maryland, Baltimore	Kynurenine-aminotransferase inhibitors
KR101748891B1 (ko)	2009-03-11	2017-06-19	교린 세이야꾸 가부시키 가이샤	Ｇｓｋ-3 억제제로서의 7-시클로알킬아미노퀴놀론
US9573902B2 (en) *	2013-02-15	2017-02-21	Laurus Labs Private Ltd.	Process for the preparation of Ivacaftor and its intermediates
KR102213991B1 (ko) *	2014-05-20	2021-02-09	동화약품주식회사	개선된 자보플록사신의 제조방법

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JPS5746986A (en) *	1980-09-02	1982-03-17	Dai Ichi Seiyaku Co Ltd	Pyrido(1,2,3-de)(1,4)benzoxazine derivative
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1986
- 1986-10-20 US US06/920,536 patent/US4822801A/en not_active Expired - Lifetime
1987
- 1987-09-18 CA CA000547233A patent/CA1336089C/en not_active Expired - Fee Related
- 1987-09-25 IE IE259087A patent/IE64492B1/en not_active IP Right Cessation
- 1987-10-16 DK DK543787A patent/DK543787A/da not_active Application Discontinuation
- 1987-10-16 FI FI874570A patent/FI874570A7/fi not_active Application Discontinuation
- 1987-10-19 JP JP62261929A patent/JP2750117B2/ja not_active Expired - Fee Related
- 1987-10-19 NO NO874350A patent/NO874350L/no unknown
- 1987-10-19 PT PT85943A patent/PT85943B/pt not_active IP Right Cessation
- 1987-10-20 ES ES198787309267T patent/ES2040261T3/es not_active Expired - Lifetime
- 1987-10-20 DE DE8787309267T patent/DE3775882D1/de not_active Expired - Fee Related
- 1987-10-20 ZA ZA877887A patent/ZA877887B/xx unknown
- 1987-10-20 PH PH35962A patent/PH24199A/en unknown
- 1987-10-20 KR KR870011656A patent/KR880005137A/ko not_active Ceased
- 1987-10-20 EP EP87309267A patent/EP0265230B1/de not_active Expired - Lifetime
- 1987-10-20 AT AT87309267T patent/ATE71375T1/de not_active IP Right Cessation
1989
- 1989-04-03 PH PH38420A patent/PH25459A/en unknown
- 1989-04-03 PH PH38421A patent/PH25423A/en unknown
1991
- 1991-01-07 AU AU69205/91A patent/AU643489B2/en not_active Ceased
1992
- 1992-01-09 GR GR910402252T patent/GR3003548T3/el unknown
1997
- 1997-10-08 JP JP27539997A patent/JP3235539B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3235539B2 (ja)	2001-12-04
PH25423A (en)	1991-07-01
NO874350L (no)	1988-04-21
JPH10114779A (ja)	1998-05-06
PH24199A (en)	1990-04-10
IE64492B1 (en)	1995-08-09
DK543787A (da)	1988-04-21
US4822801A (en)	1989-04-18
PT85943B (pt)	1990-07-31
CA1336089C (en)	1995-06-27
PT85943A (en)	1987-11-01
EP0265230A1 (de)	1988-04-27
PH25459A (en)	1991-07-01
GR3003548T3 (de)	1993-03-16
AU643489B2 (en)	1993-11-18
AU606618B2 (en)	1991-02-14
FI874570A7 (fi)	1988-04-21
JP2750117B2 (ja)	1998-05-13
AU6920591A (en)	1991-03-28
FI874570A0 (fi)	1987-10-16
EP0265230B1 (de)	1992-01-08
ES2040261T3 (es)	1993-10-16
ZA877887B (en)	1989-05-30
NO874350D0 (no)	1987-10-19
IE872590L (en)	1988-04-20
DE3775882D1 (de)	1992-02-20
JPS63104974A (ja)	1988-05-10
DK543787D0 (da)	1987-10-16
AU7987987A (en)	1988-04-21
KR880005137A (ko)	1988-06-28

Legal Events

Date	Code	Title	Description
2004-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3775882D1 (de)	1992-02-20	Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeuren ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
HUT43843A (en)	1987-12-28	Process for production of derivatives of benzimidasole and medical compounds containing thereof
AT380252B (de)	1986-05-12	Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen
ATE139232T1 (de)	1996-06-15	Bizyklische pyrimidinderivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE3588095D1 (de)	1996-04-25	Polypeptid, dessen Verfahren zur Herstellung und dieses enthaltende pharmazeutische Zusammensetzung und deren Benutzung
ATE63124T1 (de)	1991-05-15	Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung.
ATE73780T1 (de)	1992-04-15	Glutaminsaeure-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische formulierungen.
NO932517L (no)	1994-01-14	5,10-metylentetrahydrofolsyre-syklo-dekstrin-inkulusjonsforbindels er
ES8606282A1 (es)	1986-04-16	Un procedimiento de preparar derivados de acidos quinolin- ynaftiridin-carboxilicos
ATE108440T1 (de)	1994-07-15	Arylaralkylether, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
HUT46664A (en)	1988-11-28	Process for producing new dihydropyridineamide derivatives and pharmaceutical compositions comprising these compounds
DE3781879D1 (de)	1992-10-29	Anthracyclinderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
FR2703048B1 (fr)	1996-01-05	Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
ATE66920T1 (de)	1991-09-15	Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten.
HUT55033A (en)	1991-04-29	Process for producing aminooligohydroxy derivatives and pharmaceutical compositions comprising same
SE7906681L (sv)	1980-02-12	Ftalazonderivat
HUT54682A (en)	1991-03-28	Process for producing 13-bromine- and 13,14-dibromine-ergoline derivatives and pharmaceutical preparatives containing these compounds
DE69017146D1 (de)	1995-03-30	Verfahren zur Herstellung von 2-(3-Pyridyl)-Tetrahydrothiopyran-2-carbonsäurethioamid-1-(1R,2R)oxyden, die so erhaltenen 2-(3-Pyridyl)-Tetrahydrothiopyran-2-carbothioamid-1-(1R,2R)oxyde und diese enthaltende pharmazeutische Zusammenstellungen.
DE3887611D1 (de)	1994-03-17	Butensäure-Amide, deren Salze, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zu deren Herstellung.
ATE52260T1 (de)	1990-05-15	Aminomethyl-6-furo(3,4-c>pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
ATE53384T1 (de)	1990-06-15	3-mercapto-2-oxo-1-pyrrolidinessigsaeurederivate verfahren zur herstellung und pharmazeutische zusammensetzungen die sie enthalten.
ATE32514T1 (de)	1988-03-15	3-(4'-aminobutylamino)-propylamino-bleomycinderivate, verfahren zur ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.