PT90039A - Processo de preparacao de oxidos de 1,2,4-benzotriazina e de composicoes faemaceuticas que os contem - Google Patents

Processo de preparacao de oxidos de 1,2,4-benzotriazina e de composicoes faemaceuticas que os contem

Info

Publication number: PT90039A
Authority: PT; Portugal
Prior art keywords: faemaceutical; compositions; contain; preparation procedure; benzotriazine oxides
Prior art date: 1988-03-18

Application number

PT90039A

Other languages

English (en)

Other versions

PT90039B (pt

Inventor

William W Lee

J Martin Brown

Edward W Grange

Abelardo P Martinez

Michael Tracy

Original Assignee

Stanford Res Inst Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-18

Filing date

1989-03-17

Publication date

1989-11-10

1989-03-17 Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int

1989-11-10 Publication of PT90039A publication Critical patent/PT90039A/pt

1994-05-31 Publication of PT90039B publication Critical patent/PT90039B/pt

Links

GDAXJBDYNVDMDF-UHFFFAOYSA-N 1,2,4-benzotriazine Chemical compound N1=NC=NC2=CC=CC=C21 GDAXJBDYNVDMDF-UHFFFAOYSA-N 0.000 title 1
239000000203 mixture Substances 0.000 title 1
229940127089 cytotoxic agent Drugs 0.000 abstract 2
239000002254 cytotoxic agent Substances 0.000 abstract 2
231100000599 cytotoxic agent Toxicity 0.000 abstract 2
BNZPFJBUHRBLNB-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-1-ium Chemical class C1=CC=C2[N+]([O-])=NC=NC2=C1 BNZPFJBUHRBLNB-UHFFFAOYSA-N 0.000 abstract 1
206010021143 Hypoxia Diseases 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001146 hypoxic effect Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)

PT90039A 1988-03-18 1989-03-17 Processo de preparacao de oxidos de 1,2,4-benzotriazina e de composicoes faemaceuticas que os contem PT90039B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16987388A	1988-03-18	1988-03-18

Publications (2)

Publication Number	Publication Date
PT90039A true PT90039A (pt)	1989-11-10
PT90039B PT90039B (pt)	1994-05-31

Family

ID=22617563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT90039A PT90039B (pt)	1988-03-18	1989-03-17	Processo de preparacao de oxidos de 1,2,4-benzotriazina e de composicoes faemaceuticas que os contem

Country Status (14)

Country	Link
EP (1)	EP0413706B1 (pt)
JP (1)	JP2793312B2 (pt)
KR (1)	KR0140894B1 (pt)
AT (1)	ATE170515T1 (pt)
AU (1)	AU637572B2 (pt)
CA (1)	CA1339217C (pt)
DE (1)	DE68928802T2 (pt)
DK (1)	DK175885B1 (pt)
ES (1)	ES2013123A6 (pt)
IE (1)	IE62911B1 (pt)
NO (1)	NO179005C (pt)
NZ (1)	NZ228323A (pt)
PT (1)	PT90039B (pt)
WO (1)	WO1989008647A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU646794B2 (en) *	1989-09-18	1994-03-10	Sri International	1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US5110347A (en) *	1990-11-26	1992-05-05	E. I Du Pont De Nemours And Company	Substituted fused heterocyclic herbicides
WO2005082867A1 (en) *	2004-03-01	2005-09-09	Auckland Uniservices Limited	Novel 1,2,4-benzotriazine-1,4-dioxides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2489352A (en) *	1946-04-10	1949-11-29	Merck & Co Inc	Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) *	1947-01-10	1949-11-29	Merck & Co Inc	Benzotriazines
CH487171A (de) *	1963-10-22	1970-03-15	Siegfried Ag	Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) *	1968-11-16	1970-06-11	Bayer Ag	Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) *	1972-11-15	1978-03-30	Bayer Ag, 5090 Leverkusen	Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IE38778B1 (en) *	1973-02-02	1978-05-24	Ciba Geigy	New 1,2,4-benzotriazine derivatives
SE7501624L (pt) *	1974-03-15	1975-09-16	Ciba Geigy Ag
DE2538179C2 (de) *	1975-08-27	1986-05-28	Bayer Ag, 5090 Leverkusen	3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) *	1977-09-10	1979-03-22	Bayer Ag	Mittel zur bekaempfung von pflanzenbakteriosen
WO1988002366A1 (en) *	1986-09-25	1988-04-07	Sri International	1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents

1989
- 1989-03-06 IE IE72189A patent/IE62911B1/en not_active IP Right Cessation
- 1989-03-08 CA CA000593060A patent/CA1339217C/en not_active Expired - Fee Related
- 1989-03-14 NZ NZ228323A patent/NZ228323A/en unknown
- 1989-03-15 EP EP89904704A patent/EP0413706B1/en not_active Expired - Lifetime
- 1989-03-15 AT AT89904704T patent/ATE170515T1/de not_active IP Right Cessation
- 1989-03-15 KR KR1019890702141A patent/KR0140894B1/ko not_active Expired - Fee Related
- 1989-03-15 WO PCT/US1989/001037 patent/WO1989008647A1/en not_active Ceased
- 1989-03-15 DE DE68928802T patent/DE68928802T2/de not_active Expired - Fee Related
- 1989-03-15 JP JP1504293A patent/JP2793312B2/ja not_active Expired - Fee Related
- 1989-03-15 AU AU34337/89A patent/AU637572B2/en not_active Ceased
- 1989-03-17 ES ES8900991A patent/ES2013123A6/es not_active Expired - Lifetime
- 1989-03-17 PT PT90039A patent/PT90039B/pt not_active IP Right Cessation
1990
- 1990-09-13 NO NO904003A patent/NO179005C/no not_active IP Right Cessation
- 1990-09-17 DK DK199002230A patent/DK175885B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU3433789A (en)	1989-10-05
KR0140894B1 (ko)	1998-06-01
AU637572B2 (en)	1993-06-03
ES2013123A6 (es)	1990-04-16
DK175885B1 (da)	2005-05-23
DK223090A (da)	1990-11-15
ATE170515T1 (de)	1998-09-15
DK223090D0 (da)	1990-09-17
DE68928802T2 (de)	1999-04-01
NZ228323A (en)	1992-09-25
CA1339217C (en)	1997-08-05
IE890721L (en)	1989-09-18
NO179005C (no)	1996-07-17
DE68928802D1 (de)	1998-10-08
EP0413706B1 (en)	1998-09-02
PT90039B (pt)	1994-05-31
WO1989008647A1 (en)	1989-09-21
NO179005B (no)	1996-04-09
EP0413706A1 (en)	1991-02-27
IE62911B1 (en)	1995-03-08
NO904003L (no)	1990-09-13
KR900700466A (ko)	1990-08-13
JP2793312B2 (ja)	1998-09-03
JPH03505867A (ja)	1991-12-19
NO904003D0 (no)	1990-09-13

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Legal Events

Date

Code

Title

Description

1994-05-31

FG3A

Patent granted, date of granting

Effective date: 19931119

2009-03-26

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20090317