DK223090D0 - Anvendelse af 1,2,4-benzotriazinoxider som straalingssensibiliserende midler og selektive cytotoksiske midler - Google Patents

Anvendelse af 1,2,4-benzotriazinoxider som straalingssensibiliserende midler og selektive cytotoksiske midler

Info

Publication number: DK223090D0
Authority: DK; Denmark
Prior art keywords: cytotoxic agents; benzotriazinoxides; application; selective cytotoxic; radiation sensitizers
Prior art date: 1988-03-18

Application number

DK223090A

Other languages

English (en)

Other versions

DK223090A (da

DK175885B1 (da

Inventor

William W Lee

J Martin Brown

Edward W Grange

Abelardo P Martinez

Michael Tracy

Original Assignee

Stanford Res Inst Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-18

Filing date

1990-09-17

Publication date

1990-09-17

1990-09-17 Application filed by Stanford Res Inst Int filed Critical Stanford Res Inst Int

1990-09-17 Publication of DK223090D0 publication Critical patent/DK223090D0/da

1990-11-15 Publication of DK223090A publication Critical patent/DK223090A/da

2005-05-23 Application granted granted Critical

2005-05-23 Publication of DK175885B1 publication Critical patent/DK175885B1/da

Links

239000002254 cytotoxic agent Substances 0.000 title abstract 3
229940127089 cytotoxic agent Drugs 0.000 title abstract 3
231100000599 cytotoxic agent Toxicity 0.000 title abstract 3
239000002534 radiation-sensitizing agent Substances 0.000 title 1
BNZPFJBUHRBLNB-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-1-ium Chemical class C1=CC=C2[N+]([O-])=NC=NC2=C1 BNZPFJBUHRBLNB-UHFFFAOYSA-N 0.000 abstract 1
206010021143 Hypoxia Diseases 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001146 hypoxic effect Effects 0.000 abstract 1
210000004881 tumor cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cosmetics (AREA)

DK199002230A 1988-03-18 1990-09-17 Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler DK175885B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US16987388A	1988-03-18	1988-03-18
US16987388		1988-03-18
PCT/US1989/001037 WO1989008647A1 (en)	1988-03-18	1989-03-15	1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
US8901037		1989-03-15

Publications (3)

Publication Number	Publication Date
DK223090D0 true DK223090D0 (da)	1990-09-17
DK223090A DK223090A (da)	1990-11-15
DK175885B1 DK175885B1 (da)	2005-05-23

Family

ID=22617563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK199002230A DK175885B1 (da)	1988-03-18	1990-09-17	Anvendelse af 1,2,4-benzotriazinoxider som strålingssensibiliserende midler og selektive cytotoksiske midler

Country Status (14)

Country	Link
EP (1)	EP0413706B1 (da)
JP (1)	JP2793312B2 (da)
KR (1)	KR0140894B1 (da)
AT (1)	ATE170515T1 (da)
AU (1)	AU637572B2 (da)
CA (1)	CA1339217C (da)
DE (1)	DE68928802T2 (da)
DK (1)	DK175885B1 (da)
ES (1)	ES2013123A6 (da)
IE (1)	IE62911B1 (da)
NO (1)	NO179005C (da)
NZ (1)	NZ228323A (da)
PT (1)	PT90039B (da)
WO (1)	WO1989008647A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU225965B1 (en) *	1989-09-18	2008-01-28	Stanford Res Inst Int	Process for producing medicaments containing 1,2,4-benzotriazine oxides as radiation sensitizers and/or selective cytotoxic agents
US5110347A (en) *	1990-11-26	1992-05-05	E. I Du Pont De Nemours And Company	Substituted fused heterocyclic herbicides
EP1723125A4 (en) *	2004-03-01	2009-11-18	Auckland Uniservices Ltd	1,2,4-benzotriazine-1,4-dioxides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2489352A (en) *	1946-04-10	1949-11-29	Merck & Co Inc	Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1
US2489359A (en) *	1947-01-10	1949-11-29	Merck & Co Inc	Benzotriazines
CH487171A (de) *	1963-10-22	1970-03-15	Siegfried Ag	Verfahren zur Herstellung therapeutisch wirksamer 1,2-Dihydro-1,2,4-benztriazine
DE1809390A1 (de) *	1968-11-16	1970-06-11	Bayer Ag	Phosphor-,Phosphon- bzw.Thionophosphor-(-phosphon)-saeureester und Verfahren zu ihrer Herstellung
DE2255825C3 (de) *	1972-11-15	1978-03-30	Bayer Ag, 5090 Leverkusen	Mikrobizide Mittel auf der Basis von S-N-Aminobenzo-l^-Triazin-di-N-oxiden (1,4)
IL44058A (en) *	1973-02-02	1978-10-31	Ciba Geigy Ag	3amino-1,2,4-benzotriazine 1,4-di-noxide derivatives, their preparation and compositions for the control of microorganisms containing them
SE7501624L (da) *	1974-03-15	1975-09-16	Ciba Geigy Ag
DE2538179C2 (de) *	1975-08-27	1986-05-28	Bayer Ag, 5090 Leverkusen	3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2740887A1 (de) *	1977-09-10	1979-03-22	Bayer Ag	Mittel zur bekaempfung von pflanzenbakteriosen
GB2203151B (en) *	1986-09-25	1991-05-29	Stanford Res Inst Int	1,2,4-benzotriazine oxides as radiosensitisers and selective cytotoxic agents

1989
- 1989-03-06 IE IE72189A patent/IE62911B1/en not_active IP Right Cessation
- 1989-03-08 CA CA000593060A patent/CA1339217C/en not_active Expired - Fee Related
- 1989-03-14 NZ NZ228323A patent/NZ228323A/en unknown
- 1989-03-15 KR KR1019890702141A patent/KR0140894B1/ko not_active Expired - Fee Related
- 1989-03-15 EP EP89904704A patent/EP0413706B1/en not_active Expired - Lifetime
- 1989-03-15 DE DE68928802T patent/DE68928802T2/de not_active Expired - Fee Related
- 1989-03-15 WO PCT/US1989/001037 patent/WO1989008647A1/en not_active Ceased
- 1989-03-15 AT AT89904704T patent/ATE170515T1/de not_active IP Right Cessation
- 1989-03-15 AU AU34337/89A patent/AU637572B2/en not_active Ceased
- 1989-03-15 JP JP1504293A patent/JP2793312B2/ja not_active Expired - Fee Related
- 1989-03-17 ES ES8900991A patent/ES2013123A6/es not_active Expired - Lifetime
- 1989-03-17 PT PT90039A patent/PT90039B/pt not_active IP Right Cessation
1990
- 1990-09-13 NO NO904003A patent/NO179005C/no not_active IP Right Cessation
- 1990-09-17 DK DK199002230A patent/DK175885B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO179005C (no)	1996-07-17
IE890721L (en)	1989-09-18
IE62911B1 (en)	1995-03-08
DK223090A (da)	1990-11-15
WO1989008647A1 (en)	1989-09-21
NO904003D0 (no)	1990-09-13
EP0413706B1 (en)	1998-09-02
EP0413706A1 (en)	1991-02-27
KR0140894B1 (ko)	1998-06-01
PT90039B (pt)	1994-05-31
DE68928802T2 (de)	1999-04-01
AU3433789A (en)	1989-10-05
AU637572B2 (en)	1993-06-03
DE68928802D1 (de)	1998-10-08
ATE170515T1 (de)	1998-09-15
KR900700466A (ko)	1990-08-13
CA1339217C (en)	1997-08-05
NO179005B (no)	1996-04-09
JP2793312B2 (ja)	1998-09-03
PT90039A (pt)	1989-11-10
ES2013123A6 (es)	1990-04-16
DK175885B1 (da)	2005-05-23
NZ228323A (en)	1992-09-25
JPH03505867A (ja)	1991-12-19
NO904003L (no)	1990-09-13

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Legal Events

Date	Code	Title	Description
2008-11-03	PBP	Patent lapsed	Country of ref document: DK