PT90301A - Processo para a preparacao de novos derivados 6-fosfono-alquilicos de purina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados 6-fosfono-alquilicos de purina e de composicoes farmaceuticas que os contem

Info

Publication number
PT90301A
PT90301A PT90301A PT9030189A PT90301A PT 90301 A PT90301 A PT 90301A PT 90301 A PT90301 A PT 90301A PT 9030189 A PT9030189 A PT 9030189A PT 90301 A PT90301 A PT 90301A
Authority
PT
Portugal
Prior art keywords
phosphone
pharmaceutical compositions
compositions containing
alkyl derivatives
preparing new
Prior art date
Application number
PT90301A
Other languages
English (en)
Other versions
PT90301B (pt
Inventor
Charles Danzin
Serge Halazy
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT90301A publication Critical patent/PT90301A/pt
Publication of PT90301B publication Critical patent/PT90301B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT90301A 1988-04-19 1989-04-18 Processo para a preparacao de novos derivados 6-fosfono-alquilicos de purina e de composicoes farmaceuticas que os contem PT90301B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88400948A EP0338168A1 (en) 1988-04-19 1988-04-19 Phosphonoalkylpurine derivatives

Publications (2)

Publication Number Publication Date
PT90301A true PT90301A (pt) 1989-11-10
PT90301B PT90301B (pt) 1994-09-30

Family

ID=8200380

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90301A PT90301B (pt) 1988-04-19 1989-04-18 Processo para a preparacao de novos derivados 6-fosfono-alquilicos de purina e de composicoes farmaceuticas que os contem

Country Status (19)

Country Link
US (1) US4988680A (pt)
EP (1) EP0338168A1 (pt)
JP (1) JP2756579B2 (pt)
KR (1) KR0139534B1 (pt)
CN (1) CN1037342A (pt)
AU (1) AU613478B2 (pt)
CA (1) CA1341027C (pt)
DE (1) DE68911192T2 (pt)
DK (1) DK186189A (pt)
ES (1) ES2062056T3 (pt)
FI (1) FI891842A7 (pt)
HU (1) HU204280B (pt)
IE (1) IE891247L (pt)
IL (1) IL90002A0 (pt)
NO (1) NO891588L (pt)
NZ (1) NZ228749A (pt)
PH (1) PH27602A (pt)
PT (1) PT90301B (pt)
ZA (1) ZA892723B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0405748A1 (en) * 1989-05-30 1991-01-02 Beecham Group p.l.c. Phosphonoderivative of purine with antiviral activity
CZ285420B6 (cs) * 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
EP0465297B1 (en) * 1990-07-04 1996-01-31 Merrell Dow Pharmaceuticals Inc. 9-Purinyl phosphonic acid derivatives
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5494912A (en) * 1991-06-26 1996-02-27 Merrell Pharmaceuticals Inc. 9-purinyl phosphonic acid derivitives for treating gout
US7371852B2 (en) * 2003-01-22 2008-05-13 Serenex, Inc. Alkyl-linked nucleotide compositions
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
AU2010292500A1 (en) * 2009-08-27 2012-03-15 Epiphany Biosciences, Inc. Novel nucleoside phosphonates and analogs
US9011817B2 (en) * 2009-09-03 2015-04-21 The Board Of Trustees Of The Leland Stanford Junior University Compounds and methods of making compounds
CN112110784B (zh) * 2020-09-02 2022-03-15 天津科技大学 一种新型高含水量造雾剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4421767A (en) * 1981-06-01 1983-12-20 Merrell Toraude Et Compagnie Compounds and methods for treating depression
NL8420134A (nl) * 1983-05-24 1985-04-01 Stanford Res Inst Int Nieuwe antivirusmiddelen.
CA1288098C (en) * 1984-08-24 1991-08-27 Richard L. Tolman 4-(guanin-9-yl)butanals and their 3-oxa, 3-thia and 2-ene derivatives having antiviral and antitumor activity
US4695654A (en) * 1985-08-21 1987-09-22 Merrell Dow Pharmaceuticals Inc. Gem-dihalo-1,8-diamino-4-aza-octanes
US4719313A (en) * 1985-08-21 1988-01-12 Merrell Dow Pharmaceuticals Inc. Gem-dihalo and tetrahalo-1,12-diamino-4,9-diaza-dodecanes
US4730006A (en) * 1986-01-27 1988-03-08 Merrell Dow Pharmaceuticals Inc. Derivatives of 2,6-diamino-3-haloheptanedioic acid
NZ222553A (en) * 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ZA892723B (en) 1989-12-27
IE891247L (en) 1989-10-19
DE68911192T2 (de) 1994-05-05
CA1341027C (en) 2000-06-13
FI891842A0 (fi) 1989-04-18
IL90002A0 (en) 1989-12-15
JP2756579B2 (ja) 1998-05-25
JPH026497A (ja) 1990-01-10
KR890016059A (ko) 1989-11-28
NZ228749A (en) 1991-05-28
EP0338168A1 (en) 1989-10-25
FI891842A7 (fi) 1989-10-20
PH27602A (en) 1993-08-31
US4988680A (en) 1991-01-29
AU613478B2 (en) 1991-08-01
PT90301B (pt) 1994-09-30
ES2062056T3 (es) 1994-12-16
HU204280B (en) 1991-12-30
DE68911192D1 (de) 1994-01-20
NO891588D0 (no) 1989-04-18
CN1037342A (zh) 1989-11-22
DK186189A (da) 1989-10-20
AU3315889A (en) 1989-10-26
NO891588L (no) 1989-10-20
KR0139534B1 (ko) 1998-06-15
DK186189D0 (da) 1989-04-18

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940317

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19950930