PT91803A - Processo para a preparacao de novos derivados da 2'-halogenometilideno-, 2'-etenilideno- e 2'-etinil-adenosina e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados da 2'-halogenometilideno-, 2'-etenilideno- e 2'-etinil-adenosina e de composicoes farmaceuticas que os contem

Info

Publication number: PT91803A
Authority: PT; Portugal
Prior art keywords: halogenomethylidene; etenylidene; etinyl; pharmaceutical compositions; compositions containing
Prior art date: 1988-09-27

Application number

PT91803A

Other languages

English (en)

Other versions

PT91803B (pt

Inventor

James Ray Mccarthy

Esa Tero Jarvi

Michael Louis Edwards

David Martin Stemerick

Nellikunja J Parakash

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-27

Filing date

1989-09-26

Publication date

1990-03-30

1989-09-26 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1990-03-30 Publication of PT91803A publication Critical patent/PT91803A/pt

1995-05-31 Publication of PT91803B publication Critical patent/PT91803B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PT91803A 1988-09-27 1989-09-26 Processo para a preparacao de novos derivados da 2'-halogenometilideno-, 2'-etenilideno- e 2'-etinil-adenosina e de composicoes farmaceuticas que os contem PT91803B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24991188A	1988-09-27	1988-09-27
US38939189A	1989-08-03	1989-08-03

Publications (2)

Publication Number	Publication Date
PT91803A true PT91803A (pt)	1990-03-30
PT91803B PT91803B (pt)	1995-05-31

Family

ID=26940460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT91803A PT91803B (pt)	1988-09-27	1989-09-26	Processo para a preparacao de novos derivados da 2'-halogenometilideno-, 2'-etenilideno- e 2'-etinil-adenosina e de composicoes farmaceuticas que os contem

Country Status (18)

Country	Link
EP (1)	EP0365849B1 (pt)
JP (1)	JP2968002B2 (pt)
KR (1)	KR0146333B1 (pt)
CN (1)	CN1046334A (pt)
AR (1)	AR248283A1 (pt)
AT (1)	ATE111477T1 (pt)
AU (1)	AU621664B2 (pt)
CA (1)	CA1336903C (pt)
DE (1)	DE68918215T2 (pt)
DK (1)	DK171237B1 (pt)
ES (1)	ES2063796T3 (pt)
FI (1)	FI94763C (pt)
HU (1)	HU204843B (pt)
IE (1)	IE63561B1 (pt)
IL (1)	IL91773A (pt)
NO (1)	NO171857C (pt)
NZ (1)	NZ230766A (pt)
PT (1)	PT91803B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5340816A (en) *	1990-10-18	1994-08-23	E. R. Squibb & Sons, Inc.	Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
US5206244A (en) *	1990-10-18	1993-04-27	E. R. Squibb & Sons, Inc.	Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
EP0640092B1 (en) *	1992-05-12	1996-12-11	Merrell Pharmaceuticals Inc.	A process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) *	1994-03-29	1997-05-06	Ribozyme Pharmaceuticals, Inc.	2'deoxy-2'-alkylnucleotide containing nucleic acid
EP0770621A4 (en) *	1994-07-12	1998-01-28	Yamasa Corp	2'-DEOXY-2 '(SUBSTITUTED OR Unsubstituted METHYLIDENE) -4-THIONUCLEOSIDE
WO2000074686A1 (en) *	1999-06-09	2000-12-14	Anticancer, Inc.	Modulators of methylation for control of bacterial virulence
US6579857B1 (en)	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
WO2003068162A2 (en) *	2002-02-14	2003-08-21	Pharmasset Ltd.	Modified fluorinated nucleoside analogues
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0267878A1 (en) *	1986-11-14	1988-05-18	Ciba-Geigy Ag	N9-cyclopentyl-substituted adenine derivatives
US5047520A (en) *	1987-03-19	1991-09-10	Yamasa Shoyu Kabushiki Kaisha	2'-alkylidenepyrimidine nucleoside derivatives, process for production thereof, and uses thereof
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Novel neplanocin derivatives

1989
- 1989-09-22 HU HU894982A patent/HU204843B/hu not_active IP Right Cessation
- 1989-09-25 IL IL9177389A patent/IL91773A/en not_active IP Right Cessation
- 1989-09-25 NZ NZ230766A patent/NZ230766A/en unknown
- 1989-09-26 ES ES89117735T patent/ES2063796T3/es not_active Expired - Lifetime
- 1989-09-26 JP JP1250413A patent/JP2968002B2/ja not_active Expired - Fee Related
- 1989-09-26 KR KR1019890013825A patent/KR0146333B1/ko not_active Expired - Fee Related
- 1989-09-26 DK DK473289A patent/DK171237B1/da not_active IP Right Cessation
- 1989-09-26 EP EP89117735A patent/EP0365849B1/en not_active Expired - Lifetime
- 1989-09-26 AT AT89117735T patent/ATE111477T1/de not_active IP Right Cessation
- 1989-09-26 PT PT91803A patent/PT91803B/pt not_active IP Right Cessation
- 1989-09-26 IE IE308089A patent/IE63561B1/en not_active IP Right Cessation
- 1989-09-26 DE DE68918215T patent/DE68918215T2/de not_active Expired - Fee Related
- 1989-09-26 CN CN89108169A patent/CN1046334A/zh active Pending
- 1989-09-26 AU AU41760/89A patent/AU621664B2/en not_active Ceased
- 1989-09-26 NO NO893826A patent/NO171857C/no not_active IP Right Cessation
- 1989-09-26 AR AR89315002A patent/AR248283A1/es active
- 1989-09-26 FI FI894546A patent/FI94763C/fi not_active IP Right Cessation
- 1989-09-27 CA CA000613429A patent/CA1336903C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK473289D0 (da)	1989-09-26
NO893826L (no)	1990-03-28
FI894546A7 (fi)	1990-03-28
EP0365849B1 (en)	1994-09-14
EP0365849A3 (en)	1990-12-27
IE63561B1 (en)	1995-05-17
NO171857C (no)	1993-05-12
JP2968002B2 (ja)	1999-10-25
FI94763B (fi)	1995-07-14
JPH02160769A (ja)	1990-06-20
FI894546A0 (fi)	1989-09-26
CA1336903C (en)	1995-09-05
NO171857B (no)	1993-02-01
NZ230766A (en)	1992-07-28
CN1046334A (zh)	1990-10-24
KR900004736A (ko)	1990-04-12
EP0365849A2 (en)	1990-05-02
KR0146333B1 (ko)	1998-08-01
DK473289A (da)	1990-03-28
IL91773A (en)	1994-02-27
AU621664B2 (en)	1992-03-19
PT91803B (pt)	1995-05-31
ATE111477T1 (de)	1994-09-15
DK171237B1 (da)	1996-08-05
DE68918215D1 (de)	1994-10-20
ES2063796T3 (es)	1995-01-16
AR248283A1 (es)	1995-07-12
HU204843B (en)	1992-02-28
DE68918215T2 (de)	1995-02-02
NO893826D0 (no)	1989-09-26
HUT50844A (en)	1990-03-28
IL91773A0 (en)	1990-06-10
AU4176089A (en)	1990-04-05
FI94763C (fi)	1995-10-25
IE893080L (en)	1990-03-27

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Legal Events

Date

Code

Title

Description

1995-05-31

FG3A

Patent granted, date of granting

Effective date: 19941121

2004-08-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040531