PT90883A - Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem - Google Patents
Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contemInfo
- Publication number
- PT90883A PT90883A PT90883A PT9088389A PT90883A PT 90883 A PT90883 A PT 90883A PT 90883 A PT90883 A PT 90883A PT 9088389 A PT9088389 A PT 9088389A PT 90883 A PT90883 A PT 90883A
- Authority
- PT
- Portugal
- Prior art keywords
- bridge
- benzazepines
- tetrahydro
- preparing
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- MWVMYAWMFTVYED-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-3-benzazepine Chemical class C1CNCCC2=CC=CC=C21 MWVMYAWMFTVYED-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK325188A DK325188D0 (da) | 1988-06-15 | 1988-06-15 | Hidtil ukendte benzazepinderivater |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT90883A true PT90883A (pt) | 1989-12-29 |
| PT90883B PT90883B (pt) | 1994-12-30 |
Family
ID=8120790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT90883A PT90883B (pt) | 1988-06-15 | 1989-06-15 | Processo de preparacao de 2,3,4,5-tetra-hidro-ih-3-benzazepinas e de composicoes farmaceuticas que as contem |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5010074A (pt) |
| EP (1) | EP0347672B1 (pt) |
| JP (1) | JP2769718B2 (pt) |
| AT (1) | ATE102188T1 (pt) |
| AU (1) | AU622911B2 (pt) |
| CA (1) | CA1317938C (pt) |
| DE (1) | DE68913367T2 (pt) |
| DK (1) | DK325188D0 (pt) |
| ES (1) | ES2061794T3 (pt) |
| FI (1) | FI93354C (pt) |
| IE (1) | IE891932L (pt) |
| IL (1) | IL90533A (pt) |
| NO (1) | NO173865C (pt) |
| NZ (1) | NZ229521A (pt) |
| PT (1) | PT90883B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK67489D0 (da) * | 1989-02-14 | 1989-02-14 | Novo Industri As | Nye benzazepinderivater |
| US5158948A (en) * | 1990-11-16 | 1992-10-27 | Abbott Laboratories | Tetracyclic spirobenzazepine dopamine antagonists |
| DK23392D0 (da) * | 1992-02-24 | 1992-02-24 | Novo Nordisk As | Heterocykliske forbindelser, deres anvendelse og fremstilling |
| US5470850A (en) * | 1992-02-24 | 1995-11-28 | Novo Nordisk A/S | 2,3,4,5-tetrahydro-1H-3-benzazepines |
| IL131670A (en) * | 1997-03-12 | 2005-07-25 | Addex Pharmaceuticals Sa | Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |
| US6277844B1 (en) | 1998-09-14 | 2001-08-21 | Sydney Spector | Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis |
| GB0130576D0 (en) * | 2001-12-20 | 2002-02-06 | Cenes Ltd | Dopamine D1 receptor agonist pro-drug compounds & derivatives |
| JP4555685B2 (ja) * | 2002-08-29 | 2010-10-06 | シェーリング コーポレイション | 肥満およびｃｎｓ障害の処置のための選択的ｄ１／ｄ５レセプターアンタゴニスト |
| PT1572215E (pt) | 2002-12-20 | 2009-12-09 | Glaxo Group Ltd | Derivados de benzo[d]azepina para o tratamento de perturbações neurológicas |
| EP1646623A2 (en) * | 2003-05-22 | 2006-04-19 | Schering Corporation | 5-h-benzo[d]naphth[2,1-b]azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA974989A (en) * | 1968-03-11 | 1975-09-23 | Wallace And Tiernan Inc. | Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby |
| US4210749A (en) * | 1974-11-12 | 1980-07-01 | Pennwalt Corporation | Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines |
| ZA792043B (en) * | 1978-05-08 | 1980-05-28 | Scherico Ltd | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them |
| US4284556A (en) * | 1980-01-31 | 1981-08-18 | Smithkline Corporation | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4327023A (en) * | 1980-01-31 | 1982-04-27 | Smithkline Corporation | Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| EP0254737B1 (en) * | 1986-01-16 | 1990-07-25 | Schering Corporation | Fused benzazepines |
| EP0244088A3 (en) * | 1986-04-03 | 1989-03-15 | Smithkline Beecham Corporation | 1-phenyl-3-benzazepine compounds and medicaments containing these compounds for treating gastrointestinal motility disorders |
-
1988
- 1988-06-15 DK DK325188A patent/DK325188D0/da not_active Application Discontinuation
-
1989
- 1989-06-05 IL IL9053389A patent/IL90533A/en unknown
- 1989-06-09 EP EP89110490A patent/EP0347672B1/en not_active Expired - Lifetime
- 1989-06-09 AT AT89110490T patent/ATE102188T1/de not_active IP Right Cessation
- 1989-06-09 ES ES89110490T patent/ES2061794T3/es not_active Expired - Lifetime
- 1989-06-09 DE DE68913367T patent/DE68913367T2/de not_active Expired - Lifetime
- 1989-06-12 US US07/365,250 patent/US5010074A/en not_active Expired - Lifetime
- 1989-06-13 CA CA000602684A patent/CA1317938C/en not_active Expired - Lifetime
- 1989-06-13 NZ NZ229521A patent/NZ229521A/en unknown
- 1989-06-14 NO NO892476A patent/NO173865C/no not_active IP Right Cessation
- 1989-06-14 AU AU36359/89A patent/AU622911B2/en not_active Expired
- 1989-06-15 FI FI892946A patent/FI93354C/fi active IP Right Grant
- 1989-06-15 IE IE891932A patent/IE891932L/xx not_active IP Right Cessation
- 1989-06-15 PT PT90883A patent/PT90883B/pt not_active IP Right Cessation
- 1989-06-15 JP JP1150662A patent/JP2769718B2/ja not_active Expired - Lifetime
-
1990
- 1990-02-07 US US07/477,450 patent/US5025009A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5010074A (en) | 1991-04-23 |
| NO173865C (no) | 1994-02-16 |
| JP2769718B2 (ja) | 1998-06-25 |
| FI93354C (fi) | 1995-03-27 |
| CA1317938C (en) | 1993-05-18 |
| IL90533A (en) | 1994-05-30 |
| NO892476L (no) | 1989-12-18 |
| ATE102188T1 (de) | 1994-03-15 |
| DE68913367T2 (de) | 1994-06-01 |
| NZ229521A (en) | 1991-12-23 |
| US5025009A (en) | 1991-06-18 |
| NO173865B (no) | 1993-11-08 |
| FI93354B (fi) | 1994-12-15 |
| AU622911B2 (en) | 1992-04-30 |
| EP0347672B1 (en) | 1994-03-02 |
| DK325188D0 (da) | 1988-06-15 |
| EP0347672A1 (en) | 1989-12-27 |
| AU3635989A (en) | 1989-12-21 |
| IE891932L (en) | 1989-12-15 |
| FI892946A7 (fi) | 1989-12-16 |
| JPH0240364A (ja) | 1990-02-09 |
| IL90533A0 (en) | 1990-01-18 |
| DE68913367D1 (de) | 1994-04-07 |
| NO892476D0 (no) | 1989-06-14 |
| FI892946A0 (fi) | 1989-06-15 |
| PT90883B (pt) | 1994-12-30 |
| ES2061794T3 (es) | 1994-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI901530A0 (fi) | Menetelmä immunomoduloivien atsaspiraanien valmistamiseksi | |
| FI945703A0 (fi) | 3,4,4-trisybstituoitujen piperidinyyli-N-alkyylikarboksylaattien ja välituotteiden valmistus | |
| NO1998008I1 (no) | Naratriptan | |
| FI874570A0 (fi) | Antibakteriska medel -ii. | |
| FI893751A0 (fi) | Kemiska foereningar. | |
| GB8828669D0 (en) | Organic compounds | |
| ATE102188T1 (de) | Benzazepinderivate. | |
| PT92180A (pt) | Processo para a preparacao de novas mevalonolactonas do tipo tienopiridina e de composicoes farmaceuticas que as contem | |
| HUT58748A (en) | Process for producing antiatherosclerotic bis/4-/2,6-dialkyl/-phenol/-silane derivatives and pharmaceutical compositions containing them | |
| PT98773A (pt) | Processo para a preparacao de di-hidropirido/4,3-d/pirimidinas substituidas na posicao 4 e de composicoes farmaceuticas analgesicas e antiinflamatorias que as contem | |
| PT91555A (pt) | Processo de preparacao de derivados de dibenzo{2,3:6,7}-(oxepino ou tiepino){4,5-c}(piridina ou pirrol)e de composicoes farmaceuticas que os contem | |
| AU3895689A (en) | Cyclic sulfur-containing amino acid derivatives | |
| DE3867652D1 (de) | N-substituierte 3,4-dihydropyrimidinverbindungen als mittel zur behandlung von erkrankungen des kardiovaskularen systems. | |
| DK0381984T3 (da) | 3- eller 4-substituerede oxotremorinderivater | |
| BR9813775A (pt) | Uso de um composto, processo para o tratamento de uma condição de cefaléia vascular, e, composição farmacêutica adequada para uso no tratamento de uma condição de cefaléia vascular. | |
| PT94472A (pt) | Processo para preparacao de acido (1,2,3,4-tetrahidro-9-acridinimino )-ciclohexano-carboxilico e seus derivados, bem como de composicoes farmaceuticas que os contem | |
| PT99331B (pt) | Processo para a preparacao de 3-difenilmetoxi-8-azabiciclo{3.2.1}octilalquil-tiazolidinomas e de composicoes farmaceuticas que as contem | |
| NO842345L (no) | Heksahydropyrrolo(2,1-a)isoquinolin-derivater. | |
| AU7589298A (en) | 5-{(heteroaryl)alkyl}-3-oxo-pyrido{1,2-(a)}benzimidazole-4-c arboxamide derivatives useful in treating central nervous system disorders | |
| PT94298A (pt) | Processo para a preparacao de derivados de 4, 5, 5a, 6-tetra-hidro-3h-isoxazolo{5,4,3-k1}acridinas e de composicoes farmaceuticas que os contem | |
| PT90717A (pt) | Processo de preparacao de 3,4,5,6-tetra-hidrofuro {4,3,2,ef}{3}benzazepinas substituidas e de composicoes farmaceuticas que as contem | |
| ATE44144T1 (de) | 6h-dibenzo(b,e)(1,4)oxathiepin-verbindungen. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940603 |
|
| PC3A | Transfer or assignment |
Free format text: 20010821 CENES LIMITED GB |
|
| PC3A | Transfer or assignment |
Free format text: ADDEX PHARMACEUTICALS, SA. CH Effective date: 20030505 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20090615 |