PT91123A - Processo para a preparacao de compostos heterociclicos derivados de tiazois e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de compostos heterociclicos derivados de tiazois e de composicoes farmaceuticas que os contem

Info

Publication number: PT91123A
Authority: PT; Portugal
Prior art keywords: alkyl; pharmaceutical compositions; thiazole; optionally substituted; thiazois
Prior art date: 1988-07-12

Application number

PT91123A

Other languages

English (en)

Other versions

PT91123B (pt

Inventor

Thomas Geoffrey Colerick Bird

Philip Neil Edwards

Graham Charles Crawley

Jean-Marc Marie Mauri Girodeau

Martin Paul Edwards

John Francis Kingston

Original Assignee

Ici Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-12

Filing date

1989-07-11

Publication date

1990-02-08

1989-07-11 Application filed by Ici Pharma filed Critical Ici Pharma

1990-02-08 Publication of PT91123A publication Critical patent/PT91123A/pt

1995-01-31 Publication of PT91123B publication Critical patent/PT91123B/pt

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
150000002391 heterocyclic compounds Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000000304 alkynyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical group O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004419 alkynylene group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
-1 oxy, thio, sulphinyl Chemical group 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Thiazole And Isothizaole Compounds (AREA)
Air Bags (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Detergent Compositions (AREA)

PT91123A 1988-07-12 1989-07-11 Processo para a preparacao de compostos heterociclicos derivados de tiazois e de composicoes farmaceuticas que os contem PT91123B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP88401816		1988-07-12

Publications (2)

Publication Number	Publication Date
PT91123A true PT91123A (pt)	1990-02-08
PT91123B PT91123B (pt)	1995-01-31

Family

ID=8200404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT91123A PT91123B (pt)	1988-07-12	1989-07-11	Processo para a preparacao de compostos heterociclicos derivados de tiazois e de composicoes farmaceuticas que os contem

Country Status (14)

Country	Link
US (1)	US5089513A (pt)
EP (1)	EP0351194B1 (pt)
JP (1)	JPH0276864A (pt)
AT (1)	ATE107294T1 (pt)
AU (1)	AU618610B2 (pt)
DE (1)	DE68916119T2 (pt)
DK (1)	DK346089A (pt)
ES (1)	ES2055791T3 (pt)
FI (1)	FI893381A7 (pt)
IE (1)	IE63681B1 (pt)
NO (1)	NO892823L (pt)
NZ (1)	NZ229761A (pt)
PT (1)	PT91123B (pt)
ZA (1)	ZA894913B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5236919A (en) *	1989-02-28	1993-08-17	Imperial Chemical Industries Plc	Quinoxalinyl derivatives suitable for use in leukotriene mediated disease
JPH03173874A (ja) *	1989-09-29	1991-07-29	Mitsubishi Kasei Corp	新規複素環化合物
US5254581A (en) *	1990-06-21	1993-10-19	Imperial Chemical Industries Plc	Pyran derivatives and their use as inhibitors of 5-lipoxygenase
IE914005A1 (en) *	1990-12-14	1992-06-17	Zeneca Ltd	Novel intermediates
DE4139751A1 (de) *	1991-12-03	1993-06-09	Bayer Ag, 5090 Leverkusen, De	Thiazolyl substituierte chinolylmethoxyphenylessigsaeurederivate
US5281720A (en) *	1991-02-28	1994-01-25	Merck Frosst Canada, Inc.	Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
WO1993016081A1 (en) *	1992-02-13	1993-08-19	Merrell Dow Pharmaceuticals Inc.	Piperidinyl thiacyclic derivatives
US5308852A (en) *	1992-06-29	1994-05-03	Merck Frosst Canada, Inc.	Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5350744A (en) *	1992-08-27	1994-09-27	Merck Frosst Canada, Inc.	Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5252599A (en) *	1992-08-27	1993-10-12	Merck Frosst Canada, Inc.	Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
US5426109A (en) *	1992-08-27	1995-06-20	Merck Frosst Canada, Inc.	Phenylnaphthalene hydroxy acids
US5428060A (en) *	1992-08-27	1995-06-27	Merck Frosst Canada, Inc.	Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5458793A (en) *	1993-05-13	1995-10-17	The Lubrizol Corporation	Compositions useful as additives for lubricants and liquid fuels
JP3061862B2 (ja) *	1994-10-14	2000-07-10	山之内製薬株式会社	アゾール誘導体
US5527827A (en) *	1994-10-27	1996-06-18	Merck Frosst Canada, Inc.	Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis
SE9804212D0 (sv) *	1998-12-04	1998-12-04	Astra Pharma Prod	Compounds
AU2002218200B2 (en) *	2000-10-03	2004-08-05	Syngenta Participations Ag	Phenylpropynyloxypyridine herbicides
US6825221B2 (en)	2001-10-18	2004-11-30	Allergan, Inc.	Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
WO2010128388A2 (en) *	2009-05-08	2010-11-11	Aurobindo Pharma Limited	An improved process for the preparation of intermediate compounds useful for the preparation of cinacalcet
CA2782797C (en)	2009-10-02	2018-08-07	Avexxin As	Anti inflammatory 2-oxothiazoles and 2 -oxooxazoles
WO2011093352A1 (ja)	2010-01-27	2011-08-04	武田薬品工業株式会社	チアゾール誘導体
CN105102438B (zh)	2013-01-29	2019-04-30	埃维克辛公司	抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
US9944664B2 (en)	2014-04-15	2018-04-17	Dow Agrosciences Llc	Metalloenzyme inhibitor compounds as fungicides
GB201413695D0 (en)	2014-08-01	2014-09-17	Avexxin As	Compound
GB201604318D0 (en)	2016-03-14	2016-04-27	Avexxin As	Combination therapy

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5835178A (ja) *	1981-08-26	1983-03-01	Santen Pharmaceut Co Ltd	チアゾリジン環を有するカルボン酸類
JPS5841872A (ja) *	1981-09-04	1983-03-11	Santen Pharmaceut Co Ltd	チアゾリジン環を有するエ−テル類
US4794188A (en) *	1982-12-01	1988-12-27	Usv Pharmaceutical Corporation	Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4778931A (en) *	1982-12-01	1988-10-18	Usv Pharmaceutical Corporation	Certain [3-(1-hydroxy hexyl-tetrahydro)naphthalenes], the corresponding naphthalenes having anti-inflammatory and anti-allergic activity
US4567184A (en) *	1982-12-01	1986-01-28	Usv Pharmaceutical Corporation	Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
IE56702B1 (en) *	1982-12-01	1991-11-06	Usv Pharma Corp	Antiinflammatory antiallergic compounds
US4644009A (en) *	1984-10-29	1987-02-17	Usv Pharmaceutical Corporation	Aryl-alkyl heterocyclic compounds
NO174506B (no) *	1984-10-30	1994-02-07	Usv Pharma Corp	Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4725619A (en) *	1985-04-16	1988-02-16	Usv Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) *	1985-04-16	1988-03-01	Usv Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4631287A (en) *	1985-04-16	1986-12-23	Usv Pharmaceutical Corp.	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) *	1985-04-16	1989-06-13	Rorer Pharmaceutical Corporation	Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4677210A (en) *	1985-06-19	1987-06-30	Rorer Pharmaceutical Corporation	1-arylalkoxy- and 1-arylalkylthioaryl-2-pyrazolines as anti-inflammatory or anti-allergic agents
JPS62142168A (ja) *	1985-10-16	1987-06-25	Mitsubishi Chem Ind Ltd	チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4868193A (en) *	1986-09-24	1989-09-19	Rorer Pharmaceutical Corporation	Styryl tetrazoles and anti-allergic use thereof
DE3783105T2 (de) *	1986-03-13	1993-04-22	Rhone Poulenc Rorer Int	Chinolinylaether tetrazole als mittel zur behandlung von hyperempfindlichen krankheiten.
US4668694A (en) *	1986-04-22	1987-05-26	Usv Pharmaceutical Corporation	1-arylalkoxyphenyl-pyrazolines, ketones or enoles as anti-inflammatory or anti-allergic agents
US4874777A (en) *	1987-04-10	1989-10-17	Eli Lilly And Company	Leukotriene antagonists

1989
- 1989-06-28 NZ NZ229761A patent/NZ229761A/en unknown
- 1989-06-28 ZA ZA894913A patent/ZA894913B/xx unknown
- 1989-07-07 NO NO89892823A patent/NO892823L/no unknown
- 1989-07-11 EP EP89307041A patent/EP0351194B1/en not_active Expired - Lifetime
- 1989-07-11 AU AU38014/89A patent/AU618610B2/en not_active Ceased
- 1989-07-11 US US07/378,163 patent/US5089513A/en not_active Expired - Fee Related
- 1989-07-11 IE IE223289A patent/IE63681B1/en not_active IP Right Cessation
- 1989-07-11 ES ES89307041T patent/ES2055791T3/es not_active Expired - Lifetime
- 1989-07-11 AT AT89307041T patent/ATE107294T1/de not_active IP Right Cessation
- 1989-07-11 PT PT91123A patent/PT91123B/pt not_active IP Right Cessation
- 1989-07-11 DE DE68916119T patent/DE68916119T2/de not_active Expired - Fee Related
- 1989-07-12 FI FI893381A patent/FI893381A7/fi not_active Application Discontinuation
- 1989-07-12 DK DK346089A patent/DK346089A/da not_active Application Discontinuation
- 1989-07-12 JP JP1178206A patent/JPH0276864A/ja active Pending

Also Published As

Publication number	Publication date
JPH0276864A (ja)	1990-03-16
IE63681B1 (en)	1995-05-31
AU3801489A (en)	1990-01-18
ZA894913B (en)	1990-03-28
NO892823D0 (no)	1989-07-07
US5089513A (en)	1992-02-18
EP0351194A3 (en)	1990-06-27
NO892823L (no)	1990-01-15
PT91123B (pt)	1995-01-31
FI893381A7 (fi)	1990-01-13
IE892232L (en)	1990-01-12
ATE107294T1 (de)	1994-07-15
DK346089D0 (da)	1989-07-12
NZ229761A (en)	1991-10-25
ES2055791T3 (es)	1994-09-01
AU618610B2 (en)	1992-01-02
FI893381A0 (fi)	1989-07-12
DK346089A (da)	1990-01-13
DE68916119T2 (de)	1994-09-22
EP0351194B1 (en)	1994-06-15
EP0351194A2 (en)	1990-01-17
DE68916119D1 (de)	1994-07-21

Legal Events

Date

Code

Title

Description

1995-01-31

FG3A

Patent granted, date of granting

Effective date: 19940720

1996-05-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960131

Publication	Publication Date	Title
PT91123A (pt)	1990-02-08	Processo para a preparacao de compostos heterociclicos derivados de tiazois e de composicoes farmaceuticas que os contem
PT93287A (pt)	1990-08-31	Processo para a preparacao de novos compostos heterociclicos e de composicoes farmaceuticas que os contem
HUT59134A (en)	1992-04-28	Process for produicng heterocyclic compounds and pharmaceutical compositions comprising same
AU626977B2 (en)	1992-08-13	Heterocyclic derivatives
FI901009A0 (fi)	1990-02-28	Heterocykliska cykloalkaner.
DE68918680D1 (de)	1994-11-10	Cycloalkanderivate.
ATE95170T1 (de)	1993-10-15	Diarylcycloalkanether.