PT92051A - Processo para a preparacao de compostos aza-alifaticos ciclicos com a funcao nitroxi, de compostos intermediarios e de composicoes farmaceuticas que contem estes compostos - Google Patents

Processo para a preparacao de compostos aza-alifaticos ciclicos com a funcao nitroxi, de compostos intermediarios e de composicoes farmaceuticas que contem estes compostos

Info

Publication number
PT92051A
PT92051A PT92051A PT9205189A PT92051A PT 92051 A PT92051 A PT 92051A PT 92051 A PT92051 A PT 92051A PT 9205189 A PT9205189 A PT 9205189A PT 92051 A PT92051 A PT 92051A
Authority
PT
Portugal
Prior art keywords
compounds
alkylene
pharmaceutical compositions
r1r2n
compositions containing
Prior art date
Application number
PT92051A
Other languages
English (en)
Other versions
PT92051B (pt
Inventor
Helmut Michel
Wolfgang Bartsch
Michael Schultz
Herbert Simon
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of PT92051A publication Critical patent/PT92051A/pt
Publication of PT92051B publication Critical patent/PT92051B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrane Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
PT92051A 1988-10-22 1989-10-20 Processo para a preparacao de compostos aza-alifaticos ciclicos com a funcao nitroxi, de compostos intermediarios e de composicoes farmaceuticas que contem estes compostos PT92051B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3836084A DE3836084A1 (de) 1988-10-22 1988-10-22 Cyclische azaaliphaten mit nitroxyfunktion, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
PT92051A true PT92051A (pt) 1990-04-30
PT92051B PT92051B (pt) 1995-06-30

Family

ID=6365728

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92051A PT92051B (pt) 1988-10-22 1989-10-20 Processo para a preparacao de compostos aza-alifaticos ciclicos com a funcao nitroxi, de compostos intermediarios e de composicoes farmaceuticas que contem estes compostos

Country Status (19)

Country Link
US (2) US5030641A (pt)
EP (1) EP0366004B1 (pt)
JP (1) JPH02169570A (pt)
KR (1) KR900006288A (pt)
AT (1) ATE103591T1 (pt)
AU (1) AU624867B2 (pt)
CA (1) CA2001256A1 (pt)
DD (1) DD284876A5 (pt)
DE (2) DE3836084A1 (pt)
DK (1) DK517789A (pt)
ES (1) ES2051955T3 (pt)
FI (1) FI895013A7 (pt)
HU (1) HUT52062A (pt)
IE (1) IE62022B1 (pt)
IL (1) IL92013A (pt)
MX (1) MX18028A (pt)
NZ (1) NZ231059A (pt)
PT (1) PT92051B (pt)
ZA (1) ZA897948B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278283A (en) * 1989-06-30 1994-01-11 Idemitsu Petrochemical Company, Limited Process for preparing polyarylene sulfides of increased molecular weight
DE4004841A1 (de) * 1990-02-16 1991-08-22 Boehringer Mannheim Gmbh Salpetersaeureester von cyclohexanol-derivaten
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
FR2703047B1 (fr) * 1993-03-25 1995-06-09 Hoechst Lab Derives nitres de la sydnonimine, leur procede de preparation et leur application comme medicament.
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
GB201020811D0 (en) * 2010-12-08 2011-01-19 Solvotrin Innovations Ltd Compounds
JO3350B1 (ar) * 2011-03-07 2019-03-13 Merck Sharp & Dohme مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869463A (en) * 1973-01-17 1975-03-04 Wyeth John & Brother Ltd N-phenyl derivatives of alkanoylamido piperidines
US4405334A (en) * 1982-09-27 1983-09-20 Ethyl Corporation Diesel fuel composition
AU574045B2 (en) * 1982-08-16 1988-06-30 Ethyl Corporation Diesel fuel composition
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3705622A1 (de) * 1987-02-21 1988-09-01 Boehringer Mannheim Gmbh Neue amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte

Also Published As

Publication number Publication date
IE893371L (en) 1990-04-22
IE62022B1 (en) 1994-12-14
DK517789A (da) 1990-04-23
AU624867B2 (en) 1992-06-25
EP0366004B1 (de) 1994-03-30
CA2001256A1 (en) 1990-04-22
ATE103591T1 (de) 1994-04-15
NZ231059A (en) 1991-08-27
ES2051955T3 (es) 1994-07-01
EP0366004A1 (de) 1990-05-02
FI895013A0 (fi) 1989-10-20
US5280031A (en) 1994-01-18
KR900006288A (ko) 1990-05-07
MX18028A (es) 1993-11-01
DK517789D0 (da) 1989-10-18
AU4354489A (en) 1990-04-26
US5030641A (en) 1991-07-09
ZA897948B (en) 1990-07-25
PT92051B (pt) 1995-06-30
IL92013A0 (en) 1990-07-12
DE58907341D1 (de) 1994-05-05
DE3836084A1 (de) 1990-04-26
DD284876A5 (de) 1990-11-28
HUT52062A (en) 1990-06-28
IL92013A (en) 1994-02-27
JPH02169570A (ja) 1990-06-29
FI895013A7 (fi) 1990-04-23

Similar Documents

Publication Publication Date Title
KR900007837A (ko) 퀴누클리딘, 약제로서 이의 용도 및 이의 제조방법
ES512381A0 (es) "procedimiento de preparacion de disacaridos".
NZ216363A (en) Quinazoline derivatives and pharmaceutical compositions
ES2032456T3 (es) Procedimiento para preparar derivados de 1,2,5,6-tetrahidropiridin-3-carboxaldehido-oxima.
ATE79392T1 (de) Verfahren fuer eine verbesserte verbrennung in verbrennungsprozessen, die kohlenwasserstoffe verwenden.
DE3477488D1 (en) Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives
ZA897948B (en) Cyclic azaaliphatic compounds with a nitroxy function and pharmaceutical compositions containing them
KR860700250A (ko) 신규 아미딘 화합물
SE8600046L (sv) Anvendning av en esterforening som temporer baktericid och produkt innehallande esterforeningen
ES2056137T3 (es) Nuevas alcanofenonas.
KR880012634A (ko) C_17-20리아제 억제제로서 유용한 17β-(사이클로프로필옥시)안드로스트-5-엔-3β-올 및 관련 화합물
KR860003247A (ko) 티아디아진 화합물 및 그 염의 제조방법
ES8708240A1 (es) Un procedimiento para la preparacion de nuevos compuestos poliprenilicos
ES479170A1 (es) Procedimiento de preparacion de un derivado esteroide-espiro-oxazolidinona.
ATE120750T1 (de) Ätherfreie organometallische amidverbindungen.
KR850000468A (ko) 사이클릭 펩타이드의 제조방법
KR880001744A (ko) 내방사선성 폴리올레핀 조성물
PT74380A (en) Process for the preparation of bis- and poly-dissulphides having a pharmaceutical effect
MA20552A1 (fr) Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations
KR950702566A (ko) 사슬형 아미딘기를 포함하는 디포스폰산 유도체, 그것의 제조방법 및 그것을 포함하는 의약 조성물(novel acyclic amidine-group-containing diphosphonic acid derivatives, process for producing them and medicaments containing these compounds)
DK19885D0 (da) 3-alkoxy-2-(n-pyrrolidino)-n-pyridyl-n-furyl (eller thienyl)-methyl-propylaminer, fremgangsmaade til fremstilling deraf, samt farmaceutiske midler indeholdende disse
GB1463043A (en) Furyl compounds
ES2051875T3 (es) Procedimiento para preparar derivados de 1-arilsulfonil-1,5-dihidro-2h-pirrol-2-ona.
KR890701118A (ko) 혈소판 감소증 예방 및 치료제
KR930000528A (ko) 아미노피롤리딘 백금화합물 및 그 제조방법

Legal Events

Date Code Title Description
MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000630