PT94468A - Processo de preparacao de novos indeno-indolos e de composicoes farmaceuticas que os contem e processo para a estabilizacao de compostos - Google Patents

Processo de preparacao de novos indeno-indolos e de composicoes farmaceuticas que os contem e processo para a estabilizacao de compostos

Info

Publication number: PT94468A
Authority: PT; Portugal
Prior art keywords: compounds; lower alkyl; hydrogen; group; indole
Prior art date: 1989-06-22

Application number

PT94468A

Other languages

English (en)

Other versions

PT94468B (pt

Inventor

Malcolm Sainsbury

Howard G Shertzer

Original Assignee

Univ Bath

Univ Cincinnati

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-22

Filing date

1990-06-22

Publication date

1991-02-08

1990-06-22 Application filed by Univ Bath, Univ Cincinnati filed Critical Univ Bath

1991-02-08 Publication of PT94468A publication Critical patent/PT94468A/pt

1997-12-31 Publication of PT94468B publication Critical patent/PT94468B/pt

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
230000006641 stabilisation Effects 0.000 title 1
238000011105 stabilization Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003282 alkyl amino group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PT94468A 1989-06-22 1990-06-22 Processo de preparacao de novos indeno-indolos e de composicoes farmaceuticas que os contem e processo para a estabilizacao de compostos PT94468B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8902274A SE8902274D0 (sv)	1989-06-22	1989-06-22	Indenoidole compounds ii

Publications (2)

Publication Number	Publication Date
PT94468A true PT94468A (pt)	1991-02-08
PT94468B PT94468B (pt)	1997-12-31

Family

ID=20376370

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT94468A PT94468B (pt)	1989-06-22	1990-06-22	Processo de preparacao de novos indeno-indolos e de composicoes farmaceuticas que os contem e processo para a estabilizacao de compostos

Country Status (34)

Country	Link
EP (1)	EP0409410B1 (pt)
JP (1)	JP3064411B2 (pt)
KR (1)	KR920702679A (pt)
CN (1)	CN1033029C (pt)
AT (1)	ATE135688T1 (pt)
BG (1)	BG60317B2 (pt)
CA (1)	CA2060897A1 (pt)
DD (1)	DD297960A5 (pt)
DE (1)	DE69025998T2 (pt)
DK (1)	DK0409410T3 (pt)
DZ (1)	DZ1428A1 (pt)
ES (1)	ES2084660T3 (pt)
FI (1)	FI100800B (pt)
GR (1)	GR3019779T3 (pt)
HR (1)	HRP920903B1 (pt)
HU (1)	HUT59097A (pt)
IE (1)	IE74682B1 (pt)
IL (1)	IL94830A (pt)
IS (1)	IS3590A7 (pt)
LT (1)	LT3675B (pt)
LV (1)	LV10253B (pt)
MX (1)	MX21244A (pt)
MY (1)	MY107311A (pt)
NO (1)	NO177932C (pt)
NZ (1)	NZ234175A (pt)
PL (1)	PL167761B1 (pt)
PT (1)	PT94468B (pt)
RO (1)	RO111573B1 (pt)
RU (1)	RU2104270C1 (pt)
SE (1)	SE8902274D0 (pt)
SI (1)	SI9011223B (pt)
WO (1)	WO1990015799A1 (pt)
YU (1)	YU122390A (pt)
ZA (1)	ZA904827B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU9301104D0 (en) *	1990-10-16	1993-07-28	Univ Bath	Method for producing tetrahydro-indeno-indole derivatves and pharmaceutical preparatives containing it
JPH0656669A (ja) *	1992-06-11	1994-03-01	Asahi Breweries Ltd	活性酸素消去作用を持つプテリン誘導体製剤
SE9302431D0 (sv) *	1993-07-16	1993-07-16	Ab Astra	Use of indenoindole compounds
AU675141B2 (en) *	1993-07-20	1997-01-23	Adir Et Compagnie	(Thia)cycloalkyl(b)indoles, process for preparing them and pharmaceutical compositions containing them
US6288099B1 (en)	1998-12-04	2001-09-11	American Home Products Corporation	Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
BR9915900A (pt) *	1998-12-04	2001-08-21	American Home Prod	Composto, composição farmacêutica, e, processo para tratar ou inibir distúrbios associados com contração da musculatura lisa.
FR2826009B1 (fr) *	2001-06-13	2003-08-15	Servier Lab	Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1910338B1 (en)	2005-07-14	2010-08-25	Irm, Llc	Heterotetracyclic compounds as tpo mimetics
DE102006047231B4 (de)	2006-10-04	2009-02-12	Hemmerling, Hans-Jörg, Dr.	Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
EA026149B1 (ru) *	2011-06-16	2017-03-31	Корея Рисерч Инститьют Оф Кемикал Текнолоджи	Производное инданона, его фармацевтически приемлемая соль или оптический изомер, способ его получения и содержащая его фармацевтическая композиция для профилактики или лечения вирусного заболевания
PL3882244T3 (pl)	2012-12-14	2025-06-16	Korea Research Institute Of Chemical Technology	ZWIĄZEK, JEGO FARMACEUTYCZNIE DOPUSZCZALNA SÓL LUB IZOMER OPTYCZNY, SPOSÓB ICH WYTWARZANIA i ZAWIERAJĄCA JE, JAKO SKŁADNIK AKTYWNY, KOMPOZYCJA FARMACEUTYCZNA DO PROFILAKTYKI LUB LECZENIA CHORÓB WIRUSOWYCH
US12286423B2 (en)	2020-04-20	2025-04-29	Novartis Ag	Antiviral 1,3-di-oxo-indene compounds
CA3176727A1 (en)	2020-04-20	2021-10-28	Novartis Ag	Antiviral 1,3-di-oxo-indene compounds

1989
- 1989-06-22 SE SE8902274A patent/SE8902274D0/xx unknown
1990
- 1990-06-13 IS IS3590A patent/IS3590A7/is unknown
- 1990-06-20 RO RO149127A patent/RO111573B1/ro unknown
- 1990-06-20 WO PCT/GB1990/000949 patent/WO1990015799A1/en not_active Ceased
- 1990-06-20 PL PL90285752A patent/PL167761B1/pl unknown
- 1990-06-20 DK DK90306718.9T patent/DK0409410T3/da active
- 1990-06-20 DE DE69025998T patent/DE69025998T2/de not_active Expired - Fee Related
- 1990-06-20 EP EP90306718A patent/EP0409410B1/en not_active Expired - Lifetime
- 1990-06-20 AT AT90306718T patent/ATE135688T1/de active
- 1990-06-20 IE IE224790A patent/IE74682B1/en not_active IP Right Cessation
- 1990-06-20 DZ DZ900114A patent/DZ1428A1/fr active
- 1990-06-20 MX MX21244A patent/MX21244A/es unknown
- 1990-06-20 CA CA002060897A patent/CA2060897A1/en not_active Abandoned
- 1990-06-20 ES ES90306718T patent/ES2084660T3/es not_active Expired - Lifetime
- 1990-06-20 HU HU904825A patent/HUT59097A/hu unknown
- 1990-06-20 RU SU5010937A patent/RU2104270C1/ru active
- 1990-06-20 JP JP2508940A patent/JP3064411B2/ja not_active Expired - Fee Related
- 1990-06-21 NZ NZ234175A patent/NZ234175A/xx unknown
- 1990-06-21 ZA ZA904827A patent/ZA904827B/xx unknown
- 1990-06-21 IL IL9483090A patent/IL94830A/en not_active IP Right Cessation
- 1990-06-21 DD DD90341939A patent/DD297960A5/de not_active IP Right Cessation
- 1990-06-21 MY MYPI90001050A patent/MY107311A/en unknown
- 1990-06-22 CN CN90104933A patent/CN1033029C/zh not_active Expired - Fee Related
- 1990-06-22 YU YU122390A patent/YU122390A/sh unknown
- 1990-06-22 PT PT94468A patent/PT94468B/pt not_active IP Right Cessation
- 1990-06-22 SI SI9011223A patent/SI9011223B/sl unknown
1991
- 1991-12-19 FI FI915999A patent/FI100800B/fi active
- 1991-12-20 BG BG095667A patent/BG60317B2/bg unknown
- 1991-12-20 NO NO915049A patent/NO177932C/no unknown
- 1991-12-23 KR KR1019910701951A patent/KR920702679A/ko not_active Ceased
1992
- 1992-10-02 HR HRP-1223/90A patent/HRP920903B1/xx not_active IP Right Cessation
1993
- 1993-06-14 LV LVP-93-568A patent/LV10253B/xx unknown
- 1993-08-30 LT LTIP912A patent/LT3675B/lt not_active IP Right Cessation
1996
- 1996-04-29 GR GR960401159T patent/GR3019779T3/el unknown

Also Published As

Publication number	Publication date
IE902247A1 (en)	1991-01-16
NZ234175A (en)	1992-12-23
HU904825D0 (en)	1992-03-30
IE902247L (en)	1990-12-22
NO177932C (no)	1995-12-20
YU122390A (sh)	1992-09-07
HRP920903B1 (en)	1998-06-30
BG60317B2 (bg)	1994-07-25
IL94830A0 (en)	1991-04-15
RU2104270C1 (ru)	1998-02-10
ATE135688T1 (de)	1996-04-15
DE69025998D1 (de)	1996-04-25
JP3064411B2 (ja)	2000-07-12
MY107311A (en)	1995-11-30
IL94830A (en)	1996-07-23
PL167761B1 (pl)	1995-10-31
IE74682B1 (en)	1997-07-30
DZ1428A1 (fr)	2004-09-13
LT3675B (en)	1996-01-25
CN1033029C (zh)	1996-10-16
ZA904827B (en)	1991-04-24
DE69025998T2 (de)	1996-08-08
JPH04505923A (ja)	1992-10-15
NO915049D0 (no)	1991-12-20
PT94468B (pt)	1997-12-31
NO177932B (no)	1995-09-11
AU644084B2 (en)	1993-12-02
EP0409410B1 (en)	1996-03-20
CN1051554A (zh)	1991-05-22
MX21244A (es)	1994-03-31
LV10253A (lv)	1994-10-20
HRP920903A2 (hr)	1994-04-30
FI915999A0 (fi)	1991-12-19
WO1990015799A1 (en)	1990-12-27
SI9011223A (en)	1997-10-31
SI9011223B (sl)	1998-08-31
NO915049L (no)	1992-02-21
FI100800B (fi)	1998-02-27
HUT59097A (en)	1992-04-28
AU5836990A (en)	1991-01-08
LTIP912A (en)	1995-03-27
KR920702679A (ko)	1992-10-06
GR3019779T3 (en)	1996-07-31
IS3590A7 (is)	1990-12-23
SE8902274D0 (sv)	1989-06-22
LV10253B (en)	1995-04-20
DK0409410T3 (da)	1996-04-29
PL285752A1 (en)	1991-03-11
DD297960A5 (de)	1992-01-30
ES2084660T3 (es)	1996-05-16
EP0409410A1 (en)	1991-01-23
RO111573B1 (ro)	1996-11-29
CA2060897A1 (en)	1990-12-23

Legal Events

Date

Code

Title

Description

1997-12-31

FG3A

Patent granted, date of granting

Effective date: 19970911

2000-07-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20000331

Publication	Publication Date	Title
PT92806A (pt)	1990-07-31	Processo para a preparacao de derivados de 2-amino-pirimidinona e de composicoes farmaceuticas que os contem
PT96890A (pt)	1991-10-31	Processo para a preparacao de novos derivados com estrutura naftalenica e de composicoes farmaceuticas que os contem
ES2082805T3 (es)	1996-04-01	Derivados de tiazol, procedimientos para su produccion y composiciones farmaceuticas que comprenden los mismos.
PT91231A (pt)	1990-02-08	Processo de preparacao de derivados substituidos purinona e de composicoes farmaceuticas que os contem
HUT35642A (en)	1985-07-29	Process for preparing mevalonolactone analogues and derivatives thereof further pharmaceutical compositions containing such compounds
MX23619A (es)	1993-10-01	Derivados de aminoacidos y procedimiento para su preparacion y medicamento que lo contiene.
MX21244A (es)	1994-03-31	Procedimiento para la preparacion de indenoindoles.
ES557647A0 (es)	1988-02-16	Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo
BR9406996A (pt)	1996-09-10	Enanciômero processo para preparar o mesmo processo para ciclizar um composto e composto intermediário
ES2063046T3 (es)	1995-01-01	Procedimiento para la preparacion y utilizacion de 4-oxo-4-((r)-fenil)-butenoil-salicilatos y composiciones farmaceuticas que los contienen.
DK105183A (da)	1983-09-06	Fremgangsmaade til fremstilling af 1,4-diaminocyclitolderivater
PT84760B (pt)	1989-12-29	Processo de preparacao de derivados de tiadiazinona, de seus intermediarios e de composicoes farmaceuticas