PT95338A - Metodo para o tratamento da dor ou de perturbacoes do snc utilizando antagonistas selectivos nos auto-receptores gaba, incluindo derivados de 3,4-di-hidro- ou 1,2,3,4-tetra-hidro-isoquinolina, e processos para a preparacao dos referidos derivados - Google Patents
Metodo para o tratamento da dor ou de perturbacoes do snc utilizando antagonistas selectivos nos auto-receptores gaba, incluindo derivados de 3,4-di-hidro- ou 1,2,3,4-tetra-hidro-isoquinolina, e processos para a preparacao dos referidos derivadosInfo
- Publication number
- PT95338A PT95338A PT95338A PT9533890A PT95338A PT 95338 A PT95338 A PT 95338A PT 95338 A PT95338 A PT 95338A PT 9533890 A PT9533890 A PT 9533890A PT 95338 A PT95338 A PT 95338A
- Authority
- PT
- Portugal
- Prior art keywords
- derivatives
- gaba
- tetrahydro
- dihydro
- pain
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898921304A GB8921304D0 (en) | 1989-09-20 | 1989-09-20 | New method of treatment and heterocyclic compounds used therein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT95338A true PT95338A (pt) | 1991-08-14 |
| PT95338B PT95338B (pt) | 1998-07-31 |
Family
ID=10663385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95338A PT95338B (pt) | 1989-09-20 | 1990-09-18 | Metodo para o tratamento da dor ou de perturbacoes do snc utilizando antagonistas selectivos nos auto-receptores gaba, incluindo derivados de 3,4-di-hidro- ou 1,2,3,4-tetra-hidro-isoquinolina, e processos para a preparacao dos referidos derivados |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5118690A (pt) |
| EP (1) | EP0419247A3 (pt) |
| JP (1) | JPH03120218A (pt) |
| KR (1) | KR910005866A (pt) |
| AU (2) | AU642428B2 (pt) |
| CA (1) | CA2025719A1 (pt) |
| GB (2) | GB8921304D0 (pt) |
| HU (1) | HUT59125A (pt) |
| IE (1) | IE65619B1 (pt) |
| PT (1) | PT95338B (pt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9127306D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| AU679765B2 (en) * | 1993-06-22 | 1997-07-10 | Abbott Gmbh & Co. Kg | Isoquinoline derivatives as therapeutic agents |
| US5389638A (en) * | 1993-09-10 | 1995-02-14 | Abbott Laboratories | Tetrahydroisoquinolines as alpha-2 antagonists and biogenic amine uptake inhibitors |
| JP2000507570A (ja) * | 1996-03-29 | 2000-06-20 | 日本ワイスレダリー株式会社 | 脳機能改善薬を製造するための１―ベンジル―１，２，３，４―テトラヒドロイソキノリンの使用 |
| EP0934061B3 (en) | 1996-07-24 | 2015-01-21 | Warner-Lambert Company LLC | Isobutylgaba and its derivatives for the treatment of pain |
| FR2772760B1 (fr) * | 1997-12-22 | 2000-02-04 | Synthelabo | Derives de 3-oxazol-5-yl-1-oxo-1,2-dihydroisoquinoleine-4- propanamide, leur preparation et leur application en therapeutique |
| US5919794A (en) * | 1998-05-11 | 1999-07-06 | Virginia Commonwealth University | Methods of using pharmaceutical tetrahydroisoquinolines |
| WO2000044725A1 (de) * | 1999-01-28 | 2000-08-03 | Boehringer Ingelheim Pharma Kg | Anellierte dihydropyridine und verwendung von anellierten dihydropyridinen für die herstellung von mitteln für die behandlung von epilepsie |
| FR2800072B1 (fr) * | 1999-10-22 | 2002-01-11 | Centre Nat Rech Scient | 1-(2-butyrolactones et 2-thiobutyrolactones)-isoquinolines n-substituees utiles comme stimulant de l'activite de l'acide gamma-aminobutyrique et dans le traitement des troubles nerveux et leur procede de preparation |
| DE10035997A1 (de) * | 2000-07-25 | 2002-02-07 | Boehringer Ingelheim Pharma | Verwendung von anellierten Dihydropyridinen zur Herstellung von Mitteln für die Behandlung von chronischen Schmerzen |
| US6476047B2 (en) | 2000-07-25 | 2002-11-05 | Boehringer Ingelheim Pharma Kg | Anellated dihydropyridines for the treatment of chronic pain |
| US6576792B2 (en) | 2001-05-04 | 2003-06-10 | Eastman Kodak Company | 2-halo-1-cycloalkenecarboxamides and their preparation |
| ES2324231T3 (es) * | 2004-12-17 | 2009-08-03 | F. Hoffmann-La Roche Ag | Derivados de tieno-piridina como intensificadores alostericos de gaba-b. |
| JP2008542328A (ja) | 2005-06-02 | 2008-11-27 | エフ．ホフマン−ラ ロシュ アーゲー | Ｇａｂａ−ｂエンハンサーとしての３−メタンスルホニルキノリン |
| US8008500B2 (en) * | 2007-06-08 | 2011-08-30 | General Electric Company | Intermediates useful for making tetrabenazine compounds |
| US8604242B2 (en) * | 2008-10-13 | 2013-12-10 | Interquim, S.A. | Process for the preparation of optically active (S)-(−)-2-(N-propylamino)-5-methoxytetraline and (S)-(−)-2-(N-propylamino)-5-hydroxytetraline compounds |
| CN107043371B (zh) * | 2017-06-09 | 2020-02-11 | 山东大学 | β2-AR激动和抗炎双功能生物碱及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA842831A (en) * | 1970-05-26 | Engel Wolfhard | Process for the production of 1-(2-pyridyl)-3,4-dihydro-isoquinolines | |
| GB642286A (en) * | 1948-06-28 | 1950-08-30 | Boots Pure Drug Co Ltd | Improvements in and relating to the manufacture of isoquinoline derivatives |
| GB1062899A (en) * | 1963-01-22 | 1967-03-22 | Trevor Edmund Thomas Weston | Improvements in and relating to therapeutic compositions |
| GB1145254A (en) * | 1965-03-18 | 1969-03-12 | Bristol Myers Co | Novel tetrahydroisoquinoline derivatives and a process for the preparation thereof |
| DE1620496A1 (de) * | 1965-03-24 | 1970-01-02 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen 1-Pyridyl-3,4-dihydroisochinolinen |
| DE1695886A1 (de) * | 1966-06-16 | 1971-05-06 | Thomae Gmbh Dr K | 1-(2-Pyridyl)-1,2,3,4-tetrahydroisochinoline und Verfahren zur Herstellung |
| DE1620549A1 (de) * | 1966-06-16 | 1970-08-20 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen Pyridyl-tetrahydroisochinolinen |
| AR204327A1 (es) * | 1973-07-20 | 1975-12-22 | Fujisawa Pharmaceutical Co | Procedimiento para la preparacion de derivados de 1,2,3,4-tetrahidroisoquinolina |
| GB1553230A (en) * | 1975-07-28 | 1979-09-26 | Fujisawa Pharmaceutical Co | 1 - aminomethyl - 6,7-dihydroxy - 1,2,3,4-tetrahydroisoquinolines and the preparation thereof |
| DE3308554A1 (de) * | 1983-03-10 | 1984-09-13 | Hoechst Ag, 6230 Frankfurt | 1-/1,3-dioxolan-2-ylmethyl)-azole, ihre salze, verfahren zu ihrer herstellung und ihre verwendung |
| BG38182A1 (en) * | 1983-06-21 | 1985-11-15 | Ivanova | Tocolytic means |
| HU191548B (en) * | 1984-04-11 | 1987-03-30 | Richter Gedeon Vegyeszet | Process for the production of 1-cyclohexyl-3,4-dihydro-iziquinoline-derivatives |
| US4755218A (en) * | 1985-12-31 | 1988-07-05 | Monsanto Company | Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes |
| CA1330560C (en) * | 1986-05-21 | 1994-07-05 | Maurits E. A. Vandewalle | Di- and tetrahydroisoquinoline derivatives |
| DE3621413A1 (de) * | 1986-06-26 | 1988-01-07 | Boehringer Ingelheim Kg | Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung |
| IL86131A0 (en) * | 1987-04-24 | 1988-11-15 | Boehringer Ingelheim Kg | Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them |
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| JP2772458B2 (ja) * | 1993-07-27 | 1998-07-02 | 裕典 久野 | 犬用糞受け器 |
-
1989
- 1989-09-20 GB GB898921304A patent/GB8921304D0/en active Pending
-
1990
- 1990-09-18 PT PT95338A patent/PT95338B/pt not_active IP Right Cessation
- 1990-09-18 KR KR1019900014728A patent/KR910005866A/ko not_active Ceased
- 1990-09-19 HU HU905967A patent/HUT59125A/hu unknown
- 1990-09-19 EP EP19900310277 patent/EP0419247A3/en not_active Withdrawn
- 1990-09-19 GB GB9020441A patent/GB2236674B/en not_active Expired - Fee Related
- 1990-09-19 CA CA002025719A patent/CA2025719A1/en not_active Abandoned
- 1990-09-19 IE IE339490A patent/IE65619B1/en not_active IP Right Cessation
- 1990-09-20 AU AU63044/90A patent/AU642428B2/en not_active Ceased
- 1990-09-20 JP JP2254024A patent/JPH03120218A/ja active Pending
-
1991
- 1991-10-21 US US07/780,372 patent/US5118690A/en not_active Expired - Lifetime
-
1993
- 1993-12-03 AU AU52120/93A patent/AU665639B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0419247A3 (en) | 1992-01-08 |
| AU5212093A (en) | 1994-02-10 |
| AU665639B2 (en) | 1996-01-11 |
| GB9020441D0 (en) | 1990-10-31 |
| JPH03120218A (ja) | 1991-05-22 |
| CA2025719A1 (en) | 1991-03-21 |
| GB2236674A (en) | 1991-04-17 |
| AU642428B2 (en) | 1993-10-21 |
| HU905967D0 (en) | 1991-03-28 |
| EP0419247A2 (en) | 1991-03-27 |
| GB8921304D0 (en) | 1989-11-08 |
| US5118690A (en) | 1992-06-02 |
| HUT59125A (en) | 1992-04-28 |
| KR910005866A (ko) | 1991-04-27 |
| PT95338B (pt) | 1998-07-31 |
| IE65619B1 (en) | 1995-11-01 |
| AU6304490A (en) | 1991-03-28 |
| GB2236674B (en) | 1994-05-04 |
| IE903394A1 (en) | 1991-04-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19910306 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19980408 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19991031 |