PT95620A - Processo para a preparacao de pro-drogas glicosil-etoposido e de composicoes farmaceuticas que as contem em combinacao com conjugados de enzima especificos para tumor funcionalizados - Google Patents

Processo para a preparacao de pro-drogas glicosil-etoposido e de composicoes farmaceuticas que as contem em combinacao com conjugados de enzima especificos para tumor funcionalizados

Info

Publication number: PT95620A
Authority: PT; Portugal
Prior art keywords: combination; enzyme conjugates; etoposid; pro; drugs
Prior art date: 1989-10-20

Application number

PT95620A

Other languages

English (en)

Other versions

PT95620B (pt

Inventor

Cenek Kolar

Joerg Czech

Klaus Bosslet

Gerhard Seemann

Hans Harald Sedlacek

Original Assignee

Behringwerke Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-20

Filing date

1990-10-18

Publication date

1991-09-13

1990-10-18 Application filed by Behringwerke Ag filed Critical Behringwerke Ag

1991-09-13 Publication of PT95620A publication Critical patent/PT95620A/pt

1997-08-29 Publication of PT95620B publication Critical patent/PT95620B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Nanotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medical Informatics (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Epidemiology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT95620A 1989-10-20 1990-10-18 Processo para a preparacao de pro-drogas glicosil-etoposido e de composicoes farmaceuticas que as contem em combinacao com conjugados de enzima especificos para tumor funcionalizados PT95620B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3935016A DE3935016A1 (de)	1989-10-20	1989-10-20	Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten

Publications (2)

Publication Number	Publication Date
PT95620A true PT95620A (pt)	1991-09-13
PT95620B PT95620B (pt)	1997-08-29

Family

ID=6391872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95620A PT95620B (pt)	1989-10-20	1990-10-18	Processo para a preparacao de pro-drogas glicosil-etoposido e de composicoes farmaceuticas que as contem em combinacao com conjugados de enzima especificos para tumor funcionalizados

Country Status (12)

Country	Link
EP (1)	EP0423747B1 (pt)
JP (1)	JP3293086B2 (pt)
KR (1)	KR910007948A (pt)
AT (1)	ATE168695T1 (pt)
AU (1)	AU638064B2 (pt)
CA (1)	CA2028086A1 (pt)
DE (2)	DE3935016A1 (pt)
DK (1)	DK0423747T3 (pt)
ES (1)	ES2119738T3 (pt)
GR (1)	GR3027569T3 (pt)
IE (1)	IE903764A1 (pt)
PT (1)	PT95620B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5851527A (en) *	1988-04-18	1998-12-22	Immunomedics, Inc.	Method for antibody targeting of therapeutic agents
US7241595B2 (en) *	1989-10-20	2007-07-10	Sanofi-Aventis Pharma Deutschland Gmbh	Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
EP0505357B1 (en) *	1989-12-11	1999-03-10	Immunomedics, Inc.	Method for antibody targeting of diagnostic or therapeutic agents
FR2676058B1 (fr) *	1991-04-30	1994-02-25	Hoechst Lab	Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
IT1250692B (it) *	1991-07-23	1995-04-21		Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
DE4236237A1 (de) *	1992-10-27	1994-04-28	Behringwerke Ag	Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
DE19702988A1 (de)	1997-01-28	1998-07-30	Hoechst Ag	Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
US6713454B1 (en)	1999-09-13	2004-03-30	Nobex Corporation	Prodrugs of etoposide and etoposide analogs
WO2001049693A1 (en) *	2000-01-03	2001-07-12	Korea Research Institute Of Chemical Technology	4-O-[2-(N,N-DIALKYLAMINO)-2-DEOXY-4,6-O,O-beta-D-GLUCOSYL]-4'-O-DEMETHYL-EPI-PODOPHYLLOTOXIN, DERIVATIVES, AND AN ANTICANCER COMPOSITION CONTAINING SAME
JP2005511550A (ja) *	2001-10-26	2005-04-28	サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィク	エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物
ES2354065T3 (es)	2001-12-03	2011-03-09	Universitätsklinikum Charité Der Humboldt- Universität Zu Berlin	Podofilotoxinas en calidad de agentes antiproliferativos.
WO2021188457A1 (en) *	2020-03-16	2021-09-23	Doublerainbow Biosciences Inc.	Etoposide glycosides, methods of making, and uses thereof as an anti-cancer drug
JPWO2025047983A1 (pt) *	2023-08-31	2025-03-06

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3329184A1 (de) *	1983-08-12	1985-02-21	Behringwerke Ag, 3550 Marburg	Monoklonale antikoerper mit spezifitaet fuer membran-assoziierte antigene
GB8705477D0 (en) *	1987-03-09	1987-04-15	Carlton Med Prod	Drug delivery systems
NZ225599A (en) *	1987-08-04	1991-09-25	Bristol Myers Co	Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
DE4002888A1 (de) *	1990-02-01	1991-08-08	Behringwerke Ag	Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten

1989
- 1989-10-20 DE DE3935016A patent/DE3935016A1/de not_active Withdrawn
1990
- 1990-10-17 EP EP90119886A patent/EP0423747B1/de not_active Expired - Lifetime
- 1990-10-17 DK DK90119886T patent/DK0423747T3/da active
- 1990-10-17 ES ES90119886T patent/ES2119738T3/es not_active Expired - Lifetime
- 1990-10-17 DE DE59010838T patent/DE59010838D1/de not_active Expired - Lifetime
- 1990-10-17 AT AT90119886T patent/ATE168695T1/de not_active IP Right Cessation
- 1990-10-18 PT PT95620A patent/PT95620B/pt not_active IP Right Cessation
- 1990-10-19 CA CA002028086A patent/CA2028086A1/en not_active Abandoned
- 1990-10-19 JP JP27953590A patent/JP3293086B2/ja not_active Expired - Lifetime
- 1990-10-19 AU AU64778/90A patent/AU638064B2/en not_active Ceased
- 1990-10-19 IE IE376490A patent/IE903764A1/en not_active IP Right Cessation
- 1990-10-20 KR KR1019900016761A patent/KR910007948A/ko not_active Ceased
1998
- 1998-08-04 GR GR980401753T patent/GR3027569T3/el unknown

Also Published As

Publication number	Publication date
JPH03135993A (ja)	1991-06-10
IE903764A1 (en)	1991-04-24
AU638064B2 (en)	1993-06-17
DE3935016A1 (de)	1991-04-25
CA2028086A1 (en)	1991-04-21
DE59010838D1 (de)	1998-08-27
EP0423747B1 (de)	1998-07-22
ES2119738T3 (es)	1998-10-16
DK0423747T3 (da)	1999-04-26
EP0423747A3 (en)	1991-09-11
AU6477890A (en)	1991-04-26
ATE168695T1 (de)	1998-08-15
PT95620B (pt)	1997-08-29
GR3027569T3 (en)	1998-11-30
EP0423747A2 (de)	1991-04-24
JP3293086B2 (ja)	2002-06-17
KR910007948A (ko)	1991-05-30

Legal Events

Date

Code

Title

Description

1991-09-13

BB1A

Laying open of patent application

Effective date: 19910401

2012-06-15

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: MAXIMUM VALIDITY LIMIT REACHED

Effective date: 20120605

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EP0513000A4 (en)	1992-09-01	QUALITY IMPROVEMENT OF MR IMAGES OF BONES AND SIMILAR TISSUE BY MEANS OF PARAMAGNETIC CATION COMPLEXES AND POLYPHOSPHONATE LIGANDS.
NO901655D0 (no)	1990-04-11	Fremgangsmaate ved fremstilling av metyltritioanti-tumorforbindelser.
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