PT95973A - Processo de preparacao de compostos da imidazoquinoxalina e de composicoes farmaceuticas - Google Patents

Processo de preparacao de compostos da imidazoquinoxalina e de composicoes farmaceuticas

Info

Publication number: PT95973A
Authority: PT; Portugal
Prior art keywords: imidazoquinoxaline; branched; alkyl; hydrogen; straight
Prior art date: 1989-11-22

Application number

PT95973A

Other languages

English (en)

Other versions

PT95973B (pt

Inventor

Holger Claus Hansen

Frank Waetjen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-22

Filing date

1990-11-22

Publication date

1991-09-13

1990-11-22 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1991-09-13 Publication of PT95973A publication Critical patent/PT95973A/pt

1998-01-30 Publication of PT95973B publication Critical patent/PT95973B/pt

Links

YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical compound N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000006196 aroyl alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000003920 cognitive function Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PT95973A 1989-11-22 1990-11-22 Processo de preparacao de compostos da imidazoquinoxalina e de composicoes farmaceuticas PT95973B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK588489A DK588489D0 (da)	1989-11-22	1989-11-22	Heterocykliske forbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number	Publication Date
PT95973A true PT95973A (pt)	1991-09-13
PT95973B PT95973B (pt)	1998-01-30

Family

ID=8145919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95973A PT95973B (pt)	1989-11-22	1990-11-22	Processo de preparacao de compostos da imidazoquinoxalina e de composicoes farmaceuticas

Country Status (20)

Country	Link
US (1)	US5116841A (pt)
EP (1)	EP0502038B1 (pt)
JP (1)	JPH05503082A (pt)
KR (1)	KR920703594A (pt)
AT (1)	ATE148703T1 (pt)
AU (1)	AU645276B2 (pt)
CA (1)	CA2073041A1 (pt)
DE (1)	DE69029910T2 (pt)
DK (2)	DK588489D0 (pt)
ES (1)	ES2098276T3 (pt)
FI (1)	FI97227C (pt)
GR (1)	GR3023124T3 (pt)
HU (1)	HUT63421A (pt)
IE (1)	IE904156A1 (pt)
IL (1)	IL96373A (pt)
NO (1)	NO180634C (pt)
NZ (1)	NZ236157A (pt)
PT (1)	PT95973B (pt)
WO (1)	WO1991007407A1 (pt)
ZA (1)	ZA909303B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
US5683998A (en) *	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
AU3443493A (en) *	1992-02-19	1993-09-13	Upjohn Company, The	3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity
US5792766A (en) *	1996-03-13	1998-08-11	Neurogen Corporation	Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
SE9902268D0 (sv) *	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
US20040180898A1 (en) *	2003-03-03	2004-09-16	Bang-Chi Chen	Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines
EP3377493B1 (en)	2015-11-20	2020-04-08	Forma Therapeutics, Inc.	Purinones as ubiquitin-specific protease 1 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK155524C (da) *	1987-03-18	1989-09-11	Ferrosan As	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) *	1990-03-09	1994-06-03	Adir	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

1989
- 1989-11-22 DK DK588489A patent/DK588489D0/da not_active Application Discontinuation
1990
- 1990-11-16 IL IL9637390A patent/IL96373A/en not_active IP Right Cessation
- 1990-11-19 IE IE415690A patent/IE904156A1/en unknown
- 1990-11-20 NZ NZ236157A patent/NZ236157A/xx unknown
- 1990-11-20 US US07/615,707 patent/US5116841A/en not_active Expired - Fee Related
- 1990-11-20 ZA ZA909303A patent/ZA909303B/xx unknown
- 1990-11-22 JP JP3500072A patent/JPH05503082A/ja active Pending
- 1990-11-22 KR KR1019920701200A patent/KR920703594A/ko not_active Ceased
- 1990-11-22 DE DE69029910T patent/DE69029910T2/de not_active Expired - Fee Related
- 1990-11-22 EP EP90917268A patent/EP0502038B1/en not_active Expired - Lifetime
- 1990-11-22 DK DK90917268.6T patent/DK0502038T3/da active
- 1990-11-22 ES ES90917268T patent/ES2098276T3/es not_active Expired - Lifetime
- 1990-11-22 AU AU67535/90A patent/AU645276B2/en not_active Ceased
- 1990-11-22 AT AT90917268T patent/ATE148703T1/de not_active IP Right Cessation
- 1990-11-22 HU HU9201710A patent/HUT63421A/hu unknown
- 1990-11-22 WO PCT/DK1990/000301 patent/WO1991007407A1/en not_active Ceased
- 1990-11-22 PT PT95973A patent/PT95973B/pt not_active IP Right Cessation
- 1990-11-22 CA CA002073041A patent/CA2073041A1/en not_active Abandoned
1992
- 1992-05-13 NO NO921887A patent/NO180634C/no unknown
- 1992-05-19 FI FI922267A patent/FI97227C/fi not_active IP Right Cessation
1997
- 1997-04-14 GR GR970400785T patent/GR3023124T3/el unknown

Also Published As

Publication number	Publication date
EP0502038A1 (en)	1992-09-09
FI922267A0 (fi)	1992-05-19
HUT63421A (en)	1993-08-30
ES2098276T3 (es)	1997-05-01
KR920703594A (ko)	1992-12-18
US5116841A (en)	1992-05-26
EP0502038B1 (en)	1997-02-05
DE69029910T2 (de)	1997-07-10
FI922267L (fi)	1992-05-19
FI97227B (fi)	1996-07-31
WO1991007407A1 (en)	1991-05-30
AU6753590A (en)	1991-06-13
PT95973B (pt)	1998-01-30
ZA909303B (en)	1991-09-25
HU9201710D0 (en)	1992-09-28
ATE148703T1 (de)	1997-02-15
DE69029910D1 (de)	1997-03-20
FI97227C (fi)	1996-11-11
IE904156A1 (en)	1991-05-22
DK588489D0 (da)	1989-11-22
NO921887D0 (no)	1992-05-13
NO180634B (no)	1997-02-10
NO921887L (no)	1992-05-13
DK0502038T3 (da)	1997-08-11
NZ236157A (en)	1992-08-26
GR3023124T3 (en)	1997-07-30
IL96373A (en)	1994-10-21
JPH05503082A (ja)	1993-05-27
IL96373A0 (en)	1991-08-16
CA2073041A1 (en)	1991-05-23
AU645276B2 (en)	1994-01-13
NO180634C (no)	1997-05-21

Legal Events

Date

Code

Title

Description

1991-09-13

BB1A

Laying open of patent application

Effective date: 19910408

1998-01-30

FG3A

Patent granted, date of granting

Effective date: 19971017

1999-08-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19990430

Publication	Publication Date	Title
NO903460D0 (no)	1990-08-07	Fremgangsmaate for fremstilling av diarylacetylen.
ZA909568B (en)	1991-09-25	Stabilized solutions of psychotropic agents
DK322088A (da)	1990-03-27	Imidazoquicxalinforbindelser, deres fremstilling og anvendelse
PT83573B (pt)	1988-10-14	Processo de preparacao de compostos heterociclicos de quinazolina e de seus intermediarios e de composicoes farmaceuticas
IL96373A0 (en)	1991-08-16	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
IL96372A0 (en)	1991-08-16	Imidazoquinoxaline compounds,their preparation and pharmaceutical compositions containing them
PT98063A (pt)	1992-03-31	Processo de preparacao de compostos de 4-amino-imidazo-quinoxalina e de 5-amino-imidazo-quinazolina e de composicoes farmaceuticas
DE58906269D1 (de)	1994-01-13	Antipsychotisch wirksames Imidazobenzodiazepin.
PT89742A (pt)	1989-10-04	Processo de preparacao de 24r-cimnol e de suas composicoes farmaceuticas
SE8304111L (sv)	1984-02-06	Aminoderivat av bensyliden-pyrrolo(2,1-b)kinazoliner och bensyliden-pyrido(2,1-b)kinazoliner
DK555688A (da)	1989-04-07	Heterocykliske forbindelser, deres fremstilling og anvendelse