ATE148703T1 - Imidazoquinoxalinverbindungen, deren herstellung und verwendung - Google Patents

Imidazoquinoxalinverbindungen, deren herstellung und verwendung

Info

Publication number: ATE148703T1
Authority: AT; Austria
Prior art keywords: branched; alkyl; hydrogen; straight; compounds
Prior art date: 1989-11-22

Application number

AT90917268T

Other languages

English (en)

Inventor

Frank Waetjen

Holger Claus Hansen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-22

Filing date

1990-11-22

Publication date

1997-02-15

1990-11-22 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-02-15 Application granted granted Critical

1997-02-15 Publication of ATE148703T1 publication Critical patent/ATE148703T1/de

Links

YELMWJNXDALKFE-UHFFFAOYSA-N 3h-imidazo[4,5-f]quinoxaline Chemical class N1=CC=NC2=C(NC=N3)C3=CC=C21 YELMWJNXDALKFE-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229940125681 anticonvulsant agent Drugs 0.000 abstract 1
239000001961 anticonvulsive agent Substances 0.000 abstract 1
239000002249 anxiolytic agent Substances 0.000 abstract 1
230000000949 anxiolytic effect Effects 0.000 abstract 1
229940005530 anxiolytics Drugs 0.000 abstract 1
125000006196 aroyl alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
230000003920 cognitive function Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003326 hypnotic agent Substances 0.000 abstract 1
230000000147 hypnotic effect Effects 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT90917268T 1989-11-22 1990-11-22 Imidazoquinoxalinverbindungen, deren herstellung und verwendung ATE148703T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK588489A DK588489D0 (da)	1989-11-22	1989-11-22	Heterocykliske forbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number	Publication Date
ATE148703T1 true ATE148703T1 (de)	1997-02-15

Family

ID=8145919

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90917268T ATE148703T1 (de)	1989-11-22	1990-11-22	Imidazoquinoxalinverbindungen, deren herstellung und verwendung

Country Status (20)

Country	Link
US (1)	US5116841A (de)
EP (1)	EP0502038B1 (de)
JP (1)	JPH05503082A (de)
KR (1)	KR920703594A (de)
AT (1)	ATE148703T1 (de)
AU (1)	AU645276B2 (de)
CA (1)	CA2073041A1 (de)
DE (1)	DE69029910T2 (de)
DK (2)	DK588489D0 (de)
ES (1)	ES2098276T3 (de)
FI (1)	FI97227C (de)
GR (1)	GR3023124T3 (de)
HU (1)	HUT63421A (de)
IE (1)	IE904156A1 (de)
IL (1)	IL96373A (de)
NO (1)	NO180634C (de)
NZ (1)	NZ236157A (de)
PT (1)	PT95973B (de)
WO (1)	WO1991007407A1 (de)
ZA (1)	ZA909303B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK151890D0 (da) *	1990-06-22	1990-06-22	Ferrosan As	Heterocykliske forbindelser deres fremstilling og brug
US5683998A (en) *	1991-04-23	1997-11-04	Toray Industries, Inc.	Tricyclic triazolo derivatives, processes for producing the same and the uses of the same
WO1993017025A1 (en) *	1992-02-19	1993-09-02	The Upjohn Company	3-substituted imidazo(1,5-a)quinoxalines and quinazolines with cns activity
US5792766A (en) *	1996-03-13	1998-08-11	Neurogen Corporation	Imidazo 1,5-c! quinazolines; a new class of GABA brain receptor ligands
SE9902268D0 (sv) *	1999-06-16	1999-06-16	Astra Ab	Pharmaceutically active compounds
US20040180898A1 (en) *	2003-03-03	2004-09-16	Bang-Chi Chen	Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines
RU2750151C2 (ru)	2015-11-20	2021-06-22	Форма Терапьютикс, Инк.	Гипоксантины в качестве ингибиторов убиквитин-специфической протеазы 1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DK155524C (da) *	1987-03-18	1989-09-11	Ferrosan As	Kondenserede imidazolderivater og farmaceutiske praeparater indeholdende disse
DK160876C (da) *	1987-12-08	1991-10-14	Novo Nordisk As	Imidazoquinoxalinforbindelser, fremgangsmaade til deres fremstilling, anvendelse af forbindelserne og farmaceutiske praeparater, hvori forbindelserne indgaar
DK626288D0 (da) *	1988-11-10	1988-11-10	Ferrosan As	Kemisk proces til fremstilling af imidazoquinoxaliner og mellemprodukter til brug i processen
DK588389D0 (da) *	1989-11-22	1989-11-22	Ferrosan As	Heterocykliske forbindelser, deres fremstilling og anvendelse
FR2659329B1 (fr) *	1990-03-09	1994-06-03	Adir	Nouveaux derives d'imidazo [1,2-c] quinazoline, leur procede de preparation et les compositions pharmaceutiques les renfermant.

1989
- 1989-11-22 DK DK588489A patent/DK588489D0/da not_active Application Discontinuation
1990
- 1990-11-16 IL IL9637390A patent/IL96373A/en not_active IP Right Cessation
- 1990-11-19 IE IE415690A patent/IE904156A1/en unknown
- 1990-11-20 ZA ZA909303A patent/ZA909303B/xx unknown
- 1990-11-20 US US07/615,707 patent/US5116841A/en not_active Expired - Fee Related
- 1990-11-20 NZ NZ236157A patent/NZ236157A/xx unknown
- 1990-11-22 KR KR1019920701200A patent/KR920703594A/ko not_active Ceased
- 1990-11-22 EP EP90917268A patent/EP0502038B1/de not_active Expired - Lifetime
- 1990-11-22 HU HU9201710A patent/HUT63421A/hu unknown
- 1990-11-22 JP JP3500072A patent/JPH05503082A/ja active Pending
- 1990-11-22 PT PT95973A patent/PT95973B/pt not_active IP Right Cessation
- 1990-11-22 ES ES90917268T patent/ES2098276T3/es not_active Expired - Lifetime
- 1990-11-22 AU AU67535/90A patent/AU645276B2/en not_active Ceased
- 1990-11-22 AT AT90917268T patent/ATE148703T1/de not_active IP Right Cessation
- 1990-11-22 CA CA002073041A patent/CA2073041A1/en not_active Abandoned
- 1990-11-22 WO PCT/DK1990/000301 patent/WO1991007407A1/en not_active Ceased
- 1990-11-22 DE DE69029910T patent/DE69029910T2/de not_active Expired - Fee Related
- 1990-11-22 DK DK90917268.6T patent/DK0502038T3/da active
1992
- 1992-05-13 NO NO921887A patent/NO180634C/no unknown
- 1992-05-19 FI FI922267A patent/FI97227C/fi not_active IP Right Cessation
1997
- 1997-04-14 GR GR970400785T patent/GR3023124T3/el unknown

Also Published As

Publication number	Publication date
NZ236157A (en)	1992-08-26
NO921887D0 (no)	1992-05-13
ZA909303B (en)	1991-09-25
IL96373A (en)	1994-10-21
AU6753590A (en)	1991-06-13
NO921887L (no)	1992-05-13
FI97227B (fi)	1996-07-31
EP0502038A1 (de)	1992-09-09
NO180634B (no)	1997-02-10
IE904156A1 (en)	1991-05-22
AU645276B2 (en)	1994-01-13
NO180634C (no)	1997-05-21
FI97227C (fi)	1996-11-11
DE69029910T2 (de)	1997-07-10
DK588489D0 (da)	1989-11-22
HU9201710D0 (en)	1992-09-28
KR920703594A (ko)	1992-12-18
JPH05503082A (ja)	1993-05-27
US5116841A (en)	1992-05-26
GR3023124T3 (en)	1997-07-30
HUT63421A (en)	1993-08-30
DK0502038T3 (da)	1997-08-11
IL96373A0 (en)	1991-08-16
PT95973B (pt)	1998-01-30
FI922267L (fi)	1992-05-19
FI922267A0 (fi)	1992-05-19
EP0502038B1 (de)	1997-02-05
ES2098276T3 (es)	1997-05-01
WO1991007407A1 (en)	1991-05-30
DE69029910D1 (de)	1997-03-20
CA2073041A1 (en)	1991-05-23
PT95973A (pt)	1991-09-13

Legal Events

Date	Code	Title	Description
1997-06-15	UEP	Publication of translation of european patent specification
1999-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE68918003D1 (de)	1994-10-13	Imidazochinoxalinverbindungen und ihre Herstellung und Verwendung.
DE3850861D1 (de)	1994-09-01	Imidazochinoxalinverbindungen und ihre Herstellung und Verwendung.
PT83573B (pt)	1988-10-14	Processo de preparacao de compostos heterociclicos de quinazolina e de seus intermediarios e de composicoes farmaceuticas
ATE148703T1 (de)	1997-02-15	Imidazoquinoxalinverbindungen, deren herstellung und verwendung
ATE106405T1 (de)	1994-06-15	Imidazoquinoxalinverbindungen, deren herstellung und verwendung.
ES553826A0 (es)	1987-03-16	Procedimiento para preparar derivados de difluorociclopropano
DK0535104T3 (da)	1997-01-13	Heterocyliske forbindelser deres fremstilling og anvendelse
ATE97811T1 (de)	1993-12-15	Antipsychotisch wirksames imidazobenzodiazepin.
ATE17945T1 (de)	1986-02-15	7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepin , ihre herstellung und verwendung.
DK555688A (da)	1989-04-07	Heterocykliske forbindelser, deres fremstilling og anvendelse