PT96068A - Processo para a producao de proteina biologicamente activa - Google Patents

Processo para a producao de proteina biologicamente activa

Info

Publication number: PT96068A
Authority: PT; Portugal
Prior art keywords: production; biologically active; active proteins; beta; tgf
Prior art date: 1989-12-06

Application number

PT96068A

Other languages

English (en)

Other versions

PT96068B (pt

Inventor

Nico Cerletti

Albert Schmitz

Gary Kent Mcmaster

David Cox

Bernd Meyhack

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-06

Filing date

1990-12-04

Publication date

1991-09-30

1990-12-04 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1991-09-30 Publication of PT96068A publication Critical patent/PT96068A/pt

1998-02-27 Publication of PT96068B publication Critical patent/PT96068B/pt

Links

102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Crystallography & Structural Chemistry (AREA)
Epidemiology (AREA)
Transplantation (AREA)
Physics & Mathematics (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Rheumatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

PT96068A 1989-12-06 1990-12-04 Processo para a producao de proteina biologicamente activa PT96068B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898927546A GB8927546D0 (en)	1989-12-06	1989-12-06	Process for the production of biologically active tgf-beta

Publications (2)

Publication Number	Publication Date
PT96068A true PT96068A (pt)	1991-09-30
PT96068B PT96068B (pt)	1998-02-27

Family

ID=10667491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96068A PT96068B (pt)	1989-12-06	1990-12-04	Processo para a producao de proteina biologicamente activa

Country Status (23)

Country	Link
US (2)	US5650494A (pt)
EP (2)	EP0891985A1 (pt)
JP (1)	JP3048061B2 (pt)
KR (1)	KR100203230B1 (pt)
AT (1)	ATE178616T1 (pt)
AU (1)	AU638075B2 (pt)
CA (1)	CA2031430C (pt)
DE (1)	DE69033040T2 (pt)
DK (1)	DK0433225T3 (pt)
ES (1)	ES2132066T3 (pt)
FI (1)	FI103278B1 (pt)
GB (1)	GB8927546D0 (pt)
GR (1)	GR3030703T3 (pt)
HU (1)	HU218144B (pt)
IE (2)	IE990992A1 (pt)
IL (1)	IL96549A (pt)
MX (1)	MX172600B (pt)
NO (1)	NO301768B1 (pt)
NZ (1)	NZ236333A (pt)
PH (1)	PH31649A (pt)
PT (1)	PT96068B (pt)
SG (1)	SG52690A1 (pt)
ZA (1)	ZA909762B (pt)

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1989
- 1989-12-06 GB GB898927546A patent/GB8927546D0/en active Pending
1990
- 1990-11-27 AU AU67018/90A patent/AU638075B2/en not_active Expired
- 1990-11-27 AT AT90810922T patent/ATE178616T1/de not_active IP Right Cessation
- 1990-11-27 DE DE69033040T patent/DE69033040T2/de not_active Expired - Lifetime
- 1990-11-27 SG SG1996007909A patent/SG52690A1/en unknown
- 1990-11-27 DK DK90810922T patent/DK0433225T3/da active
- 1990-11-27 EP EP98113487A patent/EP0891985A1/en not_active Withdrawn
- 1990-11-27 EP EP90810922A patent/EP0433225B1/en not_active Expired - Lifetime
- 1990-11-27 ES ES90810922T patent/ES2132066T3/es not_active Expired - Lifetime
- 1990-11-30 JP JP2330871A patent/JP3048061B2/ja not_active Expired - Lifetime
- 1990-12-03 FI FI905956A patent/FI103278B1/fi active IP Right Grant
- 1990-12-04 MX MX023579A patent/MX172600B/es unknown
- 1990-12-04 CA CA002031430A patent/CA2031430C/en not_active Expired - Lifetime
- 1990-12-04 NZ NZ236333A patent/NZ236333A/en unknown
- 1990-12-04 PT PT96068A patent/PT96068B/pt not_active IP Right Cessation
- 1990-12-05 IL IL9654990A patent/IL96549A/xx not_active IP Right Cessation
- 1990-12-05 NO NO905264A patent/NO301768B1/no not_active IP Right Cessation
- 1990-12-05 HU HU084/90A patent/HU218144B/hu unknown
- 1990-12-05 IE IE19990992A patent/IE990992A1/en not_active IP Right Cessation
- 1990-12-05 KR KR1019900019881A patent/KR100203230B1/ko not_active Expired - Lifetime
- 1990-12-05 IE IE438690A patent/IE904386A1/en not_active IP Right Cessation
- 1990-12-05 ZA ZA909762A patent/ZA909762B/xx unknown
1994
- 1994-03-25 PH PH8001A patent/PH31649A/en unknown
1995
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1997
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1999
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Also Published As

Publication number	Publication date
AU6701890A (en)	1991-06-13
IL96549A (en)	2000-10-31
US5650494A (en)	1997-07-22
FI905956L (fi)	1991-06-07
ZA909762B (en)	1991-08-28
HU218144B (hu)	2000-06-28
ES2132066T3 (es)	1999-08-16
AU638075B2 (en)	1993-06-17
CA2031430A1 (en)	1991-06-07
NO905264L (no)	1991-06-07
FI905956A0 (fi)	1990-12-03
US5922846A (en)	1999-07-13
EP0433225A1 (en)	1991-06-19
JPH03191791A (ja)	1991-08-21
KR100203230B1 (ko)	1999-06-15
EP0433225B1 (en)	1999-04-07
HUT56880A (en)	1991-10-28
FI103278B (fi)	1999-05-31
FI103278B1 (fi)	1999-05-31
IL96549A0 (en)	1991-09-16
ATE178616T1 (de)	1999-04-15
CA2031430C (en)	2003-05-27
IE990992A1 (en)	2000-12-13
NO301768B1 (no)	1997-12-08
PT96068B (pt)	1998-02-27
KR910012240A (ko)	1991-08-07
EP0891985A1 (en)	1999-01-20
NZ236333A (en)	1992-03-26
HU908084D0 (en)	1991-06-28
JP3048061B2 (ja)	2000-06-05
DK0433225T3 (da)	1999-10-25
DE69033040T2 (de)	1999-09-09
DE69033040D1 (de)	1999-05-12
GR3030703T3 (en)	1999-11-30
GB8927546D0 (en)	1990-02-07
MX172600B (es)	1994-01-03
PH31649A (en)	1999-01-12
SG52690A1 (en)	1998-09-28
IE904386A1 (en)	1991-06-19
NO905264D0 (no)	1990-12-05

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1991-09-30	BB1A	Laying open of patent application	Effective date: 19910412
1998-02-27	FG3A	Patent granted, date of granting	Effective date: 19971118
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2012-11-27	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20121119

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