ATE156491T1 - Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen - Google Patents

Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen

Info

Publication number
ATE156491T1
ATE156491T1 AT88903676T AT88903676T ATE156491T1 AT E156491 T1 ATE156491 T1 AT E156491T1 AT 88903676 T AT88903676 T AT 88903676T AT 88903676 T AT88903676 T AT 88903676T AT E156491 T1 ATE156491 T1 AT E156491T1
Authority
AT
Austria
Prior art keywords
oxidized
microorganisms
guanidine hydrochloride
renatured
recombinant
Prior art date
Application number
AT88903676T
Other languages
English (en)
Inventor
Sidney N Wolfe
Glenn Dorin
John T Davis
Flint Smith
Amy Lim
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE156491T1 publication Critical patent/ATE156491T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT88903676T 1987-05-11 1988-03-31 Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen ATE156491T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4840887A 1987-05-11 1987-05-11
US16714488A 1988-03-25 1988-03-25

Publications (1)

Publication Number Publication Date
ATE156491T1 true ATE156491T1 (de) 1997-08-15

Family

ID=26726091

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88903676T ATE156491T1 (de) 1987-05-11 1988-03-31 Prozess zur gewinnung von gereinigtem, oxidiertem, renaturiertem, rekombinantem interleukin-2 aus mikroorganismen

Country Status (9)

Country Link
EP (1) EP0368857B1 (de)
JP (1) JP2955294B2 (de)
AT (1) ATE156491T1 (de)
AU (1) AU622860B2 (de)
DE (1) DE3855986T2 (de)
DK (1) DK10189A (de)
IL (1) IL86326A (de)
NO (1) NO176797C (de)
WO (1) WO1988008849A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339757C (en) * 1987-04-16 1998-03-17 Robert F. Halenbeck Production of purified biologically active, bacterially produced recombinant human csf-1
US4929700A (en) * 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
EP0337243A1 (de) * 1988-04-14 1989-10-18 F. Hoffmann-La Roche Ag Verfahren zur Reinigung von rekombinantem Interleukin-2
DK580789D0 (da) * 1989-11-20 1989-11-20 Novo Nordisk As Fremgangsmaade til oprensning af polypeptider
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5258496A (en) * 1990-07-10 1993-11-02 Scios Nova Inc. Isolation and purification of lung surfactant protein
CA2077906A1 (en) * 1991-01-10 1992-07-11 Kimihiko Matsuzawa Method for measurement of tissue factor in high sensitivity and measurement kit therefor
US5288931A (en) * 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
AU685835B2 (en) * 1993-08-04 1998-01-29 Novartis Ag High molecular weight desulphatohirudin
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
TW517059B (en) 1994-07-25 2003-01-11 Ciba Geigy Ag New process for the production of biologically active protein
AU707719B2 (en) * 1995-07-21 1999-07-15 Amgen, Inc. Process for protein refolding by means of buffer exchange using a continuous stationary phase capable of separating proteins from salt
AU2003223936A1 (en) * 2002-05-17 2003-12-02 Kobenhavns Universitet Method for purifying denatured proteins having a desired disulfide bond configuration

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
US4569790A (en) * 1984-03-28 1986-02-11 Cetus Corporation Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US4572798A (en) * 1984-12-06 1986-02-25 Cetus Corporation Method for promoting disulfide bond formation in recombinant proteins
JPH0640832B2 (ja) * 1985-05-10 1994-06-01 味の素株式会社 インタ−ロイキン２ポリペプチドの回収方法
US4748234A (en) * 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery
US4801686A (en) * 1986-09-04 1989-01-31 Immunex Corporation Purification of recombinant interleukin-1
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2

Also Published As

Publication number Publication date
IL86326A0 (en) 1988-11-15
DE3855986D1 (de) 1997-09-11
AU622860B2 (en) 1992-04-30
NO885678L (no) 1988-12-21
DK10189D0 (da) 1989-01-11
NO176797C (no) 1995-05-31
AU1627988A (en) 1988-12-06
NO176797B (no) 1995-02-20
JP2955294B2 (ja) 1999-10-04
EP0368857A1 (de) 1990-05-23
WO1988008849A1 (en) 1988-11-17
NO885678D0 (no) 1988-12-21
DK10189A (da) 1989-01-11
EP0368857B1 (de) 1997-08-06
JPH02503384A (ja) 1990-10-18
IL86326A (en) 1997-02-18
DE3855986T2 (de) 1998-02-05

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time