PT96258A - Processo para a preparacao de esteroides com pontes 2,19-metileno-oxi e 2,19-metileno-tio como inibidores da aromatase e 19-hidroxilase - Google Patents

Processo para a preparacao de esteroides com pontes 2,19-metileno-oxi e 2,19-metileno-tio como inibidores da aromatase e 19-hidroxilase

Info

Publication number
PT96258A
PT96258A PT96258A PT9625890A PT96258A PT 96258 A PT96258 A PT 96258A PT 96258 A PT96258 A PT 96258A PT 9625890 A PT9625890 A PT 9625890A PT 96258 A PT96258 A PT 96258A
Authority
PT
Portugal
Prior art keywords
methylene
sodiums
aromatase
hydroxylase
oxy
Prior art date
Application number
PT96258A
Other languages
English (en)
Other versions
PT96258B (pt
Inventor
Norton Paul Peet
John O'neal Johnston
Joseph Paul Burkhart
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of PT96258A publication Critical patent/PT96258A/pt
Publication of PT96258B publication Critical patent/PT96258B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0073—Sulfur-containing hetero ring
    • C07J71/0078—Sulfur-containing hetero ring containing only sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT96258A 1989-12-20 1990-12-19 Processo para a preparacao de esteroides com pontes 2,19-metileno-oxi e 2,19-metileno-tio como inibidores da aromatase e 19-hidroxilase PT96258B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45344189A 1989-12-20 1989-12-20

Publications (2)

Publication Number Publication Date
PT96258A true PT96258A (pt) 1991-09-30
PT96258B PT96258B (pt) 1998-09-30

Family

ID=23800602

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96258A PT96258B (pt) 1989-12-20 1990-12-19 Processo para a preparacao de esteroides com pontes 2,19-metileno-oxi e 2,19-metileno-tio como inibidores da aromatase e 19-hidroxilase

Country Status (20)

Country Link
EP (1) EP0434020B1 (pt)
JP (1) JP2922653B2 (pt)
KR (1) KR100187781B1 (pt)
CN (1) CN1035768C (pt)
AR (1) AR248410A1 (pt)
AT (1) ATE124417T1 (pt)
AU (1) AU630008B2 (pt)
CA (1) CA2032311C (pt)
DE (1) DE69020520T2 (pt)
DK (1) DK0434020T3 (pt)
ES (1) ES2076286T3 (pt)
FI (1) FI107925B (pt)
GR (1) GR3017136T3 (pt)
HU (1) HU208024B (pt)
IE (1) IE67557B1 (pt)
IL (1) IL96695A (pt)
NO (1) NO177676C (pt)
NZ (1) NZ236473A (pt)
PT (1) PT96258B (pt)
ZA (1) ZA9010082B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5491136A (en) * 1989-12-20 1996-02-13 Merrell Dow Pharmaceuticals Inc. 2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase, 19-hydroxylaser inhibitors and methods of their use in the treatment of estrogen mediated disorders
US5126488A (en) * 1990-11-30 1992-06-30 Merrell Dow Pharmaceuticals Inc. 2β,19-methyleneamino bridged steroids as aromatase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627756A (en) * 1970-04-23 1971-12-14 Searle & Co N-dialkylaminoalkyl-n-(2{62 ,19-epoxy-5{60 -androstan-17{62 -yl)amines/formamides and 3{60 -halo derivatives thereof
US3954980A (en) * 1971-10-19 1976-05-04 Derek Harold Richard Barton Chemical compounds
US4814324A (en) * 1987-03-06 1989-03-21 Merck & Co., Inc. Sterol inhibitors of testosterone 5α-reductase

Also Published As

Publication number Publication date
JP2922653B2 (ja) 1999-07-26
NO905494L (no) 1991-06-21
FI906269A0 (fi) 1990-12-19
CN1035768C (zh) 1997-09-03
NO177676C (no) 1995-11-01
KR100187781B1 (ko) 1999-06-01
HU208024B (en) 1993-07-28
HU908299D0 (en) 1991-06-28
ZA9010082B (en) 1991-10-30
AR248410A1 (es) 1995-08-18
NZ236473A (en) 1993-04-28
DE69020520T2 (de) 1995-11-30
IE67557B1 (en) 1996-04-17
CA2032311A1 (en) 1991-06-21
CN1052678A (zh) 1991-07-03
EP0434020B1 (en) 1995-06-28
AU6808390A (en) 1991-10-17
DE69020520D1 (de) 1995-08-03
FI107925B (fi) 2001-10-31
CA2032311C (en) 2002-08-27
KR910011888A (ko) 1991-08-07
EP0434020A1 (en) 1991-06-26
GR3017136T3 (en) 1995-11-30
AU630008B2 (en) 1992-10-15
FI906269L (fi) 1991-06-21
JPH04128297A (ja) 1992-04-28
IE904597A1 (en) 1991-07-03
DK0434020T3 (da) 1995-08-28
PT96258B (pt) 1998-09-30
IL96695A (en) 1996-08-04
IL96695A0 (en) 1991-09-16
HUT56380A (en) 1991-08-28
NO177676B (no) 1995-07-24
ES2076286T3 (es) 1995-11-01
NO905494D0 (no) 1990-12-19
ATE124417T1 (de) 1995-07-15

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Effective date: 19910509

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Effective date: 20011231

NF3A Restitutio in integrum

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Effective date: 20041215