PT96287A - Processo para a preparacao de derivados do acido 2-formilbenzilfosfonico e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de derivados do acido 2-formilbenzilfosfonico e de composicoes farmaceuticas que os contem

Info

Publication number: PT96287A
Authority: PT; Portugal
Prior art keywords: contain; alkynyl; cycloalkyl; alkenyl; hydrogen
Prior art date: 1989-12-21

Application number

PT96287A

Other languages

English (en)

Other versions

PT96287B (pt

Inventor

Eugen Uhlmann

Anuschirwan Peyman

Irvin Winkler

Matthias Helsberg

Christoph Meichsner

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-21

Filing date

1990-12-20

Publication date

1991-09-30

1990-12-20 Application filed by Hoechst Ag filed Critical Hoechst Ag

1991-09-30 Publication of PT96287A publication Critical patent/PT96287A/pt

1998-06-30 Publication of PT96287B publication Critical patent/PT96287B/pt

Links

239000002253 acid Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000304 alkynyl group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
125000003172 aldehyde group Chemical group 0.000 abstract 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
229910052782 aluminium Inorganic materials 0.000 abstract 1
239000004411 aluminium Substances 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
-1 cyclic diester Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000651 prodrug Chemical group 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PT96287A 1989-12-21 1990-12-20 Processo para a preparacao de derivados do acido 2-formilbenzilfosfonico e de composicoes farmaceuticas que os contem PT96287B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3942318A DE3942318A1 (de)	1989-12-21	1989-12-21	2-formylbenzylphosphonsaeure-derivate, deren herstellung und ihre verwendung zur behandlung von durch viren verursachte krankheiten

Publications (2)

Publication Number	Publication Date
PT96287A true PT96287A (pt)	1991-09-30
PT96287B PT96287B (pt)	1998-06-30

Family

ID=6396038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96287A PT96287B (pt)	1989-12-21	1990-12-20	Processo para a preparacao de derivados do acido 2-formilbenzilfosfonico e de composicoes farmaceuticas que os contem

Country Status (17)

Country	Link
EP (1)	EP0433928B1 (pt)
JP (1)	JP2997552B2 (pt)
KR (1)	KR100191087B1 (pt)
AT (1)	ATE119908T1 (pt)
AU (1)	AU640723B2 (pt)
CA (1)	CA2032772C (pt)
DE (2)	DE3942318A1 (pt)
FI (1)	FI102280B (pt)
HU (1)	HU208144B (pt)
IE (1)	IE67439B1 (pt)
IL (1)	IL96730A (pt)
NO (1)	NO179614C (pt)
NZ (1)	NZ236554A (pt)
PL (1)	PL288361A1 (pt)
PT (1)	PT96287B (pt)
RU (1)	RU2039063C1 (pt)
ZA (1)	ZA9010269B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2116790C1 (ru) *	1997-07-02	1998-08-10	Закрытое акционерное общество "Рефарм"	Наружное противоинфекционное средство "рефарм"
JP2006335737A (ja) *	2005-06-03	2006-12-14	Ihara Nikkei Kagaku Kogyo Kk	ベンゾ［ｃ］ヘテロ５員環化合物の製造方法
CA2616314A1 (en) *	2005-07-27	2007-02-01	Gilead Sciences, Inc.	Antiviral phosphonate conjugates for inhibition of hiv
JP5789430B2 (ja)	2011-06-27	2015-10-07	イハラニッケイ化学工業株式会社	２−クロロメチルベンズアルデヒドの製造方法、２−クロロメチルベンズアルデヒド含有組成物及びその保管方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4918064A (en) *	1987-10-21	1990-04-17	G. D. Searle & Co.	Phenyl glycines for use in reducing neurotoxic injury

1989
- 1989-12-21 DE DE3942318A patent/DE3942318A1/de not_active Withdrawn
1990
- 1990-12-15 DE DE59008715T patent/DE59008715D1/de not_active Expired - Fee Related
- 1990-12-15 AT AT90124305T patent/ATE119908T1/de not_active IP Right Cessation
- 1990-12-15 EP EP90124305A patent/EP0433928B1/de not_active Expired - Lifetime
- 1990-12-19 NZ NZ236554A patent/NZ236554A/en unknown
- 1990-12-19 FI FI906268A patent/FI102280B/fi not_active IP Right Cessation
- 1990-12-19 IL IL9673090A patent/IL96730A/en not_active IP Right Cessation
- 1990-12-20 ZA ZA9010269A patent/ZA9010269B/xx unknown
- 1990-12-20 PT PT96287A patent/PT96287B/pt not_active IP Right Cessation
- 1990-12-20 JP JP2417963A patent/JP2997552B2/ja not_active Expired - Fee Related
- 1990-12-20 AU AU68304/90A patent/AU640723B2/en not_active Ceased
- 1990-12-20 PL PL28836190A patent/PL288361A1/xx unknown
- 1990-12-20 IE IE462590A patent/IE67439B1/en not_active IP Right Cessation
- 1990-12-20 NO NO905521A patent/NO179614C/no unknown
- 1990-12-20 RU SU4894049/04A patent/RU2039063C1/ru not_active IP Right Cessation
- 1990-12-20 CA CA002032772A patent/CA2032772C/en not_active Expired - Fee Related
- 1990-12-21 KR KR1019900021297A patent/KR100191087B1/ko not_active Expired - Fee Related
- 1990-12-21 HU HU908412A patent/HU208144B/hu not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT96287B (pt)	1998-06-30
AU640723B2 (en)	1993-09-02
EP0433928B1 (de)	1995-03-15
CA2032772A1 (en)	1991-06-22
AU6830490A (en)	1991-06-27
KR910011874A (ko)	1991-08-07
HUT56111A (en)	1991-07-29
FI102280B1 (fi)	1998-11-13
IE67439B1 (en)	1996-04-03
PL288361A1 (en)	1992-07-13
EP0433928A1 (de)	1991-06-26
NO905521L (no)	1991-06-24
JP2997552B2 (ja)	2000-01-11
IL96730A (en)	1996-10-31
DE59008715D1 (de)	1995-04-20
CA2032772C (en)	2001-10-23
JPH0616685A (ja)	1994-01-25
KR100191087B1 (ko)	1999-06-15
RU2039063C1 (ru)	1995-07-09
ATE119908T1 (de)	1995-04-15
FI906268A0 (fi)	1990-12-19
ZA9010269B (en)	1991-09-25
NO179614B (no)	1996-08-05
FI906268L (fi)	1991-06-22
DE3942318A1 (de)	1991-06-27
NO179614C (no)	1996-11-13
HU208144B (en)	1993-08-30
FI102280B (fi)	1998-11-13
IL96730A0 (en)	1991-09-16
NO905521D0 (no)	1990-12-20
NZ236554A (en)	1992-12-23
IE904625A1 (en)	1991-07-17

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Legal Events

Date	Code	Title	Description
1991-09-30	BB1A	Laying open of patent application	Effective date: 19910509
1998-06-30	FG3A	Patent granted, date of granting	Effective date: 19980320
2001-06-29	PC3A	Transfer or assignment	Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE
2003-12-31	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20030930