PT96852A - Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole - Google Patents

Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole

Info

Publication number: PT96852A
Authority: PT; Portugal
Prior art keywords: tetrahydrobenz; aminocarbonyl; propyl; amino; indole
Prior art date: 1990-02-26

Application number

PT96852A

Other languages

English (en)

Other versions

PT96852B (pt

Inventor

Thomas Joseph Kress

David Lee Varie

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1991-02-22

Publication date

1991-10-31

1991-02-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1991-10-31 Publication of PT96852A publication Critical patent/PT96852A/pt

1998-07-31 Publication of PT96852B publication Critical patent/PT96852B/pt

Links

YTOJFUORFUYGSV-UHFFFAOYSA-N 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide Chemical compound C1=C(C(N)=O)C(CC(N(CCC)CCC)C2)=C3C2=CNC3=C1 YTOJFUORFUYGSV-UHFFFAOYSA-N 0.000 title abstract 2
150000003839 salts Chemical class 0.000 title 1
QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT96852A 1990-02-26 1991-02-22 Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole PT96852B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48518590A	1990-02-26	1990-02-26

Publications (2)

Publication Number	Publication Date
PT96852A true PT96852A (pt)	1991-10-31
PT96852B PT96852B (pt)	1998-07-31

Family

ID=23927224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96852A PT96852B (pt)	1990-02-26	1991-02-22	Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole

Country Status (28)

Country	Link
US (1)	US5397799A (pt)
EP (1)	EP0444852B1 (pt)
JP (1)	JP3157007B2 (pt)
KR (1)	KR100208114B1 (pt)
CN (1)	CN1027503C (pt)
AT (1)	ATE126506T1 (pt)
AU (1)	AU629453B2 (pt)
BR (1)	BR9100767A (pt)
CA (1)	CA2037099C (pt)
CY (1)	CY1887A (pt)
DE (1)	DE69112099T2 (pt)
DK (1)	DK0444852T3 (pt)
ES (1)	ES2077796T3 (pt)
FI (1)	FI95464C (pt)
GR (1)	GR3017940T3 (pt)
HK (1)	HK175495A (pt)
HU (1)	HU217118B (pt)
IE (1)	IE67801B1 (pt)
IL (1)	IL97306A (pt)
LV (1)	LV10251B (pt)
NO (1)	NO174149C (pt)
NZ (1)	NZ237181A (pt)
PT (1)	PT96852B (pt)
RU (2)	RU2034837C1 (pt)
SG (1)	SG69975A1 (pt)
TW (1)	TW219933B (pt)
YU (1)	YU47594B (pt)
ZA (1)	ZA911258B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
IL97309A (en) *	1990-02-26	1996-11-14	Lilly Co Eli	Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
US5648356A (en) *	1991-03-28	1997-07-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (pt) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
UA53205C2 (en) *	2002-04-03	2006-06-15	Pharmatech Close Joint Stock C	Antidepressant formulation and method for its manufacture
US7588924B2 (en)	2006-03-07	2009-09-15	Procter & Gamble Company	Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
PL3357911T3 (pl)	2006-06-26	2022-09-05	Akebia Therapeutics Inc.	Inhibitory prolilohydroksylazy i sposoby ich użycia
RS54010B1 (sr)	2009-11-06	2015-10-30	Aerpio Therapeutics Inc.	Inhibitori prolil hidroksilaze
WO2012170439A1 (en)	2011-06-06	2012-12-13	The Ohio State University	Methods for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NO2686520T3 (pt)	2011-06-06	2018-03-17
JP2016521747A (ja)	2013-06-13	2016-07-25	アケビアセラピューティクスインコーポレイテッドＡｋｅｂｉａＴｈｅｒａｐｅｕｔｉｃｓＩｎｃ．	貧血治療のための組成物及び方法
MY180626A (en)	2013-11-15	2020-12-03	Akebia Therapeutics Inc	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
US10150734B2 (en)	2015-01-23	2018-12-11	Akebia Therapeutics, Inc.	Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
US11324734B2 (en)	2015-04-01	2022-05-10	Akebia Therapeutics, Inc.	Compositions and methods for treating anemia
US11713298B2 (en)	2018-05-09	2023-08-01	Akebia Therapeutics, Inc.	Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
WO2021117767A1 (ja)	2019-12-10	2021-06-17	田辺三菱製薬株式会社	含窒素ヘテロアリールカルボキサミド酢酸誘導体の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
1991
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active Expired - Fee Related
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown

Also Published As

Publication number	Publication date
CY1887A (en)	1996-04-05
EP0444852A3 (en)	1992-02-19
FI95464C (fi)	1996-02-12
DK0444852T3 (da)	1995-12-11
HU217118B (hu)	1999-11-29
LV10251B (en)	1995-04-20
PT96852B (pt)	1998-07-31
RU2083561C1 (ru)	1997-07-10
YU47594B (sh)	1995-10-24
DE69112099D1 (de)	1995-09-21
FI910895L (fi)	1991-08-27
IE67801B1 (en)	1996-05-01
CN1027503C (zh)	1995-01-25
HUT56542A (en)	1991-09-30
EP0444852B1 (en)	1995-08-16
FI95464B (fi)	1995-10-31
NO174149B (no)	1993-12-13
TW219933B (pt)	1994-02-01
LV10251A (lv)	1994-10-20
JP3157007B2 (ja)	2001-04-16
ES2077796T3 (es)	1995-12-01
GR3017940T3 (en)	1996-02-29
IL97306A0 (en)	1992-05-25
YU32791A (sh)	1994-01-20
IE910625A1 (en)	1991-08-28
AU7197191A (en)	1991-08-29
US5397799A (en)	1995-03-14
IL97306A (en)	1996-10-16
JPH04217662A (ja)	1992-08-07
BR9100767A (pt)	1991-10-29
NO174149C (no)	1994-03-23
ZA911258B (en)	1992-10-28
EP0444852A2 (en)	1991-09-04
HK175495A (en)	1995-11-24
SG69975A1 (en)	2000-01-25
NZ237181A (en)	1992-06-25
DE69112099T2 (de)	1996-02-08
RU2034837C1 (ru)	1995-05-10
CA2037099C (en)	2001-09-11
NO910735L (no)	1991-08-27
CA2037099A1 (en)	1991-08-27
CN1054589A (zh)	1991-09-18
FI910895A0 (fi)	1991-02-25
KR100208114B1 (ko)	1999-07-15
KR910021375A (ko)	1991-12-20
AU629453B2 (en)	1992-10-01
ATE126506T1 (de)	1995-09-15
NO910735D0 (no)	1991-02-25

Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910704

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980408

2007-10-19

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20071008

Publication	Publication Date	Title
PT96852A (pt)	1991-10-31	Processo para a preparacao de um sal cristalino de 4-(di-n-propil)amino-6-aminocarbonil-1,3,4,5-tetra-hidrobenz{cd}indole
GB2187456B (en)	1990-04-18	Dyeing compoitions for keratinous fibres based on indole derivatives, and new compounds
DK29989A (da)	1989-07-26	Bifunktionelt vaekstmodulerende glycoprotein benaevnt amphiregulin
FI883744L (fi)	1989-02-14	Menetelmä valmistaa farmaseuttisesti käyttökelpoisia indolijohdoksia
ZA875690B (en)	1988-02-11	Apparatus for performing ophthalmic laser surgery
PT97906A (pt)	1992-03-31	Processo para a preparacao de novos derivados de tiofeno
GR871752B (en)	1988-03-17	Method for dying keratin fibres with indol derivatives combined withiodide salts
RU92004575A (ru)	1995-09-27	Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
PT100041A (pt)	1993-03-31	Processo para a preparacao de derivados de indol e de composicoes farmaceuticas que os contem
NO913745L (no)	1992-03-26	Fremgangsmaate for fremstilling av 1,3-benzoksazinderivater
AU7306891A (en)	1991-07-24	Hydrothermal process for growing optical-quality single crystals
FI905536A7 (fi)	1991-05-14	Menetelmä N-glykosidijohdannaisten valmistamiseksi
MX9200793A (es)	1992-08-01	Tetrahidropirinas y metodo para su preparacion.
ES2061481T3 (es)	1994-12-16	Derivados de 3,4-dihidrobenzoazina opticamente activos y procedimiento para la preparacion de los mismos.
AU586757B2 (en)	1989-07-20	Lid for improved dendritic web growth
DE68900145D1 (de)	1991-08-22	Brillengestell-traeger fuer eine reproduzier-maschine.
AU590603B2 (en)	1989-11-09	A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU1741592A (en)	1992-10-21	Improved process for preparing benzenesulfonate salts
FI890658A7 (fi)	1989-08-13	Menetelmä 1,2-disulfoniyhdisteiden valmistamiseksi
KR900005865A (ko)	1990-04-14	1,3,5-티아디아진-4-온 유도체의 제조방법
EP0275104A3 (en)	1989-08-30	Process for preparing 2,3-dihydro-1h-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts
FI924769A7 (fi)	1993-04-26	Menetelmä substituoitujen indolien valmistamiseksi
EP0951815A3 (en)	2000-12-20	Flail cutter for brush cutting maching
ZA912473B (en)	1992-12-30	Epithelins:novel cysteine-rich growth modulating proteins
KR900009464A (ko)	1990-07-04	GaAs단결정 성장방법