PT96973A - Processo para a preparacao de precursores acilados de o-3-amino-3-desoxi-alfa-d-glucopiranosil (1-->6)-o-6-amino-6-desoxi-alfa-d-glucopiranosil-(1-->4)-n'-(4-amino-2-hidroxi-1-oxobutil)-2-desoxi-d-estreptamina (amicacina) - Google Patents

Processo para a preparacao de precursores acilados de o-3-amino-3-desoxi-alfa-d-glucopiranosil (1-->6)-o-6-amino-6-desoxi-alfa-d-glucopiranosil-(1-->4)-n'-(4-amino-2-hidroxi-1-oxobutil)-2-desoxi-d-estreptamina (amicacina)

Info

Publication number: PT96973A
Authority: PT; Portugal
Prior art keywords: amino; deoxy; acyl; glucopyranosyl; kanamycin
Prior art date: 1990-03-08

Application number

PT96973A

Other languages

English (en)

Other versions

PT96973B (pt

Inventor

Leone Dall Asta

Engenio Garegnani

Original Assignee

Opos Biochimica Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-08

Filing date

1991-03-07

Publication date

1991-10-31

1990-03-08 Priority claimed from IT19620A external-priority patent/IT1239940B/it

1990-07-30 Priority claimed from IT02112790A external-priority patent/IT1243380B/it

1991-03-07 Application filed by Opos Biochimica Srl filed Critical Opos Biochimica Srl

1991-10-31 Publication of PT96973A publication Critical patent/PT96973A/pt

1998-07-31 Publication of PT96973B publication Critical patent/PT96973B/pt

Links

-1 1-cyclohexyl Chemical group 0.000 title 2
LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title 1
229960004821 amikacin Drugs 0.000 title 1
229960000318 kanamycin Drugs 0.000 abstract 5
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 3
229930182823 kanamycin A Natural products 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
229910052782 aluminium Inorganic materials 0.000 abstract 2
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000536 complexating effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PT96973A 1990-03-08 1991-03-07 Processo para a preparacao de precursores acilados de o-3-amino-3-desoxi-alfa-d-glucopiranosil (1-->6)-o-6-amino-6-desoxi-alfa-d-glucopiranosil-(1-->4)-n'-(4-amino-2-hidroxi-1-oxobutil)-2-desoxi-d-estreptamina (amicacina) PT96973B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT19620A IT1239940B (it)	1990-03-08	1990-03-08	Procedimento per la preparazione di precursori dall'amikacina
IT02112790A IT1243380B (it)	1990-07-30	1990-07-30	Procedimento per la preparazione di precursori di amikacina

Publications (2)

Publication Number	Publication Date
PT96973A true PT96973A (pt)	1991-10-31
PT96973B PT96973B (pt)	1998-07-31

Family

ID=26327238

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96973A PT96973B (pt)	1990-03-08	1991-03-07	Processo para a preparacao de precursores acilados de o-3-amino-3-desoxi-alfa-d-glucopiranosil (1-->6)-o-6-amino-6-desoxi-alfa-d-glucopiranosil-(1-->4)-n'-(4-amino-2-hidroxi-1-oxobutil)-2-desoxi-d-estreptamina (amicacina)

Country Status (7)

Country	Link
US (2)	US5656735A (pt)
EP (1)	EP0446670B1 (pt)
JP (1)	JP2502412B2 (pt)
AT (1)	ATE111917T1 (pt)
BR (1)	BR9100921A (pt)
DE (1)	DE69104092T2 (pt)
PT (1)	PT96973B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0446670B1 (en) *	1990-03-08	1994-09-21	Biochimica Opos Spa	Method of preparation of amikacin precursors
TW465235B (en)	1998-09-17	2001-11-21	United Video Properties Inc	Electronic program guide with digital storage
US7794713B2 (en)	2004-04-07	2010-09-14	Lpath, Inc.	Compositions and methods for the treatment and prevention of hyperproliferative diseases
MX348936B (es)	2005-09-29	2017-07-03	Nektar Therapeutics	Formulaciones de antibioticos, dosis unitarias, equipos y metodos.
US20080213274A1 (en) *	2005-10-28	2008-09-04	Sabbadini Roger A	Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) *	2005-10-28	2009-03-19	Sabbadini Roger A	Methods for decreasing immune response and treating immune conditions
US7862812B2 (en)	2006-05-31	2011-01-04	Lpath, Inc.	Methods for decreasing immune response and treating immune conditions
WO2010031820A1 (en) *	2008-09-19	2010-03-25	Novartis Ag	Glucoside derivatives and uses thereof as sglt inhibitors
CN102256989B (zh)	2008-10-03	2016-01-06	聚糖生物科学有限责任公司	糖基化细菌代谢物的阴离子轭合物
KR20120130078A (ko) *	2009-11-09	2012-11-28	메디비르 아베	신규한 1,3-옥사졸리딘 화합물 및 이의 레닌 억제제로서의 용도

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4140849A (en) *	1977-05-23	1979-02-20	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	Kanamycin C derivatives
JPS5564598A (en) *	1978-11-11	1980-05-15	Microbial Chem Res Found	Preparation of aminoglycoside antibiotic having selectively protected amino group
IE48972B1 (en) *	1978-11-11	1985-06-26	Microbial Chem Res Found	The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
IT1200774B (it) *	1985-10-10	1989-01-27	Pierrel Spa	Procedimento di sentisi dell'amikacina
IT1237490B (it) *	1989-09-22	1993-06-07	Chementecno S R L Monza Milano	Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
EP0446670B1 (en) *	1990-03-08	1994-09-21	Biochimica Opos Spa	Method of preparation of amikacin precursors
DE9002998U1 (de) *	1990-03-12	1991-07-18	Vießmann, Hans, Dr.h.c., 3559 Battenberg	Heizkessel

1991
- 1991-02-20 EP EP91102411A patent/EP0446670B1/en not_active Expired - Lifetime
- 1991-02-20 AT AT91102411T patent/ATE111917T1/de not_active IP Right Cessation
- 1991-02-20 DE DE69104092T patent/DE69104092T2/de not_active Expired - Fee Related
- 1991-03-07 PT PT96973A patent/PT96973B/pt not_active IP Right Cessation
- 1991-03-07 BR BR919100921A patent/BR9100921A/pt not_active Application Discontinuation
- 1991-03-08 JP JP3043854A patent/JP2502412B2/ja not_active Expired - Lifetime
1995
- 1995-03-10 US US08/402,328 patent/US5656735A/en not_active Expired - Fee Related
- 1995-06-02 US US08/459,649 patent/US5621085A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5656735A (en)	1997-08-12
EP0446670B1 (en)	1994-09-21
JPH04211696A (ja)	1992-08-03
EP0446670A1 (en)	1991-09-18
PT96973B (pt)	1998-07-31
DE69104092T2 (de)	1995-01-26
JP2502412B2 (ja)	1996-05-29
BR9100921A (pt)	1991-11-05
DE69104092D1 (de)	1994-10-27
ATE111917T1 (de)	1994-10-15
US5621085A (en)	1997-04-15

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Legal Events

Date

Code

Title

Description

1991-10-31

BB1A

Laying open of patent application

Effective date: 19910710

1998-07-31

FG3A

Patent granted, date of granting

Effective date: 19980416

2000-02-29

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19991031