PT97692A - Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico) - Google Patents

Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico)

Info

Publication number: PT97692A
Authority: PT; Portugal
Prior art keywords: methyl; preparation; aspartic acid; heterocyclic derivatives; nmda antagonist
Prior art date: 1990-05-17

Application number

PT97692A

Other languages

English (en)

Other versions

PT97692B (pt

Inventor

Jeffrey Paul Whitten

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-17

Filing date

1991-05-16

Publication date

1992-02-28

1991-05-16 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-02-28 Publication of PT97692A publication Critical patent/PT97692A/pt

1998-09-30 Publication of PT97692B publication Critical patent/PT97692B/pt

Links

HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 2
HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 title 1
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 1
MNQZHTRAKIMKJF-UHFFFAOYSA-N piperidin-3-ylphosphonic acid Chemical class OP(O)(=O)C1CCCNC1 MNQZHTRAKIMKJF-UHFFFAOYSA-N 0.000 abstract 1
150000003235 pyrrolidines Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

PT97692A 1990-05-17 1991-05-16 Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico) PT97692B (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US52529090A	1990-05-17	1990-05-17
US07/675,156 US5194430A (en)	1990-05-17	1991-03-28	Heterocyclic-nmda antagonists

Publications (2)

Publication Number	Publication Date
PT97692A true PT97692A (pt)	1992-02-28
PT97692B PT97692B (pt)	1998-09-30

Family

ID=27061745

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97692A PT97692B (pt)	1990-05-17	1991-05-16	Processo para a preparacao de derivados heterociclicos antagonistas de nmda (acido n-metil-d-aspartico)

Country Status (20)

Country	Link
US (2)	US5194430A (pt)
EP (1)	EP0457324B1 (pt)
JP (1)	JP2977950B2 (pt)
KR (1)	KR100196239B1 (pt)
CN (1)	CN1027695C (pt)
AT (1)	ATE131172T1 (pt)
AU (1)	AU641657B2 (pt)
CA (1)	CA2042473C (pt)
DE (1)	DE69115116T2 (pt)
DK (1)	DK0457324T3 (pt)
ES (1)	ES2083478T3 (pt)
FI (1)	FI97388C (pt)
GR (1)	GR3019047T3 (pt)
HU (1)	HU208831B (pt)
IE (1)	IE70437B1 (pt)
IL (1)	IL98148A (pt)
NO (1)	NO300502B1 (pt)
NZ (1)	NZ238124A (pt)
PT (1)	PT97692B (pt)
TW (1)	TW308596B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5260286A (en) *	1992-10-16	1993-11-09	Japan Tobacco, Inc.	2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists
WO2002072542A2 (en) *	2001-03-08	2002-09-19	Emory University	Ph-dependent nmda receptor antagonists
CN103058957A (zh)	2007-06-29	2013-04-24	埃莫里大学	用于神经保护的nmda受体拮抗剂
CN102952065A (zh) *	2011-08-24	2013-03-06	重庆华邦胜凯制药有限公司	一种拆分顺式2,3-吡啶二甲酸酯的方法
CN102952130B (zh) *	2011-08-24	2016-03-23	重庆华邦胜凯制药有限公司	手性合成(s,s)-2,8-二氮杂双环壬烷的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2706194A (en) *	1951-05-14	1955-04-12	Shell Dev	Esters of phosphonic acids
NL299935A (pt) *	1963-10-30	1965-08-25
JPS5251028A (en) *	1975-10-22	1977-04-23	Nippon Tokushu Noyaku Seizo Kk	Herbicide
US4094974A (en) *	1977-02-24	1978-06-13	Stauffer Chemical Company	Isoxazole phosphates and phosphonates
US4139708A (en) *	1977-05-24	1979-02-13	Sk&F Lab Co.	Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts
CA1248531A (en) *	1984-04-17	1989-01-10	Jeffrey C. Watkins	4-substituted piperazine-2-carboxylic acids
US4906621A (en) *	1985-05-24	1990-03-06	Ciba-Geigy Corporation	Certain 2-carboxypiperidyl-alkylene phosphonic acids and esters thereof useful for the treatment of disorders responsive to N-methyl-D-aspartate receptor blockade
PH23848A (en) *	1985-05-24	1989-11-23	Ciba Geigy Ag	Certain phosphonic acids and derivatives
US4746653A (en) *	1986-02-28	1988-05-24	Ciba-Geigy Corporation	Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
US4657899A (en) *	1986-04-09	1987-04-14	Nova Pharmaceutical Corporation	Antagonists of specific excitatory amino acid neurotransmitter receptors
IL84492A0 (en) *	1986-11-21	1988-04-29	Ciba Geigy Ag	Unsaturated phosphonic acids and derivatives
SE9003652D0 (sv) *	1990-11-15	1990-11-15	Astra Ab	New heterocyclic compounds

1991
- 1991-03-28 US US07/675,156 patent/US5194430A/en not_active Expired - Fee Related
- 1991-05-13 NZ NZ238124A patent/NZ238124A/xx unknown
- 1991-05-13 CA CA002042473A patent/CA2042473C/en not_active Expired - Fee Related
- 1991-05-14 AU AU76498/91A patent/AU641657B2/en not_active Ceased
- 1991-05-14 TW TW080103761A patent/TW308596B/zh active
- 1991-05-15 IL IL9814891A patent/IL98148A/en active IP Right Grant
- 1991-05-16 FI FI912382A patent/FI97388C/fi not_active IP Right Cessation
- 1991-05-16 DK DK91107955.6T patent/DK0457324T3/da active
- 1991-05-16 PT PT97692A patent/PT97692B/pt not_active IP Right Cessation
- 1991-05-16 DE DE69115116T patent/DE69115116T2/de not_active Expired - Fee Related
- 1991-05-16 NO NO911916A patent/NO300502B1/no not_active IP Right Cessation
- 1991-05-16 EP EP91107955A patent/EP0457324B1/en not_active Expired - Lifetime
- 1991-05-16 CN CN91103185A patent/CN1027695C/zh not_active Expired - Fee Related
- 1991-05-16 ES ES91107955T patent/ES2083478T3/es not_active Expired - Lifetime
- 1991-05-16 IE IE167691A patent/IE70437B1/en unknown
- 1991-05-16 AT AT91107955T patent/ATE131172T1/de not_active IP Right Cessation
- 1991-05-16 HU HU911649A patent/HU208831B/hu not_active IP Right Cessation
- 1991-05-17 KR KR1019910008036A patent/KR100196239B1/ko not_active Expired - Fee Related
- 1991-05-17 JP JP3140636A patent/JP2977950B2/ja not_active Expired - Fee Related
1993
- 1993-11-30 US US08/159,913 patent/US5470844A/en not_active Expired - Lifetime
1996
- 1996-02-21 GR GR960400451T patent/GR3019047T3/el unknown

Also Published As

Publication number	Publication date
FI912382A0 (fi)	1991-05-16
PT97692B (pt)	1998-09-30
AU7649891A (en)	1991-11-21
ATE131172T1 (de)	1995-12-15
EP0457324B1 (en)	1995-12-06
KR100196239B1 (ko)	1999-06-15
DK0457324T3 (da)	1996-01-02
CN1056499A (zh)	1991-11-27
FI97388C (fi)	1996-12-10
IL98148A (en)	1996-10-16
FI97388B (fi)	1996-08-30
HUT59150A (en)	1992-04-28
CA2042473A1 (en)	1991-11-18
DE69115116D1 (de)	1996-01-18
TW308596B (pt)	1997-06-21
HU208831B (en)	1994-01-28
FI912382A7 (fi)	1991-11-18
US5470844A (en)	1995-11-28
NO911916L (no)	1991-11-18
CA2042473C (en)	2002-01-01
ES2083478T3 (es)	1996-04-16
AU641657B2 (en)	1993-09-30
DE69115116T2 (de)	1996-06-13
IE70437B1 (en)	1996-11-27
NO911916D0 (no)	1991-05-16
CN1027695C (zh)	1995-02-22
KR910020023A (ko)	1991-12-19
IE911676A1 (en)	1991-11-20
GR3019047T3 (en)	1996-05-31
NZ238124A (en)	1993-09-27
JP2977950B2 (ja)	1999-11-15
US5194430A (en)	1993-03-16
NO300502B1 (no)	1997-06-09
EP0457324A1 (en)	1991-11-21
HU911649D0 (en)	1991-11-28
JPH0812691A (ja)	1996-01-16

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Legal Events

Date	Code	Title	Description
1992-02-28	BB1A	Laying open of patent application	Effective date: 19911028
1998-09-30	FG3A	Patent granted, date of granting	Effective date: 19980602
2002-04-29	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20011231
2002-08-30	NF3A	Restitutio in integrum	Free format text: 20020604 RESTITUTIO IN INTEGRUM
2005-02-28	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20041202