PT97734A - Processo para a preparacao de trifluorometilfeniltetrahidropiridinas n-substituidas, de intermediarios para a execucao do processo, e de composicoes farmaceuticas que as contem - Google Patents

Processo para a preparacao de trifluorometilfeniltetrahidropiridinas n-substituidas, de intermediarios para a execucao do processo, e de composicoes farmaceuticas que as contem

Info

Publication number
PT97734A
PT97734A PT97734A PT9773491A PT97734A PT 97734 A PT97734 A PT 97734A PT 97734 A PT97734 A PT 97734A PT 9773491 A PT9773491 A PT 9773491A PT 97734 A PT97734 A PT 97734A
Authority
PT
Portugal
Prior art keywords
substituted
naphthyl
group
trifluoromethylphenyripyridines
intermediaries
Prior art date
Application number
PT97734A
Other languages
English (en)
Other versions
PT97734B (pt
Inventor
Umberto Guzzi
Constantino Palmieri
Tiziano Croci
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of PT97734A publication Critical patent/PT97734A/pt
Publication of PT97734B publication Critical patent/PT97734B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT97734A 1990-05-23 1991-05-22 Processo para a preparacao de trifluorometilfeniltetrahidropiridinas n-substituidas, de intermediarios para a execucao do processo, e de composicoes farmaceuticas que as contem PT97734B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9006474A FR2662442A1 (fr) 1990-05-23 1990-05-23 Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
PT97734A true PT97734A (pt) 1992-02-28
PT97734B PT97734B (pt) 1998-09-30

Family

ID=9396904

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97734A PT97734B (pt) 1990-05-23 1991-05-22 Processo para a preparacao de trifluorometilfeniltetrahidropiridinas n-substituidas, de intermediarios para a execucao do processo, e de composicoes farmaceuticas que as contem

Country Status (9)

Country Link
US (5) US5281606A (pt)
EP (1) EP0458697B1 (pt)
JP (1) JP2610718B2 (pt)
AT (1) ATE109135T1 (pt)
CA (1) CA2043136C (pt)
DE (1) DE69103087T2 (pt)
FR (1) FR2662442A1 (pt)
IE (1) IE65540B1 (pt)
PT (1) PT97734B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672213B1 (fr) * 1991-02-05 1995-03-10 Sanofi Sa Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres.
FR2690158B1 (fr) * 1992-04-17 1994-07-22 Sanofi Elf Nouveau derive arylpiperidinique, procede pour sa preparation et compositions pharmaceutiques le contenant.
CA2279326A1 (fr) * 1997-02-03 1998-08-06 Sanofi-Synthelabo Utilisation du 1-[4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyrid-1yl]-2-(6,7-dimethoxynapht-2-yl)ethane pour la preparation de medicaments destines aux traitements de troubles cerebraux et neuronaux
FR2763847B1 (fr) 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
US7666052B2 (en) * 2001-10-01 2010-02-23 Lionel L.L.C. Variable-heat smoke unit for model vehicle
FR2831166B1 (fr) * 2001-10-18 2004-02-27 Sanofi Synthelabo Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
UA80399C2 (en) * 2001-11-13 2007-09-25 Glaxo Group Ltd Use of specific dose of fondaparinux sodium for the treatment of acs
EP1581497A4 (en) * 2002-12-20 2009-03-18 Merck & Co Inc INHIBITORS OF MITOTIC KINESINE
AU2003299672B2 (en) * 2002-12-20 2010-02-25 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
MX382868B (es) 2012-09-11 2025-03-13 Norgine Bv Composiciones que comprenden polietilenglicol y ascorbato.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4934984B1 (pt) * 1969-07-12 1974-09-19
US4246268A (en) * 1979-02-09 1981-01-20 Richardson-Merrell Inc. Neuroleptic-4-(naphthylmethyl)piperidine derivatives
GB2083476B (en) * 1980-09-12 1984-02-08 Wyeth John & Brother Ltd Heterocyclic compounds
FR2531707A1 (fr) * 1982-08-16 1984-02-17 Midy Spa Trifluoromethylphenyltetrahydropyridines substituees a activite anorexigene, un procede de preparation et compositions pharmaceutiques
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
US5266573A (en) * 1989-08-07 1993-11-30 Elf Sanofi Trifluoromethylphenyltetrahydropyridines for the treatment and/or prophylaxis of intestinal motility disorders
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
FR2672213B1 (fr) * 1991-02-05 1995-03-10 Sanofi Sa Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres.

Also Published As

Publication number Publication date
US5596101A (en) 1997-01-21
IE65540B1 (en) 1995-11-01
FR2662442B1 (pt) 1994-08-19
US5599941A (en) 1997-02-04
US5559238A (en) 1996-09-24
IE911744A1 (en) 1991-12-04
US5462945A (en) 1995-10-31
FR2662442A1 (fr) 1991-11-29
US5281606A (en) 1994-01-25
JP2610718B2 (ja) 1997-05-14
DE69103087D1 (de) 1994-09-01
CA2043136A1 (en) 1991-11-24
EP0458697B1 (fr) 1994-07-27
CA2043136C (en) 1998-03-10
JPH04226959A (ja) 1992-08-17
EP0458697A1 (fr) 1991-11-27
DE69103087T2 (de) 1995-05-04
ATE109135T1 (de) 1994-08-15
PT97734B (pt) 1998-09-30

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19911028

FG3A Patent granted, date of granting

Effective date: 19980615

PC3A Transfer or assignment

Free format text: SANOFI-SYNTHELABO FR

Effective date: 20050126

PD3A Change of proprietorship

Free format text: SANOFI-AVENTIS FR

Effective date: 20050126

TE3A Change of address (patent)

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Effective date: 20050215

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

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Effective date: 20081215