PT98645A - Processo para a preparacao de 3-(1,2-benzisoxazol-3-il-)-4-piridinaminas e seus derivados - Google Patents

Processo para a preparacao de 3-(1,2-benzisoxazol-3-il-)-4-piridinaminas e seus derivados

Info

Publication number: PT98645A
Authority: PT; Portugal
Prior art keywords: pyridinamines; benzisoxazol; hydrogen; derivatives; loweralkyl
Prior art date: 1990-08-13

Application number

PT98645A

Other languages

English (en)

Other versions

PT98645B (pt

Inventor

Joseph Thomas Klein

Richard C Effland

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-13

Filing date

1991-08-12

Publication date

1992-06-30

1991-08-12 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1992-06-30 Publication of PT98645A publication Critical patent/PT98645A/pt

1999-01-29 Publication of PT98645B publication Critical patent/PT98645B/pt

Links

-1 1,2-BENZISOXAZOL-3-YL Chemical class 0.000 title abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
XFGBLXXLIPBUAV-UHFFFAOYSA-N 3-(1,2-benzoxazol-3-yl)pyridin-4-amine Chemical class NC1=CC=NC=C1C1=NOC2=CC=CC=C12 XFGBLXXLIPBUAV-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
206010039966 Senile dementia Diseases 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
230000006949 cholinergic function Effects 0.000 abstract 1
230000019771 cognition Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

PT98645A 1990-08-13 1991-08-12 Processo para a preparacao de 3-(1,2-benzisoxazol-3-il-)-4-piridinaminas e seus derivados PT98645B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/566,932 US5055476A (en)	1990-08-13	1990-08-13	3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives

Publications (2)

Publication Number	Publication Date
PT98645A true PT98645A (pt)	1992-06-30
PT98645B PT98645B (pt)	1999-01-29

Family

ID=24265033

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98645A PT98645B (pt)	1990-08-13	1991-08-12	Processo para a preparacao de 3-(1,2-benzisoxazol-3-il-)-4-piridinaminas e seus derivados

Country Status (24)

Country	Link
US (1)	US5055476A (pt)
EP (1)	EP0471297B1 (pt)
JP (1)	JP3057829B2 (pt)
KR (1)	KR100191386B1 (pt)
AT (1)	ATE130004T1 (pt)
AU (1)	AU633791B2 (pt)
CA (1)	CA2048959C (pt)
CZ (1)	CZ280568B6 (pt)
DE (1)	DE69114405T2 (pt)
DK (1)	DK0471297T3 (pt)
ES (1)	ES2079531T3 (pt)
FI (1)	FI103970B1 (pt)
GR (1)	GR3018184T3 (pt)
HU (1)	HU213201B (pt)
IE (1)	IE70597B1 (pt)
IL (1)	IL99166A (pt)
MX (1)	MX9100639A (pt)
NO (1)	NO179519C (pt)
NZ (1)	NZ239326A (pt)
PT (1)	PT98645B (pt)
RU (1)	RU2012561C1 (pt)
TW (1)	TW202446B (pt)
YU (1)	YU140991A (pt)
ZA (1)	ZA916342B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5308826A (en) *	1993-04-22	1994-05-03	Zeneca Limited	Herbicidal 4-substituted pyridyl-3-carbinols
EP0758323A1 (en) *	1994-05-02	1997-02-19	Zeneca Limited	Herbicidal hydroxybenzyl-substituted heteroaryl compounds and derivatives thereof
US5595958A (en) *	1994-05-02	1997-01-21	Zeneca Limited	3-substituted pyridine compounds and derivatives thereof
JP4263240B2 (ja) *	1995-11-09	2009-05-13	サノフィ−アベンティス	５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途
FR2762316B1 (fr) *	1997-04-18	1999-12-17	Sanofi Synthelabo	Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
US9073947B2 (en)	2011-06-10	2015-07-07	Merck Patent Gmbh	Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
RU2626650C2 (ru) *	2015-08-31	2017-07-31	Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет"	2-Арил-2,4-дигидрокси-2,5-дигидро-3-гетерил-5-оксо-1Н-пиррол-1-ил-4-метилбелзолсульфаниламиды, обладающие анальгетической активностью
EP4429465A1 (en)	2021-11-10	2024-09-18	Symrise AG	Compositions comprising trpm8 agonistic cooling agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4355037A (en) *	1981-11-12	1982-10-19	Hoechst-Roussel Pharmaceuticals	3-(4-Piperidyl)-1,2-benzisoxales
IL66866A (en) *	1982-04-09	1987-08-31	Hoechst Roussel Pharma	1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
CA1335289C (en) *	1987-10-26	1995-04-18	Fujio Antoku	Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
MY107955A (en) *	1990-07-27	1996-07-15	Ici Plc	Fungicides.

1990
- 1990-08-13 US US07/566,932 patent/US5055476A/en not_active Expired - Fee Related
1991
- 1991-08-03 TW TW080106082A patent/TW202446B/zh active
- 1991-08-08 ES ES91113335T patent/ES2079531T3/es not_active Expired - Lifetime
- 1991-08-08 DK DK91113335.3T patent/DK0471297T3/da active
- 1991-08-08 DE DE69114405T patent/DE69114405T2/de not_active Expired - Fee Related
- 1991-08-08 EP EP91113335A patent/EP0471297B1/en not_active Expired - Lifetime
- 1991-08-08 AT AT91113335T patent/ATE130004T1/de not_active IP Right Cessation
- 1991-08-09 NZ NZ239326A patent/NZ239326A/en unknown
- 1991-08-09 FI FI913800A patent/FI103970B1/fi active
- 1991-08-12 AU AU81765/91A patent/AU633791B2/en not_active Ceased
- 1991-08-12 NO NO913142A patent/NO179519C/no unknown
- 1991-08-12 MX MX9100639A patent/MX9100639A/es not_active IP Right Cessation
- 1991-08-12 CZ CS912489A patent/CZ280568B6/cs not_active IP Right Cessation
- 1991-08-12 IE IE285191A patent/IE70597B1/en not_active IP Right Cessation
- 1991-08-12 ZA ZA916342A patent/ZA916342B/xx unknown
- 1991-08-12 RU SU915001260A patent/RU2012561C1/ru active
- 1991-08-12 PT PT98645A patent/PT98645B/pt not_active IP Right Cessation
- 1991-08-12 CA CA002048959A patent/CA2048959C/en not_active Expired - Fee Related
- 1991-08-12 IL IL9916691A patent/IL99166A/en not_active IP Right Cessation
- 1991-08-12 JP JP3201713A patent/JP3057829B2/ja not_active Expired - Fee Related
- 1991-08-12 HU HU912673A patent/HU213201B/hu not_active IP Right Cessation
- 1991-08-13 KR KR1019910013939A patent/KR100191386B1/ko not_active Expired - Fee Related
- 1991-08-14 YU YU140991A patent/YU140991A/sh unknown
1995
- 1995-11-22 GR GR950403309T patent/GR3018184T3/el unknown

Also Published As

Publication number	Publication date
ZA916342B (en)	1992-04-29
CA2048959C (en)	2003-07-29
US5055476A (en)	1991-10-08
FI103970B (fi)	1999-10-29
NZ239326A (en)	1994-04-27
FI913800A0 (fi)	1991-08-09
KR920004383A (ko)	1992-03-27
HUT61755A (en)	1993-03-01
ATE130004T1 (de)	1995-11-15
DE69114405D1 (de)	1995-12-14
TW202446B (pt)	1993-03-21
ES2079531T3 (es)	1996-01-16
EP0471297B1 (en)	1995-11-08
PT98645B (pt)	1999-01-29
NO913142D0 (no)	1991-08-12
IL99166A (en)	1995-12-08
NO179519C (no)	1996-10-23
AU8176591A (en)	1992-02-20
KR100191386B1 (ko)	1999-06-15
HU912673D0 (en)	1992-01-28
RU2012561C1 (ru)	1994-05-15
CA2048959A1 (en)	1992-02-14
IE70597B1 (en)	1996-12-11
FI913800L (fi)	1992-02-14
NO913142L (no)	1992-02-14
NO179519B (no)	1996-07-15
GR3018184T3 (en)	1996-02-29
CS248991A3 (en)	1992-03-18
JP3057829B2 (ja)	2000-07-04
FI103970B1 (fi)	1999-10-29
HU213201B (en)	1997-03-28
EP0471297A1 (en)	1992-02-19
YU140991A (sh)	1995-01-31
DK0471297T3 (da)	1996-03-04
AU633791B2 (en)	1993-02-04
DE69114405T2 (de)	1996-05-02
IE912851A1 (en)	1992-02-26
MX9100639A (es)	1992-04-01
CZ280568B6 (cs)	1996-02-14
JPH05112562A (ja)	1993-05-07
IL99166A0 (en)	1992-07-15

Legal Events

Date

Code

Title

Description

1992-06-30

BB1A

Laying open of patent application

Effective date: 19920225

1999-01-29

FG3A

Patent granted, date of granting

Effective date: 19981022

2005-06-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20050422

Publication	Publication Date	Title
FI102069B1 (fi)	1998-10-15	Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi
PT91417A (pt)	1990-03-08	Processo para a preparacao de derivados indolicos
GR3030798T3 (en)	1999-11-30	2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors.
AU633791B2 (en)	1993-02-04	3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives
PT97637A (pt)	1992-02-28	Processo para a preparacao de derivados piperidiloxi- e quinuclidiniloxi-isoxazolicos e de composicoes farmaceuticas que os contem
PT92234A (pt)	1990-05-31	Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
AU640590B2 (en)	1993-08-26	3-(1h-indazol-3-yl)-4-pyridinamines
BR9200475A (pt)	1992-10-20	Composto e processo para a sua preparacao,composicao farmaceutica e uso do dito composto
MX9100638A (es)	1992-04-01	1-(piridinilalquil)-1h-indoles,indolinas y compuestos analogos afines
PT98646A (pt)	1992-06-30	Processo para a preparacao de carbamoil-1-(piridinalquil)-1h-indois indolinas e os seus analogos