PT99675A - Processo para a preparacao de conjugados de antraciclinas e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de conjugados de antraciclinas e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99675A PT99675A PT99675A PT9967591A PT99675A PT 99675 A PT99675 A PT 99675A PT 99675 A PT99675 A PT 99675A PT 9967591 A PT9967591 A PT 9967591A PT 99675 A PT99675 A PT 99675A
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- conjugates
- anthraciclin
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Temperature Or Quantity Of Heat (AREA)
- Catching Or Destruction (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909026491A GB9026491D0 (en) | 1990-12-05 | 1990-12-05 | Anthracycline-conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99675A true PT99675A (pt) | 1992-10-30 |
| PT99675B PT99675B (pt) | 1999-05-31 |
Family
ID=10686550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99675A PT99675B (pt) | 1990-12-05 | 1991-12-03 | Processo para a preparacao de conjugados de antraciclinas e de composicoes farmaceuticas que os contem |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0514515B1 (pt) |
| JP (1) | JP3169223B2 (pt) |
| KR (1) | KR100249067B1 (pt) |
| AT (1) | ATE151644T1 (pt) |
| AU (1) | AU649506B2 (pt) |
| CA (1) | CA2075288C (pt) |
| DE (1) | DE69125707T2 (pt) |
| DK (1) | DK0514515T3 (pt) |
| ES (1) | ES2103317T3 (pt) |
| FI (1) | FI103765B (pt) |
| GB (1) | GB9026491D0 (pt) |
| GR (1) | GR3024050T3 (pt) |
| HU (2) | HU221857B1 (pt) |
| IE (1) | IE914211A1 (pt) |
| IL (2) | IL114303A (pt) |
| MX (1) | MX9102357A (pt) |
| MY (1) | MY107821A (pt) |
| NZ (1) | NZ240827A (pt) |
| PT (1) | PT99675B (pt) |
| RU (1) | RU2107690C1 (pt) |
| WO (1) | WO1992010212A1 (pt) |
| ZA (1) | ZA919562B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9309663D0 (en) * | 1993-05-11 | 1993-06-23 | Erba Carlo Spa | Biologically active compounds |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| AU708475B2 (en) * | 1995-10-18 | 1999-08-05 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
| US6030941A (en) * | 1996-05-01 | 2000-02-29 | Avi Biopharma, Inc. | Polymer composition for delivering substances in living organisms |
| WO1997040854A2 (en) * | 1996-05-01 | 1997-11-06 | Antivirals Inc. | Polypeptide conjugates for transporting substances across cell membranes |
| WO1998047496A2 (en) * | 1997-04-18 | 1998-10-29 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
| US5965118A (en) * | 1997-04-18 | 1999-10-12 | Access Pharmaceuticals, Inc. | Polymer-platinum compounds |
| RU2196604C1 (ru) * | 2001-12-21 | 2003-01-20 | Северин Евгений Сергеевич | Полипептид, являющийся аналогом рецепторсвязывающего фрагмента эпидермального фактора роста с 21-й по 31-ю аминокислоту, его конъюгат с доксорубицином и фармацевтическая композиция на его основе |
| US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| WO2010009124A2 (en) * | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK160616C (da) * | 1979-02-03 | 1991-09-02 | Zaidan Hojin Biseibutsu | Fremgangsmaade til fremstilling af anthracyclinderivater eller syreadditionssalte deraf |
| JPS56156300A (en) * | 1980-04-26 | 1981-12-02 | Microbial Chem Res Found | Novel preparative method of anthracyclin derivative |
| GB2172594B (en) * | 1985-03-22 | 1988-06-08 | Erba Farmitalia | New morpholino derivatives of daunorubicin and doxorubicin |
| EP0318948B1 (en) * | 1987-12-02 | 1992-08-19 | Neorx Corporation | Cleavable immunoconjugates for the delivery and release of agents in native form |
| FI102355B1 (fi) * | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
| DE68919366T2 (de) * | 1988-09-30 | 1995-05-18 | Neorx Corp | Spaltbare linker zur reduzierung der akkumulierung von immunokonjugaten in nicht-zielorganen. |
| DE4002888A1 (de) * | 1990-02-01 | 1991-08-08 | Behringwerke Ag | Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten |
-
1990
- 1990-12-05 GB GB909026491A patent/GB9026491D0/en active Pending
-
1991
- 1991-12-02 IL IL114303A patent/IL114303A/xx not_active IP Right Cessation
- 1991-12-02 IL IL10021891A patent/IL100218A/en not_active IP Right Cessation
- 1991-12-02 NZ NZ240827A patent/NZ240827A/en not_active IP Right Cessation
- 1991-12-03 MY MYPI91002231A patent/MY107821A/en unknown
- 1991-12-03 HU HU9202544A patent/HU221857B1/hu not_active IP Right Cessation
- 1991-12-03 WO PCT/EP1991/002284 patent/WO1992010212A1/en not_active Ceased
- 1991-12-03 PT PT99675A patent/PT99675B/pt not_active IP Right Cessation
- 1991-12-03 ES ES91920862T patent/ES2103317T3/es not_active Expired - Lifetime
- 1991-12-03 DK DK91920862.9T patent/DK0514515T3/da active
- 1991-12-03 EP EP91920862A patent/EP0514515B1/en not_active Expired - Lifetime
- 1991-12-03 HU HU9602873A patent/HU222114B1/hu not_active IP Right Cessation
- 1991-12-03 KR KR1019920701869A patent/KR100249067B1/ko not_active Expired - Fee Related
- 1991-12-03 RU SU5053085/14A patent/RU2107690C1/ru not_active IP Right Cessation
- 1991-12-03 AU AU90231/91A patent/AU649506B2/en not_active Ceased
- 1991-12-03 JP JP50033692A patent/JP3169223B2/ja not_active Expired - Fee Related
- 1991-12-03 AT AT91920862T patent/ATE151644T1/de not_active IP Right Cessation
- 1991-12-03 CA CA002075288A patent/CA2075288C/en not_active Expired - Fee Related
- 1991-12-03 DE DE69125707T patent/DE69125707T2/de not_active Expired - Fee Related
- 1991-12-04 IE IE421191A patent/IE914211A1/en not_active Application Discontinuation
- 1991-12-04 MX MX9102357A patent/MX9102357A/es unknown
- 1991-12-04 ZA ZA919562A patent/ZA919562B/xx unknown
-
1992
- 1992-08-03 FI FI923499A patent/FI103765B/fi active
-
1997
- 1997-07-09 GR GR970401705T patent/GR3024050T3/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920612 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990210 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20040810 |