PT99683A - Processo para a preparacao de derivados de indoles 3-alquilados - Google Patents

Processo para a preparacao de derivados de indoles 3-alquilados

Info

Publication number: PT99683A
Authority: PT; Portugal
Prior art keywords: preparation; alked; indole derivatives; afford; reacting
Prior art date: 1990-12-05

Application number

PT99683A

Other languages

English (en)

Other versions

PT99683B (pt

Inventor

Roberts Toms Jacobs

Gerard Francis Costello

Stephen Alan Brook

Peter John Harrison

Original Assignee

Ici Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-05

Filing date

1991-12-04

Publication date

1992-10-30

1991-12-04 Application filed by Ici Plc filed Critical Ici Plc

1992-10-30 Publication of PT99683A publication Critical patent/PT99683A/pt

1999-05-31 Publication of PT99683B publication Critical patent/PT99683B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Dermatology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT99683A 1990-12-05 1991-12-04 Processo para a preparacao de derivados de indoles 3-alquilados PT99683B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909026427A GB9026427D0 (en)	1990-12-05	1990-12-05	Chemical process

Publications (2)

Publication Number	Publication Date
PT99683A true PT99683A (pt)	1992-10-30
PT99683B PT99683B (pt)	1999-05-31

Family

ID=10686509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99683A PT99683B (pt)	1990-12-05	1991-12-04	Processo para a preparacao de derivados de indoles 3-alquilados

Country Status (22)

Country	Link
US (1)	US5280125A (pt)
EP (1)	EP0489547B1 (pt)
JP (1)	JP3160040B2 (pt)
KR (1)	KR100228328B1 (pt)
AT (1)	ATE168998T1 (pt)
AU (1)	AU652002B2 (pt)
CA (1)	CA2056065C (pt)
CZ (1)	CZ282019B6 (pt)
DE (1)	DE69129894T2 (pt)
DK (1)	DK0489547T3 (pt)
ES (1)	ES2118743T3 (pt)
FI (1)	FI102170B1 (pt)
GB (1)	GB9026427D0 (pt)
HU (1)	HU222123B1 (pt)
IE (1)	IE913936A1 (pt)
IL (1)	IL100055A (pt)
NO (1)	NO175680C (pt)
NZ (1)	NZ240624A (pt)
PT (1)	PT99683B (pt)
RU (1)	RU2054417C1 (pt)
SK (1)	SK278987B6 (pt)
ZA (1)	ZA919079B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9119001D0 (en) *	1991-09-05	1991-10-23	Ici Plc	Pharmaceutical agents
WO1998015530A1 (en) *	1996-10-08	1998-04-16	Fujisawa Pharmaceutical Co., Ltd.	Indole derivatives
HN2004000536A (es) *	2003-12-16	2009-02-18	Wyeth Corp	Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
CN112457235B (zh) *	2020-12-02	2023-04-25	烟台凯博医药科技有限公司	一种7-甲基吲哚的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3976639A (en) *	1970-11-04	1976-08-24	Hoffmann-La Roche Inc.	Intermediates for indoles
US3732245A (en) *	1970-11-04	1973-05-08	Hoffmann La Roche	Process and intermediates for the preparation of indoles from ortho-nitrotoluenes
US3979410A (en) *	1974-01-21	1976-09-07	Hoffmann-La Roche Inc.	Intermediate α-acyl-β-dialkylamino-2-nitrostyrenes
US4137404A (en) *	1977-12-20	1979-01-30	Hoffmann-La Roche Inc.	Synthesis of tryptophans
US4665087A (en) *	1982-02-22	1987-05-12	Ciba-Geigy Corporation	1-(carbamyl, thiocarbamyl, and iminocarbamyl)-indoline derivatives
GB8607294D0 (en) *	1985-04-17	1986-04-30	Ici America Inc	Heterocyclic amide derivatives
GB8623429D0 (en) *	1985-10-17	1986-11-05	Ici America Inc	Carboximide derivatives
US5180728A (en) *	1989-09-25	1993-01-19	Fujisawa Pharmaceutical Company, Ltd.	Pyrimidoindole derivatives and processes for preparation thereof
GB8927981D0 (en) *	1989-12-11	1990-02-14	Ici Plc	Carbamoyl derivative
GB9026425D0 (en) *	1990-12-05	1991-01-23	Ici Plc	Process

1990
- 1990-12-05 GB GB909026427A patent/GB9026427D0/en active Pending
1991
- 1991-11-12 IE IE393691A patent/IE913936A1/en not_active IP Right Cessation
- 1991-11-14 IL IL10005591A patent/IL100055A/en active IP Right Grant
- 1991-11-15 ZA ZA919079A patent/ZA919079B/xx unknown
- 1991-11-18 NZ NZ240624A patent/NZ240624A/en not_active IP Right Cessation
- 1991-11-19 AU AU87946/91A patent/AU652002B2/en not_active Ceased
- 1991-11-22 CA CA002056065A patent/CA2056065C/en not_active Expired - Fee Related
- 1991-11-29 AT AT91311072T patent/ATE168998T1/de not_active IP Right Cessation
- 1991-11-29 EP EP91311072A patent/EP0489547B1/en not_active Expired - Lifetime
- 1991-11-29 CZ CS913633A patent/CZ282019B6/cs not_active IP Right Cessation
- 1991-11-29 DK DK91311072T patent/DK0489547T3/da active
- 1991-11-29 ES ES91311072T patent/ES2118743T3/es not_active Expired - Lifetime
- 1991-11-29 DE DE69129894T patent/DE69129894T2/de not_active Expired - Fee Related
- 1991-11-29 SK SK3633-91A patent/SK278987B6/sk unknown
- 1991-12-02 HU HU9103759A patent/HU222123B1/hu not_active IP Right Cessation
- 1991-12-04 US US07/803,315 patent/US5280125A/en not_active Expired - Fee Related
- 1991-12-04 KR KR1019910022262A patent/KR100228328B1/ko not_active Expired - Fee Related
- 1991-12-04 PT PT99683A patent/PT99683B/pt not_active IP Right Cessation
- 1991-12-04 RU SU915010306A patent/RU2054417C1/ru not_active IP Right Cessation
- 1991-12-04 NO NO914775A patent/NO175680C/no unknown
- 1991-12-05 FI FI915735A patent/FI102170B1/fi not_active IP Right Cessation
- 1991-12-05 JP JP32180091A patent/JP3160040B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0489547A1 (en)	1992-06-10
RU2054417C1 (ru)	1996-02-20
FI102170B (fi)	1998-10-30
KR100228328B1 (ko)	1999-11-01
NO914775L (no)	1992-06-09
JP3160040B2 (ja)	2001-04-23
NZ240624A (en)	1994-01-26
NO175680B (no)	1994-08-08
DE69129894D1 (de)	1998-09-03
EP0489547B1 (en)	1998-07-29
HUT60716A (en)	1992-10-28
JPH04266870A (ja)	1992-09-22
FI915735A0 (fi)	1991-12-05
SK278987B6 (sk)	1998-05-06
US5280125A (en)	1994-01-18
CS363391A3 (en)	1992-06-17
GB9026427D0 (en)	1991-01-23
AU652002B2 (en)	1994-08-11
DK0489547T3 (da)	1999-04-26
IL100055A0 (en)	1992-08-18
FI915735L (fi)	1992-06-06
DE69129894T2 (de)	1998-12-10
CA2056065A1 (en)	1992-06-06
ES2118743T3 (es)	1998-10-01
ATE168998T1 (de)	1998-08-15
PT99683B (pt)	1999-05-31
AU8794691A (en)	1992-06-11
ZA919079B (en)	1992-09-30
CZ282019B6 (cs)	1997-04-16
IL100055A (en)	1996-12-05
KR920012029A (ko)	1992-07-25
NO914775D0 (no)	1991-12-04
HU222123B1 (hu)	2003-04-28
FI102170B1 (fi)	1998-10-30
IE913936A1 (en)	1992-06-17
CA2056065C (en)	2003-07-29
NO175680C (no)	1994-11-16
HU913759D0 (en)	1992-02-28

Legal Events

Date	Code	Title	Description
1992-10-30	BB1A	Laying open of patent application	Effective date: 19920612
1999-05-31	FG3A	Patent granted, date of granting	Effective date: 19990210
2004-09-30	PC3A	Transfer or assignment	Free format text: ASTRAZENECA UK LIMITED GB Effective date: 20040722
2004-09-30	PD3A	Change of proprietorship	Free format text: SYNGENTA LIMITED GB Effective date: 20040722
2005-10-31	MM3A	Annulment or lapse	Effective date: 20050810

Publication	Publication Date	Title
PT84075B (pt)	1989-07-31	Processo para a preparacao de derivados de indol
TR199600478A1 (tr)	1997-03-21	Antidiabetik maddeler olarak, ikame edilmis N-(indol-2-karbonil)-B-alanimamidler ve türevleri.
NL300181I1 (nl)	2005-05-02	N-(pyrroloÄ2,3-dÜpyrimidine-3-ylacyl)-glutaminezuurderivaten.
DE3861178D1 (de)	1991-01-10	Nachspannendes bohrfutter.
FI924847A0 (fi)	1992-10-26	2-aminometyl-kromaner
BR8802066A (pt)	1988-11-29	Processo para preparacao de azois n-substituidos,especialmente imidazois n-substituidos
DE58904089D1 (de)	1993-05-19	Nachspannendes bohrfutter.
DE58904539D1 (de)	1993-07-08	1,3,4,5-tetrahydrobenz(c,d)indole.
PT98205A (pt)	1992-05-29	Processo para a preparacao de novos derivados beta-lactamicos
MX162676A (es)	1991-06-17	Procedimiento para la preparacion de derivados de 2-(piridilalquensulfinii.)benzimidazoles n-substituidos
NO880511L (no)	1988-08-08	Substituerte aminderivater og fremgangsmaater for deres fremstilling.
NO914775D0 (no)	1991-12-04	Fremgangsmaate for fremstilling av en 3-alkylert indol
NO860733L (no)	1986-08-29	N-(2-klor-4-trifluormethylfenyl)-3-trifluormethyl-benzensulfonamidderivat, fremgangsmaate for fremstilling av dette, og fungicid middel inneholdende dette.
BR9611683A (pt)	1999-03-02	Processo para a preparação de compostos
ES532464A0 (es)	1985-06-16	Procedimiento para la preparacion de derivados de anilina.
DK83984A (da)	1984-08-23	Phenylethylaminderivater, deres fremstilling og anvendelse som vaekstfremmende midler til dyr
DK0462837T3 (da)	2000-09-11	Fremstilling af indol-derivater
FI843667L (fi)	1984-09-19	Nya 2-/n-(2,2,5,5-tetrametyl-3- pyrrolin-3-karbonyl)/aminoderivat.
PT86771A (pt)	1988-03-01	Process for preparing 4-substituted benzamide derivatives with anticonvulsant activity
FI971492L (fi)	1997-04-10	Indolijohdannaiset 5-HT1-tyyppisinä agonisteina
TR200001122T2 (tr)	2000-08-21	Farmasötikler olarak bifenil türevleri.
ES2060930T3 (es)	1994-12-01	Preparacion de n-(3-(((aril)amino)sulfonil)-1h-1,2,4-triazol-5-il)aminas.
ES8706649A1 (es)	1987-07-01	Un procedimiento para preparar derivados de 6-amino-3-hidrazinopiridazina
PT854862E (pt)	2002-04-29	Processo para a preparacao de um aminoacido activado
DE69905376D1 (de)	2003-03-20	Enanthioauswählende synthese